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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 2 | Low rates of adherence for tumor necrosis factor-α inhibitors in Crohn's disease and rheumatoid arthritis: Results of a systematic review显示文摘AIM:To investigate adherence rates in tumor necrosis factor-α (TNF-α)-inhibitors in Crohn's disease (CD) and rheumatoid arthritis (RA) by systematic review of medical literature. METHODS:A structured search of PubMed between 2001 and 2011 was conducted to identify publications that assessed treatment with TNF-α inhibitors providing data about adherence in CD and RA. Therapeutic agents of interest where adalimumab, infliximab and etanercept, since these are most commonly used for both diseases. Studies assessing only drug survival or continuation rates were excluded. Data describing adherence with TNF-α inhibitors were extracted for each selected study. Given the large variation between definitions of measurement of adherence, the definitions as used by the authors where used in our calculations. Data were tabulated and also presented descriptively. Sample size-weighted pooled proportions of patients adherent to therapy and their 95%CI were calculated.To compare adherence between infliximab, adalimumab and etanercept, the adherence rates where graphed alongside two axes. Possible determinants of adherence were extracted from the selected studies and tabulated using the presented OR. RESULTS:Three studies on CD and three on RA were identified, involving a total of 8147 patients (953 CD and 7194 RA). We identified considerable variation in the definitions and methodologies of measuring adherence between studies. The calculated overall sample size-weighted pooled proportion for adherence to TNF-α inhibitors in CD was 70% (95%CI:67%-73%) and 59% in RA (95%CI:58%-60%). In CD the adherence rate for infliximab (72%) was highercompared to adalimumab (55%), with a relative risk of 1.61 (95%CI:1.27-2.03), whereas in RA adherence for adalimumab (67%) was higher compared to both infliximab (48%) and etanercept (59%), with a relative risk of 1.41 (95%CI:1.3-1.52) and 1.13 (95%CI:1.10-1.18) respectively. In comparative studies in RA adherence to infliximab was better than etanercept and etanercept did better than adalimumab. In three studies, the most consistent factor associated with lower adherence was female gender. Results for age, immunomodulator use and prior TNF-α inhibitors use were conflicting. CONCLUSION:One-third of both CD and RA patients treated with TNF-α inhibitors are non-adherent. Female gender was consistently identified as a negative determinant of adherence. | Herma H Fidder Maartje MJ Singendonk Mike van der Have Bas Oldenburg Martijn GH van Oijen | 2013 | World Journal of Gastroenterology2013，19，27： | 2 |
| 3 | Levels of C-reactive Protein Are Associated With Response to Infliximab Therapy in Patients With Crohn’s Disease显示文摘 | Matthias Jürgens Jestinah M. Mahachie John Isabelle Cleynen Fabian Schnitzler Herma Fidder Wouter van Moerkercke Vera Ballet Maja Noman Ilse Hoffman Gert van Assche Paul J. Rutgeerts Kristel van Steen Severine Vermeire | 2011 | Clinical Gastroenterology and Hepatology2011，，5： | 2 |
| 4 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 5 | Corrosion inhibi- tion of carbon-steels by propargyhriphenyl phosphonium bromide in H2SO4 solution 显示文摘 | Wahdan M H Hermas A A Morad M S | 2002 | Materials Chemistry and Physics2002，76，2： | 1 |
| 6 | The Problem of the Amber Signal Light in Traffic Flow显示文摘 | Gazi D Herma R Maradudin A | 1995 | Traffic Engineering Journal Research Laboratories General Motors Corporation Warren1995，，： | 1 |
| 7 | Corrosion inhibition of carbon - steels by propargyltriphenylphosphonium bromide in H2SO4 solution显示文摘 | M H Wahdan A A Hermas M S Morad | 2002 | Materials Chemistry and Physics2002，76，： | 1 |
| 8 | Formation of stable passive film on stainless steel by electrochemical deposi- tion of polypyrrole 显示文摘 | Hermas A A Nakayama Ogura K | 2005 | Electrochimica Acta2005，50，18： | 1 |
| 9 | A randomized,double-blind,placebo-controlled safety study of high-dised dextro-methorphan in methadone-maintained male inpatinents显示文摘 | Corhish JW Herma BH Ehrman RN | 2002 | Drug Alcohol depend2002，67，2： | 1 |
| 10 | Accumulation of copper layer on a surface in the anodic polarization of stainless steel containing Cu at different temperatures显示文摘 | HERMAS A A OGURA K ADACHI T | 1999 | Electrochemical Acta1999，40，7： | 1 |
| 11 | Enrichment of chromiumcontent in passive layers on stainless steel coated with polyaniline显示文摘 | Hermas A A Nakayama M Ogura K | 2005 | Electrochimica Acta2005，50，： | 1 |
| 12 | A review of the yellow interval dilemma 显示文摘 | Liu C Herma R Gazis D C | 1996 | Traffic Engineering Journal Transportation Research: Part A1996，30，5： | 1 |
| 13 | The joint–gut axis in inflammatory bowel diseases显示文摘 | Lianne K.P.M. Brakenhoff Désirée M. van der Heijde Daniel W. Hommes Tom W.J. Huizinga Herma H. Fidder | 2009 | Journal of Crohn’s and Colitis2009，，3： | 1 |
| 14 | Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suisserotype 2显示文摘 | Astrid G Herma B Robin V | 2002 | Infect Imm2002，70，3： | 1 |
| 15 | Cervical corpectomy and plate fixation for postlami-ectmy kyphosis显示文摘 | Herma JM Sonntag VKH | | 0，，06： | 1 |
| 16 | Formation of Stable Passive Film on Stainless Steel by Electrocbemical Deposition of Polypyrrole 显示文摘 | Hermas A A Nakayama M Ogura K | 2005 | Electrochimica Acta2005，50，18： | 1 |
| 17 | US examination of the appendix in children with suspected appendicitis: the additional value of secondary signs显示文摘 | Fraukje Wiersma Boudewijn R. Toorenvliet Johan L. Bloem Jan Hein Allema Herma C. Holscher | 2009 | European Radiology2009，，2： | 1 |
| 18 | Osteosarcoma:chemotherapy-induced changes at MR imaging显示文摘 | Johan L B Daniel V | 1992 | Radiology1992，182，： | 1 |
| 19 | Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2显示文摘 | Astrid DG Herma B Robin V | 2002 | Inefct Immun2002，70，3： | 1 |
| 20 | Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2显示文摘 | Greeff A Herma B Robin V | 2000 | Infect Immun2000，68，2： | 1 |
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