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| 1 | Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: A review显示文摘Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases(IBD) including ulcerative colitis and Crohn's disease are at increased risk of developing colorectal cancer in comparison to healthy individuals. Furthermore, the risk of hyperhomocysteinaemia is significantly higher in IBD patients when compared with controls. In the present article, we review the mechanisms in which hyperhomocysteinemia may contribute to increased risk of colorectal cancer in IBD patients. | Ammar Hassanzadeh Keshteli Vickie E Baracos Karen L Madsen | 2015 | World Journal of Gastroenterology2015，21，4： | 21 |
| 2 | Investigating the first-order flotation kinetics models for Sarcheshmeh copper sulfide ore显示文摘This study was performed in two phases of work.In the first stage,four conventional first-order flotation kinetics models were fitted to the measured recoveries data and the best model were selected.In the second stage,influence of pH,solid concentration,water chemistry and the amount of collector dosage were investigated on kinetics parameters including flotation rate constant and ultimate recovery.The results indicated that that perfectly mixed reactor model and Kelsall model gave the best and the weakest fit to the experimental data,respectively.It was observed that flotation rate constant and ultimate recovery were strongly affected by chemical factors investigated especially water quality.The flotation rate constant decreased with increasing the solids content,while ultimate recovery increased to certain value and thereafter reduced.It was also found that the most values of flotation rate constant and ultimate recovery obtained in dosage of collector are 30 and 40 g/t,respectively. | Asghar Azizi Ahmad Hassanzadeh Behnam Fadaei | 2015 | International Journal of Mining Science and Technology2015，25，5： | 12 |
| 3 | Investigation of factors affecting on viscosity reduction of sludge from Iranian crude oil storage tanks显示文摘Crude oil is a kind of water/oil emulsion, which the oil phase consists of organic molecules with different molecular weights such as alkanes, paraffin, asphaltene, and resins. Due to the change in physicochemical conditions during the production, transportation, storage, and refining, heavier molecules can precipitate from crude oil. Thus, viscous sludge formed at the bottom of storage tanks can cause many problems including reduction of storage capacity of tank, oil contamination, corrosion, repair costs, environmental pollution, etc. The reduction of sludge viscosity can be achieved by reduction of its interfacial tension. In this study, different chemical and physical factors, influencing prepared emulsions(made of sludge, water and surfactant), such as surfactants, solvents, temperature, pressure, and mixing conditions were investigated. Results showed that non-ionic surfactants(like bitumen emulsifier), and solvents(such as mixed xylene, AW-400, and AW-402), injection of additives, applying pressure, and mixing operations had a positive effect on reduction of emulsion viscosity. All experiments were carried out with sludge obtained from crude oil storage tanks at Kharg Island,Iran. | Masoumeh Hassanzadeh Leila Tayebi Hedieh Dezfouli | 2018 | Petroleum Science2018，15，3： | 11 |
| 4 | COORDINATING PRODUCTION AND RECYCLING DECISIONS WITH STOCHASTIC DEMAND AND RETUR显示文摘In this paper, the joint production and recycling problem is investigated for a hybrid manufacturing and remanufacturing system where brand-new products are produced in the manufacturing plant and recycled products are remanufactured into as-new products in the remanufacturing facility. Both the brand-new products and remanufactured products are used to satisfy customer demands. Returns of used products that are recycled from customers are assumed to be stochastic and nonlinearly price-dependent. A mathematical model is proposed to maximize the overall profit of the system through simultaneously optimizing the production and recycling decisions, subject to two capacity constraints ? the manufacturing capacity and the remanufacturing capacity. Based on Lagrangian relaxation method, subgradient algorithm and heuristic algorithm, a solution approach is developed to solve the problem. A representative example is presented to illustrate the system, and managerial analysis indicates that the uncertainties in demand and return have much influence on the production and recycling policy. In addition, twenty randomly produced examples are solved, and computational results show that the solution approach can obtain very good solutions for all examples in reasonable time. | Jianmai SHI Guoqing ZHANG Jichang SHA Saman Hassanzadeh AMIN | 2010 | Journal of Systems Science and Systems Engineering2010，19，4： | 10 |
