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| 1 | Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle显示文摘在到最糟的最高的注意在航线上吸烟以及薄雾侮辱的全球付钱的时间,所有人知道两个外长、显著。然而,包括许多医药人员,人们主要不知道 gastroesophageal 倒流(GER ) 怎么糟糕在我们的自己的航线上侮辱。GER 的症状通常被看作心痛和流回,它能主要被容忍。不管多么起来在它出现的地方,去的胃的内容相对地传递食管然后远侧的咽象苛评一样的鸟喙,用作一张嘴,以便生产众多微粒子并且到达oro鼻的洞并且另外引起的航线过敏鼻炎和气喘的攻击,甚至肺的实质损害。它将减少生活质量或甚至使受危险生活。内长的侮辱在呼吸系统出现,但是从消化的道发源的点不是众所周知的并且经常 undiagnosed 并且不正确地对待。导致的航线挑战是的 GER 一个可对待、预防的实体一旦诊断被做,好消除能通过 radiofrequency 或 fundoplication 借助于张开的贲门的生活方式调整,药,或固定被期望。作者王忠高博士承受了它为长并且症状在反倒流外科以后消失了 8 年。这是王忠高博士和他的队工作的一个演讲并且将引起注意到公众以便认出作为吸烟或薄雾从人的本身,然而并非从外面的环境发生的一个可对待的条件做的这个相对未知的实体。 | Zhonggao Wang Zhiwei Hu Jimin Wu Feng Ji Hongtao Wang Yungang Lai Xiang Gao Yachan Ning Chengchao Zhang Zhitong Li Weitao Liang Jianjun Liu | 2015 | Frontiers of Medicine2015，9，1： | 21 |
| 2 | Stepwise advance of the Mu Us Desert since late Pliocene:Evidence from a red clay-loess record显示文摘Analyses of paleomagnetic polarity reversals, magnetic susceptibility and grain size on the red clay-loess sequence, about 280 m thick, at Jingbian show that this sequence contains most of the stratigraphic units recorded in the standard red clay-loess sections of the Loess Plateau over the past 3.5 Ma. Using sand particle percentage ( > 63 μm%) of the eolian sequence as a proxy indicator of desert extent and aridity in the dust source regions, it is found that during the past 3.5 Ma, there are three important climatic events indicating the advance of the Mu Us Desert. The events occurred at about 2.6, 1.1 and 0.6 MaBP, respectively. The stepwise advance of the Mu Us Desert may be linked closely to increase in global ice volume and uplift of the Tibetan Plateau in the late Cenozoic. | Zhongli Ding Jimin Sun Dongsheng Liu | 1999 | Chinese Science Bulletin1999，44，13： | 12 |
| 3 | Degradation and detoxification of microcystin-LR in drinking water by sequential use of UV and ozone显示文摘Microcystins (MCs) produced by cyanobacteria are strong hepatotoxins and classified as possible carcinogens.MCs pose a considerable threat to human health through tainted drinking and surface waters.Herein filtrated water from a waterworks in Harbin,China,was spiked with microcystin-LR (MC-LR) extracted from a toxic scum of microcystis aeruginosa,and the spiked sample waters were treated using UV irradiation with consequent ozonation process (UV/O3),compared with ozonation at a dose range commonly applied in water treatment plants,UV irradiation at 254 nm and UV irradiation combined with ozonation (UV+O3),respectively.The remaining of toxins were analyzed using high-performance liquid chromatography and also determined using a protein phosphatase type 2A inhibition assay,which was utilized to evaluate the reduction in toxicity.Results indicated that in comparison to other three processes (O3,UV,and UV+O3),UV/O 3 process could effectively decrease both the concentration and toxicity of MC-LR at 100 μg/L level after 5 min UV irradiation with consequent 5 min ozonation at 0.2 mg/L (below 1 μg/L),while 0.5 mg/L ozone dose was required for the level below 0.1 μg/L.The addition of an UV treatment step to the existing treatment train may induce significant transformation of micropollutants and breaks down the natural organic matters into moieties unfavorable for ozone decomposition,stabilizing the ozone residual.These findings suggested that sequential use of UV and ozone may be a suitable method for the removal of these potentially hazardous microcystins from drinking water. | Xiaowei Liu Zhonglin Chen Nan Zhou Jimin Shen Miaomiao Ye | 2010 | Journal of Environmental Sciences2010，22，12： | 11 |
