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| 1 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 2 | Thoracic myelopathy caused by ossifcation of the ligamentum fiavum: a report of 18 cases 显示文摘 | Ben Hamouda K Jemel H Haouet S | 2003 | J Neurosurg2003，2，： | 1 |
| 3 | Modeling of the thermal history of the sand casting process 显示文摘 | Sulaiman S Hamouda A M S | 2001 | Journal of Materials Processing Technology2001，113，： | 1 |
| 4 | A doubleblind randomized trial of wound and intercostal space infiltration with ropivacaine during breast cancer surgery:effects on chronic postoperative pain显示文摘 | Albi-Feldzer A Hamouda S Motamed C | 2013 | Anesthesiology2013，118，2： | 1 |
| 5 | Fatigue cracking resistance of fiber-reinforced asphalt concrete 显示文摘 | LEE S JOON RUST JONP HAMOUDA H | 2005 | Textile Research Journal2005，75，2： | 1 |
| 6 | Fabrica- tion of fiber reinforced metal matrix composites by squeeze casting technology显示文摘 | VIJAYARAM T R SULAIMAN S HAMOUDA A M S | 2006 | Journal of Materials Processing Technology2006，178，： | 1 |
| 7 | A reliable protocol for the isolation of viable,chondrogenically differentiated human mesenchymal stem cells from high-density pellet cultures显示文摘 | Ullah M Hamouda H Stich S | 2012 | Biores Open Access2012，1，6： | 1 |
| 8 | Klebsiella pneumoniae susceptibility to biocides and its association with cepA,qacΔE and qacE efflux pump genes and antibiotic resistance显示文摘 | Abuzaid A Hamouda A Amyes S G | 2012 | J Hosp Infect2012，81，2： | 1 |
| 9 | Eleven novelOXA-51-like enzymes from clinical isolates of Acineto-bacter baumannii 显示文摘 | Evans B A Brown S Hamouda A | 2007 | Clin Microbiol Infect2007，13，： | 1 |
| 10 | Fabrieation of fiber reinforced metal matrix composite by squeeze casting technology显示文摘 | VIJAYARAM T R SULAIMAN S HAMOUDA A M S | 2006 | Journal of Materials Processing Technology2006，178，： | 1 |
| 11 | Simulation of metal filling progress during the casting process 显示文摘 | Sulaiman S Hamouda AMS Abedin S | 2000 | Journal of Materials Processing Technology2000，100，8： | 1 |
| 12 | Fatigue cracking resistance of fiber reinforced asphalt concrete显示文摘 | Lee S J Rust J P Hamouda Hechmi | 2005 | Textile Research Journal2005，75，2： | 1 |
| 13 | An adap- tive-learning algorithm to solve the inverse kinematics prob- lem of a 6-DOF serial robot manipulator显示文摘 | Hasan A T Hamouda A M S Ismail N | 2006 | Advances inEngineering Software2006，37，7： | 1 |
| 14 | Put-tag: Personalized user-centric tag recommendation for social bookmarking systems 显示文摘 | Hamouda S Wanas N | 2011 | Social Network Analysis and Mining2011，1，4： | 1 |
| 15 | Thoracic myelopathy caused by ossification of the ligainentum flavum:a report of 18 cases 显示文摘 | Ben Hamouda K Jemel H Haouet S | 2003 | J Neurosurg Spine2003，99，2： | 1 |
| 16 | Nanoholes by soft UV nanoimprint lithography applied to study of membrane proteins 显示文摘 | Hamouda F Barbillon G Held S | 2009 | Microelectronic Engineering2009，86，456： | 1 |
| 17 | Surgical treatment of secondary hyperparathyroidism in patients with chronic renal failure显示文摘 | Hamouda M Ben Dhia N Aloui S | 2011 | Néphrologie & Thérapeutique2011，，： | 1 |
| 18 | Allergic rhinitis in children with asthma: a question naire-based study 显示文摘 | HAMOUDA S KARILA C CONNAULT T | 2008 | Clin Exp Allergy2008，38，： | 1 |
| 19 | Development of Machine Learning Strategy for Acquiring On--Line Machining Skills During Turning Process显示文摘 | Al Assadi H M A A Wong S V Hamouda A M S | 2004 | Journal of Materials Processing Technology2004，，： | 1 |
| 20 | Win-win relation-ship between raacrocell and femtocells for spectrum sha-ring in LTE-A显示文摘 | Hamouda S Zitoun M Tabbane S | 2014 | IET Communications2014，8，7： | 1 |
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