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| 1 | 晚期实体癌患者对不含聚氧乙烯蓖麻油注射用紫杉醇白蛋白纳米粒悬浮液的临床耐受性研究显示文摘背景与目的:不含聚氧乙烯蓖麻油注射用紫杉醇白蛋白纳米粒悬浮液(中国商品名:凯素)是美国生物科学公司(AmericanBioSceince,Inc.)研制的全新的紫杉醇制剂。本文目的旨在评价其在国内患者的临床耐受性,建立该药在国内患者的最大耐受剂量,并为下一阶段临床研究的推荐剂量提供临床依据。方法:剂量递增Ⅰ期临床试验,剂量范围为135~350mg/m2,每一剂量组至少有3例患者。凯素静脉滴注30min,每3周重复一疗程。每疗程用药前不给予患者抗过敏预治疗。结果:22例患者接受了至少一个疗程的治疗,共完成94个疗程。患者能较好地耐受凯素治疗,整个治疗过程未发现严重过敏反应;绝大部分(95%)AEs为CTC1度或2度,3度或以上仅占5%。骨髓抑制导致外周血白细胞减少及外周感觉神经毒性是最常见的毒性反应,但程度均较轻。4度ANC减少仅1次报告,整个研究过程无患者需要G-CSF支持。剂量限制性毒性见于350mg/m2剂量组,表现为1例患者出现4度ANC减少及1例患者出现3度复视/视物模糊,但症状均在短时间内恢复正常。凯素在国内患者的MTD为300mg/m2。在21例可评价疗效的患者中,CR1例,PR7例,SD9例,PD4例,总有效率(CR+PR)为38%。结论:Ⅰ期临床研究显示凯素具有不需使用预治疗,滴注时间短,较高的紫杉醇MTD及毒性较低的临床特点。 | 滕小玉 管忠震 姚志文 刘冬耕 周宁宁 罗汉钰 Michael Hawkins Patrick Soon-Shiong | 2004 | 癌症2004，23，z1： | 39 |
| 2 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 3 | Recent progress in alfalfa(Medicago sativa L.)genomics and genomic selection显示文摘Alfalfa(M. sativa L.) is a highly valuable forage crop, providing >58 Mt of hay, silage, and pasture each year in the United States. As alfalfa is an outcrossing autotetraploid crop,however, breeding for enhanced agronomic traits is challenging and progress has historically not been rapid. Methods that make use of genotypic information and statistical models to generate a genomic estimated breeding value(GEBV) for each plant at a young age hold a great deal of promise to accelerate breeding gains. An emerging genomic breeding pipeline employs SNP chips or genotyping-by-sequencing(GBS) to identify SNP markers in a training population, followed by the use of a statistical model to find associations between the discovered SNPs and traits of interest, followed by genomic selection(GS), a breeding program utilizing the trained model to predict breeding values and making selections based on the estimated breeding value(EBV). Much work has been done in recent years in all of these areas, to generate marker sets and discover SNPs associated with desirable traits, and the application of these technologies in alfalfa breeding programs is under way. However, GBS/GWAS/GS is still a new breeding paradigm,and work is ongoing to evaluate different models, software, and methods for use in such programs. In this review, we look at the progress of alfalfa genomics over the past halfdecade, and review work comparing models and methods relevant to this new type of breeding strategy. | Charles Hawkins Long-Xi Yu | 2018 | The Crop Journal2018，6，6： | 6 |
| 4 | An eFP browser for visualizing strawberry fruit and flower transcriptomes显示文摘Wild strawberry Fragaria vesca is emerging as an important model system for the cultivated strawberry due to its diploid genome and availability of extensive transcriptome data and a range of molecular genetic tools.Being able to better utilize these tools,especially the transcriptome data,will greatly facilitate research progress in strawberry and other Rosaceae fruit crops.The electronic fluorescent pictograph(eFP)software is a useful and popular tool to display transcriptome data visually,and is widely used in other model organisms including Arabidopsis and mouse.Here we applied eFP to display wild strawberry RNA sequencing(RNA-seq)data from 42 different tissues and stages,including various flower and fruit developmental stages.In addition,we generated eight additional RNA-seq data sets to represent tissues from ripening-stage receptacle fruit from yellow-colored and red-colored wild strawberry varieties.Differential gene expression analysis between these eight data sets provides additional information for understanding fruit-quality traits.Together,this work greatly facilitates the utility of the extensive transcriptome data for investigating strawberry flower and fruit development as well as fruit-quality traits. | Charles Hawkins Julie Caruana Jiaming Li Chris Zawora Omar Darwish Jun Wu Nadim Alkharouf Zhongchi Liu | 2017 | Horticulture Research2017，4，1： | 6 |
