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| 1 | Vision,Requirements and Network Architecture of 6G Mobile Network beyond 2030显示文摘With the 5th Generation(5G)Mobile network being rolled out gradually in 2019,the research for the next generation mobile network has been started and targeted for 2030.To pave the way for the development of the 6th Generation(6G)mobile network,the vision and requirements should be identified first for the potential key technology identification and comprehensive system design.This article first identifies the vision of the society development towards 2030 and the new application scenarios for mobile communication,and then the key performance requirements are derived from the service and application perspective.Taken into account the convergence of information technology,communication technology and big data technology,a logical mobile network architecture is proposed to resolve the lessons from 5G network design.To compromise among the cost,capability and flexibility of the network,the features of the 6G mobile network are proposed based on the latest progress and applications of the relevant fields,namely,on-demand fulfillment,lite network,soft network,native AI and native security.Ultimately,the intent of this article is to serve as a basis for stimulating more promising research on 6G. | Guangyi Liu Yuhong Huang Na Li Jing Dong Jing Jin Qixing Wang Nan Li | 2020 | China Communications2020，17，9： | 37 |
| 2 | Proteomics Associated with Virulence Differentiation of Curvularia lunata in Maize in China显示文摘蛋白质的一个维的电气泳动(1-DE ) ,蛋白质的 two-dimensionalelectrophoresis (2-DE ) 并且 cDNA 顺序克隆被用来学习 Curvularia lunata 的毒力区别[Cochliobolus lunatus ] 在中国从玉米(Zea maydis ) 孤立。从蛋白质的 1-DE 胶化侧面, 110 个可再现的乐队与六被分开 C 孤立。lunata CX-3, SD-6, C-152, C107-1, DD-60 和 W-18。68 个乐队(61.82%) 是多态的,建议在 isolates 之中的巨大的生物多样性。所有孤立组由 0.605 的系数价值由不同剧毒的类型组成因为实验被聚类进三。组织 1,由有高毒力的 CX-3, SD-6 和 C-152 组成比组显示了更多的蛋白质乐队第 2a 3,与低毒力由 C107-1 和 DD-60 组成。Proteomics 途径基于 2-DEtechniques 被使用识别在 CX-3 和 DD-60 与毒力区别联系的特定的蛋白质。423 个蛋白质点的一个总数被分开。从他们, 75 个特定的蛋白质点在 2-DE 胶化被显示。在他们之中, 28 个蛋白质点在 CX-3 是唯一的, 8 在两 2-DE 胶化上在 DD-60,和 39 个蛋白质点被显示出,但是在紧张不同地表示。包括三个唯一的蛋白质点和 17 差别的 Twentyprotein 点在 CX-3 表示了蛋白质点(超过 2 褶层 DD-60 ) 进一步与 MALDI-TOF MS/MS 被识别。结果显示大多数识别蛋白质被发现与毒力区别,新陈代谢,压力反应和信号转导被联系。他们之一作为 Brn1 蛋白质被识别,它被报导了在真菌与黑素生合成和毒力区别有关。与我们的以前的调查结果结合了,我们假设那 Brn1 蛋白质和它的调整产品可能涉及 C 的毒力区别。lunata。因而,我们克隆 Brn1cDNA 碎片并且在另外的真菌与碎片联盟。结果显示 Brn1 的 633-bpsequence 在 C 克隆。lunata 是高度与比较真菌逻辑的人。为在我们的情况中的 Brn1 的准确基因角色的进一步的工作是在进行之中的…… | Shufa Xu Jie Chen Lixing Liu Xiaofei Wang Xiuli Huang Yuhong Zhai | 2007 | Journal of Integrative Plant Biology2007，49，4： | 25 |
| 3 | Dusty cloud radiative forcing derived from satellite data for middle latitude regions of East Asia显示文摘尘封的云在东亚的中间的纬度区域上的放射的强迫被使用估计 2 年(7 月 2002-June 日 2004 ) 并置的云和地球的绚烂的精力系统(谷神星) 的数据从水编辑 1B SSF (单个扫描仪脚印) 的扫描仪和中等分辨率成像分光辐射函数(MODIS ) 。尘封的云在灰尘暴风雨环境被定义为云或灰尘污染了云。为面对灰尘成长的云,在空气(TOA ) 的顶强迫的即时短波(SW ) 关于 -275.7 W/m 2 为阴郁灰尘(货到付款) 区域。在没有灰尘开发云(CLD ) 区域的云产出最否定的短波(SW ) forcint (是大约 12.8% 的 -311.0 W/m 2), 比那些强壮在货到付款区域。为长波浪(LW ) 放射的强迫,没有灰尘云(CLD ) 在是 20% 的 102.8 W/m 2, 附近不到从货到付款区域强迫的 LW。为 CLD 区域的放射的强迫关于是 42.1% 的 -208.2W/m2, 的即时 TOA 网比货到付款区域的价值大。在云下面的灰尘喷雾器的存在显著地减少云的冷却效果。 | HUANG Jianping WANG Yujie WANG Tianhe YI Yuhong | 2006 | Progress in Natural Science:Materials International2006，16，10： | 20 |
| 4 | Characteristics and accumulation mechanisms of the Dongfang 13-1 high temperature and overpressured gas field in the Yinggehai Basin, the South China Sea显示文摘The Dongfang 13-1 is located in the diapiric structure belt of the Yinggehai Basin. The formation pressure of its main gas reservoir in the Miocene Huangliu Formation is up to 54.6 MPa(pressure coefficient=1.91) and the temperature is as high as 143°C(geothermal gradient 4.36°C/100 m), indicating that it is a typical high-temperature and overpressured gas reservoir. The natural gas is interpreted to be coal-type gas derived from the Miocene mature source rocks containing type II2-III kerogens as evidenced by high dryness index of up to 0.98 and heavy carbon isotopes, i.e., the δ13C1 ranging from -30.76‰ to -37.52‰ and δ13C2 ranging from -25.02‰ to -25.62‰. The high temperature