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| 1 | Strong motion observations and recordings from the great Wenchuan Earthquake显示文摘The National Strong Motion Observation Network System (NSMONS) of China is briefly introduced in this paper. The NSMONS consists of permanent free-field stations, special observation arrays, mobile observatories and a network management system. During the Wenchuan Earthquake, over 1,400 components of acceleration records were obtained from 460 permanent free-field stations and three arrays for topographical effect and structural response observation in the network system from the main shock, and over 20,000 components of acceleration records from strong aftershocks occurred before August 1, 2008 were also obtained by permanent free-field stations of the NSMONS and 59 mobile instruments quickly deployed after the main shock. The strong motion recordings from the main shock and strong aftershocks are summarized in this paper. In the ground motion recordings, there are over 560 components with peak ground acceleration (PGA) over 10 Gal, the largest being 957.7 Gal. The largest PGA recorded during the aftershock exceeds 300 Gal. | Li Xiaojun Zhou Zhenghua Yu Haiyin Wen Ruizhi Lu Dawei Huang Moh Zhou Yongnian Cu Jianwen | 2008 | Earthquake Engineering and Engineering Vibration2008，7，3： | 71 |
| 2 | Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarclnoma显示文摘有证据建议那刺激滤泡的荷尔蒙(FSH ) 能由在癌症细胞增加脉管的 endothelial 生长因素(VEGF ) 表示便于卵巢的癌症的 neovascularization,尽管这个过程的内在的分子的机制不是众所周知的。因此,我们在卵巢的癌症房间线 SKOV-3 和 ES-2 在 VEGF 表示上调查了 FSH 的效果。有 FSH 的治疗显著地在一个剂量依赖者和时间依赖者举止增加了 VEGF 表示。另外, FSH 治疗提高了 survivin 和组织缺氧可诱导的 factor-1 (HIF-1 ) 的表示。survivin 或 HIF-1 击倒压制的 VEGF 表示,但是 survivin 仅仅击倒禁止的刺激 FSH 的 VEGF 表示。有 LY294002 的预告的处理,一个 phosphoinositide 3-kinase (PI3K )/AKT 禁止者,抵销 FSH,而是治疗与 U0126 导致的 survivin 的提高的表示,激活 mitogen 的蛋白质 kinase/extracellular 调整信号的 kinase 禁止者,没有如此的效果。我们进一步证明卵巢的浆液的 cystadenocarcinoma 样品有积极 AKT 和比的染色的 phosphorylated AKT (pAKT ) 蛋白质的许多更高的发生良性的卵巢的 cystadenoma 取样了(p < 0.01 ) 。5 年的幸存率仅仅在有卵巢的浆液的 cystadenocarcinoma 的病人是大约 15% 有 AKT 和 pAKT 表示,而它在没有 AKT 或 pAKT 表示的那些是大约 80% 。一起拿,这些结果显示 FSH 由 upregulating 增加 VEGF 的表示 survivin 的表示,它被发信号的 PI3K/AKT 激活小径。在 survivin 和 VEGF 的刺激 FSH 的表示理解 PI3K/AKT 小径的角色将为与卵巢的浆液的 cystadenocarcinoma 为病人评估预后并且为对这疾病追求有效治疗是有益的。 | Yan Huang Keqin Hua Xianrong Zhou Hongyan Jin Xiaojun Chen Xin Lu Yinhua Yu Xiliang Zha Youji Feng | 2008 | Cell Research2008，18，7： | 17 |
| 3 | USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy显示文摘Macrophage polarization to proinflammatory M1-like or anti-inflammatory M2-like cells is critical to mount a host defense or repair tissue.The exact molecular mechanisms controlling this process are still elusive.Here,we report that ubiquitin-specific protease 19(USP19)acts as an anti-inflammatory switch that inhibits inflammatory responses and promotes M2-like macrophage polarization.USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species.In addition,USP19 inhibited the proteasomal degradation of inflammasome-independent NLRP3 by cleaving its polyubiquitin chains.USP19-stabilized NLRP3 promoted M2-like macrophage polarization by direct association with interferon regulatory factor 4,thereby preventing its p62-mediated selective autophagic degradation.Consistent with these observations,compared to wild-type mice,Usp19−/−mice had decreased M2-like macrophage polarization and increased interleukin-1βsecretion,in response to alum and chitin injections.Thus,we have uncovered an unexpected mechanism by which USP19 switches the proinflammatory function of NLRP3 into an anti-inflammatory function,and suggest that USP19 is a potential therapeutic target for inflammatory interventions. | Tao Liu Liqiu Wang Puping Liang Xiaojuan Wang Yukun Liu Jing Cai Yuanchu She Dan Wang Zhi Wang Zhiyong Guo Samuel Bates Xiaojun Xia Junjiu Huang Jun Cui | 2021 | Cellular & Molecular Immunology2021，18，10： | 15 |
