|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes. | Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust | 2008 | World Journal of Gastroenterology2008，14，7： | 29 |
| 2 | Intraarterial Adjuvant Chemotherapy after Pancreaticoduodenectomy for Pancreatic Cancer: Significant Reduction in Occurrence of Liver Metastasis显示文摘 | Hans G. Beger Frank Gansauge Markus W. Büchler Karl Heinz Link | 1999 | World Journal of Surgery1999，，9： | 2 |
| 3 | Ecological footprint time series of Austria, the Philippines, and South Korea for 1961 - 1999: Comparing the conventional approach to an 'actual land area' approach 显示文摘 | WACKERNAGEL M MONFREDA C ERB KARL- HEINZ HABERL H SCHULZ N B | 2004 | Land Use Policy2004，，21： | 1 |
| 4 | Microfluidic im- munosensor for rapid and sensitive detection of bovine vi- ral diarrhea virus 显示文摘 | Heinze B C Song J Y Yoon J Y | 2009 | Sens Actuator B-Chem2009，138，2： | 1 |
| 5 | Complete reversal of paraplegia after thoracic endovascular aortic repair in a patient with complicated acute aortic dissection using immediate cerebrospinal fluid drainage显示文摘 | Holger Eggebrecht Dirk B?se Thomas Gasser Jaroslav Benedik Petra Mummel Oliver Müller Philipp Kahlert Konstantinos Tsagakis Heinz G. Jakob Raimund Erbel | 2009 | Clinical Research in Cardiology2009，，12： | 1 |
| 6 | Fungal bio-transformation of benzo quinoline,benzo quino-line ,and phenanthridine显示文摘 | Sutherland J B Cross E L Heinze T M | 2005 | Appl Microbiol Biotechn-ol2005，67，： | 1 |
| 7 | Functional polymers based on dextran显示文摘 | Heinze T Liebert T Heublein B Hornig S | | 0，，09： | 1 |
| 8 | General considerations on structure and reactivity of cellulose显示文摘 | Klemm D Philipp B Heinze T | 2004 | Comprehensive Cellulose Chemistry2004，12，3： | 1 |
| 9 | Mating type loci of Sporisorium reilianum:Novel pattern with three a and multiple b specificities显示文摘 | Schirawski J Heinze B | 2005 | Eukaryotic Cell2005，，4： | 1 |
| 10 | True protein digestibility and amounts of endogenous protein measured with 15N-dilution technique in piglets fed on peas (Pisum sativum)and common beans (Phaseolus vulgaris)显示文摘 | Huisman J Heinz T H van der Poel A F B | 1992 | BrJ Nutr1992，68，： | 1 |
| 11 | Oxida-tion of phenothiazine and phenoxazine by cunninghamel-la elegans显示文摘 | Sutherland J B Freeman J P Heinze T M | 2001 | Xenobiotica2001，31，： | 1 |
| 12 | Disclosure of new and recurrent microbial metabolites by mass spectrometric methods显示文摘 | U Grafe S Heinze B Schlegel and A Hartl | 2001 | Journal of Industrial Microbiology & Biotechnology2001，27，： | 1 |
| 13 | Chromatographic analysis of endogenous retinoids in tissues and serum显示文摘 | CARSTEN K S ABRAHAM B HEINZ N | 2003 | Anal Biochem2003，315，： | 1 |
| 14 | Quality considerations with high pressure processing of fresh and value added meat products显示文摘 | Bajovic B Bolumar T Heinz V | 2012 | Meat Science2012，92，3： | 1 |
| 15 | Variability in the Ant Camponotus Foridanus Detected by Muhilocus DNA Finger-printing显示文摘 | HEINZE J GADUE J HOLLDOBLER B | 1994 | Naturvissenschaften1994，81，1： | 1 |
| 16 | The european cancer anaemia survey(ECAS) : a large ,multinational ,prospective survey defining the prevalence, incidence, and tream~ent of anemia in cancer pa- tients显示文摘 | Heinz L Simon B Peter BL etal | 2004 | European Journal of Cancer2004，40，： | 1 |
| 17 | A new practical modal method for rotor balancing显示文摘 | HEINZ B | 2002 | Journal of Mechanical Engineering Science2002，216，10： | 1 |
| 18 | Force field for mica-type silicates and dynamics of octadecylammonium chains grafted to montmorillonite 显示文摘 | Heinz H Koemer H Anderson K L Vaia R A Farmer B | 2005 | Chemistry of Materials2005，17，23： | 1 |
| 19 | Self-assembly of alkylammonium chains on montmorillonite: effect of chain length, head group structure, and cation exchange capacity 显示文摘 | Heinz H Vaia R A Krishnamoorti R Farmer B L | 2007 | Chemistry of Materials2007，19，1： | 1 |
| 20 | Accurate simulation of surfaces and interfaces of face-centered cubic metals using 12-6 and 9-6 Lennard-Jones potentials 显示文摘 | Heinz H Vaia R A Farmer B L | 2008 | J Phys Chem C2008，112，17： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员