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| 1 | Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?显示文摘Artemisinin from the plant Artemisia annua(A. annua) L., and used as artemisinin combination therapy(ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in developing countries. Traditionally, A. annua was used by the Chinese as a tea to treat 'fever'. More recently, investigators have shown that tea infusions and oral consumption of the dried leaves of the plant have prophylactic and therapeutic efficacy. The presence of a complex matrix of chemicals within the leaves seems to enhance both the bioavailability and efficacy of artemisinin. Although about 1000-fold less potent than artemisinin in their antiplasmodial activity, these plant chemicals are mainly small molecules that include other artemisinic compounds, terpenes(mainly mono and sesqui), flavonoids, and polyphenolic acids. In addition, polysaccharide constituents of A. annua may enhance bioavailability of artemisinin. Rodent pharmacokinetics showed longer T? and T max and greater C max and AUC in Plasmodium chabaudi-infected mice treated with A. annua dried leaves than in healthy mice. Pharmacokinetics of deoxyartemisinin, a liver metabolite of artemisinin, was more inhibited in infected than in healthy mice. In healthy mice, artemisinin serum levels were > 40-fold greater in dried leaf fed mice than those fed with pure artemisinin. Human trial data showed that when delivered as dried leaves, 40-fold less artemisinin was required to obtain a therapeutic response compared to pure artemisinin. ACTs are still unaffordable for many malaria patients, and cost estimates for A. annua dried leaf tablet production are orders of magnitude less than for ACT, despite improvements in the production capacity. Considering that for > 2000 years this plant was used in traditional Chinese medicine for treatment of fever with no apparent appearance of artemisinin drug resistance, the evidence argues for inclusion of affordable A. annua dried leaf tablets into the arsenal of drugs to combat malaria and other artemisinin-susceptible diseases. | Pamela J Weathers Melissa Towler Ahmed Hassanali Pierre Lutgen Patrick Ogwang Engeu | 2014 | World Journal of Pharmacology2014，3，4： | 2 |
| 2 | Fe(HSO_4)_3:An efficient,heterogeneous and reusable catalyst for the synthesis of 14-aryl- or alkyl-14H-dibenzo[a,j]xanthenes显示文摘Fe (HSO4 ) 3 是被使用了一有效并且为 14-aryl- 或 alkyl-14H-dibenzo 的一个壶合成的 recyclable 催化剂[一, j ] 由 2-naphtol 和醛的反应的氧杂蒽衍生物。芳香、脂肪族的醛的不同类型在反应被使用,在所有情况中,产品被获得在对优秀收益好。 | Hossein Eshghi Mehdi Bakavoli Hassanali Moradi | 2008 | Chinese Chemical Letters2008，19，12： | 2 |
| 3 | Chemical composition and mosquito repellency of essential oil of Conyza newii propagated in different geographical locations of Kenya显示文摘 | W. P. MAYEKU N. I. OMOLLO O. J. ODALO A. HASSANALI | 2014 | Med Vet Entomol2014，，3： | 1 |
| 4 | Desmodiumspecies and associated biochemical traits for controlling Striga显示文摘 | Khan Z R Pickett J A Hassanali A | 2008 | Weed Research2008，48，4： | 1 |
| 5 | Cognitive bias and unusual experiences in childhood显示文摘 | Hassanali N Ruffell T Browning S | 2015 | European Child&Adolescent Psychiatry2015，24，8： | 1 |
