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| 1 | Phase I study of chimeric anti-CD20 monoclonal antibody in Chinese patients with CD20-positive non-Hodgkin's lymphoma显示文摘Objective: This study was designed to determine the safety, pharmacokinetics and biologic effects of a humanmouse chimeric anti-CD20 monoclonal antibody(SCT400) in Chinese patients with CD20-positive B-cell nonHodgkin's lymphoma(CD20+ B-cell NHL). SCT400 has an identical amino acid sequence as rituximab, with the exception of one amino acid in the CH1 domain of the heavy chain, which is common in Asians.Methods: Fifteen patients with CD20+ B-cell NHL received dose-escalating SCT400 infusions(250 mg/m^2: n=3; 375 mg/m^2: n=9; 500 mg/m^2: n=3) once weekly for 4 consecutive weeks with a 24-week follow-up period. The data of all patients were collected for pharmacokinetics and pharmacodynamics analyses.Results: No dose-limiting toxicities were observed. Most drug-related adverse events were grade 1 or 2. Two patients had grade 3 or 4 neutropenia. Under premedication, the drug-related infusion reaction was mild. A rapid, profound and durable depletion of circulating B cells was observed in all dose groups without significant effects on T cell count, natural killer(NK) cell count or immunoglobulin levels. No patient developed antiSCT400 antibodies during the course of the study. SCT400 serum half-life(T1/2), maximum concentration(Cmax) and area under the curve(AUC) generally increased between the first and fourth infusions(P<0.05). At the 375 mg/m^2 dose, the T1/2 was 122.5±46.7 h vs. 197.0±75.0 h, respectively, and the Cmax was 200.6±20.2 μg/m L vs. 339.1±71.0 μg/m L, respectively. From 250 mg/m^2 to 500 mg/m^2, the Cmax and AUC increased significantly in a dose-dependent manner(P<0.05). Patients with a high tumor burden had markedly lower serum SCT400 concentrations compared with those without or with a low tumor burden. Of the 9 assessable patients, 1 achieved complete response and 2 achieved partial responses.Conclusions: SCT400 is well-tolerated and has encouraging preliminary efficacy in Chinese patients with CD20+ B-cell NHL. | Lin Gui Xiaohong Han Xiaohui He Yuanyuan Song Jiarui Yao Jianliang Yang Peng Liu Yan Qin Shuxiang Zhang Weijing Zhang Wenlin Gai Liangzhi Xie Yuankai Shi | 2016 | Chinese Journal of Cancer Research2016，28，2： | 5 |
| 2 | Study of rare earth element effect on microstructures and mechanical properties of an Al-Cu-Mg-Si cast alloy显示文摘The improvements of microstructures and properties of a high strength aluminum cast alloy were studied. The effects of rare earth elements on the microstructures and mechanical properties of the high strength cast alloy Al-Cu-Mg-Si were investigated. The result shows that the addition of rare earth elements can change the microstructures in refining the grain size of the alloy and making the needle-like and laminar eutectic Si to a granular Si. With the increase of the rare earth, the tensile strength and elongation of the alloy increase first and then fall down. The mechanical properties of the alloy will reach the highest value when the content of rare earth elements is about 0.7%. | WAN Weiwei HAN Jianmin LI Weijing WANG Jinhua | 2006 | Rare Metals2006，25，z2： | 5 |
| 3 | A complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system显示文摘Using a pyrosequencing-based custom-made sequencer BIGIS-4, we sequenced a Gram-negative bacterium Glaciecola mesophila sp. nov. (Gmn) isolated from marine invertebrate specimens. We generated 152043 sequencing reads with a mean high-quality length of 406 bp, and assembled them using the BIGIS-4 post-processing module. No systematic low-quality data was detected beyond expected homopolymer-derived errors. The assembled Gmn genome is 5144318 bp in length and harbors 4303 annotated genes. A large number of metabolic genes correspond to various nutrients from surface marine invertebrates. Its abundant cold-tolerant and cellular signaling and related genes reveal a fundamental adaptation to low-temperature marine environment. | YUAN LiNa REN LuFeng LI YunTao HAN WeiJing YU Yong CHU YaNan LIU GuiMing YU Dan TENG MingJing WANG Liang WANG XuMin ZHOU XiaoGuang YU YuDe YU Jun | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 4 | Structure and Corrosion Resistance of Microarc Oxidation Coatings on AZ91D Magnesium Alloy显示文摘Magnesium alloys are widely used as shells of 3C (computer, mobile phone and consumer electronics) equipments