| 4 | Structural reliability analysis and reliability-based design optimization: Recent advances显示文摘We review recent research activities on structural reliability analysis,reliability-based design optimization(RBDO) and applications in complex engineering structural design.Several novel uncertainty propagation methods and reliability models,which are the basis of the reliability assessment,are given.In addition,recent developments on reliability evaluation and sensitivity analysis are highlighted as well as implementation strategies for RBDO. | QIU ZhiPing HUANG Ren WANG XiaoJun QI WuChao | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 14 |
| 5 | Comparison of dust emissions, transport, and deposition between the Taklimakan Desert and Gobi Desert from 2007 to 2011显示文摘The Taklimakan Desert(TD) and Gobi Desert(GD) are two of the most important dust sources in East Asia, and have important impact on energy budgets, ecosystems and water cycles at regional and even global scales. To investigate the contribution of the TD and the GD to dust concentrations in East Asia as a whole, dust emissions, transport, and deposition over the TD and the GD in different seasons from 2007 to 2011 were systematically compared, based on the Weather Research and Forecasting model coupled with Chemistry(WRF-Chem). Dust emissions, uplift, and long-range transport related to these two dust source regions were markedly different due to differences in topography, elevation, thermal conditions, and atmospheric circulation. Specifically,the topography of the GD is relatively flat, and at a high elevation, and the area is under the influence of two jet streams at high altitudes, resulting in high wind speeds in the upper atmosphere. Deep convective mixing enables the descending branch of jet streams to continuously transport momentum downward to the mid-troposphere, leading to enhanced wind speeds in the lower troposphere over the GD which favors the vertical uplift of the GD dust particles. Therefore, the GD dust was very likely to be transported under the effect of strong westerly jets, and thus played the most important role in contributing to dust concentrations in East Asia. Approximately 35% and 31% of dust emitted from the GD transported to remote areas in East Asia in spring and summer, respectively. The TD has the highest dust emission capabilities in East Asia, with emissions of about 70.54 Tg yr.1 in spring, accounting for 42% of the total dust emissions in East Asia. However, the TD is located in the Tarim Basin and surrounded by mountains on three sides. Furthermore, the dominant surface wind direction is eastward and the average wind speed at high altitudes is relatively small over the TD. As a result, the TD dust particles are not easily transported outside the Tarim Basin, such that most of the dust particles are re-deposited after uplift, at a total deposition rate of about 40 g m.2. It is only when the TD dust particles are uplifted above 4 km, and entrained in westerlies that they begin to undergo a long-range transport. Therefore,the contribution of the TD dust to East Asian dust concentrations was relatively small. Only 25% and 23% of the TD dust was transported to remote areas over East Asia in spring and summer, respectively. | CHEN SiYu HUANG JianPing LI JingXin JIA Rui JIANG NanXuan KANG LiTai MA XiaoJun XIE TingTing | 2017 | Science China Earth Sciences2017，60，7： | 14 |
| 6 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 7 | Research progress on electrical signals in higher plants显示文摘This review introduces the characteristics of electrical signals in higher plants and their corresponding physiological significance, and describes in detail the impact of environmental factors (e.g. light and temperature) on the electrical potential of the plants. Also, we evaluate the measurement techniques used for electrical signals in plants, including intracellular measurement, extracellular measurement, measurement of the ion channel based on the patch-clamp technique and on the non-invasive microelectrode vibrating probe technique. We also give a brief review of the applications of these methods