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| 1 | Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRLIIpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation显示文摘我们以前报导了那 SM934,水溶性的 artemisinin 衍生物,是在鼠科的豺狼座模型的一个可行处理。在当前的学习,我们进一步在豺狼座容易的 MRL/lpr 老鼠上调查了 SM934 的修改剂量政体的治疗学的效果并且在 B 房间回答上探索了它的效果,在全身的豺狼座 erythematosus (SLE ) 的一个中央病原的事件。当口头上地管理了时两次每日, SM934 显著地延长了 MRL/lpr 老鼠的寿命,改善 lymphadenopathy 症状并且减少浆液的层次反原子的抗体(言论集) 并且病原的 cytokines IL-6, IL-10 和 IL-21。而且, SM934 处理由增加静止 B 房间数字在 MRL/lpr 老鼠的怒气恢复了 B 房间分隔空间,维持幼芽的中心 B 房间数字,减少激活的 B 房间数字和减少的血浆房间(PC ) 数字。前 vivo, SM934 压制了触发的像使用费的受体(TLR ) B 房间的激活和增长,以及抗体分泌物。而且,现在的学习证明 SM934 由 downregulating TLR7/9 mRNA 表示, MyD88 蛋白质表示和 NF-κ 防碍 B 房间内在的小径; B phosphorylation。在人的外部血 mononuclear 房间(PBMC ) ,与在 MRL/lpr 鼠标的结果一致, SM934 禁止了联系 TLR 的 B 房间激活和 PC 区别。在结论, SM934 的两次每日的 dosing 政体由压制 B 房间激活和血浆房间形成在豺狼座容易的 MRL/lpr 老鼠上有治疗学的效果。 | Yanwei Wu Shijun He Bingxin Bai Luyao Zhang Lu Xue Zemin Lin Xiaoqian Yang Fenghua Zhu Peilan He Wei Tang Jianping Zuo | 2016 | Cellular & Molecular Immunology2016，13，3： | 31 |
| 2 | The Origin and Tectonic Significance of the Volcanic Rocks of the Yeba Formation in the Gangdese Magmatic Belt, South Tibet显示文摘Zircon U-Pb geochronology, Hf isotope and whole-rock geochemistry were performed on the tuffs of the Yeba Formation in the Gangdese magmatic belt, South Tibet. The results are used to detail the age, source nature and tectonic processes that led to the formation of the Gangdese belt. Dating results indicate that the rhyolitic-andesitic tuffs were formed at 174–170 Ma. Positive and variable zircon ε_(Hf)(t) values of the rhyolitic tuffs reveal that the source was dominated by juvenile material, however, experienced crustal contamination. The basaltic tuffs have low HREEs, high contents of compatible elements(V and Cr) and no Eu anomaly. In contrast, the rhyolitic-andesitic tuffs show low compatible trace elements, depletion in Eu but enrichment in incompatible elements(Rb, Zr and Hf). According to the discrimination diagrams of P_2O_5-SiO_2 and Th-Rb, the rhyolitic-andesitic tuffs show a close affinity to Ⅰ-type granitoids. Moreover, these tuffs are marked by significant depletion in Nb, Ta and Ti, plotted in calc-alkaline field, and with the andesitic-rhyolitic tuffs falling into an active continental margin setting. We suggest that these tuffs of the Yeba Formation were probably generated in an active continental margin above the northward subduction of the Neo-Tethyan oceanic lithosphere. | Xuxuan Ma Zhiqin Xu Xijie Chen Joseph G.Meert Zhenyu He Fenghua Liang Yuanku Meng Shiwei Ma | 2017 | Journal of Earth Science2017，28，2： | 20 |
| 3 | How Chinese Financial Centers Integrate into Global Financial Center Networks:An Empirical Study Based on Overseas Expansion of Chinese Financial Service Firms显示文摘The increasing globalization of the Chinese economy has been enabled by both Chinese financial institutions operating globally as well as international firms operating within China. In geographical terms, this has been organized through a number of strategic cities serving as gateways for the exchange of financial functions, products and practices between China and the global economy. Drawing on location data of financial service firms in China listed on stock exchanges in Shenzhen, Shanghai and Hong Kong, this paper shows that Chinese financial firms are expanding globally and how Chinese financial centers are positioned and connected in the urban networks shaped by these financial service firms. It is found that Hong Kong, China, holds strategic positions in the integration of Chinese cities into global financial center networks, and that establishing a foothold in global financial centers such as New York and London has been a priority for Chinese financial institutions. The increasing capital flows directed by Chinese financial institutionssuggests a shifting global financial geography, with numerous Chinese cities playing increasingly important roles within global financial center networks. | PAN Fenghua HE Ziyun Thomas SIGLER Kirsten MARTINUS Ben DERUDDER | 2018 | Chinese Geographical Science2018，28，2： | 15 |
