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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Rotating machinery prognostics : State of the art, challenges and opportunities显示文摘 | Heng A Zhang S Tan A C C | 2009 | Mechanical Systems and Signal Processing2009，23，3： | 1 |
| 3 | Model for the coal hydrogenation process and its applications显示文摘 | SHIBAOKA M HENG S | 1984 | Fuel1984，63，2： | 1 |
| 4 | Novel polymeric microspheres containing norcantharidin for chemoembolization显示文摘 | Liu X Heng W S Paul | 2006 | J Control Release2006，116，1： | 1 |
| 5 | White matter abnormalities in bipolar disorder: insights from diffusion tensor imaging studies显示文摘 | Heng S Song AW Sim K | 2010 | Neural Transm2010，117，： | 1 |
| 6 | Response of inertinites from some Australian coals to non-catalytic hydrogenation in tetralin显示文摘 | SHIBAOKA M HENG S OKADA K | 1985 | Fuel1985，64，5： | 1 |
| 7 | Chinese Visible Human Project显示文摘 | Zhang S X Heng P A Liu Z J | 2006 | Clin Anat2006，19，3： | 1 |
| 8 | Chinese Visible Human Project: the Present and Future 显示文摘 | Zhang S X Heng P A Liu Z J | 2006 | Clinical Anatomy2006，19，3： | 1 |
| 9 | Celecoxib inhibits serum amyloid a-induced matrix metalloproteinase-10 expression in human endothelial cells显示文摘 | Zhao Y Zhou S Heng C K | 2009 | J Vasc Res2009，46，1： | 1 |
| 10 | In vitro assessment of cellular responses to rod-shaped hydroxyapatite nanoparticles of varying lengths and surface areas显示文摘 | Zhao X Heng BC Xiong S | 2011 | Nanotoxicology2011，5，2： | 1 |
| 11 | Cross sectional echocardiography, 3: analysis of mathematic models for quantifying volume of symmetric and asymmetric left ventricles显示文摘 | WYATT H L MEERBAUM S HENG M K | 1980 | Am Heart J1980，100，： | 1 |
| 12 | The Composition of Public Expenditure and Economic Growth 显示文摘 | Devarajan Shantayanan Vinaya S Heng fu Zou | 1996 | Journal of Monetary Economics1996，，37： | 1 |
| 13 | Existence of low-cycling limbal epithelialbasal cells that can be pref-erentially stimulated to proliferate:implications on epithelial stem cells显示文摘 | COTSARELIS G C HENG S Z DONG G | 1989 | Cell1989，57，2： | 1 |
| 14 | Keyword guessing attacks on secure searchable public key encryption schemes with a designated tester显示文摘 | Yan W C Phan R C Heng S H | 2013 | International Journal of Computer Mathematics2013，90，12： | 1 |
| 15 | Chinese visible human project 显示文摘 | Zhang S X Heng P A Liu Z J | 2006 | Clin Anat2006，19，3： | 1 |
| 16 | The Chinese Visible Human (CVH) datasets incorporate technical and imaging advances on earlier digital humans显示文摘 | Zhang S X Heng P A Liu Z J | 2004 | J Anat2004，204，3： | 1 |
| 17 | Late complication after singie-rod instrumentation显示文摘 | Hengeness M H Esses S I Wellborn C C | 2010 | Spine2010，24，1： | 1 |
| 18 | Composite structural components under blast loading显示文摘 | HENG L | 2001 | Structures under Shock and Impact2001，，： | 1 |
| 19 | Rotating machinery prognostics: state of the art, challenges and opportunities 显示文摘 | Heng A Zhang S Tan A C C | 2009 | Mechanical Systems and Signal Processing2009，23，3： | 1 |
| 20 | Fundamental Differences in Dedifferentiation and Stem Cell Recruitment during Skeletal Muscle Regeneration in Two Salamander Species显示文摘 | Tatiana Sandoval-Guzmán Heng Wang Shahryar Khattak Maritta Schuez Kathleen Roensch Eugeniu Nacu Akira Tazaki Alberto Joven Elly M. Tanaka András Simon | 2013 | Cell Stem Cell2013，，： | 1 |
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