|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 2 | The albumin cobalt binding test:analytical performance of a new automated chemistry 0assay for the detection of ischemia modified albumin(IMA)显示文摘 | Fagan G J Hollie Wayment Deborah L | 2002 | Clin Leg Assay2002，25，5： | 1 |
| 3 | Aspartame consumption in relation to childhood brain tumour risk: results from a case-control study显示文摘 | GURNEY J G POGODA J M HOLLY E A | 1997 | J Nat Cancer Inst1997，89，14： | 1 |
| 4 | Hydrological modelling and the sustainable development of the Hadejia-Nguru Wetland, Nigeria显示文摘 | Thompson J R Hollis G E | 1995 | Hydrological Sciences Journal1995，40，1： | 1 |
| 5 | PB1-F2 expedition from the whole protein through the domain to aa residue function 显示文摘 | Kosik I Holly J Russ G | 2013 | Acta Virol2013，57，： | 1 |
| 6 | Massive pncumocephalus following Merocel nasal tamponade for epistaxis显示文摘 | HOLLIS G J | 2000 | Acad Emerg Med2000，7，9： | 1 |
| 7 | Effects of Hatha Yago Practice on the Health-Related Aspects of Physical Fitness 显示文摘 | Tran M D Holly R G Lashbrook J | 2001 | Previous C ardiol2001，4，： | 1 |
| 8 | Phosphorus nuclear magnetic resonance of per fused working rat hearts显示文摘 | JACOBUS W E TAYLOR IV G J HOLLIS | 1977 | Nature1977，265，24： | 1 |
| 9 | The Role of Insulin-like Growth Factor Binding Proteins显示文摘 | HOLLY J PERKS G | 2006 | Neuroendocrinology2006，83，34： | 1 |
| 10 | Safety of 25-hy-droxycholecalciferol as a source of cholecalcif- erol in poultry rations 显示文摘 | Yarger J G Quarles C L Hollis B W | 1995 | Poult Sci1995，74，： | 1 |
| 11 | Cervical spine trauma associated with moderate and severe head injury:incidence,risk factors,and injury characteristics显示文摘 | Holly L T Kelly D F Counelis G J | 2002 | J Neurosurg2002，96，3： | 1 |
| 12 | Massive pneumocephalus following Merocel nasal tamponade for epistaxis显示文摘 | Hollis G J | | 0，，09： | 1 |
| 13 | Safety of 25-hydroxycholecalciferol as a source of cholecalciferol in poultry rations显示文摘 | Yarger J G Quar!es C L Hollis B W | 1995 | Poult Sci1995，74，： | 1 |
| 14 | A human perception analysis approach to clothing comfort显示文摘 | N R S Hollies A G Custer C J Morin | 1979 | Textile Research Journal1979，49，： | 1 |
| 15 | A human perception analysis approach to clothing comfort显示文摘 | HOLLIES N R S CUSTER A G MORIN C J | 1979 | Textile Research Journal1979，49，9： | 1 |
| 16 | Cadmium accumulation,gillCd binding,acclimation,and physiological effects during long termsublethal Cd exposure in rainbow trout显示文摘 | Hollis L Mcgeer J C Mcdonald D G | 1999 | Aquatic Toxicology1999，46，2： | 1 |
| 17 | Pesticides in rainfall in Europe显示文摘 | DUBUSI G HOLLIS J M BROWN CD | 2000 | Environmental Pollution2000，110，： | 1 |
| 18 | Hydrological modelling and the sustainable development of the Hadejia-Nguru Wetlands,Nigeria显示文摘 | Thompson J R G E Hollis | 1995 | Hydrological Sciences Journal1995，40，： | 1 |
| 19 | Resistant Starch: Promise for Improving Human Health 显示文摘 | Birt D F Boylston T Hendrich S Jane J L Hollis J Li L MeClelland J Moore S Phillips G J Rowling M Schalinske K Scott M P Whitley E M | 2013 | Advances in Nutrition2013，4，6： | 1 |
| 20 | Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050 显示文摘 | Fridman J S Scherle P A Collins R Bum T C Li Y Li J Covington M B Thomas B Collier P Favata M F Wen X Shi J McGee R Haley P J Shepard S Rodgers J D Yeleswaram S Hollis G Newton R C Metcalf B Friedman S M Vaddi K | 2010 | J Immunol2010，184，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员