for its impressive mechanical and physical properties, such as low density, good resistance to electromagnetic radiation, suitable for high pressure diecasting and easily recycling, etc. But poor corrosion resistance confines its extensively application. In this paper, protective coatings was successfully prepared on AZ91D magnesium alloys by micro-arc oxidation (MAO) and painting process. Microstructures and phases of MAO coatings were invesgated with scanning electron microscope (SEM) and X-Ray diffractometer. Mechanical properties of MAO coating, such as adhesive force and corrosion resistance, were also tested. Results showed that MAO coatings were a good base for painting process. MAO coatings with paint have good adhesive properties to base metal and excellent corrosion resistance. Micro-arc oxidation with painting process is a good kind of surface treatment to improve the corrosion resistance of mobile phone shell made of AZ91D magnesium alloys. | Cui Shihai Han Jianmin Li Weijing Li Ronghua Zhu Xiaowen Wang Jinhua | 2004 | Journal of Rare Earths2004，22，z2： | 3 |
| 5 | BRAKE TEST OF SiCp/A356 BRAKE DISK AND INTERPRETATION OF EXPERIMENTAL RESULTS显示文摘材料性质是明显的在铝矩阵 composites 和铁和钢材料之间不同。在以一样的速度的刹车磁盘 braked 以后,铝刹车磁盘的平均温度 1.5 倍高于铁和钢刹车磁盘之一,铝刹车磁盘的热扩大值 2 倍大于铁和钢刹车磁盘之一。材料的机械性质减少,在另一方面,温度在 braking 期间通常增加因为材料扩大被抑制,在刹车磁盘的大热压力发生。第一,产生和刹车磁盘的破裂失败在 braking 期间是由三酒吧的应力的优点的分析品质上的热压力的原因在药品,然后引起热压力的五限制装裱并且夹变丑原则被总结。在 1:1 紧急情况刹车测试上的试验性的结果的底上,热压力和温度地被模仿;破裂失败的行为是由有限元素分析的解释半份量上。以二个方法为部分位置有重合的预报。最后根据分析和计算结果,它是结构设计和被总结的刹车磁盘的汇编观察的一般原则。 | YANG Zhiyong HAN Jianmin LI Weijing WANG Jinhua | 2007 | Chinese Journal of Mechanical Engineering2007，20，5： | 3 |
| 6 | CETP as a Target in HDL-raising Therapy:lessons from APOE*3-Leiden. CETP Transgenic Mice显示文摘Background Cardiovascular disease (CVD) is mainly caused by atherosclerosis,for which dyslipidemia (i.e. high (V)LDL-cholesterol (C),high triglycerides and low HDLC is a major risk factor. To reduce the risk to develop CVD,patients with dyslipidemia are usually treated with lipid-lowering drugs including statins and fibrates. | Willeke de Haan Jitske de Vries-van der Weij Caroline C. van der Hoogt José W.A. van der Hoorn Johannes A. Romijn J. Wouter Jukema Louis M. Havekes Hans M.G. Princen Patrick C.N. Rensen | 2009 | 中国动脉硬化杂志2009，17，7： | 2 |
| 7 | Successful Treatment of Coeliac Disease by Allogeneic Haematopoietic Stem Cell Transplantation显示文摘 | J Hans Hoekstra Jacqueline J Groot-Loonen Annemieke van der Weij Peter M Hoogerbrugge Yvonne Kooy Frits Koning | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，6： | 1 |
| 8 | Analyzing the mechanisms of fatigue crack initiation and propagation in CRH EMU brake discs显示文摘 | YANG Zhiyong HAN Jianming LI Weijing | 2013 | Engineering Failure Analysis2013，34，8： | 1 |
| 9 | Effect of Silicon on the casting properties of Al-5.0%Cu alloy显示文摘Poor casting properties restrict the application of high strength casting Al-5.0%Cu alloy. The addition of element can improve the casting properties of this alloy. Effect of Si on the casting properties of Al-5.0%Cu alloy was studied. It has been found that the addition of Si can improve the casting properties of Al-5.0%Cu alloy obviously. With the increase of Si content, the hot cracking tendency of the alloy decreases significantly, and the fluidity of the alloy increases firstly and then decreases slowly. When the content of Si element is higher than 2wt.%, the fluidity of the alloy increases greatly with the increasing of Si content. | LI Weijing CUI Shihai HAN Jianmin XU Chao | 2006 | Rare Metals2006，25，z2： | 1 |
| 10 | Morphologies and Properties of Micro-Arc Oxidation on Plate and Cylinder 2024 Al Alloy显示文摘Samples with two different shapes of 2024 aluminum alloy were treated with micro-arc oxidation (MAO), and the formation process and mechanism of oxidation film was analyzed. The results show that different geometrical curvature of the material has an influence upon the uniformity of films and the corrosion-resistance. | Zhu Xiaowen Han Jianmin Cui Shihai Li Ronghua Li Weijing Wang Jinhua | 2004 | Journal of Rare Earths2004，22，z2： | 1 |
| 11 | Electrochemical degradation of nitrobenzene by anodic oxidation on the constructed TiO 2 -NTs/SnO 2 -Sb/PbO 2 electrode显示文摘 | Yong Chen Hongyi Li Weijing Liu Yong Tu Yaohui Zhang Weiqing Han Lianjun Wang | 2014 | Chemosphere2014，，： | 1 |
