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| 1 | The next-generation sequencing technology and application显示文摘As one of the key technologies in biomedical research,DNA sequencing has not only improved its productivity with an exponential growth rate but also been applied to new areas of application over the past few years.This is largely due to the advent of newer generations of sequencing platforms,offering ever-faster and cheaper ways to analyze sequences.In our previous review,we looked into technical characteristics of the nextgeneration sequencers and provided prospective insights into their future development.In this article,we present a brief overview of the advantages and shortcomings of key commercially available platforms with a focus on their suitability for a broad range of applications. | Xiaoguang Zhou Lufeng Ren Qingshu Meng Yuntao Li Yude Yu Jun Yu | 2010 | Protein & Cell2010，1，6： | 13 |
| 2 | Effect of trace Sc and Zr on aging behavior and tensile properties of 2618 alloy显示文摘The aging behavior of 2618 (Al Cu Mg Fe Ni) alloy added trace Sc and Zr was studied by Vicker’s hardness measurement at 200 and 300 ℃, and the tensile properties(yield strength, ultimate tensile strength and elongation) of alloys were measured at 20, 200, 250 and 300 ℃. The microstructures were observed by using optical microscope, SEM and TEM. It was found that the addition of Sc and Zr to 2618 alloy resulted in a uniform distribution of fine coherent Al 3(Sc,Zr) precipitates which had obvious aging hardening effect and made the S’ phase precipitate more homogeneously. The strength of alloy increased at ambient and elevated temperature without a decrease of ductility because of the precipitation strengthening and thermal stability of Al 3(Sc,Zr) particles. The ductile fracture of alloy occurred by microviod nucleation, growth and coalescence, so the microvoid coalescence was the dominant fracture mechanism. Al 3(Sc,Zr) particles could inhabit the recrystallization process of alloy 2618. | Yu Kun(余琨) Li Songrui(李松瑞) Li Wenxian(黎文献) Xiao Yude(肖于德) | 1999 | 中国有色金属学会会刊:英文版1999，9，3： | 5 |
| 3 | Development of silicon photonic devices for optical interconnects显示文摘Silicon photonic devices based on complementary-metal-oxide-semiconductor(CMOS) compatible technologies have shown attractive performances on very-large-scale monolithic optoelectronic integration,high speed modulation and switching,and efficient off-chip optical coupling.This paper presents the recent progress on fast silicon optical modulation,wavelength-insensitive optical switching and efficient optical coupling techniques in our group.Several CMOS-compatible silicon optical couplers with different structures have been developed,showing the highest coupling efficiency of 65%.Broadband silicon-based optical switches with sub-nanosecond switching on-off time are experimentally realized.Silicon modulators with novel PN junctions are demonstrated with the speed up to 50 Gb s-1. | XIAO Xi LI ZhiYong CHU Tao XU Hao LI XianYao NEMKOVA Anastasia KANG Xiong YU YuDe YU JinZhong | 2013 | Chinese Science Bulletin2013，58，7： | 4 |
| 4 | A complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system显示文摘Using a pyrosequencing-based custom-made sequencer BIGIS-4, we sequenced a Gram-negative bacterium Glaciecola mesophila sp. nov. (Gmn) isolated from marine invertebrate specimens. We generated 152043 sequencing reads with a mean high-quality length of 406 bp, and assembled them using the BIGIS-4 post-processing module. No systematic low-quality data was detected beyond expected homopolymer-derived errors. The assembled Gmn genome is 5144318 bp in length and harbors 4303 annotated genes. A large number of metabolic genes correspond to various nutrients from surface marine invertebrates. Its abundant cold-tolerant and cellular signaling and related genes reveal a fundamental adaptation to low-temperature marine environment. | YUAN LiNa REN LuFeng LI YunTao HAN WeiJing YU Yong CHU YaNan LIU GuiMing YU Dan TENG MingJing WANG Liang WANG XuMin ZHOU XiaoGuang YU YuDe YU Jun | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 5 | Progress in Space Material Researches显示文摘New progress in the post researches on space grown materials, the development of experiment facilities, and the experiment techniques for space materials researches were introduced. Besides the conventional materials, such as alloys, semiconductors, and optical crystals, new materials have also been prepared on the ground. | CHEN Nuofu CHEN Wanchun LIU Yan HOU Yanfei LUO Xinghong HUANG Qing YU Yude | 2006 | 空间科学学报2006，26，z1： | 3 |