for investigating electrical signals in plants. The ionic mechanism of electrical activity in plants is then discussed in terms of environmental response in higher plants, and this is used to provide a theoretical basis for quantitative description of the electrical signals in plants. A model for interpretation of the electrical signal mechanisms in higher plants is discussed, but further experiments are required for the verification of this model. | Xiaofei Yana, Zhongyi Wang a, Lan Huang a, Cheng Wang b, Ruifeng Hou b, Zhilong Xu b, Xiaojun Qiao b a College of Information and Electrical Engineering, China Agricultural University, Beijing 100083, China b National Engineering Research Center for Information Technology in Agriculture, Beijing 100097, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 13 |
| 8 | Spatial-temporal Dynamics and Driving Forces of Land Development Intensity in the Western China from 2000 to 2015显示文摘The change in land development intensity is an important perspective to reflect the variation in regional social and economic development and spatial differentiation.In this paper,spatial statistical analysis,Ordinary Least Squares(OLS),and Geographically weighted regression(GWR)methods are used to systematically analyse the spatial-temporal characteristics and driving forces of land development intensity for 131 spatial units in the western China from 2000 to 2015.The findings of the study are as follows:1)The land development intensity in the western China has been increasing rapidly.From 2000 to 2015,land development intensity increased by 3.4 times on average.2)The hotspot areas have shifted from central Inner Mongolia,northern Shaanxi and the Beibu Gulf of Guangxi to the Guanzhong Plain and the Chengdu-Chongqing urban agglomeration.The areas of cold spots were mainly concentrated in the Qinghai-Tibet Plateau,Yunnan,and Xinjiang.3)Investment intensity and the natural environment have always been the main drivers of land development intensity in the western China.Investment played a powerful role in promoting land development intensity,while the natural and ecological environment distinctly constrained such development.The effect of the economic factors on land development intensity in the western China has changed,which is reflected in the driving factor of construction land development shifting from economic growth in 2000 to economic structure,especially industrial structure,in 2015. | HUANG Xin HUANG Xiaojun LIU Mengmeng WANG Bo ZHAO Yonghua | 2020 | Chinese Geographical Science2020，30，1： | 12 |
| 9 | Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing chemotherapy:China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study显示文摘Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies.In this study,we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset (n=3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression,which included the following variables: male patients,induction chemotherapy for newly diagnosed or relapsed disease,neutropenia,neutropenia longer than 10 days,hypoalbuminemia,central-venous catheter,and history of IFD.The patients were classified into three groups,which had low (0-10,~1.2%),intermediate (11-15,6.4%),and high risk (> 15,17.5%) of IFD.In the validation set (n=1389),the IFD incidences of the groups were ~1.4%,5.0%,and 21.4%.In addition,we demonstrated that antifungal prophylaxis offered no benefits in low-risk patients,whereas benefits were documented in intermediate (2.1% vs.6.6%,P=0.007) and high-risk patients (8.4% vs.23.3%,P=0.007).To make the risk score applicable for clinical settings,a pre-chemo risk score that deleted all unpredictable factors before chemotherapy was established,and it confirmed that anti-fungal prophylaxis was beneficial in patients with intermediate and high risk of IFD.In conclusion,an objective,weighted risk score for IFD was developed,and it may be useful in guiding antifungal prophylaxis. | Ling Wang Ying Wang Jiong Hu Yuqian Sun He Huang Jing Chen Jianyong Li Jun Ma Juan Li Yingmin Liang Jianmin Wang Yan Li Kang Yu Jianda Hu Jie Jin Chun Wang Depei Wu Yang Xiao Xiaojun Huang | 2019 | Frontiers of Medicine2019，13，3： | 10 |
