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| 1 | Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRLIIpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation显示文摘我们以前报导了那 SM934,水溶性的 artemisinin 衍生物,是在鼠科的豺狼座模型的一个可行处理。在当前的学习,我们进一步在豺狼座容易的 MRL/lpr 老鼠上调查了 SM934 的修改剂量政体的治疗学的效果并且在 B 房间回答上探索了它的效果,在全身的豺狼座 erythematosus (SLE ) 的一个中央病原的事件。当口头上地管理了时两次每日, SM934 显著地延长了 MRL/lpr 老鼠的寿命,改善 lymphadenopathy 症状并且减少浆液的层次反原子的抗体(言论集) 并且病原的 cytokines IL-6, IL-10 和 IL-21。而且, SM934 处理由增加静止 B 房间数字在 MRL/lpr 老鼠的怒气恢复了 B 房间分隔空间,维持幼芽的中心 B 房间数字,减少激活的 B 房间数字和减少的血浆房间(PC ) 数字。前 vivo, SM934 压制了触发的像使用费的受体(TLR ) B 房间的激活和增长,以及抗体分泌物。而且,现在的学习证明 SM934 由 downregulating TLR7/9 mRNA 表示, MyD88 蛋白质表示和 NF-κ 防碍 B 房间内在的小径; B phosphorylation。在人的外部血 mononuclear 房间(PBMC ) ,与在 MRL/lpr 鼠标的结果一致, SM934 禁止了联系 TLR 的 B 房间激活和 PC 区别。在结论, SM934 的两次每日的 dosing 政体由压制 B 房间激活和血浆房间形成在豺狼座容易的 MRL/lpr 老鼠上有治疗学的效果。 | Yanwei Wu Shijun He Bingxin Bai Luyao Zhang Lu Xue Zemin Lin Xiaoqian Yang Fenghua Zhu Peilan He Wei Tang Jianping Zuo | 2016 | Cellular & Molecular Immunology2016，13，3： | 31 |
| 2 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 3 | Stem cell transplantation for treatment of cerebral ischemia in rats Effects of human umbilical cord blood stem cells and human neural stem cells显示文摘BACKGROUND: Exogenous neural stem cell transplantation promotes neural regeneration. However, various types of stem cells transplantation outcomes remain controversial. OBJECTIVE: To explore distribution, proliferation and differentiation of human neural stem cells (hNSCs) and human umbilical cord blood stem cells (hUCBSCs) following transplantation in ischemic brain tissue of rats, and to compare therapeutic outcomes between hNSCs and hUCBSCs. DESIGN, TIME AND SETTING: Randomized controlled animal studies were performed at the Experimental Animal Center of Nanjing Medical University and Central Laboratory of Second Affiliated Hospital of Nanjing Medical University of China from September 2008 to April 2009. MATERIALS: hNSCs were harvested from brain tissue of 10-13 week old fetuses following spontaneous abortion, and hUCBSCs were collected from umbilical cord blood of full-term newborns at the Second Affiliated Hospital of Nanjing Medical University of China. hNSCs and hUCBSCs were labeled by 5-bromodeoxyuridine (BrdU) prior to transplantation. METHODS: Rat models of cerebral ischemia were established by the suture method. A total of 60 healthy male Sprague Dawley rats aged 7-9 weeks were randomly assigned to hNSC transplantation, hUCBSC transplantation and control groups. The rat models in the hNSC transplantation, hUCBSC transplantation and control groups were infused with hNSC suspension, hUCBSC suspension and saline via the caudal vein, respectively. MAIN OUTCOME MEASURES: The distribution, proliferation and differentiation of hNSCs and hUCBSCs in ischemic brain tissue were observed using immunohistochemical methods. Neurological function in rats was assessed using the neurological severity score. RESULTS: The number of BrdU-positive cells was significantly greater in the hNSC transplantation group compared with hUCBSC transplantation group at 14 days following transplantation (P < 0.05). The number of BrdU-positive cells reached a peak at 28 days following transplantation. Nestin-positive, glial fibrillary acidic protein-positive, cyclic nucleotide 3' phosphohydrolase-positive and neuron specific enolase-positive cells were visible following transplantation. No significant difference was determined in the constituent ratio of various cells between hNSC and hUCBSC transplantation groups (P > 0.05). The neurological severity score was significantly decreased in rats at 21 days following transplantation (P < 0.05). No significant difference was detected in neurological severity score between hNSC and hUCBSC transplantation groups at various time points (P > 0.05). CONCLUSION: The transplanted hNSCs and hUCBSCs can migrate into ischemic brain tissue, proliferate and differentiate into neuron-like, astrocyte-like and oligodendrocyte-like cells, and improve neurological function in rats with cerebral ischemia. | Fenghua Pan Xinsheng Ding Haixia Ding Weimin Zhang Xiaoxuan Deng Juan Yao | 2010 | Neural Regeneration Research2010，5，7： | 10 |
