|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 2 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 3 | The effect of cop- per and cadmium on 65 - zinc absorption in zinc - defi- cient and zinc supplemented rats 显示文摘 | Evans G W Grace C I and Hahn C | 1974 | Bioinorg Chem1974，3，11： | 1 |
| 4 | Elasto-plastic coupled temperature-displacement f'mite element analysis of two-dimensional rolling-sliding contact with a translating heat source 显示文摘 | Kulkami S M Rubin C A Hahn G T | 1991 | Journal of Tribology1991，113，1： | 1 |
| 5 | Thermal-Mechanical Modeling of the Rolling-Plus-Sliding with Frictional Heating of a Locomotive Wheel 显示文摘 | Gupta V Hahn G T Bostias P C et aI | 1995 | Transactions of ASME1995，117，8： | 1 |
| 6 | A fast algo- rithm for Euler's elastic method using augmented Lagrangian method显示文摘 | TAI X C HAHN J CHUNG G J | 2010 | SIAM J Imaging Sci2010，4，5： | 1 |
| 7 | Cytokine induction by streptococ- cus mutans and pulpal pathagenesis显示文摘 | Hahn C L Best A M Tew J G | 2000 | Infect Immun2000，68，12： | 1 |
| 8 | Elastoplastic finite element analysis of repeated three-di- mensional elliptical rolling contact with rail wheel prop- erties 显示文摘 | KULKARMI S M HAHN G T RUBIN C A | 1991 | ASME Journal of Tribology1991，113，3： | 1 |
| 9 | U(l)trastructure of compatible and incompatible interaction of soybean roots infected with the plant pathogenic oom ycete Phytophthora sojae显示文摘 | Enkerli K Hahn M G Mims C W | | 0，，09： | 1 |
| 10 | Tile effect of dent size on the pressure distribution and failure rolling contacts 显示文摘 | Howell M Rubin C Hahn G | 2004 | Journal of ASME2004，126，： | 1 |
| 11 | Direction of causality in inno-vation-exporting linkage:evidence from micro data on Korean manufacturing显示文摘 | HAHN C H PARK C G | 2011 | Korea and the World Econo-my2011，12，2： | 1 |
| 12 | The effect of biodiversity on carbon storage in soils显示文摘 | Gleixner G Kramer C Hahn V | | 0，，： | 1 |
| 13 | Absorption of trace element in the zinc-deficient rat 显示文摘 | Hahn C Evans G | 1975 | American Journal of Physiology1975，228，4： | 1 |
| 14 | Volume of ringer solution,dextran 70,and hypertonic saline in male volunteers显示文摘 | Srensen C Hahn R G | 1997 | Anesthesiology1997，87，2： | 1 |
| 15 | Overview of the mechanism of action of lithium in the brain,fifty-year update显示文摘 | Lenox R H Hahn C G | 2000 | J Clin Psychiatry2000，61，9： | 1 |
| 16 | Chronic intermittent hypoxia and incremental cycling exercise independently depress muscle in vitro maximal Na +,K + ATPase activity in well-trained athletes显示文摘 | AUGHEY R J GORE C J HAHN A G | 2005 | J Appl Physiol2005，98，1： | 1 |
| 17 | Use of Pi-5 (t) markers in marker assisted selection to screen for cultivars with resistance to Magnaporthe grisea 显示文摘 | Yi G Lee S K Hong Y K Cho Y C Nam M H Kim S C Han S S Wang G L Hahn T R Ronald P C Jeon J S | 2004 | Theoretical and Applied Genetics2004，109，5： | 1 |
| 18 | A survey of changes in cloud cover and cloud types over land from surface observations, 1971 -96 显示文摘 | Warren S G Eastman R M Hahn C J | 2007 | Journal of Climate2007，20，4： | 1 |
| 19 | Microstructural evolution of Cr-Mn-N austenitic steels during cold work hardening 显示文摘 | Sailer G Hahn K S Scheu C | 2006 | Materials Science and Engineering A2006，427，： | 1 |
| 20 | Characterization of indeter- minate ( lipid - poor) adrenal masses: use of washout characteristics at contrast - enhanced CT显示文摘 | Pena C S Boland G W Hahn P F | 2000 | Radiology2000，217，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员