|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plasticity of language pathways in patients with low-grade glioma A diffusion tensor imaging study显示文摘Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively. | Gang Zheng Xiaolei Chen Bainan Xu Jiashu Zhang Xueming Lv Jinjiang Li Fangye Li Shen Hu Ting Zhang Ye Li | 2013 | Neural Regeneration Research2013，8，7： | 3 |
| 2 | Intraoperative diffusion tensor imaging predicts the recovery of motor dysfunction after insular lesions显示文摘Insular lesions remain surgically challenging because of the need to balance aggressive resection and functional protection. Motor function deficits due to corticospinal tract injury are a common complication of surgery for lesions adjacent to the internal capsule and it is therefore essential to evaluate the corticospinal tract adjacent to the lesion. We used diffusion tensor imaging to evaluate the corticospinal tract in 89 patients with insular lobe lesions who underwent surgery in Chinese PLA General Hospital from February 2009 to May 2011. Postoperative motor function evaluation revealed that 57 patients had no changes in motor function, and 32 patients suffered motor dysfunction or aggravated motor dysfunction. Of the affected patients, 20 recovered motor function during the 6-12-month follow-up, and an additional 12 patients did not recover over more than 12 months of follow-up. Following reconstruction of the corticospinal tract, fractional anisotropy comparison demonstrated that preoperative, intraoperative and follow-up normalized fractional anisotropy in the stable group was higher than in the transient deficits group or the long-term deficits group. Compared with the transient deficits group, intraoperative normalized fractional anisotropy significantly decreased in the long-term deficits group. We conclude that intraoperative fractional anisotropy values of the corticospinal tracts can be used as a prognostic indicator of motor function outcome. | Jinjiang Li Xiaolei Chen Jiashu Zhang Gang Zheng Xueming Lv Fangye Li Shen Hu Ting Zhang Bainan Xu | 2013 | Neural Regeneration Research2013，8，15： | 2 |
| 3 | Research on thermal-structure coupled analysis of mechanical seal rings显示文摘 | Zhu Xueming Liu Zhenglin Zhu Hanhua Hu Shelai | 2005 | Journal of Wuhan University of Technology (Transportation Science & Engineering)2005，29，2： | 1 |
| 4 | A Novel Approach for Crowd Video Monitoring of Subway Platforms 显示文摘 | HU Xueming ZHEN Hong WNAG Wenwei | 2013 | Optik International Journal for Light and Electron Optics2013，46，11： | 1 |
| 5 | Retrogradation properties of rice starch gelatinized by heat and high hydrostatic pressure (HHP) 显示文摘 | Hu Xiuting Xu Xueming Jin Zhengyn | 2011 | Journal of Food Engineering2011，106，3： | 1 |
| 6 | Study on void formation in multi-layer woven fabrics显示文摘 | Hu Jinlian Liu Yi Shao Xueming | 2004 | Composites Part A:Applied Science and Manufacturing2004，35，5： | 1 |
| 7 | Slowly digestible starch prepared from rice starches by temperature-cycled retrogradation显示文摘 | Lulu Zhang Xiuting Hu Xueming Xu Zhengyu Jin Yaoqi Tian | 2010 | Carbohydrate Polymers2010，，3： | 1 |
| 8 | Nanoalignment mask fabricated directly on Si by AFM显示文摘 | Dang Xueming Hu Qiao | 2001 | Surf Interface Anal2001，32，： | 1 |
| 9 | Rctrogra- dation properties of rice starch gelatinized by heat and high hydrostatic pressure (HHP) 显示文摘 | Zhengyu Jin Xiuting Hu Xueming Xu | 2011 | Journal of Food Engineering2011，106，3： | 1 |
| 10 | Study on void formation in multi-layer woven fabrics显示文摘 | Hu Jinlian Liu Yi Shao Xueming | 2004 | Composites Part A:Applied Science and Manufacturing2004，35，5： | 1 |
| 11 | Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγactivation显示文摘Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of IBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD. | TAO Lei DOU Renjie CHEN Xueming CAO Yu DAI Zhen HU Ziyan MA Zhi GE Xiaoming ZHANG Ling WANG Xiaoping | 2024 | Chinese Journal of Natural Medicines2024，22，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员