and overpressured Miocene petroleum system is related mainly to diapir in the Yinggehai Basin and contains more pore water in the overpressured reservoirs due to undercompaction process. The experimental and calculated results show that the solubility of natural gas in formation water is as high as 10.5 m3/m3 under the temperature and pressure conditions of the Sanya Formation, indicating that at least part of the gas may migrate in the form of water-soluble phase. Meanwhile, the abundant gas source in the Basin makes it possible for the rapid saturation of natural gas in formation water and exsolution of soluble gas. Therefore, the main elements controlling formation of the Dongfang 13-1 gas pool include that(1) the diapir activities and accompanying changes in temperature and pressure accelerate the water-soluble gas exsolution and release a lot of free gas;(2) submarine fan fine sandstone in the Huangliu Formation provides good gas-water segregation and accumulation space; and(3) the overlying overpressured mud rocks act as effective caps. The accumulation mechanism reveals that the high temperatural and high pressure structure belt near the diapir structures has a good potential for large and medium-sized gas field exploration. | XIE YuHong HUANG BaoJia | 2014 | Science China Earth Sciences2014，57，11： | 12 |
| 5 | Comparison analysis between haplo identical stem cell transplantation and matched sibling donor stem cell transplantation for high-risk acute myeloid leukemia in first complete remission显示文摘In order to compare the effect between haploidentical(HID) stem cell transplantation(HSCT) and matched sibling donor(MSD)stem cell transplantation for high-risk acute myeloid leukemia(AML) in first complete remission status(CR1), we retrospectively studied 170 cases who received stem cell transplantation from Jan 2008 to Jul 2015 in Peking University People's Hospital. We divided all cases into MSD group(43 cases) and HID(127 cases) group. Patients in HID and MSD group displayed similar baseline characteristics except for age distribution. There were no statistic differences for overall survival(OS), cumulative incidence of relapse, leukemia free survival(LFS), transplantation related mortality(TRM) between HID and MSD group. The 3-year OS, LFS for all patients was 63.9% and 59.7% respectively. Multivariate analysis showed that grade III-IV acute graft versus host disease(aGVHD) was an independent risk factor for treatment related mortality(HR=8.134, 95% CI:3.210–20.611, P<0.001), monosomy/complex chromosomal karyotype and white blood cell count more than 50×109 L-1 were two independent factors for relapse(HR=1.533, 95% CI: 1.040–2.260, P=0.031)(HR=1.004, 95% CI: 1.001–1.008, P=0.015).Grade III-IV aGVHD was an independent factor for mortality(HR=3.184, 95% CI: 1.718–5.902, P<0.001). These results demonstrated some risk factors for high-risk AML leukemia transplantation and indicated for AML patients in CR1 status, haplo stem cell transplantation could have the same therapeutic effect as MSD transplantation. | Yang Liu Xiaojun Huang Qian Fei Lanping Xu Xiaohui Zhang Kaiyan Liu Yuhong Chen Huan Chen Yu Wang | 2019 | Science China(Life Sciences)2019，62，5： | 9 |
| 6 | The SOLIDS 6G Mobile Network Architecture:Driving Forces,Features,and Functional Topology显示文摘With the large-scale commercial launch of fifth generation(5G)mobile network,the development of new services and applications catering to the year 2030,along with the deep convergence of information,communication,and data technologies(ICDT),and the lessons and experiences from 5G practice will drive the evolution of the next generation of mobile networks.This article surveys the history and driving forces of the evolution of the mobile network architecture and proposes a logical function architecture for sixth generation(6G)mobile network.The proposed 6G network architecture is termed SOLIDS(related to the following basic features:soft,on-demand fulfillment,lite,native intelligence,digital twin,and native security),which can support self-generation,self-healing,self-evolution,and self-immunity without human involvement and address the primary issues in the legacy 5G network(e.g.,high cost,high power consumption,and highly complicated operation and maintenance),significantly well. | Guangyi Liu Na Li Juan Deng Yingying Wang Junshuai Sun Yuhong Huang | 2022 | Engineering2022，8，1： | 8 |