| 5 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 6 | Cell signalling pathways underlying induced pluripotent stem cell reprogramming显示文摘Induced pluripotent stem(i PS) cells, somatic cells reprogrammed to the pluripotent state by forced expression of defined factors, represent a uniquely valuable resource for research and regenerative medicine. However, this methodology remains inefficient due to incomplete mechanistic understanding of the reprogramming process. In recent years, various groups have endeavoured to interrogate the cell signalling that governs the reprogramming process, including LIF/STAT3, BMP, PI3 K, FGF2, Wnt, TGFβ and MAPK pathways, with the aim of increasing our understanding and identifying new mechanisms of improving safety, reproducibility and efficiency. This has led to a unified model of reprogramming that consists of 3 stages: initiation, maturation and stabilisation. Initiation of reprogramming occurs in almost all cells that receive the reprogramming transgenes; most commonly Oct4, Sox2, Klf4 and c Myc, and involves a phenotypic mesenchymal-to-epithelial transition. The initiation stage is also characterised by increased proliferation and a metabolic switch from oxidative phosphorylation to glycolysis. The maturation stage is considered the major bottleneck within the process, resulting in very few 'stabilisation competent' cells progressing to the final stabilisation phase. To reach this stage in both mouse and human cells, pre-i PS cells must activate endogenous expression of the core circuitry of pluripotency, comprising Oct4, Sox2, and Nanog, and thus reach a state of transgene independence. By the stabilisation stage, i PS cells generally use the same signalling networks that govern pluripotency in embryonic stem cells. These pathways differ between mouse and human cells although recent work has demonstrated that this is context dependent. As i PS cell generation technologies move forward, tools are being developed to interrogate the process in more detail, thus allowing a greater understanding of this intriguing biological phenomenon. | Kate Hawkins Shona Joy Tristan Mc Kay | 2014 | World Journal of Stem Cells2014，6，5： | 5 |
| 7 | Modelling mitochondrial dysfunction in Alzheimer’s disease using human induced pluripotent stem cells显示文摘Alzheimer’s disease (AD) is the most common form of dementia. To date, only five pharmacological agents have been approved by the Food and Drug Administration for clinical use in AD, all of which target the symptoms of the disease rather than the cause. Increasing our understanding of the underlying pathophysiology of AD will facilitate the development of new therapeutic strategies. Over the years, the major hypotheses of AD etiology have focused on deposition of amyloid beta and mitochondrial dysfunction. In this review we highlight the potential of experimental model systems based on human induced pluripotent stem cells (iPSCs) to provide novel insights into the cellular pathophysiology underlying neurodegeneration in AD. Whilst Down syndrome and familial AD iPSC models faithfully reproduce features of AD such as accumulation of Aβ and tau, oxidative stress and mitochondrial dysfunction, sporadic AD is much more difficult to model in this way due to its complex etiology. Nevertheless, iPSC-based modelling of AD has provided invaluable insights into the underlying pathophysiology of the disease, and has a huge potential for use as a platform for drug discovery. | Kate Elizabeth Hawkins Michael Duchen | 2019 | World Journal of Stem Cells2019，11，5： | 5 |
| 8 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 9 | Antecedents and consequences of opportunism in buyer–supplier relations: Research synthesis and new frontiers显示文摘 | Timothy G. Hawkins C. Michael Wittmann Michael M. Beyerlein | 2007 | Industrial Marketing Management2007，，8： | 3 |
| 10 | “Sideways”: Results of Repair of Biliary Injuries Using a Policy of Side-To-Side Hepatico-Jejunostomy显示文摘 | Emily R. Winslow Elizabeth A. Fialkowski David C. Linehan William G. Hawkins Daniel D. Picus Steven M. Strasberg | 2009 | Annals of Surgery2009，，3： | 3 |
| 11 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 12 | National assessment of the fragmentation,accessibility and anthropogenic pressure on the forests in Mexico显示文摘Forest managers and policy makers increasingly demand to have access to estimates of forest fragmentation,human accessibility to forest areas and levels of anthropogenic pressure on the remaining forests to integrate them into monitoring systems,management and conservation plans.Forest fragmentation is defined as the breaking up of a forest unit,where the number of patches and the amount of expose edge increase while the amount of core area decreases.Forest fragmentation studies in Mexico have been limited to local or regional levels and have concentrated only on specific forest types.This paper presents an assessment of the fragmentation of all forest types at the national level,their effective proximity to anthropogenic influences,and the development of an indicator of anthropogenic pressure on the forests areas.Broadleaf forests,tropical evergreen forests and tropical dry deciduous forests show the greatest