| 5 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 6 | Effects of Matricaria chamomilla Extract on Growth and Maturation of Isolated Mouse Ovarian Follicles in a Three-dimensional Culture System显示文摘 | Hamed Shoorei Arash Khaki Nava Ainehchi Mohammad Mehdi Hassanzadeh Taheri Moloud Tahmasebi Giti Seyedghiasi Ziba Ghoreishi Majid Shokoohi Amir Afshin Khaki Sayed Haidar Abbas Raza | 2018 | Chinese Medical Journal2018，，2： | 4 |
| 7 | A Robust Damage Detection Method Developed for Offshore Jacket Platforms Using Modified Artificial Immune System Algorithm显示文摘Steel jacket-type platforms are the common kind of the offshore structures and health monitoring is an important issue in their safety assessment.In the present study,a new damage detection method is adopted for this kind of structures and inspected experimentally by use of a laboratory model.The method is investigated for developing the robust damage detection technique which is less sensitive to both measurement and analytical model uncertainties.For this purpose,incorporation of the artificial immune system with weighted attributes(AISWA) method into finite element(FE) model updating is proposed and compared with other methods for exploring its effectiveness in damage identification.Based on mimicking immune recognition,noise simulation and attributes weighting,the method offers important advantages and has high success rates.Therefore,it is proposed as a suitable method for the detection of the failures in the large civil engineering structures with complicated structural geometry,such as the considered case study. | Mojtahedi A. Lotfollahi Yaghin M.A. Hassanzadeh Y. Abbasidoust F. Ettefagh M.M. Aminfar M.H. | 2012 | China Ocean Engineering2012，26，3： | 4 |
| 8 | Effect of pyrite content of feed and configuration of locked particles on rougher flotation of copper in low and high pyritic ore types显示文摘Misreported pyrite into copper concentrates dramatically declines copper grade and recovery. Copper flotation can be also more complicated if flotation feed comes from an elevated-pyritic copper ore. In this investigation, the effect of two different ore types(high pyritic and low pyritic feeds) was studied on rougher stage of industrial copper flotation circuit. Samples were taken from different streams and the structure of chalcopyrite within the pyrite and non-sulfide gangue minerals was examined in various size fractions for mentioned ore types. Results indicated that 72% and 56% of the total floated pyrite was transferred to concentrate in first four cells in the low and high pyritic feeds, respectively. Whereas, this proportion for floated SiO_2 in last ten cells was detected as 72% and 71%, respectively. A detailed interpretation of the effect of locked particles in different size fractions on rougher flotation cells is studied from industrial point of view. | Sahar Agheli Ahmad Hassanzadeh Behzad Vaziri Hassas Mohammad Hasanzadeh | 2018 | International Journal of Mining Science and Technology2018，28，2： | 3 |
| 9 | Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of microribonucleic acids显示文摘5-flurouracil(5-FU)-based chemotherapy is the main pharmacological therapy for advanced colorectal cancer(CRC).Despite significant progress in the treatment of CRC during the last decades,5-FU drug resistance remains the most important cause of failure in CRC therapy.Resistance to 5-FU is a complex and multistep process.Different mechanisms including microsatellite instability,increased expression level of key enzyme thymidylate synthase and its polymorphism,increased level of 5-FU-activating enzymes and mutation of TP53 are proposed as the main determinants of resistance to 5-FU in CRC cells.Recently,microribonucleic acids(miRNA)and their alterations were found to have a crucial role in 5-FU resistance.In this regard,the miRNA-mediated mechanisms of 5-FU drug resistance reside among the new fields of pharmacogenetics of CRC drug response that has not been completely discovered.Identification of the biological markers that are related to response to 5-FU-based chemotherapy is an emerging field of precision medicine.This approach will have an important role in defining those patients who are most likely to benefit from 5-FU-based chemotherapy in the future.Thereby,the identification of 5-FU drug resistance mechanisms is an essential step to predict and eventually overcome resistance.In the present comprehensive review,we will summarize the latest knowledge regarding the molecular determinants of response to 5-FU-based chemotherapy in CRC by emphasizing the role of miRNAs. | Amirsaeed Sabeti Aghabozorgi Mostafa Moradi Sarabi Reza Jafarzadeh-Esfehani Shabnaz Koochakkhani Marziyeh Hassanzadeh Soudabeh Kavousipour Ebrahim Eftekhar | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 3 |