| 4 | Regional Difference in Social Capital and Its Impact on Regional Economic Growth in China显示文摘Social capital has played an increasingly important role in regional development.China is a country with high stocks of social capital.Using several different indicators of social capital,this study tries to research the regional disparities in social capital and the influence of social capital on economic growth of China in 1978-2004.Measuring social capital with indicators of associations,charities and blood donation rates,this study finds significant regional disparities in social capital at provincial level in China.Those indicators for social capital are highly correlated with regional economic performance.Statistical analysis shows that social capital has a significant and positive effect on a long-term provincial economic growth.This relationship exists after controlling policy,macro location factors,and per capita GDP in the initial year.The empirical findings indicate that institutions,culture and social relations are critical for regional development in China.Therefore,the creation and support of social capital should be paid more attention to when making regional policy. | PAN Fenghua HE Canfei | 2010 | Chinese Geographical Science2010，20，5： | 14 |
| 5 | Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation显示文摘The surrogate reproduction technique,such as inter-specific spermatogonial stem cells(SSCs)transplantation(SSCT),provides a powerful tool for production of gametes derived from endangered species or those with desirable traits.However,generation of genome-edited gametes from a different species or production of gametes from a phylogenetically distant species such as from a different subfamily,by SSCT,has not succeeded.Here,using two small cyprinid fishes from different subfamilies,Chinese rare minnow(gobiocypris rarus,for brief:Gr)and zebrafish(danio rerio),we successfully obtained Gr-derived genome-edited sperm in zebrafish by an optimized SSCT procedure.The transplanted Gr SSCs supported the host gonadal development and underwent normal spermatogenesis,resulting in a reconstructed fertile testis containing Gr spermatids and zebrafish testicular somatic cells.Interestingly,the surrogate spermatozoa resembled those of host zebrafish but not donor Gr in morphology and swimming behavior.When pou5f3 and chd knockout Gr SSCs were transplanted,Gr-derived genome-edited sperm was successfully produced in zebrafish.This is the first report demonstrating surrogate production of gametes from a different subfamily by SSCT,and surrogate production of genome-edited gametes from another species as well.This method is feasible to be applied to future breeding of commercial fish and livestock. | Fenghua Zhang Yongkang Hao Xianmei Li Yi Li Ding Ye Ru Zhang Xiaosi Wang Mudan He Houpeng Wang Zuoyan Zhu Yonghua Sun | 2022 | Science China(Life Sciences)2022，65，5： | 7 |
| 6 | A novel cooperative mid-course guidance scheme for multiple intercepting missiles显示文摘In the interception engagement,if the target movement information is not accurate enough for the mid-course guidance of intercepting missiles,the interception mission may fail as a result of large handover errors.This paper proposes a novel cooperative mid-course guidance scheme for multiple missiles to intercept a target under the condition of large detection errors.Under this scheme,the launch and interception moments are staggered for different missiles.The earlier launched missiles can obtain a relatively accurate detection to the target during their terminal guidance,based on which the latter missiles are permitted to eliminate the handover error in the mid-course guidance.A significant merit of this scheme is that the available resources are fully exploited and less missiles are needed to achieve the interception mission.To this end,first,the design of cooperative handover parameters is formulated as an optimization problem.Then,an algorithm based on Monte Carlo sampling and stochastic approximation is proposed to solve this optimization problem,and the convergence of the algorithm is proved as well.Finally,simulation experiments are carried out to validate the effectiveness of the proposed cooperative scheme and algorithm. | Long WANG Yu YAO Fenghua HE Kai LIU | 2017 | Chinese Journal of Aeronautics2017，30，3： | 7 |
