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| 1 | The human TTAGGG repeat factors I and 2 bind to a subsetof interstitial telomeric sequences and satellite repeats显示文摘 | Thomas Simonet Laure-Emmanuelle Zaragosi Claude Philippe Kevin Lebrigand Cldmentine Schouteden Adeline Augereau Serge Bauwens Jing Ye Marco Santagostino Elena Giulotto Frederique Magdinier Beatrice Horard Pascal Barbry Rainer Waldmann Eric Gilson | 2011 | Cell Research2011，21，7： | 7 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Recurrent Clostridium difficile infections:The importance of the intestinal microbiota显示文摘Clostridium difficile infections(CDI)are a leading cause of antibiotic-associated and nosocomial diarrhea.Despite effective antibiotic treatments,recurrent infections are common.With the recent emergence of hypervirulent isolates of C.difficile,CDI is a growing epidemic with higher rates of recurrence,increasing severity and mortality.Fecal microbiota transplantation(FMT)is an alternative treatment for recurrent CDI.A better understanding of intestinal microbiota and its role in CDI has opened the door to this promising therapeutic approach.FMT is thought to resolve dysbiosis by restoring gut microbiota diversity thereby breaking the cycle of recurrent CDI.Since the first reported use of FMT for recurrent CDI in 1958,systematic reviews of case series and case report have shown its effectiveness with high resolution rates compared to standard antibiotic treatment.This article focuses on current guidelines for CDI treatment,the role of intestinal microbiota in CDI recurrence and current evidence about FMT efficacy,adverse effects and acceptability. | Marie Céline Zanella Terrier Martine Louis Simonet Philippe Bichard Jean Louis Frossard | 2014 | World Journal of Gastroenterology2014，20，23： | 5 |
| 4 | Molecular markers of phase transition in locusts显示文摘提炼伴随转变从的变化对在蝗虫的独居的阶段状态群居是那么激烈的很长时间,这些阶段被看作不同种类。是鲍里斯·乌瓦罗夫介绍了 polyphenism 的概念。研究的十年表明阶段转变在 morphometry,表皮的颜色,行为和生理学的几个方面暗示变化。在最近的十年,特别地,相当很多分子的研究被承担了揭开阶段相关的差别。他们导致了新奇卓见进 corazonin 的角色, neuroparsins,一些朊酶禁止者, phenylacetonitrile 等等。蝗虫的 EST 数据库的来临(例如坑等, 2004 ) 是在生理、行为的蝗虫研究的很令人鼓舞的新奇开发。然而,最吸引人的问题的答案,也就是是否有阶段转变的初发的分子的 inducer,在不久的将来可能不在活动范围以内。 | ARNOLD DE LOOF ILSE CLAEYS GERT SIMONET PETER VERLEYEN TIM VANDERSMISSEN FILIP SAS JURGEN HUYBRECHTS | 2006 | Insect Science2006，13，1： | 3 |
| 5 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 6 | Determination of pesticides by capillary chromatography and SERS detection using a novel Silver-Quantum dots “sponge” nanocomposite显示文摘 | Carolina Carrillo-Carrión Bartolomé M. Simonet Miguel Valcárcel Bernhard Lendl | 2012 | Journal of Chromatography A2012，，： | 2 |
| 7 | Osteoprotegerin:a novel secreted protein involved in the regulation of bone density显示文摘 | Lacey DL Dunstan CR | 1997 | Cell1997，89，2： | 1 |
| 8 | Rapid fluores- cence determination of diquat herbicide in food grains using quan- tum dots as new reducing agent 显示文摘 | Carrillo-Carri6n C Simonet B M Valctrcel M | 2011 | Anal Chim Acta2011，692，12： | 1 |
| 9 | Osteoclast differentiation andactivation显示文摘 | Boyle WJ Simonet WS Lacey DL | 2003 | Nature2003，423，： | 1 |
| 10 | Osteoprotegerin: a novel secreted protein involved in the regulation of bone density 显示文摘 | Simonet WS Lacey DL Dunstan CR | 1997 | Cell1997，89，： | 1 |
| 11 | In situ synthesis of magnetic multiwalled carbon nanotube composites for the clean - up of ( fluoro ) quinolones from human plasma prior to ultrahigh pressure liquid chromatography analysis 显示文摘 | Morales -Cid G Fekete A Simonet B M | 2010 | Anal Chem2010，82，： | 1 |
| 12 | Osteoclast differentiation and activation显示文摘 | Boyle WJ Simonet WS Lacey DL | 2003 | Nature2003，423，3： | 1 |
| 13 | Osteoprotegerin:a novel secreted protain involved in the regulation of bone density显示文摘 | Simonet WS Lacey DL Dunstan CR | 1997 | Cell1997，89，2： | 1 |
| 14 | Osteoprotegerin:a novel secreted protein involved in the regulation of bone density显示文摘 | Lacey DL Dunstan CR | 1997 | Cell1997，89，2： | 1 |
| 15 | Frankia Genus-Specific Characterization by Polymerase Chain Reaction显示文摘 | SIMONET P GROSJEAN M C MISRA A K | 1991 | Appl Environ Microbiol1991，57，11： | 1 |
| 16 | Osteoprotegerin:A novel secreted protein involved in the regulation of bone density显示文摘 | Simonet WS Lacey DL Dunstan CR | 1997 | Cell1997，89，2： | 1 |
| 17 | Osteoprotegerin:A novel secreted protein involved in the reggulation of bone density显示文摘 | Simonet WS Lacey DL Dunstan CR | 1997 | Cell1997，89，2： | 1 |
| 18 | Optimal timing of preoperative intraaortic balloon pump support in high-risk coronary patients显示文摘 | Christenson JT Simonet F Badel P | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 19 | Bioactivepolar triterpenoids from Melilotus messanensis显示文摘 | Macias F A Simonet A M Galindo J C G er al | 1998 | Phytochemistry1998，49，3： | 1 |
| 20 | Osteoclast differentiation and ac- tivation显示文摘 | Boyle W J Simonet W S Lacey D L | 2003 | Nature2003，423，6937： | 1 |
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