| 4 | Enhanced vasoconstriction to α_1 adrenoceptor autoantibody in spontaneously hypertensive rats显示文摘Autoimmune activities have been implicated in the pathogenesis of hypertension.High levels of autoantibodies against the second extracellular loop of α1-adrenoceptor(α1-AR autoantibody,α1-AA) are found in patients with hypertension,and α1-AA could exert a α1-AR agonist-like vasoconstrictive effect.However,whether the vasoconstrictive effect of α1-AA is enhanced in hypertension is unknown.Using aortic rings of spontaneously hypertensive rats(SHR) and normotensive Wistar-Kyoto(WKY) rats,we observed the vasoconstrictive responses to α1-AA with phenylephrine(α1-AR agonist) as a positive control drug.Aortic nitrotyrosine levels were also measured by ELISA and immunohistochemistry.The results showed that the aortic constrictive responses to α1-AA and phenylephrine(both 1 nmol L-1-10 μmol L-1) were greater in SHR than in WKY rats.Endothelial denudation or L-NAME(a non-selective NOS inhibitor)(100 μmol L-1) increased α1-AA- or phenylephrine-induced vasoconstrictions both in SHR and WKY.However,selective iNOS inhibitor 1400W(10 μmol L-1) enhanced the α1-AA-induced aortic constriction in WKY,but not in SHR.The aortic nitrotyrosine level was significantly higher in SHR than WKY,as shown by both ELISA and immunohistochemistry.These results indicate that the vasoconstrictive response to α1-AA is enhanced in SHR,and this altered responsiveness is due to endothelial dysfunction and decreased NO bioavailability.The study suggests an important role of α1-AR autoimmunity in the pathogenesis and management of hypertension especially in those harboring high α1-AA levels. | YAN Li TAN XiaoQiu CHEN WenXuan ZHU Hong CAO JiMin LIU HuiRong | 2014 | Science China(Life Sciences)2014，57，7： | 10 |
| 5 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 6 | Cardiovascular magnetic resonance imaging findings in children with myocarditis显示文摘 | Liu Guiying Yang Xi Su Ying Xu Jimin Wen Zhaoying | 2014 | Chinese Medical Journal2014，，21： | 9 |
| 7 | Zacopride selectively activates the Kir2.1 channel via a PKA signaling pathway in rat cardiomyocytes显示文摘We recently reported that zacopride is a selective inward rectifier potassium current (IK1 ) channel agonist, suppressing ventricular arrhythmias without affecting atrial arrhythmias. The present study aimed to investigate the unique pharmacological properties of zacopride. The whole-cell patch-clamp technique was used to study IK1 currents in rat atrial myocytes and Kir2.x currents in human embryonic kidney (HEK)-293 cells transfected with inward rectifier potassium channel (Kir)2.1, Kir2.2, Kir2.3, or mutated Kir2.1 (at phosphorylation site S425L). Western immunoblots were performed to estimate the relative protein expression levels of Kir2.x in rat atria and ventricles. Results showed that zacopride did not affect the IK1 and transmembrane potential of atrial myocytes. In HEK293 cells, zacopride increased Kir2.1 homomeric channels by 40.7%±9.7% at 50 mV, but did not affect Kir2.2 and Kir2.3 homomeric channels, and Kir2.1-Kir2.2, Kir2.1-Kir2.3 and Kir2.2-Kir2.3 heteromeric channels. Western immunoblots showed that similar levels of Kir2.3 protein were expressed in rat atria and ventricles, but atrial Kir2.1 protein level was only 25% of that measured in the ventricle. In addition, 5-hydroxytryptamine (5-HT) 3 receptor was undetectable, whereas 5-HT 4 receptor was weakly expressed in HEK293 cells. The Kir2.1-activating effect of zacopride in these cells was abolished by inhibition of protein kinase A (PKA), but not PKC or PKG. Furthermore, zacopride did not activate the mutant Kir2.1 channel in HEK293 cells but selectively activated the Kir2.1 homomeric channel via a PKA-dependent pathway, independent to that of the 5-HT receptor. | ZHANG Li LIU QingHua LIU ChengFang ZHAI XuWen FENG QiLong XU RuiLing CUI XiangLi ZHAO ZhiQing CAO JiMin WU BoWei | 2013 | Science China(Life Sciences)2013，56，9： | 7 |
