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| 1 | Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: A review显示文摘Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases(IBD) including ulcerative colitis and Crohn's disease are at increased risk of developing colorectal cancer in comparison to healthy individuals. Furthermore, the risk of hyperhomocysteinaemia is significantly higher in IBD patients when compared with controls. In the present article, we review the mechanisms in which hyperhomocysteinemia may contribute to increased risk of colorectal cancer in IBD patients. | Ammar Hassanzadeh Keshteli Vickie E Baracos Karen L Madsen | 2015 | World Journal of Gastroenterology2015，21，4： | 21 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | Identification of a common gene signature for type Ⅱ cytokine-associated myeloid cells elicited in vivo in different pathologic conditions显示文摘 | De Baetselier P Brys L | 2006 | Blood2006，108，： | 1 |
| 4 | lntrace- rebroventricular administration of riluzole prevents mor- phine-induced apoptosis in the lumbar region of the rat spinal cord 显示文摘 | Hassanzadeh K Habibi-asl B Roshangar L | 2010 | Pharmacol Rep2010，62，： | 1 |
| 5 | Riluzole prevents morphine-induced apoptosis in rat cerebral cortex显示文摘 | Hassanzadeh K Roshangar L Habibi-asl B | | 0，，03： | 1 |
| 6 | Intracerebroventricular administration of riluzole prevents morphine-induced apoptosis in the lumbar region of the rat spinal cord 显示文摘 | Hassanzadeh K Habibi-asl B Roshangar L | 2010 | Pharmacological Rep2010，62，4： | 1 |
| 7 | Intracerebroventricular administration of riluzole prevents morphine-induced apoptosis in the rat lumbar spinal cord显示文摘 | Hassanzadeh K Habibi-asl B Roshangar L | 2010 | Pharmacol Rep2010，62，： | 1 |
| 8 | Fault diagnosis competitive neural network with prioritized modification rule of connection weights显示文摘 | KHANMOHAMMADI S HASSANZADEH L ZAREI P R | 2000 | Artificial Intelligence in Engineering2000，14，： | 1 |
| 9 | Riluzole prevents morphine-induced apoptosis in rat cerebral cortex显示文摘 | Hassanzadeh K Roshangar L Habibi-asl B | 2011 | Pharmacol Rep2011，62，： | 1 |
| 10 | Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration显示文摘 | Rostovtseva T K Sheldon K L Hassanzadeh E | 2008 | Proc Natl Acad Sci U S A2008，105，18： | 1 |
| 11 | Scalable parallel seismic processing显示文摘 | Siamak Hassanzadeh Charles C Mosher Calvin L Joyner | | 0，，12： | 1 |
| 12 | 查看详情显示文摘 | Andrews L Hassanzadeh P Lanzisera D V Brabson G D | | 0，，： | 1 |
| 13 | Intracerebro-ventricular administration of riluzole prevents morphine-induced apoptosis in the lumbar region of the rat spinal cord显示文摘 | Hassanzadeh K Habibiasl B Roshangar L | 2010 | Pharmacol Rep2010，62，4： | 1 |
| 14 | Kinetic Study of Sodium Cocoyl Sarcosinate Synthesis and Factors Affecting the Reaction on Bench and Pilot Scales显示文摘 | Hassanzadeh M Kambarani M Tayebi L | 2012 | J Surfact Deterg2012，1，： | 1 |
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