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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | A qualitative and quanti- tative review of antecedents of counterproductive behav- ior in organizations 显示文摘 | Lau V S Au W T & Ho J C | 2003 | Journal of Business and Psy- chology2003，18，1： | 1 |
| 3 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 4 | Micro-Doppler Effect in Radar-Phenomenon,Model and Simulation Study显示文摘 | Chen V C Li F Y Ho S S | 2006 | IEEE Trans on Aerospace and Electronic Systems2006，42，1： | 1 |
| 5 | Micro-doppler effect in radar:phenomenon,model,and simulation study显示文摘 | Chen V C Li F Y Ho S | 2006 | IEEE Transactionson Aerospace and Electronic Systems2006，42，1： | 1 |
| 6 | p53-dependent DNA repair and apoptosis respond differently to high-and low-dose ultraviolet radiation显示文摘 | Li G Ho V C | 1998 | Br J Dermatol1998，139，1： | 1 |
| 7 | The effects of compression and gas diffusion layers on the performance of a PEM fuel cell 显示文摘 | Lee Wk Ho C H Zee J W V | 1999 | Journal of Power Sources1999，84，： | 1 |
| 8 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 9 | Analysis of micro-Doppler signatures 显示文摘 | Chen V C Li F Y Ho S S | 2003 | IEEE Proceedings of Raddar Sonar and Nav- igation2003，150，4： | 1 |
| 10 | Micro-Doppler effect in radar: phenomenon,model, and simulation study 显示文摘 | Chen V C Li F Ho S S | 2006 | IEEE Trans- actions on Aerospace and Electronic Systems2006，42，1： | 1 |
| 11 | SHIP represses the Generation of alternatively activated macrophages显示文摘 | Rauh MJ Ho V Pereira C | 2005 | Immunity2005，23，4： | 1 |
| 12 | Micro-Doppler effect in radar: phenomenon, model, and simulation study 显示文摘 | V C Chen F Y Li S-S Ho H Wechsler | 2006 | IEEE Transactions on Aerospace and Electronic Sys- tems2006，42，1： | 1 |
| 13 | Analysis of microdoppler signatures 显示文摘 | Chen V C Li F Ho S S Wechsler H | 2003 | IEE Proceedings Radar Sonar and Navigation2003，150，4： | 1 |
| 14 | Constant-frequency hysteresis current control of grid-connected VSI without bandwidth control显示文摘 | Ho C N Cheung V S Chung H S | 2009 | IEEE Transactions on Power Electronics2009，24，11： | 1 |
| 15 | Work Group Diversity and Group Per?formance: An Integrative Model and Research Agenda显示文摘 | V AN KNIPPENBERG D DE DREU C K W HO?MAN A C | 2004 | Journal of Applied Psychology2004，89，6： | 1 |
| 16 | Evaluation of the normal and abnormal bicipital tendon with MR imaging显示文摘 | Cervilla V Motta A Ho C | 1990 | Radiolo gy1990，179，： | 1 |
| 17 | SHIP represses the generation of alternatively activated macrophages显示文摘 | Rauh M J Ho V Pereira C | 2005 | Immunity2005，23，4： | 1 |
| 18 | A qualitative and quantitative review of antecedents of counterproductive behavior in organi zations显示文摘 | Lau V C S Au W T and Ho J M C | 2003 | Journal of Business and Psychology2003，18，1： | 1 |
| 19 | L-arginine enhances aerobic exercise capacity in association with augmented nitric oxide production 显示文摘 | MAXWELL A J HO H V LE C Q | 2001 | Journal Applied Physiology2001，90，3： | 1 |
| 20 | Micru-Doppler effect in radar-phe- nomenon, model and simulation study 显示文摘 | Chen V C Li F Y Ho S S | 2006 | IEEE Transactions on Aerospace and Electronic Systems2006，42，1： | 1 |
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