| 8 | Characteristics of distribution of Mycobacterium tuberculosis lineages in China显示文摘The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905(2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases(975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages(Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation(farmer), and degree of education(non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment. | Haixia Chen Li He Chao Cai Jingyi Liu Junnan Jia Liang Ma Hairong Huang Lixia Wang Xumin Ni Jimin Gao Weimin Li | 2018 | Science China(Life Sciences)2018，61，6： | 7 |
| 9 | Chronology of environmental events over East Asia during the past 130 ka显示文摘In the transitional region between the Loess Plateau and deserts, 4 sections located respectively at Yuling, Hengshan, Dingbian and Huining of China are studied. The high-resolution paleoclimatic records obtained show that environmental events on varying time scales have happened over East Asia. These events are dated with the time scales established using the recently-developed approach of Automatic Orbital Tuning. This leads to the establishment of the chronology of the environmental events. | Zhongli Ding Jimin Sun Zhiwei Yu Dongsheng Liu | 1998 | Chinese Science Bulletin1998，43，21： | 6 |
| 10 | High-resolution anisotropy of magnetic susceptibility record in the central Chinese Loess Plateau and its paleoenvironment implications显示文摘We analyze high-resolution anisotropy of magnetic susceptibility (AMS) of the loess-paleosol successions at Luochuan, central Chinese Loess Plateau, in order to investigate the AMS characteristics and their climatic implications. Our results indicate a normal sedimentary magnetic fabric for almost of all samples, characterized by minimum susceptibility axes grouped in an almost vertical direction. Magnetic foliation and anisotropy degree show upwards decreasing trend due to decreasing post-depositional compaction. Magnetic lineations show no preferred directions and thus cannot indicate paleowind patterns. AMS parameters at Luochuan are controlled by particle size, pedogenesis, and sedimentary compaction. The high peaks of magnetic foliation and anisotropy degree of L2, L3, L6, L9, and L15 correspond to the coarse particle sizes of these loess beds, indicating the grain-size dependence of AMS. | LIU WeiMing SUN JiMin | 2012 | Science China Earth Sciences2012，55，3： | 5 |
| 11 | Fingerprint segmentation based on an AdaBoost classifier显示文摘指纹分割是在一个自动指纹鉴定系统(AFIS ) 的最重要的预处理步之一。一条指纹的精确分割将极大地重要地减少下列处理的步,和大多数的计算时间,排除在前景的边界定位的许多假琐事。在这份报纸,一个新指纹分割算法被介绍。首先,二个新特征,块熵和块坡度熵,被建议。然后,一个 AdaBoost 分类器被设计基于这二个特征在前景和背景块之间区别,五其它通常使用了特征。分类错误率(犯错) 并且 McNemars 测试被用来评估我们的方法的表演。FVC2000, FVC2002 和 FVC2004 上的试验性的结果证明我们的方法超过在精确性和稳定性两个都在文学建议的另外的方法。 | Eryun LIU Heng ZHAO Fangfei GUO Jimin LIANG Jie TIAN | 2011 | Frontiers of Computer Science2011，5，2： | 4 |
| 12 | TLR4 inactivation protects from graft-versus-host disease after allogeneic hematopoietic stem cell transplantation显示文摘Graft-versus-host 疾病(GVHD ) 是在造血的干细胞移植以后的最普通的复杂并发症。澄清像使用费的受体的角色 4 (TLR4 ) ,它是为细菌的 lipopolysaccharides (LPS ) 的主要受体在尖锐 GVHD 的发展,我们使用了一个 TLR4 大美人(TLR4 −/−) 老鼠 GVHD 模型并且分析了内在的免疫学的机制。当 TLR4 −/− 老鼠被用作骨头髓和 splenocyte 房间接枝施主或接受者时, GVHD 症状出现和死亡被推迟与相比野类型(TLR4 +/+) 老鼠。另外,组织病理学说的分析在 TLR4 −/− BALB/c 怪物,肝和小肠织物损坏与最小的淋巴球的渗入被减少。与 TLR4 +/+, TLR4 −/− 老鼠相对照,树枝状的房间没在处于一个不成熟的状态感应、留下的 LPS 期间表示 CD80, CD86, CD40, MHC-II 或 IL-12。而且, TLR4 −/− 鼠标怒气的能力支持 allogeneic T 房间增长的树枝状的房间和,特别地 T 助手房间 1 (Th1 ) 开发显然与 TLR4 +/+ 鼠标相比被稀释 interferon-γ 的树枝状的房间,和层次;(IFN-γ) 并且 IL-10, Th2 房间特定的 cytokines,在 TLR4 −/− BALB/c 比在 TLR4 +/+ BALB/c 妄想的老鼠。总的来说,我们的数据表明 TLR4 可以在 GVHD 和基因治疗可能提供的那指向的 TLR4 的致病起一个作用减少 GVHD 的风险的一条新处理途径。 | Yi Zhao Qiuyan Liu Li Yang Donghua He Lijuan Wang Jun Tian Yi Li Fuming Zi Hanying Bao Yang Yang Yuanyuan Zheng Jimin Shi Xingkui Xue Zhen Cai | 2013 | Cellular & Molecular Immunology2013，10，2： | 4 |