| 7 | Variation of Antarctic seal population in response to human activities in the 20th century显示文摘A sediment core was collected from the Fildes Peninsula of Antarctica, which contained numerous seal hairs and was identified to be seal excrement deposition. By analyzing its total organic carbon (TOC) and concentrations of bio-elements, the seal population changes of the past century were reconstructed. The variation of seal population in the last century on the Fildes Peninsula is primarily controlled by human activities. The sealing industry in the early 20th century caused the dramatic decline of seal popula-tion. The protection of the Antarctic seals since the 1960s and the reduced seal's competition with whales for prey resources due to whaling lead to the recovery of seal population and make the high level of the seal population sustainable. | YANG QiChao SUN LiGuang KONG DeMing HUANG Tao WANG YuHong | 2010 | Chinese Science Bulletin2010，55，11： | 7 |
| 8 | Improved clinical outcomes of rhG-CSF-mobilized blood and marrow haploidentical transplantation compared to propensity score-matched rhG-CSF-primed peripheral blood stem cell haploidentical transplantation:a multicenter study显示文摘The effects of haploidentical rhG-CSF-mobilized blood and marrow transplantation(HBMT) on hematological malignances are well established. Previous prospective single-center studies have demonstrated better survival after HBMT versus haploidentical rhG-CSF-mobilized peripheral blood stem cell transplantation(HPBSCT) for acute leukemia(AL) not in remission(NR) or in more than the second complete remission(>CR2). To test the hypothesis that HBMT is still superior to HPBSCT for patients with AL, multiple myeloma(MM), or non-Hodgkin lymphoma(NHL) in CR1/CR2 and for patients with chronic myeloid leukemia in the first and second chronic phase lacking a matched donor, we designed a propensity score method-based multicenter study.Hematopoietic recovery, acute graft-versus-host disease(aGVHD), and chronic GVHD were comparable between the HBMT group(n=168) and the HPBSCT group(n=42). No significant differences were found in non-relapse mortality rate(20.17%±3.58%and 27.24%±7.16%, P=0.18) or relapse rate(19.96%±3.72% and 28.49%±8.25%, P=0.32) between the HBMT group and the HPBSCT group. HBMT recipients had better overall survival(65.0%±4.2% and 54.2%±8.3%, P=0.037) and disease-free survival(59.9%±4.6% and 44.3%±8.7%, P=0.051). Multivariate analysis showed that HPBSCT was associated with poorer DFS(HR(95%CI), 1.639(0.995–2.699), P=0.052). Our comparisons showed that HBMT was superior to HPBSCT as a post-remission treatment for patients lacking an identical donor. | Xiangyu Zhao Feng Gao Xiaohui Zhang Yu Wang Lanping Xu Kaiyan Liu Xiaosu Zhao Yingjun Chang Han Wei Huan Chen Yuhong Chen Zhengfan Jiang Xiaojun Huang | 2016 | Science China(Life Sciences)2016，59，11： | 7 |
| 9 | Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Disease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation显示文摘Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL). Relapsed patients with BALL after allo-HSCT have a very short median survival. Minimal residual disease (MRD) is predictive of forthcoming hematological relapse after hematopoietic stem cell transplantation (HSCT);furthermore, eliminating MRD effectively prevents relapse. Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCT. However, about one-third of patients with MRD are non-responsive to DLI and their prognosis worsens. Although donor-derived cluster of differentiation (CD)19-directed chimeric antigen receptor-modified (CAR) T cells (CART19s) can potentially cure leukemia, the efficiency and safety of infusions with these cells have not yet been investigated in patients with MRD after HSCT. Between September 2014 and February 2018, six patients each received one or more infusions of CART19s from HSCT donors. Five (83.33%) achieved MRD-negative remission, and one case was not responsive to the administration of CAR T cells. Three of the six patients are currently alive without leukemia. No patient developed acute graft-versus-host disease (aGVHD), and no patient died of cytokine release syndrome. Donor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRD in B-ALL after allo-HSCT and for those who were not responsive to DLI. | Yifei Cheng Yuhong Chen Chenhua Yan Yu Wang Xiangyu Zhao Yao Chen Wei Han Lanping Xu Xiaohui Zhang Kaiyan Liu Shasha Wang Lungji Chang Lei Xiao Xiaojun Huang | 2019 | Engineering2019，5，1： | 7 |
