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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Oligodendroglial cell death with DNA fragmentation in the white matter under chronic cerebral hypoperfusion: comparison between normotensive and spontaneously hypertensive rats显示文摘 | Masumura M Hata R Nagai Y | 2001 | Neurosci Res2001，39，4： | 1 |
| 3 | Co-expression of vascular endometrial growth factor and thymidine phosphorylase in endometrial cancer显示文摘 | Hata K Iida K | 1999 | Acta Obstet Gynecol Scand1999，78，8： | 1 |
| 4 | Brainstem auditory evoked potentials during brainstem ischemia and reperfusion in gerbils显示文摘 | Hata R Matsumoto M Matsuyama T | 1998 | Neuroscience1998，83，1： | 1 |
| 5 | Aggravation of brain injury after transient focal ischemia in p53-deficient mice显示文摘 | Maeda K Hata R Gillardon F Hossmann KA | 2001 | Mol Brain Res2001，88，12： | 1 |
| 6 | Expression and molecular pharmacology of the mouse CRTH2 receptor显示文摘 | Hata AN Zent R Breyer MD | 2003 | J Pharmacol Exp Ther2003，306，2： | 1 |
| 7 | A reproducible model of middle cerebral artery occlusion in mice : hemodynamic, biochemical, and magnetic resonance imaging显示文摘 | Hata R Mies G Wiessner C | 1998 | J Cereb Blood Flow Metab1998，18，4： | 1 |
| 8 | Spontaneousperforation of the rectum with possible stercoral etiology:report of a case and review of the literature显示文摘 | Tokunaga Y Hata K Nishitai R | 1998 | Surg Today1998，28，9： | 1 |
| 9 | Evolution of bnain infarction after transient focal cerebral ischemia in mice显示文摘 | Hata R Maeda K Hermann D | 2000 | J Cereb Blood Flow Metab2000，20，6： | 1 |
| 10 | Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusion in mice显示文摘 | Hata R Maeda K Hermann D | 2000 | Cereb Blood Flow Metab2000，20，2： | 1 |
| 11 | Expression of thymidine phosphorylase in epithelial ovarian cancer:correlation with angiogenesis,apoptosis,and ultrasound-derived peak systolic velocity显示文摘 | Fujiwaki R Maede Y | 2000 | Gynecol Oncol2000，77，1： | 1 |
| 12 | Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusionin mice显示文摘 | Hata R Maeda K Hermann D | 2000 | Cereb Blood Flow Metab2000，20，： | 1 |
| 13 | Immunohistochemical expression of thymidine phosphorylase in human endometrial cancer显示文摘 | Fujiwaki R Hata K Iida K | 1998 | Gynecol Oncol1998，68，3： | 1 |
| 14 | Fas antigen mRNA induction in postischemic murine brain显示文摘 | Matsuyama T Hata R Tagaya M | 1994 | Brain Research1994，657，： | 1 |
| 15 | Investigation of chemical composition of Alchemilla vulgaris 显示文摘 | Khimiya R Kafuku K Hata C | 2000 | Biol Chem2000，66，2： | 1 |
| 16 | Identification of residual breast carcinoma following neoadjuvant chemotherapy: diffusion- weighted imaginge-comparison with contrast-enhanced MR imaging and pathologic findings 显示文摘 | Woodhams R Kakita S Hata H | 2010 | Radiology2010，254，2： | 1 |
| 17 | Isolation of bitter peptides from tryptic hydroly-sate of casein and their chemical structure 显示文摘 | Matoba T Hayashi R Hata T | 1970 | Agricultural and Biological Chemistry1970，，8： | 1 |
| 18 | Regulation ofbone and cartilage development by network between BMPsignalling and transcription factors 显示文摘 | Nishimura R Hata K Matsubara T | 2012 | J Biochem2012，151，3： | 1 |
| 19 | Ginsenoside Rbl protects against damage to the spiralganglion ceils after cochlear ische mia显示文摘 | Fujita K Hakuha N Hata R | 2007 | Neurosci Lett2007，415，： | 1 |
| 20 | Pilomatricoma with abullous appearance显示文摘 | Inui S Kanda R Hata S | 1997 | J Dermatol1997，24，1： | 1 |
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