| 10 | Consumption of spicy foods and the prevalence of irritable bowel syndrome显示文摘AIM:To explore the association between consumption of spicy foods and prevalence of irritable bowel syndrome(IBS)among Iranian adults.METHODS:In this cross-sectional study,data from4763 Iranian adult participants were used.Consumption of spicy foods was estimated using a dietary habits questionnaire that included a question on spicy foods consumption:'how frequently do you use spicy foods(pepper,curry,ginger,cinnamon and turmeric)during a week?'Participants could respond to the question by choosing one of these choices:never,1-3 times,4-6times,7-9 times,or more than 10 times per week.A modified Persian version of the RomeⅢquestionnaire was used to determine the prevalence of IBS.RESULTS:IBS was prevalent in 21.7%(18.6%of men and 24.1%of women)of the study population.After controlling for potential confounders including dietary behaviors,those consuming spicy foods≥10 times per week were 92%more likely to have IBS compared with those who never consumed spicy foods(OR=1.92;95%CI:1.23-3.01,Ptrend<0.01).The association remained significant even after taking lactose intolerance into account(OR=1.85;95%CI:1.18-2.90,Ptrend<0.01).Stratified analysis by gender revealed that the association between consumption of spicy foods and IBS was not significant in men;however,a significant association was found among women after taking potential cofounders,including meal regularity and lactose intolerance,into account.Women who consumed spicy foods≥10 times per week were two times more likely to have IBS compared with those who never consumed spicy foods(OR=2.03;95%CI:1.09-3.77,Ptrend=0.02).CONCLUSION:Consumption of spicy foods is directly associated with IBS,particularly in women.Further,prospective studies are warranted to(1)examine this association in other populations;and(2)evaluate whether dietary interventions,for example a reduction in spice consumption,would improve IBS symptoms. | Ahmad Esmaillzadeh Ammar Hassanzadeh Keshteli Maryam Hajishafiee Awat Feizi Christine Feinle-Bisset Peyman Adibi | 2013 | World Journal of Gastroenterology2013，19，38： | 3 |
| 11 | Calculation of dpa rate in graphite box of Tehran Research Reactor(TRR)显示文摘Radiation damage is an important factor that must be considered while designing nuclear facilities and nuclear materials. In this study, radiation damage is investigated in graphite, which is used as a neutron reflector in the Tehran Research Reactor (TRR) core. Radiation damage is shown by displacement per atom (dpa) unit. A cross section of the material was created by using the SPECOMP code. The concentration of impurities present in the non-irradiated graphite was measured by using the ICP-AES method. In the present study the MCNPX code had identified the most sensitive location for radiation damage inside the reactor core. Subsequently, the radiation damage (spectral-averaged dpa values) in the aforementioned location was calculated by using the SPECTER, SRIM Monte Carlo codes, and Norgett, Robinson and Torrens (NRT) model. The results of “Ion Distribution and Quick Calculation of Damage”(QD) method groups had a minor difference with the results of the SPECTER code and NRT model. The maximum radiation damage rate calculated for the graphite present in the TRR core was 1.567 9 10^-8 dpa/s. Finally, hydrogen retention was calculated as a function of the irradiation time. | Mohamad Amin Amirkhani Mohsen Asadi Asadabad Mostafa Hassanzadeh Seyed Mohammad Mirvakili Ali Mohammadi | 2019 | Nuclear Science and Techniques2019，30，6： | 2 |
| 12 | Design of an optofluidic biosensor using the slow - light effect in photonic crystal structures显示文摘 | Hosseinibalam F Hassanzadeh S Ebnali tteidari A | 2012 | Appl Opt2012，51，5： | 1 |
| 13 | A genetic algorithm for solving fuzzy shortest path problems with mixed fuzzy arc lengths显示文摘 | Hassanzadeh R Mahdavi I Mahdavi-Amiri N | 2013 | Mathematical and Computer Modelling2013，57，1： | 1 |
| 14 | Effect of surfactants on the synthesis of Al2O3 - CeO2 nanocomposite using a reverse microemulsion method 显示文摘 | Pournajaf R Hassanzadeh - Tabrizi S A Ghashang M | 2014 | Ceramics International2014，40，3： | 1 |
| 15 | Pelvic Fixation in adult and pediatric spine surgery:historical perspective,indications,and techniques:AAOS exhibit selection显示文摘 | Jain A Hassanzadeh H Strike SA | 2015 | J Bone Joint Surg Am2015，97，18： | 1 |
| 16 | Classical and alternative activation of mononuclear phagocytes:picking the best of both worlds for tumor promotion显示文摘 | Movahedi K Hassanzadeh Ghassabeh G | 2006 | Immunobiology2006，211，： | 1 |
| 17 | Classical and alternative activation of mono-nuclear phagocytes: picking the best of both worlds fortumor promotion 显示文摘 | Van Ginderachter JA Movahedi K Hassanzadeh Ghas-sabeh G | 2006 | Immunobiolo- gy2006，211，68： | 1 |
| 18 | Survival anal-ysis of drug abuse relapse in addiction treatment centers 显示文摘 | KASSANI A NIAZI M HASSANZADEH J | 2015 | HighRisk Behav Addict2015，4，23： | 1 |
| 19 | Identification of a common gene signature for type Ⅱ cytokine-associated myeloid cells elicited in vivo in different pathologic conditions显示文摘 | De Baetselier P Brys L | 2006 | Blood2006，108，： | 1 |
| 20 | lntrace- rebroventricular administration of riluzole prevents mor- phine-induced apoptosis in the lumbar region of the rat spinal cord 显示文摘 | Hassanzadeh K Habibi-asl B Roshangar L | 2010 | Pharmacol Rep2010，62，： | 1 |
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