| 10 | Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directed donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation显示文摘The efficacy of salvage interferon-α(IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donor lymphocyte infusion (DLI)(n=24). Patients who did not become MRD-negative at 1 month after DLI were those with unsatisfactory response and were eligible to receive salvage IFN-α treatment within 3 months of DLI. Recombinant human IFN-α-2b injections were subcutaneously administered 2–3 times a week for 6 months. Nine (37.5%), 6 (25.0%), and 3 (12.5%) patients became MRD-negative at 1, 2, and>2 months after the salvage IFN-α treatment, respectively. Two-year cumulative incidences of relapse and non-relapse mortality were 35.9% and 8.3%, respectively. Two-year probabilities of event-free survival, disease-free survival, and overall survival were 51.6%, 54.3%, and 68.0%, respectively. Outcomes of patients subjected to salvage IFN-α treatment after DLI were significantly better than those with persistent MRD without IFN-α treatment. Moreover, clinical outcomes were comparable between the salvage DLI and IFN-α treatment groups. Thus, salvage IFN-α treatment may help improve the outcome of patients with unsatisfactory responses to MRD-directed DLI and could be a potential salvage treatment for these patients after allogeneic hematopoietic stem cell transplantation. | Xiaodong Mo Xiaohui Zhang Lanping Xu Yu Wang Chenhua Yan Huan Chen Yuhong Chen Wei Han Fengrong Wang Jingzhi Wang Kaiyan Liu Xiaojun Huang | 2019 | Frontiers of Medicine2019，13，2： | 6 |
| 11 | Efficacy and safety of the Qiguiyin formula in severe pneumonia: study protocol for a randomized, double-blind, placebo-controlled clinical trial显示文摘OBJECTIVE: To evaluate the clinical efficacy and safety of Qiguiyin(QGY) formula in patients with severe pneumonia in China compared with a placebo.METHODS: This is a multicenter double-blind, placebo-controlled, randomized clinical trial with two parallel arms. There will be 530 patients enrolled and randomized into either the experimental group(QGY formula) or the control group(placebo). Therapies for patients in the two groups above will be based on the conventional therapy. The primary outcome is 28-day mortality. Secondary outcomes include:(a) duration of hospital stay;(b) duration of time in the intensive care unit(ICU) stays;(c) duration of mechanical ventilation;(d) antibiotic DDD value(which means the doses of antibotics during the treatment period);(e) serum procalcitonin(PCT) level;(f) serum C-reactive protein(CRP)level;(g) Pneumonia severity index(PSI) score;(h)Sequential Organ Failure Assessment(SOFA) score;(i) sputum culture results;(j) blood routine examination results;(k) routine urine test results;(l) stool routine examination results;(m) electrocardiogram results;(n) alanine aminotransferase levels;(o) aspartate amino transferase levels;(p) total bilirubin;(q) creatinine levels;(r) urea nitrogen levels;and(s)adverse events.ETHICS AND DISSEMINATION: The protocol has been approved by the Research Ethics Committee of Beijing Hospital of Traditional Chinese Medicine,Affiliated with Capital Medical University(2018 BL-053-02). This trial aims to provide evidence for QGY formula combined with conventional therapy in treating patients with severe bacterial pneumonia,and to verify the clinical effectiveness and safety of QGY formula in China compared with placebo. Additionally, this trial will reveal the effect of QGY formula on delaying/reversing the characteristics of drug-resistant bacteria.Trial registration number: Chi CTR1800019785. | Huang Po Guo Yuhong Zhao Jingxia Li Bo Wu Yanqing Liu Qingquan | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 6 |
