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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Damage to Daikai subway station显示文摘 | IIDA H HIROTO T YOSHIDA N IWAFUJI M | 1996 | Soils and Foundations1996，，： | 1 |
| 3 | Damage to Daikai Subway Station显示文摘 | Iida H Hiroto T Yoshida N | 1996 | Japanese Geotechnical Society Special Issue of Soils and Foundation1996，，1： | 1 |
| 4 | A sum of squares ap- proach to modeling and control of nonlinear dynamical sys terns with polynomial fuzzy systems显示文摘 | Kazuo T Hiroto Y Hiroshi O | 2009 | IEEE Transac tions On Fuzzy Systems2009，17，4： | 1 |
| 5 | Loop-mediated isothermal amplification of DNA 显示文摘 | NOTOMI T HIROTO O HARUMI M | 2000 | Nucleic Acids Reaearch2000，28，12： | 1 |
| 6 | Loop-mediated isothetmal amplification of DNA显示文摘 | T Notomi Hiroto Okayama Harumi Masubuchi | 2000 | Nucleic Acids Research2000，28，12： | 1 |
| 7 | Damage to Dakai Subway Station显示文摘 | Iida H Hiroto T Yoshida N | 1996 | Special Issue of Soils and Foundations JSCE1996，36，8： | 1 |
| 8 | Damage to Daikai subway station显示文摘 | LIDA H HIROTO T | 1996 | Soil and Foundations1996，，： | 1 |
| 9 | Seasonal changes in semen characteristics, composition of seminal plasma and frequency of acro- some reaction induced by calcium and calcium ionophore A23187 in large white boars 显示文摘 | Murase T Imaeda N Hiroto Y | 2007 | J Reprod Develop2007，53，： | 1 |
| 10 | Damage to Dakai subway station显示文摘 | LIDA H HIROTO T YOSHIDA N | 1996 | Special Issue of Soils and Foundation1996，36，8： | 1 |
| 11 | Dynamic MR imaging:value of differentiating subtypes of peripheral small adenocarcino- ma of the lung显示文摘 | Yoshiharu O Hiroto H Daisuke T | 2004 | Eur J Radiol2004，52，2： | 1 |
| 12 | Treatment of ischemic limbs based on local recruitment of vascular endothelial growth factor-producing inflammatory cells with ultrasonic microbubble destruction显示文摘 | JUNJI Y KOJI O HIROTO T | 2005 | J Am Coll Cardiol2005，46，： | 1 |
| 13 | Iridium-catalyzed directtetraborylation of perylene bisimides显示文摘 | Teraoka T Hiroto S Shinokubo H | 2011 | Org Lett2011，13，： | 1 |
| 14 | Interleukin-17 gene expression in patients wilh thetmaatoid arlhdfis显示文摘 | Mika K Akito T Hiroto M | 2008 | Mod Rhetanatol2008，18，1： | 1 |
| 15 | Human coronary arteriolar dilation to adrenomedullin: role of nitric oxide and K+channels 显示文摘 | Hiroto M Yanping L | 2000 | Heart circul physiol2000，279，6： | 1 |
| 16 | Damage to Dakai subway station显示文摘 | IIDA H HIROTO T YOSHIDA N | 1996 | Soils and Foundations1996，，： | 1 |
| 17 | Production of alpha-fetoprotein, normal serum proteins, and human chorionic gonaditropin in stomach cancer: histologic and immunohistochemical analysis of 35 cases显示文摘 | Kodama T Kameya T Hiroto T | 1981 | Cancer1981，48，： | 1 |
| 18 | Thrombotic microangiopathy-like disorder after living-donor liver transplantation:A single-center experience in Japan显示文摘AIM:To investigate thrombotic microangiopathy (TMA)in liver transplantion,because TMA is an infrequent but life-threatening complication in the transplantation field. METHODS:A total of 206 patients who underwent living-donor liver transplantation (LDLT) were evaluated,and the TMA-like disorder (TMALD) occurred in seven recipients. RESULTS:These TMALD recipients showed poor outcomes in comparison with other 199 recipients. Although two TMALD recipients successfully recovered,the other five recipients finally died despite intensive treatments including repeated plasma exchange (PE) and re-transplantation. Histopathological analysis of liver biopsies after LDLT revealed obvious differences according to the outcomes. Qualitative analysis of antibodies against a disintegrin-like domain and metalloproteinase with thrombospondin type 1 motifs (ADAMTS-13) were negative in all patients. The fragmentation of red cells,the microhemorrhagic macules and the platelet counts were early markers for the suspicion of TMALD after LDLT. Although the absolute values of von Willebrand factor (vWF) and ADAMTS-13 did not necessarily reflect TMALD,the vWF/ADAMTS-13 ratio had a clear diagnostic value in all cases. The establishment of adequate treatments for TMALD,such as PE for ADAMTS-13 replenishment or treatments against inhibitory antibodies,must be decided according to each case. CONCLUSION:The optimal induction of adequate therapies based on early recognition of TMALD by the reliable markers may confer a large advantage for TMALD after LDLT. | Tomohide Hori Toshimi Kaido Fumitaka Oike Yasuhiro Ogura Kohei Ogawa Yukihide Yonekawa Koichiro Hata Yoshiya Kawaguchi Mikiko Ueda Akira Mori Yasutsugu Takada Hiroto Egawa Atsushi Yoshizawa Shinji Uemoto Hajime Segawa Kimiko Yurugi Takuma Kato Kanako Saito Linan Wan Mie Torii Feng Chen Ann-Marie T Baine Lindsay B Gardner | 2011 | World Journal of Gastroenterology2011，17，14： | 1 |
| 19 | Transgenic silkworms produce recombinant human typeIII procollagen in cocoons显示文摘 | Masahiro T Hiroto M Tsutomu S | 2003 | Nature2003，21，1： | 1 |
| 20 | 显示文摘 | Nagasawa T Hirotoe S Tachibana K | 1996 | Nature1996，382，： | 1 |
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