| 10 | One-way wave equation seismic prestack forward modeling with irregular surfaces显示文摘数学地震检波器(MG )(et ) 并且相等时间的叠原则被用来实现向前用单程的声学的波浪方程与不规则的表面当模特儿的地震 prestack。这个方法从表面下的使用受到地震主要思考一套虚拟 MG。接收装置能位于在任何地方不规则的观察表面。而且, ETS 方法利用单程的声学的波浪方程到容易并且快速想象并且外推地震思考数据。方法用普通射击集合由二个简单模型,的数字前面的建模计算了的高单个噪音的比率被说明有扁平的表面的和有不规则的表面的,和复杂正常指责模型。为不规则的表面地形学的一个 prestack 深度迁居方法被用来与高精确性复制正常差错模型。 | Xiong Xiaojun He Zhenhua Huang Deji | 2006 | Applied Geophysics2006，3，1： | 9 |
| 11 | Rapid reconstitution of NK1 cells after allogeneic transplantation is associated with a reduced incidence of graft-versus-host disease显示文摘The balance between immunostimulation and immunoregulation in T cell immunity is achieved by maintaining specific ratios of Th1, Th2, Th3 and Tr1 cells. Here, we investigate levels of type 1(IFN-gamma; NK1), type 2(IL-13; NK2), type 3(TGF-beta;NK3) and regulatory(IL-10; NKr) cytokines in peripheral blood to assess the cytokine profiles of natural killer(NK) cells following human allogeneic hematopoietic stem cell transplantation(allo-HSCT). NK2 and NK3 cell expansion was observed after allo-HSCT; levels of NKr cells reached donor levels at day 15, though levels of NK1 cells were consistently lower than donor levels until day 60 after allo-HSCT. Multivariate analysis showed that a higher level of NK1 cells by day 15 was associated with a lower overall risk of acute graft-versus-host disease(GVHD)(HR 0.157, P=0.010) as well as II-IV acute GVHD(HR0.260, P=0.059). Furthermore, higher levels of NK1 cells by day 15 were correlated with lower rates of cytomegalovirus(CMV)reactivation(HR 0.040, 0.005–0.348, P=0.003). These results indicate that rapid reconstitution of NK cells, especially NK1 cells,can help prevent the development of GVHD as well as CMV reactivation after allogeneic transplantation. | Xingxing Yu Lingling Xu Yingjun Chang Xiaojun Huang Xiangyu Zhao | 2018 | Science China(Life Sciences)2018，61，8： | 9 |
| 12 | Comparison analysis between haplo identical stem cell transplantation and matched sibling donor stem cell transplantation for high-risk acute myeloid leukemia in first complete remission显示文摘In order to compare the effect between haploidentical(HID) stem cell transplantation(HSCT) and matched sibling donor(MSD)stem cell transplantation for high-risk acute myeloid leukemia(AML) in first complete remission status(CR1), we retrospectively studied 170 cases who received stem cell transplantation from Jan 2008 to Jul 2015 in Peking University People's Hospital. We divided all cases into MSD group(43 cases) and HID(127 cases) group. Patients in HID and MSD group displayed similar baseline characteristics except for age distribution. There were no statistic differences for overall survival(OS), cumulative incidence of relapse, leukemia free survival(LFS), transplantation related mortality(TRM) between HID and MSD group. The 3-year OS, LFS for all patients was 63.9% and 59.7% respectively. Multivariate analysis showed that grade III-IV acute graft versus host disease(aGVHD) was an independent risk factor for treatment related mortality(HR=8.134, 95% CI:3.210–20.611, P<0.001), monosomy/complex chromosomal karyotype and white blood cell count more than 50×109 L-1 were two independent factors for relapse(HR=1.533, 95% CI: 1.040–2.260, P=0.031)(HR=1.004, 95% CI: 1.001–1.008, P=0.015).Grade III-IV aGVHD was an independent factor for mortality(HR=3.184, 95% CI: 1.718–5.902, P<0.001). These results demonstrated some risk factors for high-risk AML leukemia transplantation and indicated for AML patients in CR1 status, haplo stem cell transplantation could have the same therapeutic effect as MSD transplantation. | Yang Liu Xiaojun Huang Qian Fei Lanping Xu Xiaohui Zhang Kaiyan Liu Yuhong Chen Huan Chen Yu Wang | 2019 | Science China(Life Sciences)2019，62，5： | 9 |