| 6 | Low-cost hybrid integrated 4 × 25 GBaud PAM-4CWDM ROSA with a PLC-based arrayed waveguide grating de-multiplexer显示文摘We demonstrate a low-cost hybrid integrated and compact 100 GBaud four-lane coarse wavelength division multiplexing (CWDM) receiver optical sub-assembly (ROSA) based on an arrayed waveguide grating de-multiplexer in the O band. To achieve the horizontal light coupling between the planar light-wave circuit (PLC) based arrayed waveguide grating de-multiplexer and photodetector array, a 42°polished facet is applied for total reflection.A flexible printed circuit with high-frequency coplanar waveguides is used for a power supply of trans-impedance amplifier and signal transmission.The fabricated CWDM ROSA module, whose size is 18mm×22mm×6mm, shows a 3 dB bandwidth of 21.2,18.4,19.6,and 19.3 GHz,respectively,in each lane. The overall symbol error rates are at a magnitude of 10^-7 for 25 GBaud four-level pulse amplitude modulation (PAM-4) transmission with an average input optical power of 5dBm. | Lei Liu Limin Chang Yingxin Kuang Zezheng Li Yang Liu Huan Guan Manqing Tan Yude Yu Zhiyong Li | 2019 | Photonics Research2019，7，7： | 3 |
| 7 | Progress of Microgravity Material Research During the Period of 2007-2009显示文摘Orbital experimental researches on crystal growth of Mn-doped GaSb and Bi2Se0.21Te2.79 are briefly summarized.The space experiments were completed in September of 2007 on broad the Foton-M3 satellite of Russia.Ground-based researches on the solidification behaviors of Al-Al3Ni,AlAl2Cu,Ag-Cu eutectic,Al-Pb monotectic and Cu-Co peritectic alloys in a 50-meter-high drop tube were investigated.New experimental results on the ultrasonic field and the temperature recycling induced to chiral symmetry breaking of NaClO3 crystal also were reported in the present paper. | Chen Nuofu Bai Yiming Chen Wanchun Zhou Yanfei Luo Xinghong Yu Yude | 2010 | 空间科学学报2010，30，5： | 3 |
| 8 | Solution processed low power organic field-effect transistor bio-chemical sensor of high transconductance efficiency显示文摘Developing organic field-effect transistor(OFET)biosensors for customizable detection of biomarkers for many diseases would provide a low-cost and convenient tool for both biological studies and clinical diagnosis.In this work,design principles of the OFET transducer for biosensors were derived to relate the signal-to-noise ratio(SNR)to the device-performance parameters.Steep subthreshold swing(SS),proper threshold voltage(Vth),good-enough bias-stress stability,and mechanical durability are shown to be the key prerequisites for realizing OFET bio-sensors of high transconductance efficiency(gm/ID)for large SNR.Combining a low trap-density channel and a high-k/low-k gate dielectric layer,low-temperature(<100℃)solution-processed flexible OFETs can meet the performance requirements to maximize the gm/ID.An extended gate-structure OFET biosensor was further implemented for label-free detection of miR-21,achieving a detection limit below 10 pM with high selectivity at a low operation voltage(<1 V). | Wei Tang Ying Fu Yukun Huang Yuanzhe Li Yawen Song Xin Xi Yude Yu Yuezeng Su Feng Yan Xiaojun Guo | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 9 | Phase relations of R-T-M temary system, crystal structure and magnetic properties of R(T,M)13 compounds (R = Light rare earth; T = Co, Fe; M = Al, Si) ( Ⅰ ) 显示文摘 | Liang Jingkui Rao Guanghui Tang Weihua Zhao Yanming Guo Yongquan Yan Xiaohua Zhang Yuling Cheng Xiangrong Xie Sishen Yu Yude Tian Jinghua Cheng Xiaolong Liang Jingmei | 1996 | Progress in Natural Science1996，6，6： | 1 |
| 10 | Color center and domain structure in single crystals of LaAlO3显示文摘 | CHANG Yingchuan HOU Desen YU Yude | 1993 | J Crystal Growth1993，129，： | 1 |
| 11 | Existence of solutions for m-point boundary value problems on a half-line显示文摘 | YU Changlong GUO Yanping JI Yude | | 0，，： | 1 |
| 12 | Microgravity Material Research in China:2016显示文摘Firstly,recent research works of high undercooling and rapid solidification of metallic alloys under ground simulation conditions in Northwestern Polytechnical University are reviewed.Secondly,under normal gravity and microgravity of binary to quinary Nickel-base single crystal alloys with different contents of W,Ta,Al and Ti elements are comparatively investigated by Institute of Metal Research using drop tube.Thirdly,solidification and crystal growth of SJ10-Recoverable Scientific Experiment Satellite by Institute of Semiconductors is introduced. | XIE Wenjun LUO Xinghong ZHANG Xingwang YU Yude | 2016 | 空间科学学报2016，36，5： | 1 |
| 13 | Microgravity Material Research in China:2012–2014显示文摘During 2012–2014, the main research activities from microgravity material research were focused on, which include study of microgravity effects on collagen fibrillogenesis and HAP crystallization, microgravity experiments using drop tube, and research of thermoelectric materials for space.This paper summarizes all these activities. | WANG Yuren DAI Guoliang WANG Jing FENG Shaobo LUO Xinghong ZHOU Yanfei CHEN Lidong YU Yude | 2014 | 空间科学学报2014，34，5： | 0 |
