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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | White spot syndrome baculovirus(WSBV) detected in cultured and captured shrimp, crabs and other arthropods 显示文摘 | Lo C F Ho C H Peng S E | 1996 | Dis Aquat Org1996，27，： | 1 |
| 3 | Characteristics of carbonaceous aerosol in Pearl River Delta Region, China during 2001 winter period 显示文摘 | CAO J J LEE S C HO K F | 2003 | Atmos Environ2003，37，： | 1 |
| 4 | Gaseous and particulate polycyclic aromatic hydrocarbons (PAHs) emissions from Commercial Restaurants in Hong Kong 显示文摘 | Chen Y Ho K F Ho S S | 2007 | Journal of Environment Monitoring2007，9，： | 1 |
| 5 | Excentral cleavage of beta- carotene in vivo in a healthy man显示文摘 | HO C C de MOURA F F KIM S H | 2007 | Clin Nutr2007，85，3： | 1 |
| 6 | Characterization of selected volatile organic compounds, polycyclie aromatic hydrocarbons and earbonyl compounds at a roadside monitoring station 显示文摘 | HO K F LEE S C GLORIA M Y | 2002 | Atmos Environ2002，36，1： | 1 |
| 7 | Positive sampling artifacts in particulate organic carbon measurements in roadside environment显示文摘 | CHENG Y LEE S C HO K F | 2010 | Environmental Monitoring and Assessment2010，168，1234： | 1 |
| 8 | Antiviral effect of epigallocatechin gallate on enterovirus 71显示文摘 | Ho H Y Cheng M L Weng S F | | 0，，14： | 1 |
| 9 | Controlling carbon emissions in China显示文摘 | Garbaccio R F Ho M S Jorgenson D W | 1999 | Environment and Development Economics1999，，04： | 1 |
| 10 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 11 | Micro-Doppler Effect in Radar-Phenomenon,Model and Simulation Study显示文摘 | Chen V C Li F Y Ho S S | 2006 | IEEE Trans on Aerospace and Electronic Systems2006，42，1： | 1 |
| 12 | Micro-doppler effect in radar:phenomenon,model,and simulation study显示文摘 | Chen V C Li F Y Ho S | 2006 | IEEE Transactionson Aerospace and Electronic Systems2006，42，1： | 1 |
| 13 | Regulation of G (1)cell-cycle progression by oncogenes and tumor suppressor genes 显示文摘 | Ho A Dowdy S F | 2002 | Curr Opin Genet Dev2002，12，1： | 1 |
| 14 | Mango malformation disease in South China caused by Fus arium p roliferotum显示文摘 | ZHAN R L YANG S J HO H H LIU F ZHAO Y L CHANG J M HE Y B | 2010 | Journal of Phytopathology2010，158，： | 1 |
| 15 | Effects of Asian dust e- vents on daily hospital admissions for chronic obstructive pul- monary disease in Taipei, Taiwan显示文摘 | Chiu H F Tiao M M Ho S C | 2008 | Inhalation Toxicology2008，20，： | 1 |
| 16 | Ion-beam-induced chemical changes in the oxyanions (Moyn-) and oxides (Mox) where M = chromium, molybdenum, tungsten, vanadium, niobium and tantalum 显示文摘 | Ho S F Contarini S Rabalais J W | 1987 | Journal of Physi- cal Chemistry1987，91，18： | 1 |
| 17 | Metaplastic breast carcinomas are basal-like tumours 显示文摘 | REIS-F H HO J S MILANEZI F | 2006 | Histopathology2006，49，1： | 1 |
| 18 | Equilibrium isotherm studies for the sorption of divalent metal ions onto peat: copper, nickel and lead single component system显示文摘 | Ho Y S Porter J F Mekay G | 2002 | Water Air Soil Poll2002，141，： | 1 |
| 19 | Why has the Energy Output Ratio Fallen in China? 显示文摘 | Garbaccio R F Ho M S Jorgenson DW | 1999 | Energy Journal1999，20，3： | 1 |
| 20 | Experimental focal segmental glomerulosclerosis in mice显示文摘 | CHEN A SHEU L F HO Y S | 1998 | Nephron1998，78，4： | 1 |
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