| 13 | Speech endpoint detection in low-SNRs environment based on perception spectrogram structure boundary parameter显示文摘The Perception Spectrogram Structure Boundary(PSSB)parameter is proposed for speech endpoint detection as a preprocess of speech or speaker recognition.At first a hearing perception speech enhancement is carried out.Then the two-dimensional enhancement is performed upon the sound spectrogram according to the difference between the determinacy distribution characteristic of speech and the random distribution characteristic of noise.Finally a decision for endpoint was made by the PSSB parameter.Experimental results show that,in a low SNR environment from-10 dB to 10 dB,the algorithm proposed in this paper may achieve higher accuracy than the extant endpoint detection algorithms.The detection accuracy of 75.2%can be reached even in the extremely low SNR at-10 dB.Therefore it is suitable for speech endpoint detection in low-SNRs environment. | WU Di ZHAO Heming HUANG Chengwei XIAO Zhongzhe ZHANG Xiaojun XU Yishen TAO Zhi | 2014 | Chinese Journal of Acoustics2014，33，4： | 8 |
| 14 | Everyone has a donor:contribution of the Chinese experience to global practice of haploidentical hematopoietic stem cell transplantation显示文摘Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) have long been scarce in China. Haploidentical (haplo) donors are available for the vast majority of patients, but toxicity has limited this approach. Three new approaches for haplo-HSCT originated from Italy, China, and USA in 1990 and have been developed to world-renowned system up to now. The Chinese approach have been greatly improved by implementing new individualized conditioning regimens, donor selection based on non-HLA systems, risk-directed strategies for graft-versus-host disease and relapse, and infection management. Haplo-HSCT has exhibited similar efficacy to HLA-matched HSCT and has gradually become the predominant donor source and the first alternative donor choice for allo-HSCT in China. Registry-based analyses and multicenter studies adhering to international standards facilitated the transformation of the unique Chinese experience into an inspiration for the refinement of global practice.This review will focus on how the new era in which 'everyone has a donor' will become a reality in China. | Meng Lv Yingjun Chang Xiaojun Huang | 2019 | Frontiers of Medicine2019，13，1： | 8 |
| 15 | Effect of moxa smoke produced during combustion of Aiye(Folium Artemisiae Argyi) on behavioral changes in mice inhaling the smoke显示文摘OBJECTIVE: To evaluate the effects that inhalation of the combustion products of the traditional Chinese herb Aiye(Folium Artemisiae Argyi) has on the central nervous system.METHODS: Forty Kunming mice(half male) were randomly assigned(n = 10/group) to a control group(C) or one of three moxa smoke concentration groups(% opacity): low(L1; 0.4%), medium(M1; 2%), and high(H1; 15%). Mice in the latter three groups were exposed to moxa smoke in a dynamic gas exposure cabinet for 20 min per day for7 days. Mice in control group were placed in the same cabinet without any intervention. For the sleep experiments, another 50 mice were divided into five groups of 10 mice each: a saline-injected control group, L1 + pentobarbital sodium(PS)-injected group, M1+PS group, H1(15%)+PS group,and a positive control group(10 mg/kg, chlorpromazine, p.o.). The weight, general activities, locomotor activities, rotarod performance, sleep duration,and sleeping rate induced by a subthreshold dose of pentobarbital sodium were recorded in the mice,and the composition of moxa smoke was analyzed using headspace gas chromatography(GC-HS).RESULTS: A low concentration of smoke significantly decreased the frequency of locomotor activities and the time for which the mice remaining on the rotarod; however, a high smoke concentration significantly prolonged the pentobarbital-induced sleeping time and sleeping rate.CONCLUSION: The concentration-dependent relaxing effects of moxa smoke on the Central Nervous System(CNS) were confirmed. Moreover, GC-HS analysis showed that the component present in the highest concentration in moxa smoke was eucalyp-tol, an essential oil well recognized for its soothing effects on the CNS. This may therefore be accountable for the sedative effects of moxa smoke. | Yang Jia Zheng Xiaojun Jin Ran Han Li Ha Lue Li Jun Wang Lei Liu Ping Chu Zhusheng Huang Chang Chang Hongsheng Lao Lixing Zhao Baixiao | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 8 |