| 4 | Assessing environmental factors associated with regional schistosomiasis prevalence in Anhui Province,Peoples’Republic of China using a geographical detector method显示文摘Background:Schistosomiasis is a water-borne disease caused by trematode worms belonging to genus Schistosoma,which is prevalent most of the developing world.Transmission of the disease is usually associated with multiple biological characteristics and social factors but also factors can play a role.Few studies have assessed the exact and interactive influence of each factor promoting schistosomiasis transmission.Methods:We used a series of different detectors(i.e.,specific detector,risk detector,ecological detector and interaction detector)to evaluate separate and interactive effects of the environmental factors on schistosomiasis prevalence.Specifically,(i)specific detector quantifies the impact of a risk factor on an observed spatial disease pattern,which were ranked statistically by a value of Power of Determinate(PD)calculation;(ii)risk detector detects high risk areas of a disease on the condition that the study area is stratified by a potential risk factor;(iii)ecological detector explores whether a risk factor is more significant than another in controlling the spatial pattern of a disease;(iv)interaction detector probes whether two risk factors when taken together weaken or enhance one another,or whether they are independent in developing a disease.Infection data of schistosomiasis based on conventional surveys were obtained at the county level from the health authorities in Anhui Province,China and used in combination with information from Chinese weather stations and internationally available environmental data.Results:The specific detector identified various factors of potential importance as follows:Proximity to Yangtze River(0.322)>Land cover(0.285)>sunshine hours(0.256)>population density(0.109)>altitude(0.090)>the normalized different vegetation index(NDVI)(0.077)>land surface temperature at daytime(LST_(day))(0.007).The risk detector indicated that areas of schistosomiasis high risk were located within a buffer distance of 50 km from Yangtze River.The ecological detector disclosed that the factors investigated have significantly different effects.The interaction detector revealed that interaction between the factors enhanced their main effects in most cases.Conclusion:Proximity to Yangtze River had the strongest effect on schistosomiasis prevalence followed by land cover and sunshine hours,while the remaining factors had only weak influence.Interaction between factors played an even more important role in influencing schistosomiasis prevalence than each factor on its own.High risk regions influenced by strong interactions need to be targeted for disease control intervention. | Yi Hu Congcong Xia Shizhu Li Michael PWard Can Luo Fenghua Gao Qizhi Wang Shiqing Zhang Zhijie Zhang | 2017 | Infectious Diseases of Poverty2017，6，1： | 9 |
| 5 | High strength and ductility Mg-8Gd-3Y-0.5Zr alloy with bimodal structure and nano-precipitates显示文摘To resolve the strength-ductility trade-off problem for high-strength Mg alloys,we prepared a high performance Mg-8Gd-3Y-0.5 Zr(wt%)alloy with yield strength of 371 MPa,ultimate tensile strength of 419MPa and elongation of 15.8%.The processing route involves extrusion,pre-deformation and aging,which leads to a bimodal structure and nano-precipitates.Back-stress originated from the deformationincompatibility in the bimodal-structure alloy can improve ductility.In addition,dislocation density in coarse grains increased during the pre-deformation strain of 2%,and the dislocations in coarse grains can promote the formation of chain-like nano-precipitates during aging treatment.The chain-like nanoprecipitates can act as barriers for dislocations slip and the existing mobile dislocations enable good ductility. | Xiaoxiao Wei Li Jin Fenghua Wang Jing Li Nan Ye Zhenyan Zhang Jie Dong | 2020 | Journal of Materials Science & Technology2020，44，9： | 9 |
| 6 | Radiative transfer models(RTMs)for field phenotyping inversion of rice based on UAV hyperspectral remote sensing显示文摘The nondestructive and rapid acquisition of rice field phenotyping information is very important for the precision management of the rice growth process.In this research,the phenotyping information LAI(leaf area index),leaf chlorophyll content(C_(ab)),canopy water content(C_(w)),and dry matter content(C_(dm))of rice was inversed based on the hyperspectral remote sensing technology of an unmanned aerial vehicle(UAV).The improved Sobol global sensitivity analysis(GSA)method was used to analyze the input parameters of the PROSAIL model in the spectral band range of 400-1100 nm,which was