| 6 | Repellent Activities of Essential Oils of Some Plants Used Traditionally to Control the Brown Ear Tick, Rhipicephalus appendiculatus显示文摘 | Wycliffe Wanzala Ahmed Hassanali Wolfgang Richard Mukabana Willem Takken C. Genchi | 2014 | Journal of Parasitology Research2014，，： | 1 |
| 7 | Products derived from the leaves of Ocimum kilimannds charicum(Labiatae)as post-harvest grain protectants against the infestation of three major stored product insect pests显示文摘 | Jembere B Obeng-Ofori D Hassanali A | 1995 | Bulletin of Entomological Research1995，85，： | 1 |
| 8 | Isoflavanones from the allelopathic aqueous root exudates of De-smodium uncinatum 显示文摘 | Tsanuo M K Hassanali A Hooper A M | 2003 | Phytochemistry2003，64，1： | 1 |
| 9 | Blend effects in the toxicity of theessential oil constituents of Ocimum kilimands charicum andOcimum kenyense(Labiateae)on two post-harvest insectpests显示文摘 | Bekele J Hassanali A | 2001 | Phytochemistry2001，57，： | 1 |
| 10 | Intra- and Interspecific Aggregation Responses of Locusta migratoria migratorioides and Schistocerca gregaria and a Comparison of Their Pheromone Emissions显示文摘 | Abdoulaye Niassy Baldwyn Torto Peter G. N. Njagi Ahmed Hassanali Daniel Obeng-Ofori Jonathan N. Ayertey | 1999 | Journal of Chemical Ecology1999，，5： | 1 |
| 11 | Slump loss,control of cement paste by adding polycarboxylic -type slump-releasing dispersant显示文摘 | GYE-GYU LIM YOUN D HASSANALI M | 1999 | Cement and Concrete Research1999，29，2： | 1 |
| 12 | Effects of Fifth-Instar Volatiles on Sexual Maturation of Adult Desert Locust Schistocerca gregaria显示文摘 | Yousif O. H. Assad Ahmed Hassanali Baldwyn Torto Hassane Mahamat Nabil H. H. Bashir Sayed El Bashir | 1997 | Journal of Chemical Ecology1997，，5： | 1 |
| 13 | Aggregation pheromone system of nymphal gregarious desert locust,Schistocerca gregaria (forsk?l)显示文摘 | Baldwyn Torto Peter G. N. Njagi Ahmed Hassanali Habert Amiani | 1996 | Journal of Chemical Ecology1996，，12： | 1 |
| 14 | Blend effects in the toxicity of the essential oil constituents of Ocimum Ki 1 imandscharicum and Ocimum kenyense(Labiateae)on two post2harvest insect pests显示文摘 | Jembere Bekele Alerted Hassanali | 2001 | phytochemistry2001，57，： | 1 |
| 15 | Isoflavanones from the allelopathic aqueous root exudate of Desmodium uncinatum 显示文摘 | Tsanuo M K Hassanali A Heoper A M | 2003 | Phytochemistry2003，64，1： | 1 |
| 16 | Aggregation pheromone system of nymphal gregarious desert locust, Schistocerca gregaria (Forskl) 显示文摘 | Torto B Njagi PG Hassanali A | 1996 | J Chem Ecol1996，22，12： | 1 |
| 17 | Aggregation pheromone system of adult gregarious desert locust schistocerca gregaria (forskal)显示文摘 | Baldwyn Torto Daniel Obeng-Ofori Peter G. N. Njagi Ahmed Hassanali Habert Amiani | 1994 | Journal of Chemical Ecology1994，，7： | 1 |
| 18 | Studies on the maturation-accelerating pheromone of the desert locustSchistocerca gregaria (Orthoptera: Acrididae)显示文摘 | Hassane Mahamat Ahmed Hassanali Hezekiel Odongo Baldwyn Torto El-Sayeed El-Bashir | 1993 | Chemoecology (-)1993，，3： | 1 |
| 19 | Sternal foramina and variant xiphoid morphology in a Kenyan population显示文摘 | El-Busaid H Kaisha W Hassanali J | | 0，，： | 1 |
| 20 | Repellent activity of catmint,Nepeta cataria,and iridoid nepetalactone isomers against Afro-tropical mosquitoes,ixodid ticks and red poultry mites显示文摘 | Birkett M A Hassanali A Hoglund S | 2011 | Phytochemistry2011，72，1： | 1 |
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