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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 3 | Machine vision and background remover-based approach for PCB solder joints inspection 显示文摘 | B C Jiang C C Wang Y N Hsu | 2007 | Inter national Journal of Production Research2007，45，： | 1 |
| 4 | Generating Finite - state Transducers for Semi-structured Data Extraction from the Web显示文摘 | Hsu C N Dung M T | 1998 | Information Systems1998，23，8： | 1 |
| 5 | Effect of brain e dema on infarct volume in a focal cerebral ischemia model in rats显示文摘 | Lin T N He Y Y Wu G Khan M Hsu C Y | 1993 | Stroke1993，24，： | 1 |
| 6 | A multipurpose reservoir real-time operation model for flood control during typhoon invasion 显示文摘 | HSU N S WEI C C | 2007 | Journal of Hydrology2007，336，34： | 1 |
| 7 | Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction显示文摘 | Paczynski R P He Y Y Diringer M N Hsu C Y | 1997 | Stroke1997，28，： | 1 |
| 8 | Quantum dot nanoparticies affect the reproductive system of Caenorhabditis elegans显示文摘 | Hsu P C O'Callaghan M Al- Salim N | 2012 | Environmental Toxicology and Chemistry2012，31，10： | 1 |
| 9 | A dynamic lot sizing problem with multiple customers: customer-specific shipping and backlogging costs 显示文摘 | Suresh C Hsu V N Sethi S Deshpande V | 2007 | IIE Transactions2007，39，： | 1 |
| 10 | Transient global ischemia alters NMDA receptor expression in rat hippocampus: Correlation with decreased immunoreactive protein levels of the NR2A/NR2B subunits, and altered NMDA receptor functionality 显示文摘 | Zhang L Hsu J C Takagi N | 1997 | J Neurochem1997，69，5： | 1 |
| 11 | Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcification显示文摘 | Hsu H H Camaeho N C Tawfik O | 2002 | Atherosclerosis2002，161，1： | 1 |
| 12 | Spatial distribution and sample size estimation of the spiraling whitefly (Aleurodicus disperses Russell) on guava显示文摘 | WEN H C HSU T C CHEN C N | 1994 | J Chinese Entomol1994，14，4： | 1 |
| 13 | The multimolecular cascade of spinal cord injury显示文摘 | Banick N Hogan E Hsu C | 1987 | Neurochem Pathol1987，7，1： | 1 |
| 14 | Berberine acti-vates Nrf2 nuclear translocation and protects against oxi-dative damage via a phosphatidylinositol 3-kinase/Akt-de-pendent mechanism in NSC34 motor neuron-like cells 显示文摘 | HSU Y Y CHEN C S WU S N | 2012 | EurJPharmSci2012，46，5： | 1 |
| 15 | Incident atrialfibrillation and risk of end-stage renal disease in adults withchronic kidney disease 显示文摘 | BANSAL N FAN D HSU C Y | 2013 | Circulation2013，127，5： | 1 |
| 16 | 查看详情显示文摘 | Chen P C Chen Y N Hsu P C Shih C C Chang H T | | 0，，16： | 1 |
| 17 | Mutational hot spot in the p53 gene in human hepatocellular carcinomas显示文摘 | Hsu I C Metcalf A Sun T Welsh J A Wang N J Harris C C | 1991 | Nature1991，350，6317： | 1 |
| 18 | Gonadal differentiation and secretions of estradiol and testosterone of the ovaries of Rana catesbeiana tadpoles treated with 4-hydroxyandrostenedione显示文摘 | Yu N W Hsu C Y Ku H H | 1993 | J Exp Zool1993，265，： | 1 |
| 19 | Seasonal occurrence of spiraling whitefly, Aleurodlcus disperses Russell and host plant effects 显示文摘 | WEN H C CHEN C N HSU T C | 1996 | Plant Protect Bull1996，38，1： | 1 |
| 20 | Optimal component stocking policy for assemble-to-ordersystemswith lead-time-dependent component and product pricing显示文摘 | Hsu V N Lee C Y So K C | 2006 | Management Science2006，52，3： | 1 |
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