obtained by hyperspectral remote sensing by the UAV.The results show that C_(ab) mainly affects the spectrum on 400-780 nm band,C_(dm) on 760-1000 nm band,C_(w) on 900-1100 nm band,and LAI on the entire band.The hyperspectral data of the 400-1100 nm band of the rice canopy were acquired by using the M600 UAV remote sensing platform,and the radiance calibration was converted to the canopy emission rate.In combination with the PROSAIL model,the particle swarm optimization algorithm was used to retrieve rice phenotyping information by constructing the cost function.The results showed the following:(1)an accuracy of R^(2)=0.833 and RMSE=0.0969,where RMSE denotes root-mean-square error,was obtained for C_(ab) retrieval;R^(2)=0.816 and RMSE=0.1012 for LAI inversion;R^(2)=0.793 and RMSE=0.1084 for C_(dm);and R^(2)=0.665 and RMSE=0.1325 for C_(w).The C_(w) inversion accuracy was not particularly high.(2)The same band will be affected by multiple parameters at the same time.(3)This study adopted the rice phenotyping information inversion method to expand the rice hyperspectral information acquisition field of a UAV based on the phenotypic information retrieval accuracy using a high level of field spectral radiometric accuracy.The inversion method featured a good mechanism,high universality,and easy implementation,which can provide a reference for nondestructive and rapid inversion of rice biochemical parameters using UAV hyperspectral remote sensing. | Yu Fenghua Xu Tongyu Du Wen Ma Hang Zhang Guosheng Chen Chunling | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 8 |
| 7 | Experimental Investigation on Noise of Cavitation Nozzle and Its Chaotic Behaviour显示文摘The researches of cavitation noise mainly focus on the incipiency and developing of cavitation to prevent the cavititation erosion in the hydraulic machinery, while there is few report about the collapse strength of cavitation bubbles produced by water jet through the cavitation nozzle to utilize efficiently the collapse energy of cavitation bubbles. The cavitation noise signals are collected with hydrophones for the cavitation nozzle and general nozzle at the target position and the nozzle exit separately in the conditions of different standoff distance. The features of signal's frequency spectrum and power spectrum are analyzed for various nozzles by way of classical methods. Meanwhile, based on chaotic theory, phase space reconstruction is processed and the maximum Lyapunov index is calculated separately for each cavitation signal's time series. The results of chaotic analysis are compared with the one of conventional analysis. The analyzed data show that there are the marked differences at the spectrum between the cavitation nozzle and general nozzle at the target position while the standoff distance is 35 mm, which mainly displays at the high frequency segment (60-120 kHz). The maximum Lyapunov index calculated appear at standoff distance 35 mm, which is an optimum standoff distance for the most bubbles to collapse at the target. At the nozzle exit, the noise signal of cavitation nozzle is different from the general nozzle, which also displays at the high frequency segment. The results demonstrate that the water jet modulated by the cavitation nozzle can produce effectually cavitation, and at the target position the amplitude and energy of noise spectrum in high frequency segment for cavitation nozzle are higher than conventional nozzle and the Lyapunov index of cavitation nozzle is larger than conventional nozzle as the standoff distance is less than 55 mm. The proposed research reveals that the cavitation noise produced by collapse of cavitation bubbles attributes mainly to the high frequency segment of the spectrum, which provides references for the research on cavitation noise. | ZHANG Fenghua LIU Haifeng XU Junchao TANG Chuanlin | 2013 | Chinese Journal of Mechanical Engineering2013，26，4： | 8 |
