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1全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T 2015中国药物依赖性杂志2015,24,6:3
2Early activation of IKKI3 during in vivo myocardial ischemia 显示文摘Li C Kao R L Ha T 2001Am J Physiol Heart Circ Physiol2001,280,3:1
3Physical activity-antidepressant treatment combination:impact on brainderived neurotrophic factor and behavior in an animal model显示文摘RUSSO-NEUSTADT A HA T RAMIREZ R 0,,01:1
4Serial measurement of integrated ultrasonic backscatter in human cardiac allografts for the recognition of acute rejection显示文摘Masuyama T Valantine HA Gibbons R 1990Circulation1990,81,3:1
5Longterm assessment of psychologic outcomes of orthognathic surgery显示文摘Lazaridou-Terzoudi T Kiyak HA Moore R 2003J Oral Maxillofac Surg2003,61,5:1
6An improved method for the measurementof the isotope ratio of ethanol in various samples,including alcoholic and non-alcoholic beverages显示文摘H A T T O R IR YAMADA K HA SEGAW AK 2008Rapid Communications in Mass Spectrometry2008,22,21:1
7Nitrification of ammonium-contaminated hanoi groundwater using swim- bed technology显示文摘Ha D T Kutsumoto R Koyama T 2005Japanese Journal of Water Treatment Biology2005,41,3:1
8Transforming growth factor-β in thermally injured patients with hypertrophic scars: Effect of interfron α-2b 显示文摘 Shahkowsky HA Pannu R Nedelec B Twashina T Ghahary A Taerum TV Scott PG 1999Plast And Reconstr Surg1999,102,5:1
9Evaluation of the swim-bed attached-growth process for nitrification of hanoi groundwater containing high levels of iron显示文摘Ha D T Kutsumoto R Koyama T 2005Japanese Journal of Water Treatment Biology2005,41,4:1
10New forms of teacherassessment显示文摘Ha e r t e 1 E 1991Review of Research inEducation1991,17,1:1
11Error probabilities of fast frequency- hopped MFSK with noise-normalization combining in a fading channel with partial-band interference显示文摘Robertson R C Ha T T 1992IEEE Transactions on Communications1992,40,2:1
12Efficacy of bacteriocin- containing cell-free culture supernatants from lactic acid bacteria to control Listeria monocytogenes in food显示文摘Hartmann HA Wilke T Erdmann R 2011International Journal of Food Microbiology2011,146,2:1
13查看详情显示文摘Zhou R B Kunzelmann S Webb M R Ha T 0,,:1
14高血压和增加的内皮机械牵张促进单核细胞分化和激活: STAT3,白细胞介素6和过氧化氢的作用显示文摘单核细胞在高血压中起重要作用。人体中循环的单核细胞以经典、中间和非经典形式存在。单核细胞的分化受到内皮的影响,而内皮又通过机械拉伸在高血压中被激活。为了检查增加的内皮牵张和高血压对单核细胞表型及功能的作用,Loperena等将人单核细胞与汇合的人主动脉内皮细胞一起培养,进行5%或10%的周期性拉伸;还在正常血压和高血压人群中验证循环单核细胞。刘莉 叶鹏 Loperena R Van Beusecum JP Itani HA Engel N Laroumanie F Xiao L Elijovich F Laffer CL Gnecco JS Noonan J Maffia P Jasiewicz-Honkisz B Czesnikiewicz-Guzik M Mikolajczyk T Sliwa T Dikalov S Weyand CM Guzik TJ Harrison DG 2019中华高血压杂志2019,27,1:1
15查看详情显示文摘Morrison E A DeKoster G T Dutta S Vafabakhsh R Clarkson M W Bald A Kern D Ha T Henzler-Wildman K A 0,,:1
16Error probability of fast frequency hopped MFSK with noise-normalization combining in a fading channel with partial-band interference显示文摘Robertson R C and Ha T T 1992IEEE Transactions on Communications1992,40,2:1
17Electrospinning applications in drug delivery and tissue engineering显示文摘SILL T J HA V R 2008Biomaterials2008,29,13:1
18Long term asses-sment of psychologic outcomes of orthognathic surgery显示文摘Lazaridou-Terzoudi T Kiyak HA Moore R 2003J OralMaxillofac Surg2003,61,5:1
19Physical activity-antidepressant treatment combination:impact on brain-derived neurotrophic factor and behavior in an animal model显示文摘Russo-Neustadt A Ha T Ramirez R 2001Behav Brain Res2001,120,:1
20Biocompatibility of calcium and phosphorus doped diamond -like carbon thin films synthesized by plasma immersion ion implantation and deposition 显示文摘Kwok S C H Ha P C T McKenzie D R 2006Diamond and Related Materials2006,15,:1
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