|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Stability improvement under high efficiency—next stage development of perovskite solar cells显示文摘With efficiency of perovskite solar cells(PSCs) overpassing 23%, to realize their commercialization, the biggest challenge now is to boost the stability to the same level as conventional solar cells. Thus, tremendous effort has been directed over the past few years toward improving the stability of these cells. Various methods were used to improve the stability of bulk perovskites,including compositional engineering, interface adjustment, dimensional manipulation, crystal engineering, and grain boundary decoration. Diverse device configurations, carrier transporting layers, and counter electrodes are investigated. To compare the stability of PSCs and clarify the degradation mechanism, diverse characterization methods were developed. Overall stability of PSCs has become one central topic for the development of PSCs. In this review, we summarize the state-of-the-art progress on the improvement of device stability and discuss the directions for future research, hoping it provides an overview of the current status of the research on the stability of PSCs and guidelines for future research. | Danni Yu Yue Hu Jiangjian Shi Haoying Tang Wenhao Zhang Qingbo Meng Hongwei Han Zhijun Ning He Tian | 2019 | Science China Chemistry2019，62，6： | 7 |
| 3 | Arabidopsis Thylakoid Formation 1 Is a Critical Regulator for Dynamics of PSII-LHCII Complexes in Leaf Senescence and Excess Light显示文摘在更高的植物, photosystem II (PSII ) 是超分子的建筑群 PSII 核心建筑群和植物特定的外部轻收获的建筑群(LHCII ) 填写了的大 pigmentprotein。PSIILHCII 建筑群在他们的数量和宏组织是高度有活力的到各种各样的环境条件。在这研究,我们报导了一个关键因素, Arabidopsis Thylakoid 形成 1 (THF1 ) 蛋白质,它在导致黑暗的老朽和轻环境适应期间控制 PSIILHCII 动力学。在 THF1 的 Loss-of-function 变化在感染病原体、衰老的叶子导致停留绿色显型。LHCII 和 PSII 核心子单元在 thf1 的导致黑暗的衰老的叶子被保留, PSIILHCII 建筑群的存在的陈述语气。当 PSIILHCII supercomplexes 的稳定性显著地减少了时,蓝土著人(BN )-polyacrylamide 胶化电气泳动(页) 和 immunoblot 分析证明在 dark-light-treated 和 high-light-treated thf1 叶子, PSIILHCII megacomplex 的一种类型有选择地被保留,建议在 PSIILHCII 建筑群的动力学的 THF1 的一个双角色。我们进一步证明 THF1 以一种 pH 依赖的方式与 Lhcb 蛋白质交往并且 thf1 的停留绿色显型依靠 LHCII 建筑群的存在。一起拿,数据建议 THF1 在更高的植物为 PSIILHCII 超分子的组织的动力学被要求。 | Weihua Huang Qingbo Chen Ying Zhu Fenghong Hu Lingang Zhang Zhaoxue Ma Zuhua He Jirong Huang | 2013 | Molecular Plant2013，6，5： | 4 |
| 4 | A time domain correction method for Doppler-distortion signal from acoustic moving source显示文摘Doppler effect widely exists in the signal from the moving acoustic source.In order to solve such problems as frequency shift and frequency band expansion,a time domain correction method is presented in this paper.First,the discrete time vector for interpolation and the amplitude restoration formula is derived based on the moving relationship and the Morse acoustic theory,then the amplitude weights are corrected and the distortion signal is interpolated.Every point of the discrete signal is operated separately in time domain.Compared with the existing frequency domain methods,this method does not need to know the characteristic frequency beforehand and would not be influenced by the blending of the frequency band.Hence,this method can be employed to correct multiple frequency signals and it is also a simple and effective Doppler effect reduction method. | LIU Fang HE Qingbo SHEN Changqing HU Fei ZHANG Ao KONG Fanrang | 2014 | Chinese Journal of Acoustics2014，33，1： | 2 |
| 5 | Subspace- based gearbox condition monitoring by kernel principal component analysis 显示文摘 | He Qingbo Kong Fanrang Yan Ruqiang | 2007 | Mechanical Systems and Sig- nal Processing2007，21，4： | 1 |
| 6 | Detection of signal transients using independent component analysis and its application in gearbox condition monitoring 显示文摘 | He Qingbo Feng Zhihua Kong Fanrang | 2007 | Mechanical Systems and Signal Processing2007，，21： | 1 |
| 7 | Cathoderay tube (CRT) recycling: Current capabilities in Chinaand research progress显示文摘 | XU Qingbo? LI Guangming HE Wenzhi | 2012 | Waste Management2012，32，8： | 1 |
| 8 | Detection of signal transients using independent component analysis and its application in gearbox condition monitoring显示文摘 | He Qingbo Feng Zhihua Kong Fanrang | 2007 | Mechanical Systems and Signal Processing2007，21，： | 1 |
| 9 | Environmental and Economic Evaluation of Cathode Ray Tube (CRT) Funnel Glass Waste Management Options in the United States显示文摘 | Qingbo Xu Mengjing Yu Alissa Kendall Wenzhi He Guangming Li Julie M. Schoenung | 2013 | Resources Conservation & Recycling2013，，： | 1 |
| 10 | Cathode ray tube (CRT) recycling: Current capabilities in China and research progress显示文摘 | Qingbo Xu Guangming Li Wenzhi He Juwen Huang Xiang Shi | 2012 | Waste Management2012，，8： | 1 |
| 11 | Cathode ray tube (CRT) recycling: current capabilities in China and research progress 显示文摘 | XU Qingbo LI Guangming HE Wenzhi | 2012 | Waste Management2012，32，8： | 1 |
| 12 | Subspace-based gearbox condition monitoring by kernel principal component analysis 显示文摘 | HE Qingbo KONG Fanrang YAN Ruqiang | 2007 | Mechanical Systems and Signal Processing2007，21，4： | 1 |
| 13 | Machine condition monitoring using principal component representations显示文摘 | Qingbo He RuqiangYan Fanrang Kong atal | 2009 | Mechanical Systems and Signal Processing2009，，23： | 1 |
| 14 | Time–frequency manifold for nonlinear feature extraction in machinery fault diagnosis显示文摘 | Qingbo He | 2013 | 2013 (1-2)2013，，1： | 1 |
| 15 | Vibration signal classification by wavelet packet energy flow manifold learning显示文摘 | Qingbo He | 2012 | Journal of Sound and Vibration2012，，： | 1 |
| 16 | Time-frequency manifold for nonlinear fea- ture extraction in machinery fault diagnosis显示文摘 | Qingbo He | 2013 | Mechani- cal Systems and Signal Processing2013，，35： | 1 |
| 17 | Effects of multiscale noise tuning on stochastic resonance for weak signal detection显示文摘 | Qingbo He Jun Wang | 2012 | Digital Signal Processing2012，，4： | 1 |
| 18 | Subspace-based gearbox condition monitoring by kernel principal component a- nalysis 显示文摘 | He Qingbo Kong Fanrang Yan Ruqiang | 2007 | Mechanical Systems and Signal Processing2007，21，4： | 1 |
| 19 | A new method to decrease ground resistances of substation grounding systems in high resistivity regions显示文摘 | Meng Qingbo He Jinliang Ma J | 1999 | IEEE Trans on PWRD1999，14，3： | 1 |
| 20 | A new meth- od to decrease ground resistances of substation grounding systems in high resistivity regions 显示文摘 | Meng Qingbo He Jinliang Dawalibi F P | 1999 | IEEE Transactions on Power Delivery1999，14，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员