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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 3 | Visualization and spectroscopy of a Metal-Molecule-Metal bridge显示文摘 | Nazin G V Qiu X H Ho W | 2003 | Science2003，302，： | 1 |
| 4 | Transport of ironbased nanoparticles: role of magnetic properties 显示文摘 | Yongsuk Ho Ryan J H Nosang V | 2009 | Environmental Science & Technology2009，43，23： | 1 |
| 5 | The effects of compression and gas diffusion layers on the performance of a PEM fuel cell 显示文摘 | Lee Wk Ho C H Zee J W V | 1999 | Journal of Power Sources1999，84，： | 1 |
| 6 | Effect of magnetite nanoparticle agglomerates on ultrasound induced inertial cavitation显示文摘 | Smith M J Ho V H B Darton N J | | 0，，06： | 1 |
| 7 | Exploring knowledge dif- fusion among nations: A study of core technologies in fuel cells显示文摘 | Ho M H Lin V H Liu J S | 2014 | Sciemometrics2014，100，1： | 1 |
| 8 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 9 | Visualization and spectroscopy of a metal-molecule-metal bridge显示文摘 | Nazin G V Qiu X H Ho W | 2003 | Science2003，302，： | 1 |
| 10 | Comparativeoutcome of nonmyeloablative and myeloablative allo-geneic hematopoietic cell transplantation for patientsolder than 50years of age显示文摘 | ALYEA E P KIM H T HO V | 2005 | Blood2005，105，： | 1 |
| 11 | Visualization and spectroscopy of a metal-molecule-metal bridge 显示文摘 | Nazin G V Qiu X H Ho W | 2003 | Science2003，302，： | 1 |
| 12 | Micro-Doppler effect in radar: phenomenon, model, and simulation study 显示文摘 | V C Chen F Y Li S-S Ho H Wechsler | 2006 | IEEE Transactions on Aerospace and Electronic Sys- tems2006，42，1： | 1 |
| 13 | Analysis of microdoppler signatures 显示文摘 | Chen V C Li F Ho S S Wechsler H | 2003 | IEE Proceedings Radar Sonar and Navigation2003，150，4： | 1 |
| 14 | Constant-frequency hysteresis current control of grid-connected VSI without bandwidth control显示文摘 | Ho C N Cheung V S Chung H S | 2009 | IEEE Transactions on Power Electronics2009，24，11： | 1 |
| 15 | Architecture of the pulmonary veins:relevance to radiofrequency ablation显示文摘 | Ho S Y Cabrera J A Tran V H | | 0，，03： | 1 |
| 16 | L-arginine enhances aerobic exercise capacity in association with augmented nitric oxide production 显示文摘 | MAXWELL A J HO H V LE C Q | 2001 | Journal Applied Physiology2001，90，3： | 1 |
| 17 | Assessment on pollu- tion by heavy metals and arsenic based on surficial and core sediments in the Cam River Mouth, Haiphong Province, Vietnam显示文摘 | Ho H H Swennen R Cappuyns V | 2013 | Soil and Sediment Contamination: An Interna- tional Journal2013，22，4： | 1 |
| 18 | Development of an enzyme-linked immunosorbent assay for bisphenol A using chicken immunoglobulins显示文摘 | Meulenaer B D Baert K Lanckriet H Van Hoed V Huyghebaert A | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 19 | Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein 显示文摘 | HO V T BUNN H F | 1996 | Biochem Biophys Res Commun1996，223，1： | 1 |
| 20 | Adaptation of duck plague virus to chicken embryo fibroblast cell culture for vaccine production:Control of Newcastle disease and duck plague in village poultry显示文摘 | NGUYEN T K NGUYEN V D HO V H | 2004 | ACIAR Proceedings2004，，117： | 1 |
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