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	题名	作者	年代	出处	被引量
1	Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy.	Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi	2016	World Journal of Gastroenterology2016，22，44：	5
2	CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc ? and Thereby Promotes Tumor Growth显示文摘	Takatsugu Ishimoto Osamu Nagano Toshifumi Yae Mayumi Tamada Takeshi Motohara Hiroko Oshima Masanobu Oshima Tatsuya Ikeda Rika Asaba Hideki Yagi Takashi Masuko Takatsune Shimizu Tomoki Ishikawa Kazuharu Kai Eri Takahashi Yu Imamura Yoshifumi Baba Mitsuyo O	2011	Cancer Cell2011，，3：	2
3	Cloning of a new cytokine that induces IFN-γ production by T cells显示文摘	Haruki O Hiroko T Toshinori K	1995	Nature1995，378，2：	1
4	Inhibitory effect of glycyrrhizin on the phosphorylation and DNA-binding abilities of high mobility group proteins 1 and 2 in vitro显示文摘	Ryoko S Maiko O Hiroko T	2001	Biol Pharm Bull2001，24，8：	1
5	The 2007 WHO classification of tumours of the central nervous system 显示文摘	David NL Hiroko O Otmar DW	2007	Acta Neuropathol2007，114，：	1
6	Development and function of bombesln-like peptides and their receptors 显示文摘	Hiroko O H Makio I Fumihiko M	2005	Int J Dev Biol2005，49，23：	1
7	Effect of super chuilling storage on maintenance of freshnessw of Kuruma prawn 显示文摘	Mami O Hiroko Nakamura Rie Harada Akihiko Yamanc	2004	Food Science and Technology Research2004，10，1：	1
8	查看详情显示文摘	Hiroko O Sukeo Y Tetsuo K Shigeyoshi H Toshiaki M Soo Ryan K Takeyuki M Kenzo K Toshiro T		0，，5：	1
9	The 2007 WHO classification of tumours of the central nervous system显示文摘	David L Hiroko O Otmar W		0，，：	1
10	Pathophysiological roles of interleukin-18 in inflammatory liver diseases显示文摘	Hiroko T Kiyoshi M Haruki O	2000	Immunological Reviews2000，174，：	1
11	New technique using galactose-specific lectin for isolation of fetal ceils from maternal blood显示文摘	Michihiro K Kentaro S Hiroko O	2002	Prenat Diagn2002，22，1：	1
12	Protective responses against experimental mycobacterium lepra infection in mice induced by recombinant bacillus Calmette-Guerin over-producing three putative protective antigen candidates显示文摘	Naoya O Matsuoka H Hiroko N	2001	Vaccine2001，19，：	1
13	The 2007 WHO classification of tumours of the central nervous system显示文摘	David NL Hiroko O Otmar D	2007	Acta Neuropathol2007，114，2：	1
14	The 2007 WHO classification of tumours of the central nervous system 显示文摘	David NL Hiroko O Otmar D	2007	Acta Neuro- pathol2007，114，2：	1
15	Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product显示文摘	Sadakazu U Hiroaki O Hiroko I	1999	J of Virol Methods1999，80，：	1
16	Effect of shosaikoto a Japanese and Chinese traditional herbal medical mixture, on the mitogenic activity of lipopolysaccharide: a new pharmacological testing method 显示文摘	Hiroko Iwama Sakae Amagaya and Y ukio O gihara	1987	Journal of Ethnopharmacology1987，21，：	1
17	Causal analysis of the invasion of broad-leaved forest by bamboo in Japan显示文摘	Kiyoshi O Shigeyuki S Hiroko F		0，，：	1
18	Anxiolytic effect of Gardeniae Fructus-extraet containing active ingredient from Kamishoyosan (KSS), a Japanese traditional Kampo medicine 显示文摘	Kazuo T Hiroko K Noriko (Yosikawa) O	2005	Life Sci2005，77，：	1
19	The 2007 WHO classification of tumours of the central nervous system显示文摘	David NL Hiroko O Otmar D	2007	Acta Neuropathol2007，114，2：	1
20	Fluorometric HPLC determination of δ- aminolevullnic acid (ALA) in theplasma and urine of lead workers:biological indicators of lead exposure 显示文摘	IROTAKA O HIROKO N KAZUO N	1996	JAnal Toxicol1996，20，：	1

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