| 7 | A simple way to make pre-stressed ceramics with high strength显示文摘A pre-stressing design and a simple fabrication technology to substantially improve the strength of ceramic components are presented.Residual surface compressive stress is generated in ceramic components by pressureless sintering of a green bulk coated with a thin layer of low coefficient of thermal expansion(CTE).The stress level can be controlled by changing the cross-section area ratio,Young's modulus ratio and CTE ratio of the coating.Pre-stressed ZrO_(2) ceramics coated with Al_(2)O_(3) can achieve a flexural strength of 1330±52MPa,45% higher than their uncoated counterpart.Similarly,the flexural strength of building porcelain tiles is increased by 70%,from 67±3 MPa to 114±5MPa.The damage tolerance of pre-stressed ZrO_(2) ceramics is excellent with a high residual strength of ~1200 MPa in a thermal shock test at 325℃.This simple technique can improve the mechanical performance of ceramic components with no limitation of size and shape. | Yiwang Bao Fenghua Kuang Yi Sun Yueming Li Detian Wan Zongyang Shen Delong Ma Lingfeng He | 2019 | Journal of Materiomics2019，5，4： | 7 |
| 8 | Optimal switching target-assignment based on the integral performance in cooperative tracking显示文摘This paper investigates a dynamic target-assignment problem.A close-loop integrated frame for target-assignment is proposed novelly which incorporates the kinematics between ?ight vehicles and targets.Based on an integral performance index which represents the energy cost,the optimal switching assignmentplan is obtained.Considering the con?guration variation introduced by a switching assignment-plan,an H∞ guidance law with switching-target is proposed which underlays a dynamic assignment process in cooperative tracking.Simulation results are given to show the e?ectiveness of the proposed guidance-law and the switchingplan for target assignment. | YAO Yu ZHANG Peng LIU Hugh HE FengHua | 2013 | Science China(Information Sciences)2013，56，1： | 5 |
| 9 | Finite time L_1 Approach for Missile Overload Requirement Analysis in Terminal Guidance显示文摘This article analyzes the problem about the missile overload requirement in a homing terminal guidance under various engagement scenarios.An augmented proportional navigation guidance(APNG) model is introduced on the basis of linear kinematics.To analyze the peak-to-peak performance of the terminal guidance system,a new finite time L1 performance measure for a linear time-varying(LTV) continuous system is proposed.Then,according to the idea of the adjoint system,a novel method for computing the L1 norm of a linear continuous system is first derived.Within the finite time L1 framework,the quantitative relation between the guidance loop dynamics and the maximum missile-target maneuver ratio is offered.This relation is expressed in the form of graphs and formulas that can be used to synthesize some of the major subsystem specifications for the missile guidance system.The illustrative examples show that a significant performance improvement is achieved with the proposed guidance loop dynamics. | Ji Denggao,He Fenghua,Yao Yu Control and Simulation Center,Harbin Institute of Technology,Harbin 150080,China | 2009 | Chinese Journal of Aeronautics2009，22，4： | 4 |
| 10 | Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA显示文摘Nasopharyngeal carcinoma(NPC)is a malignant tumor that usually occurs in people from Southeast Asia and Southern China.NPC is prone to migration and invasion,leading to poor prognosis.A large number of circular RNAs(circ RNAs)exacerbate the process of metastasis in NPC;however,their underlying mechanisms remain unclear.We found that the circular RNA circ CCNB1,encoded by the oncogene CCNB1,was downregulated in NPC biopsies and cell lines.In vitro assays show that circ CCNB1 inhibits NPC cell migration and invasion.Moreover,circ CCNB1 induces a protein,nuclear factor 90(NF90),to bind and prolong the half-life of tight junction protein 1(TJP1)m RNA.Upregulation of TJP1 enhances tight junctions between cancer cells and inhibits NPC cell migration and invasion.This study reveals a novel biological function of circ CCNB1 in the migration and invasion of NPC by enhancing the tight junctions of cancer cells by binding to NF90 proteins and TJP1 m RNA,and may provide a potential therapeutic target for NPC. | Mengyao Zhao Yian Wang Fenghua Tan Lingyun Liu Xiangchan Hou Chunmei Fan Le Tang Yongzhen Mo Yumin Wang Qijia Yan Zhaojian Gong Zheng Li Qianjin Liao Can Guo He Huang Xi Zeng Guiyuan Li Zhaoyang Zeng Wei Xiong Fuyan Wang | 2022 | Science China(Life Sciences)2022，65，11： | 4 |
