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| 1 | Mapping QTL associated with Verticillium dahliae resistance in the cultivated strawberry(Fragaria×ananassa)显示文摘A biparental cross of octoploid strawberry segregating for resistance to Verticillium dahliae,the causative agent of Verticillium wilt,was screened under field conditions for three seasons.Average wilt scores were significantly associated with multiple QTL,which were mostly significant across all years.Markers significantly associated with the traits were used to screen material with known wilt resistance and susceptibility phenotypes.A clear and statistically significant relationship was observed between resistant,tolerant and susceptible material and the total number of markers present in the different resistance classes.In field situations resistance QTL appear to behave in an additive manner.These markers are abundant in the cultivated strawberry germplasm indicating that,despite the large number of markers,clear genetic gain is possible through marker-assisted breeding. | L Antanaviciute NŠurbanovski N Harrison K J McLeary D W Simpson F Wilson D J Sargent R J Harrison | 2015 | Horticulture Research2015，2，1： | 5 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | The value of lesion cross sectional area determined by quantitative coronary angiography in assessing the physiologic significance of proximal left anterior descending coronary arterial stenoses 显示文摘 | Harrison D G White C W Hiratzka L F | 1984 | Circulation1984，69，6： | 1 |
| 4 | Effect of spacing and age on nitrogen and phosphorus distribution in biomass of Eucalyptus camaldulensis,Eucalyptus pellita and Eucalyptus urophylla plantations in southeastern Brazil显示文摘 | Harrison R B Reis G G Reis M D G F | 2000 | Forest Ecology and Management2000，133，3： | 1 |
| 5 | Optical and Radio Observations of the Afterglow from GRB 990510: Evidence for a Jet显示文摘 | Harrison F A Bloom J S Frail D A | 1999 | APJ1999，523，： | 1 |
| 6 | Cloud radiative forcing and climate: results from the Earth radiation budget experiment 显示文摘 | Ramanathan V Cess R D Harrison E F | 1989 | Sci- ence1989，243，4887： | 1 |
| 7 | The pathology and management of subglottic cancer显示文摘 | Harrison D F | | 0，，01： | 1 |
| 8 | The effect of CO2 availability on the growth, iron oxidation and CO,-fixation rates of pure cultures of Leptospirillum Jerriphilum and Acidithiobacillus Jerrooxidans 显示文摘 | BRYAN C G DAVIS-BELMAR C S van WYK N FRASER M K DEW D RAUTENBACH G F HARRISON | 2012 | Biotechnology and Bioengineering2012，109，7： | 1 |
| 9 | Epigenetic targeting of histone deacetylase: therapeutic potential in Parkinson's disease? 显示文摘 | HARRISON 1 F DEXTER D T | 2013 | Pharmacol Ther2013，140，1： | 1 |
| 10 | Effects of copper on early life history stages of northern anchovy EnCraulis mordax显示文摘 | RICE D W HARRISON F L JEARLD A J | 1980 | Fishery Bulletin1980，78，3： | 1 |
| 11 | Effects of copper of early life history stages of northern anchvy EnCraul is mordax显示文摘 | Rice D W Harrison F L Jearld A J | 1980 | Fishery Bulletin1980，78，3： | 1 |
| 12 | Response of two sweet potato cultivars to weed interference显示文摘 | HARRISON H F JR JACKSON D M | 2011 | Crop protection2011，30，10： | 1 |
| 13 | A randomized prospective assessor-blind evaluation of luteinizing hormone dosage and in vitro fertilization outcome显示文摘 | Gordon U D Harrison R F Fawxy M | 2001 | Fertil Steril2001，75，2： | 1 |
| 14 | Cloud-radiative forcing and climate:results from the earth radiation budget experiment显示文摘 | Ramanathan V Cess R D Harrison E F | 1989 | Science1989，243，4887： | 1 |
| 15 | The relationship of potato black ringspot virus to tobacco ringspot and allied viruses显示文摘 | HARRISON B D SALAZAR L F | 1978 | Annals of Applied Biology1978，，7： | 1 |
| 16 | Effects of subsoil loosening on soil physical properties,plant root growth,and pasture yield显示文摘 | HARRISON D F CAMERON K C MCLAREN R G | 1994 | New Zealand Journal of Agricultural Research1994，37，4： | 1 |
| 17 | Hydrological discharges and motion of fels and Black-Rapids Glaciers, Alaska, USA-Implications for the structure of their drainage systems 显示文摘 | Raymond C F Benedict R J Harrison W D | 1995 | Journal of Glaciology1995，41，138： | 1 |
| 18 | Antigenic and genetic char- acteristics of swine - origin 2009 A( H1N1 ) influenza viruses cir- culating in humans 显示文摘 | Garten R J Davis C T Russell C A Shu B Lindstrom S Balish A Sessions W M Xu X Skepner E Deyde V Okomo - Adhi- ambo M Gubareva L Barnes J Smith C B Emery S L Hillman M J Rivailler P Smagala J de Graaf M Burke D F Fouchier R A Pappas E Alpuche - Aranda C M Lopez - Gatell H Ohvera H Lopez I Myers C A Faix D Blair P J Yu C Keene K M Dotson P D Jr Boxrud D Sambol A R Abid S H St George K Bannerman T Moore A L Stringer D J Blevins P Demmler - Harrison G J Ginsberg M Kriner P Waterman S Smole S Guevara H F Belongia E A Clark P A Beatrice S T Donis R Katz J Finelli L Bridges C B Shaw M Jernigan D B Uyeki T M Smith D J Klimov A I Cox N J | 2009 | Science2009，325，5937： | 1 |
| 19 | Plaque-associated immune reactivity as a tool for the diagnosis and treatment of atherosclerosis显示文摘 | HARRISON D C CALENOFF E CHEN F W | 1992 | Proc Am Clin Climatological Assoc1992，103，： | 1 |
| 20 | The combined effect of rain and wind on air-water gas exchange: A feasibility study显示文摘 | Ho D T Veron F Harrison E | 2007 | J Mar Sys2007，66，： | 1 |
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