fragmentation.Almost half(47%) of the tropical forests are in close effective proximity to anthropogenic influences and only 12% of their area can be considered isolated from anthropogenic influences.The values for the temperate forests are 23% and 29% respectively.Anthropogenic pressure in the immediate vicinity of anthropogenic activities is much higher in the tropical forests(75 in a scale 0-100) than in the temperate forests(30).When considering these results jointly,the tropical forests,and more specifically,the tropical evergreen forests and tropical dry deciduous forests are under the greatest pressure and risks of degradation. | Rafael Moreno-Sanchez Juan Manuel Torres-Rojo Francisco Moreno-Sanchez Sue Hawkins Justin Little Susan McPartland | 2012 | Journal of Forestry Research2012，23，4： | 3 |
| 13 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 14 | Variable change in renal function by hypertonic saline显示文摘AIM: To investigate the effects of hypertonic saline in the neurocritical care population.METHODS: We retrospectively reviewed our hospital's use of hypertonic saline(HS) since March of 2005, and prospectively since October 2010. Comparisons were made between admission diagnoses, creatinine change(Cr), and HS formulation(3% Na Cl, 3% Na Cl/sodium acetate mix, and 23.4% Na Cl) to patients receiving normal saline or lactated ringers. The patients(n = 1329) of the retrospective portion were identified. The data presented represents the first 230 patients with data. RESULTS: Significant differences in Acute Physiology and Chronic Health Evaluation Ⅱ scores and GlasgowComa Scale scores occurred between different saline formulations. No significant correlation of Cl- or Na+ with Cr, nor with saline types, occurred. When dichotomized by diagnosis, significant correlations appear. Traumatic brain injury(TBI) patients demonstrated moderate correlation between Na+ and Cr of 0.45. Stroke patients demonstrated weak correlations between Na+ and Cr, and Cl- and Cr(0.19 for both). Patients receiving HS and not diagnosed with intracerebral hemorrhage, stroke, subarachnoid hemorrhage, or TBI demonstrated a weak but significant correlation between Cl- and Cr at 0.29.CONCLUSION: Cr directly correlates with Na+ or Cl- in stroke, Na+ in TBI, and Cl- in other populations. Prospective comparison of HS and renal function is needed. | Jesse J Corry Panayiotis Varelas Tamer Abdelhak Stacey Morris Marlisa Hawley Allison Hawkins Michelle Jankowski | 2014 | World Journal of Critical Care Medicine2014，3，2： | 3 |
| 15 | Jaundice: an important, poorly recognized risk factor for diminished survival in patients with adenocarcinoma of the head of the pancreas显示文摘 | Steven M. Strasberg Feng Gao Dominic Sanford David C. Linehan William G. Hawkins Ryan Fields Danielle H. Carpenter Elizabeth M. Brunt Carolyn Phillips | 2014 | HPB2014，，2： | 2 |
| 16 | CpG Island methylation in sporadic colorectal cancers and its relationship to microsatellite instability显示文摘 | Nicholas Hawkins Mark Norrie Kay Cheong Elisa Mokany Su-Lyn Ku Alan Meagher Terence O’connor Robyn Ward | 2002 | Gastroenterology2002，，： | 2 |
| 17 | 激活β_3肾上腺素能受体恢复一氧化氮/氧化还原平衡,增强高血糖患者的内皮功能显示文摘一氧化氮与O_2^-之间的平衡紊乱(即一氧化氮/氧化还原失衡)是糖尿病引起的血管功能障碍的中心病理环节。该研究目的为在高血糖动物模型中探索β_3肾上腺素能受体(β_3adrenergic receptor,β3AR)激活能否耦合激活内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)。 | 刘莉 叶鹏 Karimi Galougahi K Liu CC Garcia A Gentile C Fry NA Hamilton EJ Hawkins CL Figtree GA | 2016 | 中华高血压杂志2016，24，3： | 2 |
| 18 | Regional Lymphadenectomy Is Indicated in the Surgical Treatment of Pancreatic Neuroendocrine Tumors (PNETs)显示文摘 | Yassar M. Hashim Kathryn M. Trinkaus David C. Linehan Steven S. Strasberg Ryan C. Fields Dengfeng Cao William G. Hawkins | 2014 | Annals of Surgery2014，，2： | 2 |
| 19 | A Multicenter Analysis of Distal Pancreatectomy for Adenocarcinoma: Is Laparoscopic Resection Appropriate?显示文摘 | David A. Kooby William G. Hawkins C. Max Schmidt Sharon M. Weber David J. Bentrem Theresa W. Gillespie Johnita Byrd Sellers Nipun B. Merchant Charles R. Scoggins Robert C.G. Martin Hong Jin Kim Syed Ahmad Clifford S. Cho Alexander A. Parikh Carrie K. Chu | 2010 | Journal of the American College of Surgeons2010，，5： | 2 |
| 20 | Long-Term Results of Resection of Adenocarcinoma of the Body and Tail of the Pancreas Using Radical Antegrade Modular Pancreatosplenectomy Procedure显示文摘 | Jonathan B. Mitchem Nicholas Hamilton Feng Gao William G. Hawkins David C. Linehan Steven M. Strasberg | 2012 | Journal of the American College of Surgeons2012，，1： | 2 |
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