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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | White spot syndrome baculovirus(WSBV) detected in cultured and captured shrimp, crabs and other arthropods 显示文摘 | Lo C F Ho C H Peng S E | 1996 | Dis Aquat Org1996，27，： | 1 |
| 3 | Control dynamics of speed drive systems using sliding mode controllers with integral compensation显示文摘 | Ho E Y Y Sen P C | 1991 | IEEE Transactions on Industry Applications1991，27，5： | 1 |
| 4 | Improvement of hybridyield by advanced backcross QTL analysis in elite maize显示文摘 | J C HO S R McCouch M E Smith | 2002 | Theor Appl Genet2002，105，： | 1 |
| 5 | Hemichorea-hemiballism: an explanation for MR signal changes显示文摘 | Shan D E Ho D M Chang C | 1998 | Am J Neuroradiol1998，19，5： | 1 |
| 6 | Extension of human cell lifespan by nicotinamide phosphoribosyltransferase显示文摘 | van der Veer E Ho C O'Neil C | 2007 | J Biol Chem2007，282，10： | 1 |
| 7 | Biological markers of oxidative stress:Applications to cardiovascular research and practice 显示文摘 | HO E KARIMI G K LIU C C | 2013 | Redox Biological2013，，1： | 1 |
| 8 | Vortex induction and mass entrainment in a small-aspect-ratio elliptic jet 显示文摘 | Ho C M Gutmark E | 1987 | J Fluid Mech1987，179，： | 1 |
| 9 | Dietary HDAC inhibitors : time to rethink weak ligands in cancer chemoprevention? 显示文摘 | DASHWOOD R H MYZAK M C Ho E | 2006 | Carcinogenesis2006，27，2： | 1 |
| 10 | Mechanism of the su- peroxide scavenging activity of neoandrographolide - a natural product from Andrographis paniculata nees 显示文摘 | Kamdem R E Sang S Ho C T | 2002 | J Agr Food Chem2002，50，： | 1 |
| 11 | Narcissism, extraversionand adolescents,self - presentation on Facebook 显示文摘 | Ong E Y L Ang R P Ho J C M | 2010 | Personality andIndividual Differences2010，50，2： | 1 |
| 12 | Vortex induction and mass entrainment in a small-aspect-ratio elliptic jet显示文摘 | HO C M GUTMARK E | 1987 | J Fluid Mech1987，107，： | 1 |
| 13 | Reaction kinetics of solder-balls with pads in BGA packages during reflow soldering 显示文摘 | HO C E CHEN Y M KAO C R | 1999 | J Elec Mater1999，28，11： | 1 |
| 14 | Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus显示文摘 | Wong C K Ho C Y Li E K | 2000 | Lupus2000，9，8： | 1 |
| 15 | Spanish nephrology nurses' views and attitudes towards caring for dying patients 显示文摘 | Ho TM Barhero E Hidalgo C | 2010 | J Ren Care2010，36，1： | 1 |
| 16 | An effective architecture for learning and evolving flexible job-shop schedules显示文摘 | Ho N B Tay J C Lai E M K | 2007 | European Journal of Operational Research2007，179，2： | 1 |
| 17 | Isolation and identification of a snake venom metalloproteinase inhibitor from California ground squirrel (Spermophilus beecheyi) blood sera 显示文摘 | BIARDI J E HO C Y MARCINCZYK J | 2011 | Toxieon2011，58，67： | 1 |
| 18 | Placement con- straints in floorplan design显示文摘 | Young E F Y Chu C CN Ho M L | 2004 | IEEE Transactions on Very Large Scale Integration Systems2004，12，7： | 1 |
| 19 | Reaction of solder with Ni/Au metallization for electronic packages during reflow soldering显示文摘 | HO C E TSAI S Y and KAO C R | 2001 | IEEE Trans Adv Packag2001，24，4： | 1 |
| 20 | An effective architecture for learning and evolving flexible job-shop schedules显示文摘 | Ho N B Tay J C Lai E M K | 2007 | European Journal of Operational Research2007，179，2： | 1 |
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