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您的检索式：作者名="HE Maolong"
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| 1 | Triterpene-Enriched Olive Extract as an Immunopotentiator in Black Sea Bream(Acanthopagrus schlegelii)显示文摘Recently,the use of natural immunopotentiators,such as plant extracts,is predicted to offer high disease-prevention potential in aquaculture.However,few reports on the immunomodulatory impacts of olive extract(OE)on teleost are available.Therefore,the effects of dietary intake of triterpene-enriched OE on black sea bream(Acanthopagrus schlegelii)were investigated in this study.Our data showed that total blood cell counts,in vivo content of lysozyme,activities of antiprotease and myeloperoxidase,and contents of IL-4 and IL-6 were significantly up-regulated by dietary intake of triterpene-enriched OE.Additionally,the hampered immune response induced by cadmium exposure was significantly mitigated by the administration of OE as were indicated by partially or completely rescued immune-relating parameters.Furthermore,the expressions of immune-related genes encoding NF-κB inhibitor alpha(IkBα),tumor necrosis factorα(TNFα),cyclooxygenase-2(COX-2),and proto-oncogene protein c-fos(FOS)were found to be significantly up-regulated by the dietary intake of OE.In general,the results suggested that the dietary intake of triterpene-enriched OE has immune enhancing effect in black sea bream.Such effect may be realized by 1)increasing the total counts of diverse blood cells;2)activating nonspecific immune biomolecules;and 3)affecting signaling pathways such as IKK and ERK and subsequently inducing IL-4 and IL-6 biosyntheses. | RONG Jiahuan HAN Yu ZHA Shanjie TANG Yu SHI Wei GUAN Xiaofan DU Xueying HE Maolong LIU Guangxu | 2020 | Journal of Ocean University of China2020，19，2： | 1 |
| 2 | The biological responses and mechanisms of endothelial cells to magnesium alloy显示文摘Due to its good biocompatibility and degradability,magnesium alloy(Mg alloy)has shown great promise in cardiovascular stent applications.Rapid stent re-endothelialization is derived from migrated and adhered endothelial cells(ECs),which is an effective way to reduce late thrombosis and inhibit hyperplasia.However,fundamental questions regarding Mg alloy affecting migration and adhesion of ECs are not fully understood.Here,we evaluated the effects of Mg alloy on the ECs proliferation,adhesion and migration.A global gene expression profiling of ECs co-culturing with Mg alloy was conducted,and the adhesion-and migration-related genes were examined.We found that Mg alloy had no adverse effects on ECs viability but significantly affected ECs migration and adhesion.Co-cultured with Mg alloy extract,ECs showed contractive adhesion morphology and decreased motility,which was supported by the down-regulation of adhesion-related genes(Paxillin and Vinculin)and migration-related genes(RAC 1,Rho A and CDC 42).Accordingly,the re-endothelialization of Mg alloy stent was inhibited in vivo.Our results may provide new inspiration for improving the broad application of Mg alloy stents. | Zhe Hou Maolong Xiang Nuoya Chen Xiao Cai Bo Zhang Rifang Luo Li Yang Xiaoyi Ma Lifeng Zhou Fugui He Hongchi Yu Yunbing Wang | 2021 | Regenerative Biomaterials2021，8，3： | 0 |
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