| 12 | Comparative proteomic analysis of the response in resistant and susceptible maize inbred lines to infection by Curvularia lunata显示文摘Proteins differentially expressed from maize leaves in response to the infection by Curvularia lunata strain CX-3 were identified through a high-resolution two-dimensional gel electrophoresis (2-DE) method. Two inbred lines, 78599-1 and E28, were used, respectively, as resistant and susceptible lines to CX-3 infection. Proteins were extracted from the fourth leaves of sixor seven-leaf stage plants sampled at 24, 36, 48, 60, and 72 h after inoculation with CX-3. Twenty-seven differentially expressed protein spots resolved on the 2-DE gels were identified by MALDI-TOF MS/MS. The results showed that these proteins are associated with photosynthesis, respiration, oxidative and drought stress tolerance as well as signal transduction in maize. Among stress-related proteins, the 22 kDa drought-inducible protein, putative glutathione peroxidase (GPX), and translation initiation factor (eIF-5A) were up-regulated in the resistant inbred line and were implicated in host defense response to C. lunata infection. It suggests that drought-inducible and oxidation stress-related proteins might directly contribute to maize resistance to C. lunata. | Xiuli Huang 1, Lixing Liu 1, Jie Chen Yuhong Zhai Department of Plant Science, School of Agriculture and Biology, Key Laboratory of Microbial Metabolism, Ministry of Education, Shanghai Jiaotong University, Shanghai 200240, China | 2009 | Progress in Natural Science:Materials International2009，19，7： | 6 |
| 13 | Development of an on-line measurement system for water-soluble organic matter in PM_(2.5) and its application in China显示文摘Water-soluble organic matter(WSOM) represents a critical fraction of fine particles(PM_(2.5))in the air, but its changing behaviors and formation mechanisms are not well understood yet, partly due to the lack of fast techniques for the ambient measurements. In this study,a novel system for the on-line measurement of water-soluble components in PM_(2.5), the particle-into-liquid sampler(PILS)–Nebulizer–aerosol chemical speciation monitor(ACSM), was developed by combining a PILS, a nebulizer, and an ACSM. High time resolution concentrations of WSOM, sulfate, nitrate, ammonium, and chloride, as well as mass spectra, can be obtained with satisfied quality control results. The system was firstly applied in China for field measurement of WSOM. The mass spectrum of WSOM was found to resemble that of oxygenated organic aerosol, and WSOM agreed well with secondary inorganic ions. All evidence collected in the field campaign demonstrated that WSOM could be a good surrogate of secondary organic aerosol(SOA). The PILS–Nebulizer–ACSM system can thus be a useful tool for intensive study of WSOM and SOA in PM_(2.5). | Huiying Li Xiaofeng Huang Liming Cao Yuhong Zhai Liwu Zeng Lingyan He | 2018 | Journal of Environmental Sciences2018，30，7： | 5 |
| 14 | Boosting photocatalytic degradation of RhB via interfacial electronic effects between Fe-based ionic liquid and g-C_3N_4显示文摘The Fe-based ionic liquid doped g-C_3N_4(Fee CN) photocatalyst was firstly prepared base on ultrathin g-C_3N_4 obtained by multiple calcination method with a metal-based reactive ionic liquid [Omim]FeCl_4 for the degradation of Rhodamine B(RhB). Experimental results revealed that Fe3+species were doped into the framework of g-C_3N_4. The effect of the amount of Fe-doping on the catalytic activity was performed. The result showed that the Fee CN could effectively degrade RhB under the condition of visible light irradiation. The photocurrent analysis showed that the incorporation of Fe^(3+)into g-C_3N_4 material could accelerate the separation of the photogenerated carriers significantly.At the same time, the reactive species generated during the photodegradation process were tested by radicals trapping experiments and electron spin resonance(ESR). It was proposed that the synergistic effect of■ and ·OH contributed to degrade RhB efficiently. | Xiaowei Li Bin Wang Yuhong Huang Jun Di Jiexiang Xia Wenshuai Zhu Huaming Li | 2019 | Green Energy & Environment2019，4，2： | 4 |