| 8 | Prognostic value of programmed death.1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1.4N+M0 gastric adenocarcinoma显示文摘Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses of patients with gastric cancer to anti-PD-1/PD-L1 immunotherapy is controversial. Some studies suggested that intra-and inter-tumoral heterogeneity of PD-L1 expression might explain the controversy.This study aimed to analyze the expression of PD-L1, PD-L2, and PD-1 as well as CD8(+) T-cell density in primary tumors and lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma to explore the heterogeneity of PD-1 signaling pathway molecules.Methods: In primary tumors and metastatic as well as non-metastatic lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma, we detected PD-L1 and PD-L2 expression with immunohistochemistry. CD8(+)T-cell density in primary tumors and PD-1 expression on CD8(+)T cells were detected with immunofluorescence. Univariate analysis was used to determine the prognostic values of them. Cox proportional hazard regression model was used to identify independent risk factors that affect patients' overall survival and disease-free survival.Results: Among 119 eligible patients who had undergone surgical resection, the positive rate of PD-L1 was higher in metastatic lymph nodes than in primary tumors(45.4% vs. 38.7%, P = 0.005); the positive rate of PD-1 on CD8(+)T cells was significantly higher in primary tumors and metastatic lymph nodes than in tumor-free lymph nodes(both P < 0.001). The intensity of PD-1 expression on CD8(+) T cells in primary tumors and in metastatic lymph nodes were stronger than that in tumor-free lymph nodes from the same patient. Beside, the positive rate of PD-L2 did not show any differences between primary tumors and metastatic lymph nodes. In multivariate analysis, PD-L1 expression,PD-L2 expression, a low density of CD8(+) T cells in primary tumors, and PD-1 expression on CD8(+) T cells in primary tumors were associated with poor prognosis.Conclusion: The expression of PD-L1 is heterogeneous in primary tumors and in metastatic lymph nodes from patients with stageT1-4 N+M0 gastric adenocarcinoma, which might explain the inconsistent results in assessing the prognostic value of PD-L1 expression in previous studies. | Yuan Gao Su Li Dazhi Xu Shangxiang Chen Yuchen Cai Wenqi Jiang Xinke Zhang Jin Sun Kefeng Wang Boyang Chang Fenghua Wang Minghuang Hong | 2017 | Chinese Journal of Cancer2017，36，11： | 8 |
| 9 | Control of Formation of Lithological Reservoirs by Surrounding Mudstone显示文摘Taking the Jiyang depression as an example, this paper discusses the control of the formation of lithological reservoir by surrounding rocks by integrated application of geological analysis, physical simulation, and the analysis of oil & gas accumulation mechanism. Geological statistical shows that the major burial depth and interval of lithological reservoirs in the Jiyang depression are related to the hydrocarbon generation in and expulsion from the Lower Tertiary source rocks and the time of the formation of most lithological reservoirs coincides with the peak of hydrocarbon generation and expulsion. The lithological traps located in the center of effective source rocks are propitious to high oil saturation than those located on the margin of effective source rocks. The hydrocarbon charge degree of the lithological reservoir has a positive correlation with the intensity of hydrocarbon expulsion from surrounding source rocks. Geological analyses and NMR experiments also show that the oil saturation of surrounding source rocks control the hydrocarbon potential of lithological traps, and a critical value for oil saturation of surrounding mudstone is required, that is, when the oil saturation of surrounding mudstone is lower than this critical value, no oil and gas accumulate in the lithological trap. The control of surrounding mudstone on the oil-bearing properties of lithological reservoirs is also analyzed by the mechanisms of hydrocarbon generation and expulsion as well as accumulation. | Jiang Zhenxue Chen Dongxia Pang Xiongqi Zhang Jun Tian Fenghua | 2006 | Petroleum Science2006，3，2： | 7 |
| 10 | Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation显示文摘The surrogate reproduction technique,such as inter-specific spermatogonial stem cells(SSCs)transplantation(SSCT),provides a powerful tool for production of gametes derived from endangered species or those with desirable traits.However,generation of genome-edited gametes from a different species or production of gametes from a phylogenetically distant species such as from a different subfamily,by SSCT,has not succeeded.Here,using two small cyprinid fishes from different subfamilies,Chinese rare minnow(gobiocypris rarus,for brief:Gr)and zebrafish(danio rerio),we successfully obtained Gr-derived genome-edited sperm in zebrafish by an optimized SSCT procedure.The transplanted Gr SSCs supported the host gonadal development and underwent normal spermatogenesis,resulting in a reconstructed fertile testis containing