| 16 | Combined prednisone and levothyroxine improve treatment of severe thrombocytopenia in hepatitis B with compensatory cirrhosis accompanied by subclinical and overt hypothyroidism显示文摘The aim of the present study was to investigate the relationship between hypothyroidism and thrombocytopenia in hepatitis Brelated compensatory liver cirrhosis and to determine whether treatment with levothyroxine and prednisone is superior in a multicenter, open-label, observational study in China. In total, 125 consecutive hepatitis B-related compensated liver cirrhosis patients with severe thrombocytopenia accompanied by hypothyroidism were included. The patients were divided into four groups according to treatment strategy: a control group(n=29), a prednisone group(n=25), a levothyroxine group(n=32) and a prednisone plus levothyroxine group(n=39). Severe thrombocytopenia was more prevalent in hepatitis B-associated compensatory liver cirrhosis patients with hypothyroidism than in euthyroid patients(29.6% vs. 14.7%, P<0.05). Combination treatment with prednisone and levothyroxine decreased the risk of bleeding and improved platelet recovery compared to control treatment and treatment with either prednisone or levothyroxine alone. The platelet count before therapy, serum thyroid stimulating hormone and combination treatment with prednisone and levothyroxine were associated with bleeding events. Therefore, the present study suggests that hypothyroidism is associated with severe thrombocytopenia in hepatitis B-associated compensatory liver cirrhosis. Treatment with prednisone plus levothyroxine may present a novel approach in these patients. | Jing Xue Ru Feng Haixia Fu Qian Jiang Hao Jiang Jing Lu Hui Liu Jingwen Wang Ting Niu Xin Wang YANDi Xie Hao Wang Lanping Xu Kaiyan Liu Xiaojun Huang Xiaohui Zhang | 2018 | Science China(Life Sciences)2018，61，8： | 8 |
| 17 | RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells显示文摘LIN28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells and developing tissues.Increasing evidence demonstrates that LIN28B is activated in cancer and serves as a critical oncogene.However,the underlying molecular mechanisms of LIN28B function in tumorigenesis are still largely unknown.Here we report that LIN28B was expressed in over half of the patients with epithelial ovarian cancer who were examined(n=584).Functional experiments demonstrated that LIN28B inhibited ovarian cancer cell apoptosis.Furthermore,we showed that the proapoptotic factor BIM played an essential role in the antiapoptotic function of LIN28B.RNA-IP microarray analysis suggested that LIN28B binds to mRNAs that are associated with the DNA damage pathway,such as AKT2,in ovarian cancer cells.By binding to AKT2 mRNA and enhancing its protein expression,LIN28B regulated FOXO3A protein phosphorylation and decreased the transcriptional level of BIM,which antagonized the antiapoptosis activity of LIN28B.Taken together,these results mechanistically linked LIN28B and the AKT2/FOXO3A/BIM axis to the apoptosis pathway.The findings may have important implications in the diagnosis and therapeutics of ovarian cancer. | Xiaojuan Lin Jianfeng Shen Dan Peng Xinhong He Congjian Xu Xiaojun Chen Janos LTanyi Kathleen Montone Yi Fan Qihong Huang Lin Zhang Xiaomin Zhong | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 8 |