| 15 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 16 | Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population显示文摘Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders. | Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 17 | Effects of acrous gramineus and its component, alpha-asarone, on apoptosis of hippocampal neurons after seizure in immature rats显示文摘BACKGROUND: α-asarone and acrous gramineus have been shown to play a necessary function in enhancing the reactivity and convulsant threshold to electric stimulation of immature rats. They have also been shown to effectively suppress epileptic seizures induced by pentylenetetrazol in young rats. However, the mechanisms for these roles have been still unclear. OBJECTIVE: To observe the effects in immature rats of acrous gramineus and α-asarone on apoptosis of hippocampal neurons after epileptic seizure at the protein level, and to analyze the mechanism for these effects. DESIGN: A randomized controlled animal experiment. SETTINGS: Department of Pediatrics, First Hospital of Jilin University; Department of Histology and Embryology, Norman Bethune Medical School of Jilin University; Department of Internal Medicine, Children's Hospital of Changchun City; Department of Neurology, First Clinical Hospital affiliated to Harbin Medical University. MATERIALS: Fifty 3-week old Wistar rats, 34-40 g, irrespective of gender, were provided by Gaoxin Research Center of Medical Animal Experiment, Changchun. The animals were treated according to the animal ethical standards. The following chemicals were used for this study: acrous gramineus powders or infusion (Batch No. 0307113, Tianjiang Medicine Company Limited, Jiangyin), α-asarone tablets (Batch No. 030219, Tianwei Pharmaceutical Factory, Shenyang), and phenobarbital sodium tablets (Batch No. 020608, Xinya Medicine Company Limited, Shanghai). The animals were divided into five groups randomly. First, ten rats were chosen as the normal controls. The remaining rats were treated with i.p. injections of pentylenetetrazol to stimulate an epileptic model. METHODS: The experiments were performed at the Neurological Laboratory of the First Hospital of Jilin University between October and December 2004. The rats were treated with i.p. injections of pentylenetetrazol (60 mg/kg) to establish an epileptic model. According to Racine' s standard, animals that reached stage 4 and 5 were chosen and randomly divided into 4 groups: model group, phenobarbital sodium, acrous gramineus, and α-asarone group. The normal control group was treated with an i.p. injection of physiological saline (0.5 mL). After modeling, the model groups were intragastrically administrated 0.5 mL saline. The phenobarbital sodium, acrous gramineus, and α -asarone groups were intragastrically administrated 18 mg/kg/d phenobarbital sodium, 2 350 mg/kg/d acrous gramineus and 29 mg/kg/d α -asarone, respectively. The course of treatment was twice a day for 7 days. The normal group received intragastric administration of 0.5 mL saline at the same time. The rats were sacrificed and brain sections were prepared for light microscopy and electron microscopy. MAIN OUTCOME MEASURES: ① Pathological changes of CA1 and CA3 hippocampal region neurons were observed by light microscopy and electronic microscopy. ② Neuronal apoptosis in the CA1 and CA3 region was measured by TUNEL staining. ③ Bcl-2 and Bax expression in CA1 and CA3 region neurons was detected by immunohistochemistry and a ratio of Bcl-2/Bax was calculated. RESULTS: All 50 immature rats were included in the final analysis. ① Pathological changes of CA1 and CA3 region hippocampal neurons: there were different pathological changes in all groups other than the normal control group. The number of damaged neurons in the model group was highest. The phenobarbital sodium, acrous gramineus, and α-asarone group exhibited different degrees of improvement. ② Neuronal apoptosis in the CA1 and CA3 regions: there