Gr spermatids and zebrafish testicular somatic cells.Interestingly,the surrogate spermatozoa resembled those of host zebrafish but not donor Gr in morphology and swimming behavior.When pou5f3 and chd knockout Gr SSCs were transplanted,Gr-derived genome-edited sperm was successfully produced in zebrafish.This is the first report demonstrating surrogate production of gametes from a different subfamily by SSCT,and surrogate production of genome-edited gametes from another species as well.This method is feasible to be applied to future breeding of commercial fish and livestock. | Fenghua Zhang Yongkang Hao Xianmei Li Yi Li Ding Ye Ru Zhang Xiaosi Wang Mudan He Houpeng Wang Zuoyan Zhu Yonghua Sun | 2022 | Science China(Life Sciences)2022，65，5： | 7 |
| 11 | World’s first spaceflight on-orbit demonstration of a flexible solar array system based on shape memory polymer composites显示文摘With a 10%reversible compressive strain in more than 10 deformation cycles,the shape memory polymer composites(SMPCs)could be used for deployable structure and releasing mechanism.In this paper,without traditional electro-explosive devices or motors/controllers,the deployable SMPC flexible solar array system(SMPC-FSAS)is studied,developed,ground-based tested,and finally on-orbit validated.The epoxy-based SMPC is used for the rolling-out variable-stiffness beams as a structural frame as well as an actuator for the flexible blanket solar array.The releasing mechanism is primarily made of the cyanate-based SMPC,which has a high locking stiffness to withstand 50 g gravitational acceleration and a large unlocking displacement of 10 mm.The systematical mechanical and thermal qualification tests of the SMPC-FSAS flight hardware were performed,including sinusoidal sweeping vibration,shocking,acceleration,thermal equilibrium,thermal vacuum cycling,and thermal cycling test.The locking function of the SMPC releasing mechanisms was in normal when launching aboard the SJ20 Geostationary Satellite on 27 Dec.,2019.The SMPC-FSAS flight hardware successfully unlocked and deployed on 5 Jan.,2020 on geostationary orbit.The triggering signal of limit switches returned to ground at the 139 s upon heating,which indicated the successful unlocking function of SMPC releasing mechanisms.A pair of epoxy-based SMPC rolled variable-stiffness tubes,which clapped the flexible blanket solar array,slowly deployed and finally approached an approximate 100%shape recovery ratio within 60 s upon heating.The study and on-orbit successful validation of the SMPC-FSAS flight hardware could accelerate the related study and associated productions to be used for the next-generation releasing mechanisms as well as space deployable structures,such as new releasing mechanisms with low-shocking,testability and reusability,and ultra-large space deployable solar arrays. | LAN Xin LIU LiWu ZHANG FengHua LIU ZhengXian WANG LinLin LI QiFeng PENG Fan HAO SiDa DAI WenXu WAN Xue TANG Yong WANG Mian HAO YanYan YANG Yang YANG Cheng LIU YanJu LENG JinSong | 2020 | Science China(Technological Sciences)2020，63，8： | 7 |
| 12 | Grain refinement and orientation of AZ31B magnesium alloy in hot flow forming under different thickness reductions显示文摘An analysis of the hot flow forming of Mg-3.0 Al-1.0 Zn-0.3 Mn(AZ31 B) alloy was conducted by experiments and numerical simulations. The effects of different thickness reductions on the microstructure and mechanical properties were investigated at a temperature of 693 K, a spindle speed of 800 rev/min and a feed ratio of 0.1 mm/rev. Thickness reductions have great influence on the uniformity of microstructure along the radial direction(RD) and the grain sizes become refined and uniform when the thickness reduction reaches 45%. The c-axes of most grains are approximately parallel to the RD, with a slight inclination towards the axial direction(AD). The best mechanical properties with UTS of 280 MPa and YS of 175 MPa near the outer surface while 266 MPa and 153 MPa near the inner surface have been achieved due to grain refinement and texture. Moreover, the material flow behavior and stress/strain distributions for singlepass reductions were studied using the ABAQUS/Explicit software. The calculated results indicate that the materials mainly suffer from triaxial compressive stresses and undergo compressive plastic strain in RD and tensile strains in other directions. The higher stress and strain rate near the outer surface lead to more refined grains than that of other regions along the RD, whereas the orientation of the maximum principal compressive stress leads to a discrepancy of the grain orientations in RD. | Yalian Zhang Fenghua Wang Jie Dong Li Jin Conghui Liu Wenjiang Ding | 2018 | Journal of Materials Science & Technology2018，34，7： | 6 |
