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| 1 | Reduced esophageal cancer incidence in statin users,particularly with cyclo-oxygenase inhibition显示文摘AIM:To examine the association between statin use and the development of esophageal cancer METHODS:We performed a systematic review and meta-analysis.Multiple databases(Pubmed,EMBASE,Cochrane Library,Web of Science,Wiley Interscience and Google Scholar) were systematically searched for studies reporting the association of statin use and the development of esophageal cancer.Literature searching and data abstraction were performed independently by two separate researchers.The quality of studies reviewed was evaluated using the Newcastle-Ottawa Quality assessment scale.Meta-analysis on the relationship between statin use and cancer incidence was performed.The effect of the combination of statin plus a cyclo-oxygenase inhibitor was also examined.RESULTS:Eleven studies met eligibility criteria,9 high and 2 medium quality.All were observational studies.Studies examining adenocarcinoma development in Barrett's esophagus included 317 cancers and 1999 controls,population-based studies examining all esophageal cancers included 371203 cancers and 6083150 controls.In the Barrett's population the use of statins(OR = 0.57;95%CI:0.43-0.75) and cyclo-oxygenase inhibitors(OR = 0.59;95%CI:0.45-0.77) were independently associated with a reduced incidence of adenocarcinoma.Combined use of a statin plus cyclooxygenase inhibitor was associated with an even lower adenocarcinoma incidence(OR = 0.26;95%CI:0.1-0.68).There was more heterogeneity in the population-based studies but pooled adjusted data showed that statin use was associated with a lower incidence of all combined esophageal cancers(OR = 0.81;95%CI:0.75-0.88).CONCLUSION:Statin use in patients with Barrett's oesophagus is associated with a significantly lower incidence of adenocarcinoma.The chemopreventive actions of statins,especially combined with cyclooxygenase inhibitors deserve further exploration. | Ian Leonard Phillip Beales Abigail Hensley Yoon Loke | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，3： | 5 |
| 2 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer显示文摘 | Catherine S.M. Diefenbach Zharna Shah Alexia Iasonos Richard R. Barakat Douglas A. Levine Carol Aghajanian Paul Sabbatini Martee L. Hensley Jason Konner William Tew David Spriggs Martin Fleisher Howard Thaler Jakob Dupont | 2006 | Gynecologic Oncology2006，，： | 2 |
| 3 | Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: results of a phase Ⅱ trial显示文摘 | Hensley ML Maki R Venkatraman E | 2002 | J Clin Oncol2002，20，12： | 1 |
| 4 | Sunitinib malate in the treatment of recurrent or persistent uterine leiomyosarcoma:a Gynecologic Oncology Group phase Ⅱ study显示文摘 | Hensley ML Sill MW Scribner DR Jr | 2009 | Gynecol Oncol2009，115，3： | 1 |
| 5 | Gecitabine and docitaxel in patients with unresected leiomyo-sarcoma:results of a phase Ⅱ trial显示文摘 | HENSLEY M L MAKI R VENKATRAMAN E | 2002 | Clin Oncol2002，20，12： | 1 |
| 6 | Estrus synchronization and artificial insemination of hair sheep ewes in the tropics显示文摘 | Godfrey R W Collins J R Hensley E L | 1999 | Theriogenology1999，51，： | 1 |
| 7 | Reactive oxygen species,cell signaling, and cell injury 显示文摘 | Hensley K Robinson KA Gabbita SP | 2000 | Free Radical Biol Med2000，28，10： | 1 |
| 8 | American Soci-ety of Clinical Oncology 2008 clinical practice guideline update:use of chemotherapy and radiation therapy protectants显示文摘 | Hensley ML Hagerty KL Kewalramani T | 2009 | J ClinOncol2009，271，： | 1 |
| 9 | Is Spine Deformity Surgery in Patients With Spastic Cerebral Palsy Truly Beneficial?: A Patient/Parent Evaluation显示文摘 | Kota Watanabe Lawrence G. Lenke Michael D. Daubs Kei Watanabe Keith H. Bridwell Georgia Stobbs Marsha Hensley | 2009 | Spine2009，，20： | 1 |
| 10 | Electrosynthesis of Organic Compounds from Car- bon Dioxide Is Catalyzed by a Diversity of Aceto- genic Microorganisms 显示文摘 | Nevin K P Hensley S A Franks A E | 2011 | Appl Environ Microbi- ol2011，77，9： | 1 |
| 11 | Lifetime prediction for organic coat- ings on steel and a magnesium alloy using electrochemical im- pedance methods 显示文摘 | Scully J R Hensley S T | 1994 | Corrosion1994，50，9： | 1 |
| 12 | Fixed-dose rate geme- itabine plus docetaxel as first-line therapy for metastatic uterine leiomyosarcoma: a Gynecologic Oncology Group phase Ⅱ trial 显示文摘 | Hensley ML Blessing JA Mannel R | 2008 | Gynecol Oncol2008，109，3： | 1 |
| 13 | Aortic disease with valvular insuffidency as the principle manifestation of systemic lupus erythematosus显示文摘 | Bernahard GC Lange RL Hensley GT | 1977 | Am Heart J1977，93，： | 1 |
| 14 | p38 kinase is activated in the Alzheimers disease brain显示文摘 | Hensley K Floyd RA Zheng NY | 1999 | J Neurochem1999，72，5： | 1 |
| 15 | Retrospective analysis of carboplatin and paclitaxel as initial second-line-therapy for recurrent epithelial ovarian carcinoma:Application toward a dynamic disease state model of ovarian cancer显示文摘 | Dizon DS Hensley ML Poynor EA | 2002 | J Clin Oncol2002，20，5： | 1 |
| 16 | Resistin induces ex- pression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messen- ger RNA stabilization 显示文摘 | Zhang Z Xing X Hensley G | 2010 | Arthritis Rheum2010，62，： | 1 |
| 17 | Pathogenesis of Ebo- la hemorrhagic fever in Cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection 显示文摘 | Geisbert TW Hensley LE Larsen T | 2003 | Am J Pathol2003，163，6： | 1 |
| 18 | American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants显示文摘 | Hensley ML Hagerty KL Kewalramani T | 2009 | J Clin Oncol2009，27，1： | 1 |
| 19 | 生动的鸟儿不启动飞行快尽管他们潜在的惹人注目显示文摘在距离接近的威胁,动物开始飞行的飞行起始距离(FID)——是变化的风险敏感的度量,但在FID具有可检测外部着色相关风险的影响是未知的。我们测试是否在羽毛鲜艳程度的变化解释鸟类飞行开始的距离变化。在体重控制,在距离实验方法开始,和系统发育关系,羽毛生动不是FID的预测。与预期相反,生动性影响的风险,因此,风险评估等,这些结果表明,鸟类不逃快接近威胁[现行生态补偿的视觉更惹人注目的61(4):773-780,2015 ]。 | Nicholai M. HENSLEY Jonathan P. DRURY Theodore GARLAND, Jr. Daniel T. BLUMSTEIN | 2015 | Current Zoology2015，61，4： | 1 |
| 20 | Formulation and chopping temperature effects on beef frankfurters显示文摘 | Hensley J L Hand L W | 1995 | Journal of Food Science1995，60，： | 1 |
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