were less TUNEL-positive cells in the CA1 and CA3 regions in the normal control group. One week after PTZ-induced seizure, numerous TUNEL-positive cells were detected in the CA1 and CA3 regions in the remaining four groups. There was a significant difference between the normal control group and the remaining four groups (t = 12.089-19.162, P < 0.01). The number of TUNEL-positive cells was less in the phenobarbital sodium, acrous gramineus, and α-asarone groupscompared to the model group (t = 4.707-6.268, P < 0.01). ③Bcl-2 and Bax expression of neurons in the CA1 and CA3 regions: The number of Bcl-2- and Bax-positive cells was less in the normal control group. The Bax-positive cells exhibited a normal shape and had large round nuclei that were predominant. One week after PTZ-induced epilepsy, the number of Bcl-2- and Bax-positive cells in the CA1 and CA2 regions was significantly increased in the remaining four groups compared to the normal control group (t = 11.606-27.042, P < 0.01). The Bax-positive cells exhibited a reduced size and nuclear pyknosis was predominant. However, there was no significant difference among the four groups (P > 0.05). The number of Bcl-2-positive cells in the phenobarbital sodium, acrous gramineus, and α -asarone groups were significantly increased compared to the model group (t = 4.051-6.404, P < 0.01). However, the number of Bax-positive cells was not significantly different among the four groups. The ratio of Bcl-2 to Bax expression was approximately 6.0 in the normal controls, 0.7 in the model group, and 1.0 in the remaining three groups. CONCLUSION: Acrous gramineus and α-asarone increased Bcl-2 expression and decreased Bax expression, and also reduced the number of apoptotic hippocampal neurons during PTZ-induced epileptic seizures in immature rats. | Libin Yang Shulei Li Yanzhi Huang Jianmin Liang Yuhong Wang | 2008 | Neural Regeneration Research2008，3，1： | 4 |
| 18 | Ecosystem evolution of seal colony and the influencing factors in the 20th century on Fildes Peninsula,West Antarctica显示文摘As the topmost predator in Antarctica,the seal is a unique indicator of Antarctic environment and climate changes.In this study,we collected a sediment core from the Fildes Peninsula of West Antarctica,and used cholesterol,cholestanol,epicoprostanol,coprostanol,and seal hair numbers as the proxy indicators of seal population size and phytol as of general vegetation,and we reconstructed the 20th century history of variation of the seal population and vegetation abundance on this island.The sealing industry in the early 20th century caused the dramatic decline of seal population,and the ban of seal hunting since the 1960s led to its recovery of seal population.The seal population during the past century was primarily controlled by human activities and krill density.The reconstructed relation between seal population and vegetation abundance may offer new insights into Antarctic environment and ecology. | Jing Huang Liguang Sun Xinming Wang Yuhong Wang Tao Huang | 2011 | Journal of Environmental Sciences2011，23，9： | 4 |
| 19 | H3K4me3 epigenomic landscape derived from ChIP-Seq of 1000 mouse early embryonic cells显示文摘 | Jie Shen Dongqing Jiang Yusi Fu Xinglong Wu Hongshan Guo Binxiao Feng Yuhong Pang Aaron M Streets Fuchou Tang Yanyi Huang | 2015 | Cell Research2015，25，1： | 4 |
| 20 | Effects of acrous gramimeus and its main component alpha-asarone on the reactivity and convulsive threshold of immature rats to electric stimulation显示文摘BACKGROUND: The traditional Chinese medicine acrous gramimeus is the dry rhizome of Acrous gramimeus Soland, a kind of Araceae familial perennial herb, which has a sedation action, anticonvulsant and antiepileptic effect. Its effective component has not been known yet, and α-asarone, the major component of the volatile oil extracted from acrous gramineus, has been supposed to play a necessary role in it. OBJECTIVE: To explore the effects of acrous gramimeu and α-asarone on the reactivity and convulsive threshold to electric stimulation in immature rats, furthermore, attempt to definitize the anticonvulsant effect of αasarone. DESIGN: A randomized controlled