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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets显示文摘 | Hommes D W Peppelenbosch M P van Deventer S J | 2003 | Gut2003，52，1： | 14 |
| 3 | 肥胖的治疗:重视高危的腹部肥胖病人显示文摘本文要点 可采用测腰围这样的简单方法作为腹部脂肪堆积的指标 中年男性内脏型肥胖的特征是可导致动脉硬化的血脂异常 在腹部肥胖的中年男性中发现,冠心病的非传统指标的三联症(高胰岛素血症、载脂蛋白B增高和小分子LDL颗粒)的出现使冠心病的危险性增20倍 每5个中年男性腰围中就有4个≥90cm,甘油三酯≥2mmol/L,这就是代谢三联症的特征 即使肥胖病人没有高胆固醇症、高糖血症和高血压,如果他们具有“高甘油三脂血症的腰围表现”,就是冠心病的高危人群。 | Jean-PierreDesprés IsabelleLemieux DenisPrud'homme 李玉秀 | 2003 | 英国医学杂志中文版2003，6，2： | 5 |
| 4 | Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer显示文摘Matrix metalloproteinases(MMPs) are implicated in cancer development and progression and are associated with prognosis.Single-nucleotide polymorphisms(SNPs) of MMPs,most frequently located in the promoter region of the genes,have been shown to influence cancer susceptibility and/or progression.SNPs of MMP-1,-2,-3,-7,-8,-9,-12,-13 and-21 and of the tissue inhibitor of metalloproteinases(TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors.The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper. | Alexandra MJ Langers Hein W Verspaget Daniel W Hommes Cornelis FM Sier | 2011 | World Journal of Gastrointestinal Oncology2011，3，6： | 4 |
| 5 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 6 | A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration显示文摘Age-related macular degeneration(AMD) is a leading cause of blindness and is becoming a global crisis since affected people will increase to 288 million by 2040.Genetics,age,diabetes,gender,obesity,hypertension,race,hyperopia,iris-color,smoking,sun-light and pyroptosis have varying roles in AMD,but oxidative stress-induced inflammation remains a significant driver of pathobiology.Eye is a unique organ as it contains a remarkable oxygengradient that generates reactive oxygen species(ROS) which upregulates inflammatory pathways.ROS becomes a source of functional and morphological impairments in retinal pigment epithelium(RPE),endothelial cells and retinal ganglion cells.Reports demonstrated that hydrogen sulfide(H_2S) acts as a signaling molecule and that it may treat ailments.Therefore,we propose a novel hypothesis that H_2S may restore homeostasis in the eyes thereby reducing damage caused by oxidative injury and inflammation.Since H_2S has been shown to be a powerful antioxidant because of its free-radicals' inhibition properties in addition to its beneficial effects in age-relatedconditions,therefore,patients may benefit from H_2S salubrious effects not only by minimizing their oxidant and inflammatory injuries to retina but also by lowering retinal glutamate excitotoxicity. | Akash K George Mahavir Singh Rubens Petit Homme Avisek Majumder Harpal S SANDhu Suresh C Tyagi | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 3 |
| 7 | Gene and cell therapy based treatment strategies for inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD)are a group of chronic inflammatory disorders most commonly affecting young adults.Currently available therapies can result in induction and maintenance of remission,but are not curative and have sometimes important side effects.Advances in basic research in IBD have provided new therapeutic opportunities to target the inflammatory process involved.Gene and cell therapy approaches are suitable to prevent inflammation in the gastrointestinal tract and show therefore potential in the treatment of IBD.In this review,we present the current progress in the field of both gene and cell therapy and future prospects in the context of IBD.Regarding gene therapy,we focus on viral vectors and their applications in preclinical models.The focus for cell therapy is on regulatory T lymphocytes and mesenchymal stromal cells,their potential for the treatment of IBD and the progress made in both preclinical models and clinical trials. | Sander van der Marel Anna Majowicz Sander van Deventer Harald Petry Daniel W Hommes Valerie Ferreira | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 8 | Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation显示文摘 | Hans F.A. Vasen Martin Wasser Anneke van Mil Rob A. Tollenaar Marja Konstantinovski Nelleke A. Gruis Wilma Bergman Frederik J. Hes Daniel W. Hommes G. Johan A. Offerhaus Hans Morreau Bert A. Bonsing Wouter H. de Vos tot Nederveen Cappel | 2011 | Gastroenterology2011，，3： | 3 |
| 9 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management显示文摘 | A. Dignass G. Van Assche J.O. Lindsay M. Lémann J. S?derholm J.F. Colombel S. Danese A. D’Hoore M. Gassull F. Gomollón D.W. Hommes P. Michetti C. O’Morain T. ?resland A. Windsor E.F. Stange S.P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 10 | Changing Crohn’s disease management: Need for new goals and indices to prevent disability and improve quality of life显示文摘 | Daniel Hommes Jean-Frédéric Colombel Paul Emery Marco Greco William J. Sandborn | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 11 | CVT夹紧系统优化显示文摘本文详细讨论了对能量损失起主要影响的两个部件。分析了在液压控制中产生的能量损失以及进一步减少损失的可能性。以及变速装置中由于夹紧力产生的机械损。 | Hartmut Faust Manfred Homm Franz Bitzer | 2004 | 传动技术2004，18，4： | 2 |
| 12 | Packing for Control of Hemorrhage in Major Liver Trauma显示文摘 | A. J. Nicol M. Hommes R. Primrose P. H. Navsaria J. E. J. Krige | 2007 | World Journal of Surgery2007，，3： | 2 |
| 13 | Structural analysis of wheat wax (Triticum aestivum, c.v. ‘Naturastar’ L.): from the molecular level to three dimensional crystals显示文摘 | K. Koch W. Barthlott S. Koch A. Hommes K. Wandelt W. Mamdouh S. De-Feyter P. Broekmann | 2006 | Planta2006，，2： | 2 |
| 14 | 肥料展望2016-2020年(摘要报告)显示文摘分析当前世界经济和政策背景,预测2016—2020年世界农业和肥料需求、肥料供应,包括:2016/2017年全球谷物库存充沛,中期内农业生产缓慢增长;2016/2017年世界肥料需求回升,2020/2021年世界肥料需求略低于2.0亿t;肥料产能明显扩大。展望2016—2020年氮素、磷酸盐、钾盐、硫素的产能、供应和需求形势。 | Patrick Heffer Michel Prud’Homme 茹铁军(译) | 2016 | 磷肥与复肥2016，31，10： | 2 |
| 15 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 16 | Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets显示文摘 | Hommes D Peppelenbosch M van Deventer S | 2003 | Gut2003，52，1： | 1 |
| 17 | Stealth PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system 显示文摘 | Bazile D Prud' Homme C Bassoulet MT | 1995 | J Pharm Sci1995，84，4： | 1 |
| 18 | Reliable Real-Time Solution of Parameterized Partial Differential Equations:Reduced-basis Output Bound显示文摘 | Prud'homme C Rovas D V Veroy K | 2002 | Journal of Fluids Engineering2002，124，： | 1 |
| 19 | Critical appraisal ofthe current practice in murine TNBS-induced colitis显示文摘 | te VeIde A A Verstege M I Hommes D W | 2006 | Inflamm Bowel Dis2006，12，10： | 1 |
| 20 | Pathobinlogy of transforming growth factor beta in cancer,fibrosis and immunologic disease,and therapeutic considerations 显示文摘 | Prud'homme GJ | 2007 | Lab Invest2007，87，11： | 1 |
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