| 18 | An Overview of Mineral Dust Modeling over East Asia显示文摘East Asian dust(EAD) exerts considerable impacts on the energy balance and climate/climate change of the earth system through its influence on solar and terrestrial radiation, cloud properties, and precipitation efficiency. Providing an accurate description of the life cycle and climate effects of EAD is therefore critical to better understanding of climate change and socioeconomic development in East Asia and even worldwide. Dust modeling has undergone substantial development since the late 1990 s, associated with improved understanding of the role of EAD in the earth system. Here, we review the achievements and progress made in recent decades in terms of dust modeling research,including dust emissions, long-range transport, radiative forcing(RF), and climate effects of dust particles over East Asia. Numerous efforts in dust/EAD modeling have been directed towards furnishing more sophisticated physical and chemical processes into the models on higher spatial resolutions. Meanwhile, more systematic observations and more advanced retrieval methods for instruments that address EAD related science issues have made it possible to evaluate model results and quantify the role of EAD in the earth system, and to further reduce the uncertainties in EAD simulations. Though much progress has been made, large discrepancies and knowledge gaps still exist among EAD simulations. The deficiencies and limitations that pertain to the performance of the EAD simulations referred to in the present study are also discussed. | Siyu CHEN Jianping HUANG Yun QIAN Chun ZHAO Litai KANG Ben YANG Yong WANG Yuzhi LIU Tiangang YUAN Tianhe WANG Xiaojun MA Guolong ZHANG | 2017 | Journal of Meteorological Research2017，31，4： | 7 |
| 19 | Platelet transfusion refractoriness after T-cell-replete haploidentical transplantation is associated with inferior clinical outcomes显示文摘Haploidentical stem cell transplantation (haplo-SCT) has been an alternative source of bone marrow for patients without human leukocyte antigen (HLA)-matched donors. The aim of this study was to investigate the relationships between platelet transfusion refractoriness (PTR) and clinical outcomes in the setting of haplo-SCT. Between May 2012 and March 2014, 345 patients who underwent unmanipulated haplo-SCT were retrospectively enrolled. PTR occurred in 20.6% of all patients. Patients in the PTR group experienced higher transplant-related mortality (TRM, 43.7% vs. 13.5%, P<0.001), lower overall survival (OS, 47.9%vs. 76.3%, P<0.001) and lower leukemia-free survival (LFS, 47.9% vs. 72.3%, P<0.001) compared to patients in the non-PTR group. The multivariate analysis showed that PTR was associated with TRM (P=0.002), LFS (P<0.001), and OS (P<0.001).The cumulative incidences of PTR in patients receiving >12 platelet (PLT) transfusions (third quartile of PLT transfusions) were higher than in patients receiving either >6 (second quartile) or >3 (first quartile) PLT transfusions (56.1% vs. 41.6% vs. 28.2%,respectively; P<0.001). The multivariate analysis also showed that PTR was associated with the number of PLT transfusions(P<0.001). PTR could predict poor transplant outcomes in patients who underwent haploidentical SCT. | Qiang Fu Lanping Xu Xiaohui Zhang Yu Wang Yingjun Chang Kaiyan Liu Xiaojun Huang | 2018 | Science China(Life Sciences)2018，61，5： | 7 |
| 20 | Differentiation of rat iPS cells and ES cells into granulosa cell-like cells in vitro显示文摘早熟的卵巢的失败(POF ) 是卵巢的滤泡的早熟的弄空在 40 岁前描绘的一个卵巢的缺点,代表女不孕的一个主要原因。干细胞为 POF 提供一个潜在的处理的可能性。在这研究,老鼠胚胎的干细胞(转换字符) 和导致的 pluripotent 干细胞(iPSCs ) 与 granulosa 房间(GC ) 是 co 有教养的区分到象 GC 一样房间。放射性免疫测定分析的 estradiol (E2 ) 的水平证明 co 有教养的老鼠 iPSCs 和转换字符的文化上层清液的 E2 集中以一种时间依赖者方式增加了,与有一个相反的趋势的 GC 组相比。刺激滤泡的荷尔蒙受体(FSHR ) 的表示被 immunostaining 证实。这些结果显示了那老鼠 iPSCs,转换字符有效地通过间接 cell-to-cell 接触被导致到象 GC 一样房间。实时聚合酶链反应被执行在 POF 分析标记基因的表示水平,包括 BMP15, FMR1, FSHR, INHA, AMH, NOBOX, FOXO3, EIF2B, FIGLA,和 GDF9。BMP15, FSHR, INHA, AMH, NOBOX,和 GDF9 基因在 iPSCs 和与与不是 co 有教养的房间比较的 GC co 有教养的转换字符是显著地起来调整的。因此,这里,我们表明了一个可得到的方法为 POF 的可能的房间治疗在 vitro 区分老鼠 iPSCs 和转换字符进象 GC 一样房间。 | Juan Zhang Hui Li Zhao Wu XiaoJun Tan Fengying Liu Xianghong Huang Xiaoling Fang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 7 |
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