| 13 | Selective Adsorption of Co(II) by Mesoporous Silica SBA-15-Supported Surface Ion Imprinted Polymer: Kinetics, Isotherms, and Thermodynamics Studies显示文摘一个新奇表面离子印了吸附物[作为支持矩阵把 polyethyleneimine (PEI ) 用作功能单体和订的 mesoporous 硅石 SBA-15 的公司(II )-IIP] 与高选择为公司(II ) 分析作好准备。准备聚合物被 Fourier 传播描绘红外线的 spectrometry,扫描电子显微镜学, X 光检查衍射和氮吸附解吸附作用等温线。公司(II ) 吸附的洗澡实验在最佳条件下面被执行到公司(II )-IIP 上。试验性的数据被伪 first-order 和 pseudo-second-order 分析运动模型。pseudo-second-order 模型最好相关,这被发现运动数据。intraparticle 散开和液体电影散开被使用讨论吸附机制。结果证明那公司(II ) 吸附被 intraparticle 散开机制控制到 IIP 上,与可观的电影散开贡献一起。Freundlich 和 Dubinin-Radushke- vich 吸附模特儿兰米尔被使用决定等温线参数。兰米尔模型适合实验数据很好,最大值计算了到达的公司(II ) 的能力在房间温度下面的 39.26 mg/g。热力学的数据公司(II ) 的吸热的吸着进程的自然是指示的到公司(II )-IIP 上。公司(II )-IIP 与非印的聚合物相比为模板离子显示出高亲密关系和选择(捏) 。 | Liu, Yan Liu, Zhanchao Dai, diangdong Gao, Jie Xie, Jimin Yan, Yongsheng | 2011 | Chinese Journal of Chemistry2011，29，3： | 3 |
| 14 | Multi-population and diffusion UMDA for dynamic multimodal problems显示文摘In dynamic environments,it is important to track changing optimal solutions over time.Univariate marginal distribution algorithm(UMDA) which is a class algorithm of estimation of distribution algorithms attracts more and more attention in recent years.In this paper a new multi-population and diffusion UMDA(MDUMDA) is proposed for dynamic multimodal problems.The multi-population approach is used to locate multiple local optima which are useful to find the global optimal solution quickly to dynamic multimodal problems.The diffusion model is used to increase the diversity in a guided fashion,which makes the neighbor individuals of previous optimal solutions move gradually from the previous optimal solutions and enlarge the search space.This approach uses both the information of current population and the part history information of the optimal solutions.Finally experimental studies on the moving peaks benchmark are carried out to evaluate the proposed algorithm and compare the performance of MDUMDA and multi-population quantum swarm optimization(MQSO) from the literature.The experimental results show that the MDUMDA is effective for the function with moving optimum and can adapt to the dynamic environments rapidly. | Yan Wu Yuping Wang Xiaoxiong Liu Jimin Ye | 2010 | Journal of Systems Engineering and Electronics2010，21，5： | 3 |
| 15 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 16 | Concentration, sources and ozone formation potential of volatile organic compounds (VOCs) during ozone episode in Beijing显示文摘 | Jingchun Duan Jihua Tan Liu Yang Shan Wu Jimin Hao | 2007 | Atmospheric Research2007，，1： | 3 |
| 17 | Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway显示文摘Cardiac fibroblast(CF)differentiation into myofibroblasts is a crucial cause of cardiac fibrosis,which increases in the extracellular matrix(ECM)stiffness.The increased stiffness further promotes CF differentiation and fibrosis.However,the molecular mechanism is still unclear.We used bioinformatics analysis to find new candidates that regulate the genes involved in stiffnessinduced CF differentiation,and found that there were binding sites for the POU-domain transcription factor,POU2F1(also known as Oct-1),in the promoters of 50 differentially expressed genes(DEGs)in CFs on the stiffer substrate.Immunofluorescent staining and Western blotting revealed that pathological stiffness upregulated POU2F1 expression and increased CF differentiation on polyacrylamide hydrogel substrates and in mouse myocardial infarction tissue.A chromatin immunoprecipitation assay showed that POU2F1 bound to the promoters of fibrosis repressors IL1R2,CD69,and TGIF2.The expression of these fibrosis repressors was inhibited on pathological substrate stiffness.Knockdown of POU2F1 upregulated these repressors and attenuated CF differentiation on pathological substrate stiffness(35 kPa).Whereas,overexpression of POU2F1 