| 12 | Ana- lyzing the Mechanisms of Fatigue Crack Initiation and Propagation in CRH EMU Brake Discs显示文摘 | YANG Zhiyong HAN Jianming LI Weijing | 2013 | Engineering Failure Analysis2013，34，： | 1 |
| 13 | Influence of Si on Interfacial Combination of SiCp/Al-Mg-Si Composite显示文摘The scanning electron microscopy (SEM) analysis results of Si distribution in the interface between SiC reinforcements and aluminum matrix of a stir casting SiCp/Al-Mg-Si composite were presented. Results show that there is Si precipitation deposit on the interface of the composite and Si connects with SiC reinforcements in one side and connects with aluminum matrix in the other side. Si phase plays as a connecting bridge, which contributes to the interfacial combination of SiCp/Al composite. | Han Jianmin Li Ronghua Li Mingwei Cui Shihai Li Weijing Wang Jinhua | 2004 | Journal of Rare Earths2004，22，z2： | 0 |
| 14 | Research on PTFE Dispersions Filled with Nanometer ZnO显示文摘PTFE dispersion composites filled with nanometer ZnO were successfully prepared by controlling stirring speed and using ultrasonic mixture with no damage to PTFE dispersion. Properties of PTFE composites, such as wear rate, friction coefficient and thermal conductivity coefficient were tested respectively. Also, the grain size of nanometer filler in composites were observed by different methods, such as small angle X-ray scattering (SAXS), transmission electron microscopy (TEM) and dynamic light scattering particle size distribution analyzer (DLSPSDA). Results show that nanometer ZnO fillers can further improve properties of PTFE-based composite, and its properties varies with the content of the fillers. | Han Jianmin Li Weijing Cui Shihai Zhao Yang Li Ronghua Wang Jinhua | 2004 | Journal of Rare Earths2004，22，z2： | 0 |
| 15 | Real-time imaging of structure and dynamics of transmembrane biomolecules by FRET-induced single-molecule fluorescence attenuation显示文摘Tracking the transmembrane topology and conformational dynamics of membrane proteins is key to understand their functions.It is however challenging to monitor position changes of individual proteins in cell membranes with high sensitivity and high resolution.We review on three single-molecule fluorescence imaging methods—SIFA,Lipo FRET and Queen FRET—recently developed in our lab for studying the dynamics of membrane proteins.They can be applied,progressively,to investigate membrane proteins in solid-supported lipid bilayers,artificial liposome membranes and live-cell plasma membranes.The techniques take advantage of the energy transfer from a fluorophore to a cloud of quenchers and are able to extract in real time positions and position changes of a single fluorophorelabeled protein in the direction normal to the membrane surface.The methods have sub-nanometer precision and have proved powerful to investigate biomolecules interacting with bio-membranes. | Dongfei Ma Wenqing Hou Chenguang Yang Shuxin Hu Weijing Han Ying Lu | 2021 | Biophysics Reports2021，7，6： | 0 |
| 16 | Improved picoliter-sized micro-reactors for high-throughput biological analysis显示文摘High-throughput pyrosequencing,carried out in millions of picoliter-sized reactors on a fiber-optic slide,is known for its longer read length.However,both optical crosstalk(which reduces the signal-to-noise ratio of CCD images)and chemical retention adversely affect the accuracy of chemiluminescence determination,and ultimately decrease the read length and the accuracy of pyrosequencing results.In this study,both titanium and oxidized aluminum films were deposited on the side walls and upper faces of micro-reactor slides to enhance optical isolation;the films reduced the inter-well crosstalk by one order of magnitude.Subsequently,chemical retention was shown to be caused by the lower diffusion coefficient of the side walls of the picolitersized reactors because of surface roughness and random pores.Optically isolated fiber-optic slides over-coated with silicon oxide showed smoother surface morphology,resulting in little chemical retention;this was further confirmed with theoretical calculations.Picoliter-sized micro-reactors coated with titanium-silicon oxide films showed the least inter-well optical crosstalk and chemical retention;these properties are expected to greatly improve the high-throughput pyrosequencing performance. | HAN WeiJing YUAN LiNa WEI QingQuan LI YunTao REN LuFeng ZHOU XiaoGuang YU Jun YU YuDe | 2013 | Science China(Life Sciences)2013，56，12： | 0 |
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