| 13 | Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo显示文摘Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer. | Guangyao Lv Dengjun Sun Jingwen Zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 6 |
| 14 | Optimal switching target-assignment based on the integral performance in cooperative tracking显示文摘This paper investigates a dynamic target-assignment problem.A close-loop integrated frame for target-assignment is proposed novelly which incorporates the kinematics between ?ight vehicles and targets.Based on an integral performance index which represents the energy cost,the optimal switching assignmentplan is obtained.Considering the con?guration variation introduced by a switching assignment-plan,an H∞ guidance law with switching-target is proposed which underlays a dynamic assignment process in cooperative tracking.Simulation results are given to show the e?ectiveness of the proposed guidance-law and the switchingplan for target assignment. | YAO Yu ZHANG Peng LIU Hugh HE FengHua | 2013 | Science China(Information Sciences)2013，56，1： | 5 |
| 15 | An oscillation phenomenon of low frequency reverberation in the shallow water and its physical explanation显示文摘An oscillation phenomenon of the low frequency reverberation intensity was observed in several shallow water reverberation experiments. This phenomenon cannot be explained by the widely used incoherent reverberation theory. In this paper, to explain the observed oscillation phenomenon, a normal mode based coherent reverberation theory is presented. The theoretical analysis and numerical results show that modal interference can cause the regular oscillation phenomenon of the low frequency reverberation intensity, and the oscillation frequency is determined by the normal mode eigen-values. A new method to estimate the bottom sound speed based on the oscillation frequency of reverberation intensity was presented in this paper. The experimental results at three different sites indicate that the bottom sound speed estimated from the oscillation frequency of reverberation intensity agrees with that inverted from Matched Field Processing (MFP) well. | LI Fenghua LIU Jianjun LI Zhenglin ZHANG Renhe | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，4： | 5 |
| 16 | A novel tobacco gene coding for a product similar to bacterial two-component regulators显示文摘The two-component signaling system has been studied in bacteria. It takes part in signal transduction of adaptive behavior. Recent studies have shown that a similar two-component system is also present in eukaryotes. Examples of this are ETR1 and CKI1 genes which may involve the signal transduction of plant hormone ethylene and cytokinin respectively. The cloning and characterization of a novel gene ( NTHK1 ) fragment from tobacco are presented.Its partial sequence codes for a product which shows similarity to many two-component signaling proteins. Southern blot analysis indicated that there are 2 to 3 copies of NTHK1 gene in tobacco genome (allotetraploid). Homologous genes may also exist in other plants such as Arabidopsis, soybean and spinach. The expression of NTHK1 gene has also been analyzed in tobacco.Further studies on the isolation of full-length cDNA of NTHK1 gene will elucidate more clearly its function in signal perception and transduction. | Jinsong Zhang Can Xie Feng Liu Fenghua Liu Shouyi Chen | 1999 | Chinese Science Bulletin1999，44，11： | 5 |
| 17 | Assessing indica-japonica differentiation of improved rice varieties using microsatellite markers显示文摘To assess the indica-japonica differentiation of improved rice varieties, a total of 512 modern varieties including 301 indica and 211 japonica accessions were analyzed using 36 microsatellites. The Fst coefficients ranged from 0.002 to 0.730 among the loci with an average of 0.315. Significant differentiation was detected at 94.4% of the loci studied (P<0.05, pairwise Fst tests), indicating that there was a high level of indica-japonica differentiation within the improved varieties. At 18 loci, about 74%-98% of the alleles of indica and japonica accessions were distributed in two ranges of amplicon length. Linkage disequilibrium analysis showed that the