| 11 | Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets显示文摘Kidney is a major target organ in both antiphospholipid syndrome(APS)and systemic lupus erythematosus(SLE).The etiology of antiphospholipid syndrome nephropathy associated lupus nephritis(APSN-LN)is intricate and remains largely unrevealed.We proposed in present work,that generation of antiphospholipid antibodies(aPLs),especially those directed towards the oxidized neoepitopes,are largely linked with the redox status along with disease progression.Moreover,we observed that compromised antioxidative capacity coincided with turbulence of inflammatory cytokine profile in the kidney of male NZW×BXSB F1 mice suffered from APSN-LN.SM934 is an artemisinin derivative that has been proved to have potent immunosuppressive properties.In current study,we elaborated the therapeutic benefits of SM934 in male NZW×BXSB F1 mice,a murine model develops syndrome resembled human APS associated with SLE,for the first time.SM934 treatment comprehensively impeded autoantibodies production,inflammatory cytokine accumulation and excessive oxidative stress in kidney.Among others,we interpreted in present work that both anti-inflammatory and antioxidative effects of SM934 is closely correlated with the enhancement of Nrf2 signaling and expression of its targets.Collectively,our finding confirmed that therapeutic strategy simultaneously exerting antioxidant and anti-inflammatory efficacy provide a novel feasible remedy for treating APSN-LN. | Zemin Lin Yuting Liu Li Chen Shiqi Cao Yueteng Huang Xiaoqian Yang Fenghua Zhu Wei Tang Shijun He Jianping Zuo | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 12 | Multi-agent coverage control design with dynamic sensing regions显示文摘一个合作区域侦察问题在一组代理人被要求侦察的这份报纸被考虑兴趣的一个区域。这个问题的主要挑战是察觉到每个代理人的区域在高度限制以内与它的高度变化。同时,一个代理人的侦察能力被它的高度和光线的距离决定。首先,区域侦察作为一个有效范围问题被提出,它意味着在给定的区域的每个点应该被调查直到预设水平被完成。然后,一条有效范围控制法律被建议由调整一个代理人的高度最小化范围性能索引。最后,建议控制法律的有效性通过数字模拟被验证。 | Longbiao MA Fenghua HE Long WANG Yu YAO | 2018 | Control Theory and Technology2018，16，3： | 2 |
| 13 | Integrated guidance and control design of a flight vehicle with side-window detection显示文摘This paper considers the guidance and control problem of a flight vehicle with sidewindow detection. In order to guarantee the target remaining in the seeker's sight of view, the line of sight and the attitude of the flight vehicle should be under some constraints caused by the sidewindow, which leads to coupling between the guidance and the attitude dynamics model. To deal with the side-window constraints and the coupling, a novel Integrated Guidance and Control(IGC)design approach is proposed. Firstly, the relative motion equations are derived in the body-Line of Sight(LOS) coordinate system. And the guidance and control problem of the flight vehicle is formulated into an IGC problem with state constraints. Then, based on the singular perturbation method, the IGC problem is decomposed into the control design of the quasi-steady-state subsystem and the boundary-layer subsystem which can be designed separately. Finally, the receding horizon control is applied to the control design for the two subsystems. Simulation results show the effectiveness of the proposed approach. | Tianyu ZHENG Yu YAO Fenghua HE Denggao JI | 2018 | Chinese Journal of Aeronautics2018，31，4： | 2 |
| 14 | Control Design for Harmonic Disturbance Rejection for Robot Manipulators with Bounded Inputs显示文摘Currently most of control methods are of one degree of freedom(1-DOF) control structure for the robot systems which are affected by unmeasurable harmonic disturbances,at the same time in order to obtain perfect disturbance attenuation level,the controller gain must be increased.In practice,however,for robotic actuators,there are physical constraints that limit the amplitude of the available torques.This paper considers the problem of tracking control under input constraints for robot manipulators which are affected by unmeasurable harmonic disturbances.A new control scheme is proposed for the problem,which is composed of a parameter-dependent nonlinear observer and a tracking controller.The parameter-dependent nonlinear observer,designed based on the internal model principle,can achieve an estimation and compensation of a class