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| 1 | On the mechanical behavior of the human biliary system显示文摘This paper reviews the progress made in understanding the mechanical behaviour of the biliary system. Gallstones and diseases of the biliary tract affect more than 10% of the adult population. The complications of gallstones, i.e. acute pancreatitis and obstructive jandice, can be lethal, and patients with acalculous gallbladder pain often pose diagnostic difficulties and undergo repeated ultrasound scans and oral cholecystograms. Moreover, surgery to remove the gallbladder in these patients, in an attempt to relieve the symptoms, gives variable results. Extensive research has been carried out to understand the physiological and pathological functions of the biliary system, but the mechanism of the pathogenesis of gallstones and pain production still remain poorly understood. It is believed that the mechanical factors play an essential role in the mechanisms of the gallstone formation and biliary diseases. However, despite the extensive literature in clinical studies, only limited work has been carried out to study the biliary system from the mechanical point of view. In this paper, we discuss the state of art knowledge of the fluid dynamics of bile flow in the biliary tract, the solid mechanics of the gallbladder and bile ducts, recent mathematical and numerical modelling of the system, and finally the future challenges in the area. | Xiaoyu Luo Wenguang Li Nigel Bird Swee Boon Chin NA Hill Alan G Johnson | 2007 | World Journal of Gastroenterology2007，13，9： | 9 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation显示文摘 | Cooke K R Hill G R Gerbitz A | 2000 | Transplantation2000，70，2： | 2 |
| 4 | Diabetic cardiomyopathy: mechanisms and therapeutic targets显示文摘 | Pavan K Battiprolu Thomas G Gillette Zhao V Wang Sergio Lavandero Joseph A Hill | 2010 | Drug Discovery Today: Disease Mechanisms2010，，2： | 2 |
| 5 | Streptococcus suis serotypes characterized by analysis of chaperonin 60 gene sequences显示文摘 | Rousseau R Hill J E Prefontaine G | 2001 | Appl Env Microbiol2001，67，： | 2 |
| 6 | Anti-hypertensive drugs in children and adolescents显示文摘Worldwide the prevalence of essential hypertension inchildren and adolescents continues to increase. Tradi-tionally providers have used 'off-label' drugs to treatpediatric hypertension, meaning that rigorous clinicaltrials of these drugs have not been specifically per-formed in pediatric patient populations. Consequentlyproviders have extrapolated dosing, safety and efficacyfrom trials in adults. This practice is sub-optimal as chil-dren demonstrate unique differences in drug metabo-lism and response. Use of unstudied or understudieddrugs increases risk of adverse events and/or can leadto sub-optimal efficacy. Recognizing these concerns,regulatory agencies have created financial incentivesfor industry to conduct pediatric clinical trials. Theseincentives, coupled with the emerging pediatric hyper-tension epidemic, have spurred over 30 clinical trialsof anti-hypertensive drugs over the past 15 years andhave resulted in labeling of 10 new drugs by the UnitedStates Food and Drug Administration for treatment ofhypertension in children and adolescents. Unfortunatelythe financial incentive structures focus on newer drugsand drug classes. Consequently there is now a relativedearth of trial data for older but sometimes commonlyprescribed pediatric antihypertensive drugs. This article reviews recent pediatric antihypertensive drug trials with a focus on trial design and endpoints, drug dosing, safety, efficacy and specific drug indications. We also review the available data and experience for some of the more commonly prescribed, but less well studied 'older' pediatric antihypertensive drugs. | Patricia Y Chu Michael J Campbell Stephen G Miller Kevin D Hill | 2014 | World Journal of Cardiology2014，6，5： | 2 |
| 7 | Preinoculation enrichment procedure enhances the performance of bacteriocinogenic Lactocoocus lactic meat starter culture 显示文摘 | Amalia G M Scannell Gerhard Schwarz Colin Hill | 2001 | International Journal of Food Microbiology2001，64，： | 1 |
| 8 | Circulating endothelial progenitor cells, vascular function, and cardiovascular risk 显示文摘 | Hill JM Zalos G Halcox JP | 2003 | N Engl J Med2003，348，7： | 1 |
| 9 | Researches in the Lunar Theory 显示文摘 | G W Hill | 1978 | American Journal of Mathematics (S0002-9327)1978，1，1： | 1 |
| 10 | Nitrification of ammonical fertilizers in some California soils显示文摘 | Broadbent F E Tyler K B Hill G N | 1957 | Hilgardia1957，27，： | 1 |
| 11 | Methods for assessing the composition and diversity of soil microbial communities显示文摘 | Hill G T Mitkowski N A Aldrich-Wolfe L | 2000 | Applied Soil Ecology2000，15，1： | 1 |
| 12 | Fit of standard models of the lactation curve to weekly records of milk production of cows in single herd显示文摘 | OLORI V E BROTHERSTONE S HILL W G | 1999 | Livest Prod Sci1999，58，： | 1 |
| 13 | Oil well casing-evidence of the sensitivity to rapid failure in an H2S environment显示文摘 | Hill M Kawasaki E P Kronbach G E | 1972 | Materials Protection&Performance1972，，11： | 1 |
| 14 | Rapid detection of infectious adenoviruses by mRNA real-time RT-PCR 显示文摘 | Ko G Jothikumar N Hill V | 2005 | J Virol Methods2005，127，2： | 1 |
| 15 | Circulating endothe- lial progenitor ceils, vascular function, and cardiovascular risk 显示文摘 | Hill JM Zalos G Halcox JPJ | 2003 | N Engl J Med2003，348，7： | 1 |
| 16 | Attack structuralvulnerability of power grids s a hybrid approach based oncomplex networks显示文摘 | CHEN G DONG Z Y HILL D J | 2010 | Physica A: Statistical Mechanics and ItsApplications2010，389，3： | 1 |
| 17 | Comprehensive assessment of perioperative fatigue: development of the Identity Consequence Fatigue Scale显示文摘 | Paddison J S Booth R J Hill A G | 2006 | J Psychosom Res2006，60，14： | 1 |
| 18 | Radiated emissions and im-munity of micmetrip transmission line theory and reverberation cham-ber measurements显示文摘 | Hill D A Camell D G Cavcey K H | | 0，，02： | 1 |
| 19 | An overlap invariantentropy measure of 3D medical image alignment 显示文摘 | StudholmeC Hill D L G Hawkes D J | 1999 | PatternRecognition1999，32，1： | 1 |
| 20 | A low-field, low-cost Halbach magnet array for open-access NMR显示文摘 | Hills B P Wright K M Gilles D G | 2005 | Journal of Magnetic Resonance2005，175，： | 1 |
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