|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 3 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 4 | Interleukin-15 can replace theIL-2 signal in IL-2-dependent adult T-cell leukemia (ATL) cell linesexpression of IL-15 receptor alpha on ATL cells 显示文摘 | Yamada Y Sugawara K Hata T | 1998 | Blood1998，91，11： | 3 |
| 5 | A case of melanonychia caused by Exophiala dermatitidis显示文摘 | Hata Y Naka W Nishikawa T | 1999 | Nippon Ishinkin Gakkai Zasshi1999，40，： | 1 |
| 6 | Status of myocardial antioxidants in ischemia-reperfusion injury显示文摘 | Dhalla N S Elmoselhi A B Hata T | 2000 | Cardiovasc Res2000，47，3： | 1 |
| 7 | Acceleration effect of human recombinant bone morphogenetic protein-2 on differentiation of human pulp cells into odontoblasts 显示文摘 | Saito T Ogawa M Hata Y | 2004 | J Endod2004，30，4： | 1 |
| 8 | Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese: the Hisayama study 显示文摘 | Hata J Doi Y Ninomiya T | 2011 | Cerebrovasc Dis2011，31，5： | 1 |
| 9 | Nanofihration membrane bioreactor for continuous asymmetric reduction of 2-ketoulutarate to produce L-glutamate with NADH regeneration显示文摘 | Lin Shu - Su Harada T Hata C | 1997 | J Ferm Bioeng1997，83，1： | 1 |
| 10 | Brainstem auditory evoked potentials during brainstem ischemia and reperfusion in gerbils显示文摘 | Hata R Matsumoto M Matsuyama T | 1998 | Neuroscience1998，83，1： | 1 |
| 11 | Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo 显示文摘 | Hisatomi T Sakamoto T Murata T Yamanaka I Oshima Y Hata Y | 2001 | Am J Pathol2001，158，4： | 1 |
| 12 | Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice显示文摘 | Nitta T Hata M Gotoh S | | 0，，03： | 1 |
| 13 | Pitfalls of pit pattern diagnosis in ulcerative colitis-associated dysplasia 显示文摘 | Hata KI Watanabe T Motoi T | 2004 | Gastroenterology2004，126，1： | 1 |
| 14 | Leucomycin, a new antibiotic显示文摘 | Hata T Sano Y Ohki N | 1953 | JAntibiot1953，6，2： | 1 |
| 15 | Diverse functions of the P75 neurotrophin receptor显示文摘 | Yamashita T Fujitani M Hata K et at | 2005 | Anat Sci Int2005，80，1： | 1 |
| 16 | New dyeing method for wild silk yarns using reactive dyes显示文摘 | KATO H HATA T OBO M | 1996 | JARQ1996，30，3： | 1 |
| 17 | Fas antigen mRNA induction in postischemic murine brain显示文摘 | Matsuyama T Hata R Tagaya M | 1994 | Brain Research1994，657，： | 1 |
| 18 | Treatment of domestic sewage from rural settlements by a membrane bioreactor显示文摘 | Ueda T Hata K Kikuoka Y 1996 | 1996 | Water Science and Technology1996，34，9： | 1 |
| 19 | Size-selective growth of double-walled carbon nanotube forests from engineered iron catalysts显示文摘 | Yamada T Namai T Hata K | 2006 | Nature Nanotechnology2006，1，2： | 1 |
| 20 | Basic fibroblast growth factor enema improves experimental colitis in rats 显示文摘 | Kojima T Watanabe T Hata K | 2007 | Hepatogastroenterology2007，54，77： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员