downregulated these repressors and enhanced CF differentiation.In conclusion,pathological stiffness upregulates the transcription factor POU2F1 to promote CF differentiation by inhibiting fibrosis repressors.Our work elucidated the crosstalk between CF differentiation and the ECM and provided a potential target for cardiac fibrosis treatment. | Mingzhe Li Jimin Wu Guomin Hu Yao Song Jing Shen Junzhou Xin Zijian Li Wei Liu Erdan Dong Ming Xu Youyi Zhang Han Xiao | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 18 | Assessing Donor Liver Quality and Restoring Graft Function in the Era of Extended Criteria Donors显示文摘Liver transplantation(LT)is the final treatment option for patients with end-stage liver disease.The increasing donor shortage results in the wide usage of grafts from extended criteria donors across the world.Using such grafts is associated with the elevated incidences of post-transplant complications including initial nonfunction and ischemic biliary tract diseases,which significantly reduce recipient survival.Although several clinical factors have been demonstrated to impact donor liver quality,accurate,comprehensive,and effective assessment systems to guide decision-making for organ usage,restoration or discard are lacking.In addition,the development of biochemical technologies and bioinformatic analysis in recent years helps us better understand graft injury during the perioperative period and find potential ways to restore graft function.Moreover,such advances reveal the molecular profiles of grafts or perfusate that are susceptible to poor graft function and provide insight into finding novel biomarkers for graft quality assessment.Focusing on donors and grafts,we updated potential biomarkers in donor blood,liver tissue,or perfusates that predict graft quality following LT,and summarized strategies for restoring graft function in the era of extended criteria donors.In this review,we also discuss the advantages and drawbacks of these potential biomarkers and offer suggestions for future research. | Yimou Lin Haitao Huang Lifeng Chen Ruihan Chen Jimin Liu Shusen Zheng Qi Ling | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 2 |
| 19 | Oridonin and its derivatives for cancer treatment and vercoming therapeutic resistance显示文摘Cancer is one of the diseases with high morbidity and mortality on a global scale.Chemotherapy remains the primary treatment option for most cancer patients,including patients with progressive,metastatic,and recurrent diseases.To date,hundreds of chemotherapy drugs are used to treat various cancers,however,the anti-cancer eficacy and outcomes are largely hampered by chemotherapy-associated toxicity and acquired therapeutic resistance.The natural product(NP)oridonin has been extensively studied for its anti-cancer efficacy.More recently,oridonin has been shown to overcome drug resistance through multiple mechanisms,with yet-to-be-defined bona fide targets.Hundreds of oridonin derivative analogs(oridonalogs)have been synthesized and screened for improved potency,bioavailability,and other drug properties.Particularly,many of these oridonalogs have been tested against oridonin for tumor growth inhibition,potential for overcoming therapeutic resistance,and immunity modulation.This concise review seeks to summarize the advances in this field in light of identifying clinical-trial level drug candidates with the promise for treating progressive cancers and reversing chemoresistance. | Xi Liu Jimin Xu Jia Zhou Qiang Shen | 2021 | Genes & Diseases2021，8，4： | 2 |
| 20 | Concentration, sources and ozone formation potential of volatile organic compounds (VOCs) during ozone episode in Beijing显示文摘 | Jingchun Duan Jihua Tan Liu Yang Shan Wu Jimin Hao | 2007 | Atmospheric Research2007，，1： | 2 |
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