of harmonic disturbances with unknown frequencies.The tracking controller,designed via adaptive control techniques,can make the systems asymptotically track the desired trajectories.In the control design,the continuous piecewise differentiable increasing function is used to limit control input amplitude,such that the control input saturation is avoided.The Lyapunov stability of closed loop systems is analyzed.To validate proposed control scheme,simulation results are provided for a two link horizontal robot manipulator.The simulation results show that the proposed control scheme ensures asymptotic tracking in presence of an uncertain external disturbance acting on the system.An important feature of the methodology consists of the fact that the designed controller is of 2-DOF control structure,namely,it has the ability to overcome the conflict between controller gain and robustness against external disturbances in the traditional 1 -DOF control structure framework. | YAO Yu WANG Xiaochen HE Fenghua | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 1 |
| 15 | Effects of adding chicken manure to cattle manure on aerobic compost process parameters at low temperature显示文摘The research was aimed at studying the effect of adding certain proportion chicken manure to cattle manure on compost below 0℃ with aerobic compost method, which was suitable for northern cold climate. The results indicated that the mixed compost completed 3 days earlier than the single compost, the temperature of the mixed compost rose to 50.7℃ at the 1st day,and achieved its highest temperature 74.4℃ at the 3rd day. The temperature of the single compost rose to 40.0℃ at the 1st day,rose to 55.6℃ at the 3rd day,and achieved its highest temperature 70.1℃ at the 5th day. Adding chicken manure had no impact on the variety trend of the process parameters such as moisture content,pH and C/N ratio, but increased the variety range of these parameters. | ZHAO Xiaofeng XU Fenghua HE Huixia WAN Shuming | 2007 | Journal of Northeast Agricultural University(English Edition)2007，14，1： | 1 |
| 16 | Symmetry-based decomposition of finite games显示文摘The symmetry-based decompositions of finite games are investigated. First, the vector space of finite games is decomposed into a symmetric subspace and an orthogonal complement of the symmetric subspace. The bases of the symmetric subspace and those of its orthogonal complement are presented.Second, the potential-based orthogonal decompositions of two-player symmetric/antisymmetric games are presented. The bases and dimensions of all dual decomposed subspaces are revealed. Finally, some properties of these decomposed subspaces are obtained. | Changxi LI Fenghua HE Ting LIU Daizhan CHENG | 2019 | Science China(Information Sciences)2019，62，1： | 1 |
| 17 | Repression of interferon regulatory factor-4(IRF4)hyperactivation restricts murine lupus显示文摘Dear Editor,Hyperactivation of the type I interferon(IFN)signature has been observed in several systemic autoimmune conditions,and the type I IFN receptor antagonist Saphnelo(anifrolumab-fnia)has been approved in 2021 by the Food and Drug Administration(FDA)in the US.The launch of Saphnelo marked the only new treatment approved for systemic lupus erythematosus(SLE)in more than 10 years. | Shijun He Huihua Ding Li Chen Yiwei Shen Yuting Liu Fenghua Zhu Xiaoqian Yang Nan Shen Zemin Lin Jianping Zuo | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 1 |
| 18 | DESIGNING A HYBRID INTELLIGENT MINING SYSTEM FOR CREDIT RISK EVALUATION显示文摘在这研究,集成不平的集合理论和支持向量机器的一个新奇混合聪明的采矿系统被开发高效地为信用风险评估和分析从原来的信息桌子提取协会规则。在建议混合聪明的系统,支持向量机器被用作一个工具提取典型特征并且过滤它的噪音,它与不平的集合仅仅为支持向量机器被用作一个预处理器的以前的研究不同。如此的一条途径能减少信息桌子并且由不平的集合从减少的信息桌子产生最后的知识。因此,建议混合聪明的系统克服从一个训练支持向量机器分类器提取规则的 dificulty 并且拥有为 rough-set-based 途径正在缺乏的坚韧性。另外,建议混合聪明的系统的有效性与二真实世界的信用数据集被说明。 | Lean YU Shouyang WANG Fenghua WEN Kin Keung LAI Shaoyi HE | 2008 | Journal of Systems Science & Complexity2008，21，4： | 1 |
| 19 | Stock price prediction based on SSA and SVM 显示文摘 | Wen Fenghua Xiao Jihong He Zhifang | 2014 | Procedia Computer Science2014，31，： | 1 |
| 20 | The Study and Practice of Constructing Featured Specialty Based on the Double Qualified Teacher and Double Mentors显示文摘 | Fenghua ZHAO Xianfang GUO Yun HE | 2014 | Advanced Materials Research2014，，97： | 1 |
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