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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | Suppression of experimental autoimmune myasthenia gravis in IL-10 gene-disrupted mice is associteed with reduced B ceils and serum cytotoxicity on mouse cell line expressing AehR显示文摘 | Poussin M A Goluszko E Hughes T K | 2000 | J Neuroimmunol2000，111，： | 2 |
| 5 | Hepatitis delta virus显示文摘 | Sarah A Hughes Heiner Wedemeyer Phillip M Harrison | 2011 | The Lancet2011，，9785： | 2 |
| 6 | Occupational exp- osure to pesticides and risk of non-hodgkln' s lymphoma显示文摘 | FRITSCHI L BENKE G HUGHES A M | 2005 | Am J Epidemiol2005，162，9： | 1 |
| 7 | The molecular biology of plantacclimation to low temperature显示文摘 | Hughes M A Durm M A | 1996 | Journal of ExperimentalBotany1996，47，： | 1 |
| 8 | Genetic immunization of chimpanzees chronically infected with the hepatitis B virus, using a recombinant retroviral vector encoding the hepatitis B virus core antigen 显示文摘 | Sallberg M Hughes J Javadian A | 1998 | Hum Gene Ther1998，9，： | 1 |
| 9 | Variation in nutritive value of commercial broiler diets 显示文摘 | Ru Y J Hughes R J Choct M Kruk J A | 2003 | Asian Australasian Journal of Animal Science2003，16，830： | 1 |
| 10 | Modeling of biological processes using self-cycling fermentation and genetic algorithms显示文摘 | Pinchuk R J Brown W A Hughes S M | 2000 | Biotechnoi Bioeng2000，，67： | 1 |
| 11 | Numerical simulation of high strain rate concrete compress test 显示文摘 | Tedesco J W Hughes M L Ross C A | 1994 | Computers & Struc- tures1994，51，1： | 1 |
| 12 | Food allergy显示文摘 | SCOTrH H SICHERER M D HUGH A | 2006 | Journal of Allergy and Clinical Immunology2006，117，2： | 1 |
| 13 | Multiple paternity in a natural population of a wild tobacco fly, Bactrocera cacuminata (Diptera: Tephritidae), assessed by microsatellite DNA markers 显示文摘 | Song S D Drew R A Hughes J M | 2007 | Molecular Ecology2007，16，11： | 1 |
| 14 | Controlled trial prednisolone in acute polyneuropathy显示文摘 | Hughes R A Newsom-Davis J M Perkin G D | 1978 | Lancet1978，2，： | 1 |
| 15 | Numerical simu-lation of high strain rate concrete compression tests显示文摘 | Tedesco J W Hughes M L Ross C A | 1994 | Computers & Structures1994，51，1： | 1 |
| 16 | Numerical analysis of high strain rate spiltting-tensile tests显示文摘 | Hughes M L Tedesco Ross A | 1993 | Computers and Structures1993，47，： | 1 |
| 17 | Tree-ring growth curves as sources of climatic information显示文摘 | Naurzbaev M M Hughes M K Vaganov E A | 2004 | Quaternary Research2004，62，： | 1 |
| 18 | Mechanisms media ting the stimulatory effects of the boar on gilt reproduction 显示文摘 | Hughes P E Pearce G P Paterson A M | 1990 | ReprodFert Supp11990，40，32： | 1 |
| 19 | Degenerative scol iosis:a review显示文摘 | Kotwal S Pumberger M Hughes A | 2011 | HSS J2011，7，3： | 1 |
| 20 | Human Delta4- 3-oxosteroid 5beta-reductase (AKR1D1) deficiency and steroid metabolism显示文摘 | Palermo M Marazzi M G Hughes B A | 2008 | Steroids2008，73，73： | 1 |
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