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| 1 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 2 | Patent indicators for the technology life cycle development 显示文摘 | HAUPT R KLOYER M LANGE M | 2007 | Research Policy2007，36，： | 1 |
| 3 | High-throughput viral expression of cDNA-green fluorescent protein fusions reveals novel subcellular addresses and identifies unique proteins that interact with plasmodesmata 显示文摘 | ESCOBAR N M HAUPT S THOW G | 2003 | The Plant Cell2003，15，： | 1 |
| 4 | High-throughput viral expression of cDNA-green fluorescent protein fusions reveals novel subcellular addresses and identifies unique proteins that interact with plasmodesmata显示文摘 | Escobar N M Haupt S Thow G | 2003 | Plant Cell2003，15，： | 1 |
| 5 | Apoptosis -the p53 network显示文摘 | HAUPT S BERGER M | 2003 | J Cell Sci2003，116，20： | 1 |
| 6 | Patent indicators for the technology life cycle development 显示文摘 | Haupt R Kloyer M Laage M | 2007 | Research Policy2007，36，3： | 1 |
| 7 | Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘 | Haupt Y Bath M L Harris A W | 1993 | Oncogene1993，8，11： | 1 |
| 8 | Patent Indicators for the Technol- ogy Life Cycle Development显示文摘 | Haupt R Kloyer M Lange M | 2007 | Research Policy2007，，36： | 1 |
| 9 | Formation and photocatalytic decomposition of a pellicle on anatase surfaces显示文摘 | Rupp F Haupt M Eichler M | 2012 | J Dent Res2012，91，1： | 1 |
| 10 | Autmnated selection and harvesting of pluripotent stem cell colonies 显示文摘 | Haupt S Grtitzner J Thier M C | 2012 | Biotechnol App] Biochem2012，59，2： | 1 |
| 11 | Cerebral glucose metabolism in acute and persistent vegetative state显示文摘 | GHAEMI M HAUPT WF | 1999 | J Neurosurg Anesthesiol1999，11，1： | 1 |
| 12 | Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘 | Haupt Y Bath M L Harris A W | 1993 | Oncogene1993，8，11： | 1 |
| 13 | Comparison of genomic DNA extraction techniques from whole blood samples: a time, cost and quality evaluation study 显示文摘 | Chaeon-Cortes D Haupt L M Lea R A | 2012 | Mol Biol Rep2012，39，5： | 1 |
| 14 | Multifunctional nature of UV-irradiated nanocrystalline anatase thin films for biomedical applications显示文摘 | Rupp F Haupt M Klostermann H | 2010 | Acta Biomater2010，6，12： | 1 |
| 15 | Adsorptionof proteins on spherical polyelectrolyte brushes in aqueous so-lution显示文摘 | WITTEMANN A HAUPT B BALLAUFF M | 2003 | Phys Chem Chem Phys2003，5，： | 1 |
| 16 | Apoptosis - the p53 network 显示文摘 | Haupt S Berger M Goldberg Z eta1 | 2003 | J Cell Sci2003，116，20： | 1 |
| 17 | Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘 | Haupt Y Bath M L Harris A W | 1993 | Oncogene1993，8，11： | 1 |
| 18 | Effect of shock waves on the healing of partial- thickness wounds in piglets显示文摘 | Haupt G Chvapil M | 1990 | J Surg Res1990，49，1： | 1 |
| 19 | Role of olfactory bulb serotonin in olfactory learning in the greater short-nosed fruit bat, Cynopterus sphinx (Chiroptera: Pteropodidae ) 显示文摘 | Ganesh A Bogdanowicz W Haupt M Marimuthu G Rajan KE | 2010 | Brain Res2010，1352，： | 1 |
| 20 | A novel photoreactor for the production ofelectrosterically stabilised colloidal particles at larger scales 显示文摘 | Schrinner M Haupt B Wittemann A | 2008 | ChemicalEngineering Journal(S1385-8947)2008，144，1： | 1 |
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