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| 1 | 利用T_1加权DCE-MRI技术对脑胶质瘤分级显示文摘应用T1加权动态对比度增强磁共振成像(DCE-MRI)技术对脑胶质瘤进行术前分级,验证其用于脑胶质瘤分级的准确性和可重复性。对26例脑胶质瘤患者团注Gd-DTPA对比剂后,以1.5TSiemens Syngo MRI扫描仪采集DCE T1加权图像。首先基于改进的Tofts两室药物动力学模型,从采集到的动态组图像建立病灶区感兴趣区内的平均信号强度-时间曲线,然后应用非线性最小二乘拟合方法对该曲线进行拟合,获取定量参数。这些参数包括:初始增强率ER、回流速率常数Kep、排泄速率常数Kel、曲线下面积AUC、峰值高度PH、到达峰值的时间TTP,最后与临床组织病理学结果进行比较,建立这些定量参数与脑胶质瘤分级之间的定量关系。采用独立样本t检验比较任意两个分级之间各定量参数的统计学差异,P<0.05作为统计学差异标准。ER、AUC和PH随着脑胶质瘤的病理分级由低到高地增加;低级别脑胶质瘤中的Ⅰ与Ⅱ级之间以及高级别中的Ⅲ与Ⅳ级之间的比较结果显示,ER、AUC和PH的值均无明显统计学差异(P>0.05);低级别与高级别级之间的比较结果显示,仅参数ER的差异具有统计学意义(P<0.05)。ER是术前准确界定脑胶质瘤低级别与高级别的最具敏感性和特异性的参数,其界定阈值约为0.68。 | 邓振生 张娜 孟莉 王小宜 廖伟华 HOU BL | 2010 | 中国生物医学工程学报2010，29，1： | 9 |
| 2 | Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex显示文摘 | Hou BL Bradbury M Peck KK | 2006 | NeuroImage2006，32，2： | 1 |
| 3 | Functional MRI in the brain tumor patient显示文摘 | Bogomolny DL Petrovich NM Hou BL | 2004 | Top Magn Reson Imaging2004，15，5： | 1 |
| 4 | Preventive effect of Ginkgo bibba extract on apoptosis in rat eerebellar neuronal cells induced by hydroxyl radicals显示文摘 | Ni Y Zhao BL Hou J | 1996 | Neurosci Lett1996，241，： | 1 |
| 5 | Studying neonatal bilirubin encephalopathy with conventional MRI, MRS, and DWI 显示文摘 | Wang X Wu W Hou BL | 2008 | Neuroradiology2008，50，10： | 1 |
| 6 | Functional MRI in the brain tumor patient显示文摘 | Bogomolny DL Petrovich NM Hou BL | 2004 | Top Magn Reson Imaging2004，15，1： | 1 |
| 7 | Isolation and retrieval of circulating tumor cells using centrifugal forces 显示文摘 | Hou HW Warkiani ME Khoo BL | 2013 | Sci Rep2013，3，： | 1 |
| 8 | The effect of prior surgery on blood oxygen level-dependent functional MR imaging in the preoperative assessment of brain tumors 显示文摘 | Kim MJ Holodny AI Hou BL | 2005 | Am J Neuroradiol2005，26，8： | 1 |
| 9 | Protective effects of sodium tanshinone 1I A sulphonate against adriamycin -induced lipid peroxidation in mice hearts in vivo and in vitro显示文摘 | Zhou GY Zhao BL Hou JW | 1999 | Pharmacol Res1999，40，6： | 1 |
| 10 | Studying neonatal bilirubin encephalopathy wilh conventional MRI, MRS, and DWI显示文摘 | Wang X Wu W Hou BL | 2008 | Neuroradiology2008，50，： | 1 |
| 11 | Functional MRI in the brain tumor patient显示文摘 | Bogomohiy DL Petrovich NM Hou BL | 2004 | Top Magn Reson Imaging2004，15，5： | 1 |
| 12 | Studying neonatal bilirubin encephalopathy with conventional MRI, MRS,and DWI 显示文摘 | Wang X Wu W Hou BL | 2008 | Neuroradiology2008，50，10： | 1 |
| 13 | Studying neonatal bilirubin encephalopathy with conventional MRI, MRS and DWI 显示文摘 | Wang X Wu W Hou BL | 2008 | Neuroradiology2008，50，10： | 1 |
| 14 | Isolation and retrieval ofcirculating tumor cells using centrifugal forces显示文摘 | Hou HW Warkiani ME’Khoo BL | 2013 | Sci Rep2013，3，2： | 1 |
| 15 | The effect of prior surgery on blood oxygen level dependent functional MR imaging in the preoperative assessment of brain tumors 显示文摘 | Kim MJ Holodny AI Hou BL | 2005 | AJNR Am J Neuroradiol2005，26，8： | 1 |
| 16 | Isolation and retrieval of circulating tumor cells using centrifugal forces显示文摘 | Hou HW Warkiani ME Khoo BL | 2013 | Sci Rep2013，3，： | 1 |
| 17 | A new cycloartane glycoside from Camptosorus sibiricus 显示文摘 | Li N Li X Hou BL | 2008 | Fitoterapia2008，79，4： | 1 |
| 18 | New triterpene glycosides from Camptosorus sibiricus 显示文摘 | Li N Xiao W Hou BL | 2010 | Nat Prod Commun2010，5，10： | 1 |
| 19 | Effect of brain tumor neo- vasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex 显示文摘 | Hou BL Bradbury M Peck KK | 2006 | Neuroimage2006，32，2： | 1 |
| 20 | Scavenging effects of salvia miltiorrhiza on free radicals and its protection for myoeardial mltochondrial membranes from ischemiareperfusion injury显示文摘 | ZHAO BL JIANG W HOU JW | 1996 | Biochem Mol Biol Int1996，38，6： | 1 |
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