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| 1 | Laboratory diagnosis for malaria in the elimination phase in China:efforts and challenges显示文摘Malaria remains a global health challenge,although an increasing number of countries will enter pre-elimination and elimination stages.The prompt and precise diagnosis of symptomatic and asymptomatic carriers of Plasmodium parasites is the key aspect of malaria elimination.Since the launch of the China Malaria Elimination Action Plan in 2010,China has formulated clear goals for malaria diagnosis and has established a network of malaria diagnostic laboratories within medical and health institutions at all levels.Various external quality assessments were implemented,and a national malaria diagnosis reference laboratory network was established to strengthen the quality assurance in malaria diagnosis.Notably,no indigenous malaria cases have been reported since 2017,but the risk of re-establishment of malaria transmission cannot be ignored.This review summarizes the lessons about malaria diagnosis in the elimination phase,primarily including the establishments of laboratory networks and quality control in China,to better improve malaria diagnosis and maintain a malaria-free status.A reference is also provided for countries experiencing malaria elimination. | Jianhai Yin Mei Li He Yan Shuisen Zhou Zhigui Xia | 2022 | Frontiers of Medicine2022，16，1： | 1 |
| 2 | Prevalence of antifolate drug resistance markers in Plasmodium vivax in China显示文摘The dihydrofolate reductase(dhfr)and dihydropteroate synthetase(dhps)genes of Plasmodium vivax,as antifolate resistance-associated genes were used for drug resistance surveillance.A total of 375 P.vivax isolates collected from different geographical locations in China in 2009–2019 were used to sequence Pvdhfr and Pvdhps.The majority of the isolates harbored a mutant type allele for Pvdhfr(94.5%)and Pvdhps(68.2%).The most predominant point mutations were S117T/N(77.7%)in Pvdhfr and A383G(66.8%)in Pvdhps.Amino acid changes were identified at nine residues in Pvdhfr.A quadruple-mutant haplotype at 57,58,61,and 117 was the most frequent(57.4%)among 16 distinct Pvdhfr haplotypes.Mutations in Pvdhps were detected at six codons,and the double-mutant A383G/A553G was the most prevalent(39.3%).Pvdhfr exhibited a higher mutation prevalence and greater diversity than Pvdhps in China.Most isolates from Yunnan carried multiple mutant haplotypes,while the majority of samples from temperate regions and Hainan Island harbored the wild type or single mutant type.This study indicated that the antifolate resistance levels of P.vivax parasites were different across China and molecular markers could be used to rapidly monitor drug resistance.Results provided evidence for updating national drug policy and treatment guidelines. | Fang Huang Yanwen Cui He Yan Hui Liu Xiangrui Guo Guangze Wang Shuisen Zhou Zhigui Xia | 2022 | Frontiers of Medicine2022，16，1： | 1 |
| 3 | Treatment of organic waste gas in a paint plant by combined technique of biotriekling filtration with photocatalytic oxidation 显示文摘 | HE Zhigui LI Jianjun CHEN Jiangyao | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 4 | Impact of living donor liver with steatosis and idiopathic portal inflammation on clinical outcomes in pediatric liver transplantation:Beijing experience显示文摘Background:To evaluate the impact of steatosis and/or idiopathic portal inflammation(IPI)in living donor livers on recipients’clinical outcomes.Methods:We assessed 305 qualified donor liver samples from June 2013 to December 2018.Donors and recipients’clinical characteristics,including follow-up data were retrieved.The graft and overall survival with/without steatosis or portal inflammation were compared by Kaplan-Meier analysis.Results:For living donors,the medium age of was 31.2(28,35.8)years old;liver histopathology showed macrovesicular steatosis:0-5%264/305(86.6%)and 5-30%41/305(13.4%),IPI:no 220/305(72.1%)and mild 85/305(27.9%).For recipients,the medium age was 1.0(0.6,1.5)years old;the median pediatric-end-stage-liver-disease score was 16(5.0,26.0)and medium follow-up time was 32.8(24.8,52.0)months.Biliary atresia(69.5%)was the main indication for liver transplantation(LT).Conclusions:The presence of steatosis and portal inflammation of the donor liver did not impact the clinical outcomes including transaminase or bilirubin normalization,short-/long-term complications and recipients’survival.However,recipients with high pediatric-end-stage-liver-disease score(>16)receiving donor liver with portal inflammation,but not steatosis,had trend negative effect on recipients’survival.In conclusion,donor livers with mild steatosis and portal inflammation were qualified for pediatric living donor LT.However,donor liver with mild portal inflammation would better not be allocated to recipients with high pediatric-end-stage-liver-disease score.This study provided new evidence in pediatric living donor liver allocation. | Xinyan Zhao Yafei He Jimin Liu Qian Zhang Liwei Liu Wei Qu Ying Liu Zhigui Zeng Haiming Zhang Jidong Jia Liying Sun Lin Wei Zhijun Zhu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 1 |
| 5 | Antimalarial Drug Resistance Surveillance in China,2016–2020显示文摘Introduction:Antimalarial drug resistance,especially artemisinin resistance,has been a global threat to reduce morbidity and mortality and to eliminate malaria.Antimalarial drug resistance surveillance could provide evidence for the efficacy of a national drug policy for treatment of all reported malaria cases.Methods:The therapeutic efficacy of dihydroartemisinin-piperaquine(DHA-PPQ)and chloroquine(CQ)for the treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax infection,respectively,was evaluated by enrolling patients between 2016 and 2020.Surveillance of molecular markers involved collecting blood samples by passive or active detection and amplifying the drug resistance genes Pfcrt,Pfmdr1,Pfdhfr,Pfdhps,and PfK13.Results:DHA-PPQ and CQ were effective for the treatment of P.falciparum and P.vivax infections,with cure rates>90%and 100%,respectively.Among the 2,492 samples,the Pfcrt wild-type CVMNK was the most frequent haplotype(70.1%,1,747/2,492),while 19.4%(484/2,492)displayed the triple mutant haplotype CVIET.In total of 228 isolates with sequencing in Pfdhfr and Pfdhps,high mutant prevalence of 98.7%and 95.2%were detected,respectively.A total of 54 non-synonymous mutations in the PfK13 propeller domain were confirmed with a prevalence of 3.5%(87/2,483),and the most common mutation was A578S,with a proportion of 16.1%(14/87),followed by Q613E(6.9%,6/87).Conclusion and Implications for Public Health Practice:DHA-PPQ and CQ,the first line drugs for P.falciparum and P.vivax treatment,showed efficacy in China.Molecular markers showed high levels of polymorphism and resistance,which revealed an early warning of drug resistance in imported cases. | Fang Huang Hui Liu He Yan Shuisen Zhou Zhigui Xia | 2021 | China CDC weekly2021，3，17： | 0 |
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