| 1 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 6 | Analytical Modelling and Experiment of Novel Rotary Electro-Mechanical Converter with Negative Feedback Mechanism for 2D Valve显示文摘The manufacturing of spiral groove structure of two-dimensional valve(2D valve)feedback mechanism has shortcomings of both high cost and time-consuming.This paper presents a novel configuration of rotary electro-mechanical converter with negative feedback mechanism(REMC-NFM)in order to replace the feedback mechanism of spiral groove and thus reduce cost of valve manufacturing.In order to rapidly and quantitative evaluate the driving and feedback performance of the REMC-NFM,an analytical model taking leakage flux,edge effect and permeability nonlinearity into account is formulated based on the equivalent magnetic circuit approach.Then the model is properly simplified in order to obtain the optimal pitch angle.FEM simulation is used to study the influence of crucial parameters on the performance of REMC-NFM.A prototype of REMC-NFM is designed and machined,and an exclusive experimental platform is built.The torque-angle characteristics,torque-displacement characteristics,and magnetic flux density in the working air gap with different excitation currents are measured.The experimental results are in good agreement with the analytical and FEM simulated results,which verifies the correctness of the analytical model.For torque-angle characteristics,the overall torque increases with both current and rotation angle,which reaches about 0.48 N·m with 1.5 A and 1.5°.While for torque-displacement characteristics,the overall torque increases with current yet decrease with armature displacement due to the negative feedback mechanism,which is about 0.16 N·m with 1.5 A and 0.8 mm.Besides,experimental results of conventional torque motor are compared with counterparts of REMC-NFM in order to validate the simplified model.The research indicates that the REMC-NFM can be potentially used as the electro-mechanical converter for 2D valves in civil servo areas. | Bin Meng Mingzhu Dai Chenhang Zhu Chenchen Zhang Chuan Ding Jian Ruan | 2022 | Chinese Journal of Mechanical Engineering2022，35，5： | 0 |
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