distribution trends were significantly nonrandomly associated. Using the differentiation trends at the 18 loci, microsatellite index (MI) was proposed for discrimination of the two subspecies. When rice accessions with MI value greater than zero were classified as indica, and those with MI value smaller than zero were classified as japonica, about 96.1% of the accessions could be classified. This result agrees with the classification based on morphological-physiological characters, indicating that this method is feasible and effective. | Yongwen Qi Hongliang Zhang Dongling Zhang Meixing Wang Junli Sun Li Ding Fenghua Wang Zichao Li | 2009 | Journal of Genetics and Genomics2009，36，5： | 5 |
| 18 | 4D printed shape memory polymers and their structures for biomedical applications显示文摘Shape memory polymers are smart materials that produce shape changes under external stimulus conditions.Four-dimensional(4D)printing is a comprehensive technology originate from deformable materials and three-dimensional(3D)printing technology.At present,4D printed shape memory polymers and shape-changing structures have been applied in various fields,especially in the field of biomedical science.4D printing technology has made a breakthrough of personalized customization in the traditional medical field,providing a new direction for the further development of the biomedical field.In this review,the recent research and development of shape memory polymer,3D printing technology,4D printed shape memory polymers and shape-changing structures in biomedical area are present.The examples and applications of 4D printed shape memory polymers and their structures in the area of biomedical are also introduced.Based on 4D printing,stimulated by different conditions,3D printed objects can be fabricated into various biomedical applications such as cell scaffolds,vascular stents,bone scaffolds,tracheal stents and cardiac stents by different 3D printing techniques.Finally,the application prospects,existing technical restriction and future development directions of 4D printed shape memory polymers and their structures in the biomedical field are summarized. | LI YueJia ZHANG FengHua LIU YanJu LENG JinSong | 2020 | Science China(Technological Sciences)2020，63，4： | 4 |
| 19 | Growth kinetics of titanium boride layers on the surface of Ti6Al4V显示文摘Dual titanium boride layers consisting of continuous TiB2 top-layer and TiB whisker sublayer were formed on the surface of Ti6Al4V alloy using powder-pack boriding technique. An iso-thickness diagram of the whole boride layer was fitted with the data of thickness of the coating, treatment time and process temperature using Sigma Plot10.0 software. Growth kinetics of the titanium boride layer were analyzed by measuring the extent of penetration of TiB2 and TiB whisker as a function of boriding time in the range of 5-20 h and boriding temperature in the range of 1000-1100 ℃. By the linear regression analysis of growth kinetics of titanium boride layer, the diffusivity K and average diffusion activation energy (Q) of boron atoms in Ti6Al4V alloy were calculated, respectively. | Fenghua LI Xiaohong YI Jinglei ZHANG Zhanguo FAN Dianting GONG Zhengping XI | 2010 | Acta Metallurgica Sinica(English Letters)2010，23，4： | 4 |
| 20 | Elemental composition and risk assessment of heavy metals in the PM10 fractions of road dust and roadside soil显示文摘A total of 64 dust samples were analyzed to determine the size distribution and elemental composition of the PM10 fraction, including42 road dust(RD), 12 roadside soil(RSD), and 10 park road dust(PRD) samples. The mass of dust smaller than 20μm was dominated by particles sized 2.5-16 μm, which accounted for 85%, 88%, and 87% of the RD, PRD, and RSD, respectively. Additionally, crustal elements accounted for 30.14%, 36.35%, and 37.14% of the PMio fractions of the RD, RSD, and PRD, respectively. The most abundant trace elements in RD, RSD, and PRD were Zn, Mn, and Cu (range, 277 to 874 mg/kg). Moreover, the /geo values revealed all dusts were contaminated with Pb, Zn, Cu, Sb, Sn, and Cd. Health risk assessment showed that Mn, Ni, Cu, Zn, Cd, Sb, and Pb in the PM10 fraction of three types of dusts posed non-cancer risks to children but posed no non-cancer risk to adults. Additionally, As, Ni, and Cd posed no cancer risk to inhabitants. | Jing Zhang Lin Wu Yanjie Zhang Fenghua Li Xiaozhen Fang Hongjun Mao | 2019 | Particuology2019，17，3： | 4 |
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