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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Synthesis of β-Boswellic Acid Analogues with a Carboxyl Group at C-17 Isolated from the Bark of Schefflera octophylla显示文摘 | Honda T Gribble GW | 2000 | J Org Chem2000，65，19： | 1 |
| 3 | Approach to establishing a liver targeting gene therapeutic vector using naturally occurring defective hepatitis B viruses devoid of immunogenic T cell epitope显示文摘 | Wang L Kaneko S Honda M | 2002 | Virus Res2002，85，2： | 1 |
| 4 | Photosynthet- ic bacteria pond system with infra-red transmitting fiher for thetreatment and recovery of organic carbon from industrial wastewater 显示文摘 | CHIEMCHAISRI C JAITRONG L HONDA R | 2007 | Water Science and Technology2007，56，7： | 1 |
| 5 | Heat resistance of Mg-Zn- A1-Ca alloy casting显示文摘 | ANYANWU L A KAMADO S HONDA T | 2000 | Materials Science Forum2000，35，： | 1 |
| 6 | Synthetic' oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages显示文摘 | Honda T Rounds BV Bore L | 2000 | J Med Chem2000，43，22： | 1 |
| 7 | Preparation and evaluation of doped celia interlayer on supported stabilized zirconia electrolyte SOFCs by wet ceramic processes显示文摘 | NGUYEN T L KOBAYASHI K HONDA T | 2004 | Solid State lonics2004，174，： | 1 |
| 8 | Structural requirements for initiation of translation by interal ribosome entry within genomelength hepatitis C virus RNA显示文摘 | Honda M Ping L H Rijnbrand R A | 1996 | Virology1996，222，： | 1 |
| 9 | Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases显示文摘 | Kamata H Honda S S Chang L | 2005 | Cell2005，120，5： | 1 |
| 10 | Extraction of Road Information Using Multisensory Data显示文摘 | Hazarika M K Honda K Samarokoon L | 2000 | International Ar- chives of Photogrammetry and Remote Sensing XXXIII Part B3 Amsterdam2000，2000，： | 1 |
| 11 | Imidase, a dihydropyrimidinaselike enzyme involved in the metabolism of cyclic inudes显示文摘 | Ogawa J Soong C L Honda M | 1997 | Eur J Biochem1997，243，： | 1 |
| 12 | Synthetic oleanane and ursane triterpenoids with modified rings A and C:a series of highly active inhibitors of nitric oxide production in mouse macrophages 显示文摘 | HONDA T ROUNDS B V BORE L | 2000 | J Med Chem2000，43，22： | 1 |
| 13 | Novel Aspects of the Sperm-Associated Antigen ll(SPAG11)Gene Organization and Expression in Cattle(Bos taurus)显示文摘 | Avellar M C W Honda L Hamil K G | 2007 | Biol Reprod2007，76，6： | 1 |
| 14 | Oxidative stress induced single-strand breaks in chromosomal telomeres of human retinal pigment epithelial cells in vitro显示文摘 | HONDA S HJELMELAND L M HANDA J T | 2001 | Invest Ophthalmol Vis Sci2001，42，9： | 1 |
| 15 | Acute effects of chemicaly dispersed crude oil on gill ion regulation, plasma ion levels and haematological parameters in tambaqui (Colossoma macropomum) 显示文摘 | Duarte R M Honda R T Val A L | 2010 | Aquatic Toxi- cology2010，97，2： | 1 |
| 16 | Activation of toll-like receptor 4 (TLR4) by in vivo and in vitro exposure of rat epididymis to lipopolysaccharide from Escherichia coli显示文摘 | Rodrigues A Queiroz D B Honda L | 2008 | Biology of Reproduction2008，79，： | 1 |
| 17 | Effect of dissolved gases and an echo contrast agent on apoptosis induced by ultrasound and its mechanism via the mitochondria-caspase pathway显示文摘 | Honda H Zhao Q L Kondo T | 2002 | Utrasound Med Bio2002，28，5： | 1 |
| 18 | Heat resistance of Mg-Zn-Al-Ca alloy casting显示文摘 | ANYANWU L A KAMADO S HONDA T | 2000 | Materials Science Forum2000，35，： | 1 |
| 19 | Male DNA typing from 25 - year - old vaginal swabs using Y chromosomal STR polymorphisms in a re- trial request case显示文摘 | Honda K Roewer L De - Knijff P | 1999 | J Forensic Sci1999，44，4： | 1 |
| 20 | Novel Aspects of the spermassociated antigen 11 (SPAGll) gene organization and expression in cattle (Bos taurus)显示文摘 | Avellar MC Honda L Hamil KG | 2007 | Biol Reprod2007，76，6： | 1 |
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