| 14 | A 640×640 ISFET array for detecting cell metabolism显示文摘Ion sensitive field effect transistor(ISFET)devices are highly accurate,convenient,fast and low-cost in the detection of ions and biological macromolecules,such as DNA molecules,antibodies,enzymatic substrates and cellular metabolites.For high-throughput cell metabolism detection,we successfully designed a very large-scale biomedical sensing application specific integrated circuit(ASIC)with a 640×640 ISFET array.The circuit design is highly integrated by compressing the size of a pixel to 7.4×7.4μm^(2)and arranging the layout of even and odd columns in an interdigital pattern to maximize the utilization of space.The chip can operate at a speed of 2.083M pixels/s and the dynamic process of the fluid flow on the surface of the array was monitored through ion imaging.The pH sensitivity is 33±4 mV/pH and the drift rate is 0.06 mV/min after 5 h,indicating the stability and robustness of the chip.Moreover,the chip was applied to monitor pH changes in CaSki cells metabolism,with pH shifting from 8.04 to 7.40 on average.This platform has the potential for continuous and parallel monitoring of cell metabolism in single-cell culture arrays. | Ling Yang Yizheng Huang Zhigang Song Manqing Tan Yude Yu Zhao Li | 2023 | Journal of Semiconductors2023，44，2： | 0 |
| 15 | Improved extinction ratio of Mach-Zehnder based optical modulators on CMOS platform显示文摘硅与改进扑灭比率基于光调节的人(嗯) 25, dB 在互补金属氧化物上被表明半导体(互补金属氧化物半导体) 站台。光吸收的效果应该在设备配置的分析由于在硅积累的自由搬运人被考虑,这被建议。在这研究介绍的试验性的结果与建议分析是相同的。调节的人与 3.2 Gbps 的数据传播率被操作。 | Zhiyong LI Liang ZHOU Xi XIAO Tao CHU Yude YU Jinzhong YU | 2012 | Frontiers of Optoelectronics2012，5，1： | 0 |
| 16 | APPLICATION OF ELECTRICAL IMPEDANCE MYOGRAPHY IN CHARACTERIZING CARPAL TUNNEL SYNDROME显示文摘Background:Electrical impedance myography(EIM)is a non-invasive,painless,and easy-to-perform technique for assessing neuromuscular disorders.We evaluated the potential of EIM for quantitatively characterizing carpal tunnel syndrome(CTS).Methods:Healthy subjects and patients with differing severity of CTS underwent EIM measurement of their small hand muscles.A bioelectrical impedance vector analysis(BIVA)method was first applied to display 50-kHz EIM data in a single plot.Results:Patients with more severe CTS had smaller EIM values in the affected muscle.The reactance and phase parameters differed significantly between any two groups(P<0.05).Their accuracy for differentiating between any two adjacent groups was approximately 80%and for other groups was approximately 90%.There was a strong association between EIM and electrophysiology results.Conclusion:BIVA is convenient and helpful for indicating the differences between healthy subjects and CTS patients.These results demonstrate EIM’s potential for quantitatively characterizing patients with CTS. | Chen Lingfen Li Zhao Zhu Yu Yang Ling Hu Shiming Chai Chunlin Tan Manqing Yu Yude Tian Dong | 2019 | 现代电生理学杂志2019，26，B03： | 0 |
| 17 | Improved picoliter-sized micro-reactors for high-throughput biological analysis显示文摘High-throughput pyrosequencing,carried out in millions of picoliter-sized reactors on a fiber-optic slide,is known for its longer read length.However,both optical crosstalk(which reduces the signal-to-noise ratio of CCD images)and chemical retention adversely affect the accuracy of chemiluminescence determination,and ultimately decrease the read length and the accuracy of pyrosequencing results.In this study,both titanium and oxidized aluminum films were deposited on the side walls and upper faces of micro-reactor slides to enhance optical isolation;the films reduced the inter-well crosstalk by one order of magnitude.Subsequently,chemical retention was shown to be caused by the lower diffusion coefficient of the side walls of the picolitersized reactors because of surface roughness and random pores.Optically isolated fiber-optic slides over-coated with silicon oxide showed smoother surface morphology,resulting in little chemical retention;this was further confirmed with theoretical calculations.Picoliter-sized micro-reactors coated with titanium-silicon oxide films showed the least inter-well optical crosstalk and chemical retention;these properties are expected to greatly improve the high-throughput pyrosequencing performance. | HAN WeiJing YUAN LiNa WEI QingQuan LI YunTao REN LuFeng ZHOU XiaoGuang YU Jun YU YuDe | 2013 | Science China(Life Sciences)2013，56，12： | 0 |
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