study. SETTINGS: Department of Pediatrics, First Hospital of Jilin University; Department of Histology and Embryology, School of Basic Medical Sciences of Jilin University; Department of Neurology, First Clinical Hospital affiliated to Harbin Medical University; Department of Internal Medicine, Children’s Hospital of Changchun City. MATERIALS: Seventy 3-week immature Wistar rats (either males or females) of 34-40 g were used. Acrous gramimeu (1 g/bag, the content of α-asarone was 0.046 26%-0.070 16%) with the batch number of 0307113 was provided by Tianjiang Medicine Company Limited, Jiangyin City. α-asarone tablet (60 mg per tablet) with the batch number of 030219 was provided by Tianwei Pharmaceutical Factory, Shenyang City. α-asarone injectable preparation (2 mL per piece) with the batch number of 030105 was provided by Shuanghe Medicine Limited Company, Beijing City. METHODS: The experiments were carried out in the Neurological Laboratory of the First Hospital of Jilin University between August and October in 2004. ① The 70 rats were randomly divided into intragastric subset and intraperitoneal subset. The intragastric subset included four groups of control, phenobarbital sodium, acrous gramimeu and α-asarone; the intraperitoneal subset included three groups of control, phenobarbital sodium and α-asarone. There were 10 rats per group. ② In the intragastric subset, different group was treated with saline (1 mL for each time, phenobarbital sodium (18 mg/kg per day), acrous gramineu (2 350 mg/kg per day) and α-asarone (29 mg/kg per day) respectively twice every day for 5 days. In the intraperitoneal subset, different group was treated with saline (0.5 mL), phenobarbital sodium (29 mg/kg) and α-asarone (2.9 mg/kg) respectively. ③ Before and after administration for 5 days in the intragastric subset as well as before and after administration for about 1 hour in the intraperitoneal subset respectively, the rats were given electric stimulation with the NIHOM KOMDEM multifunctional electrophysiological recorder, and the reactivity and convulsive threshold to electric stimulation of the rats were recorded. MAIN OUTCOME MEASURES: The reactivity and convulsive threshold to electric stimulation in immature rats were compared. RESULTS: All the rats were involved in the analysis of results. ① Results for intragastric administration: Before intragastric administration, there were no obvious differences in the reactivity and convulsive threshold to electric stimulation among the groups (P > 0.05). After intragastric administration for 5 days, the reactivity and convulsive threshold to the electric stimulation had no obvious changes in the control group, but those were significantly higher than before administration in the drug administration groups (t=3.317-7.401, P < 0.01), which were also obviously higher than those in the control group (t=3.027-8.941, P < 0.01), and those in the acrous gramimeu group and α-asarone group were not markedly different from those in the phenobarbital sodium group. ② Results for intraperitoneal injection: Before intraperitoneal injection, the reactivity and convulsive threshold to the electric stimulation had no obvious differences among the groups. After the intraperitoneal injection for 1 hour, the reactivity and convulsive threshold to the electric stimulation had no obvious change in the control group, but those were significantly higher than before administration in the drug administration groups (P < 0.01), which were also obviously higher than those in the control group (t=6.211-7.237, P < 0.01; t=4.085-5.633, P < 0.05), and there was no marked difference between α-asarone group and phenobarbital sodium group (P > 0.05). CONCLUSION: ① As effective anticonvulsants, both acrous gramineu and α-asarone can enhance the reactivity and convulsive threshold of immature rats to electric stimulation. ② As one of the major effective components against convulsion of acrous gramineu, α-asarone is equivalent to phenobarbital sodium. | Libin Yang Shulei Li Yuhong Wang Yanzhi Huang | 2006 | Neural Regeneration Research2006，1，1： | 3 |
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