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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 3 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 4 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 5 | P6 aeupoint injec- tion reduce postoperative nausea and vomiting显示文摘 | Shyr M H Hsu J C Wu Y W Hui Y L Tan P P | 1990 | Ma Tsui Hsueh Tsa Chi Anaesthesiol Sinica1990，28，6： | 1 |
| 6 | Preva- lence and Molecular haracterization of Tetracycline Re- sistance in Enterococcus Isolates from Food 显示文摘 | HUYS G HAENE K D COLLARD J M | 2004 | Appl Environ Microbiol2004，70，3： | 1 |
| 7 | GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta ceils 显示文摘 | Egan J M Bulotta A Hui H | 2003 | Diabetes Metab Res Rev2003，19，： | 1 |
| 8 | Lipophilic statins preventmatrix metalloproteinase-mediated cartilage collagen breakdown by inhib-iting protein geranylgeranylation显示文摘 | Barter M J Hui W Lakey R L | 2010 | Ann Rheum Dis2010，69，21： | 1 |
| 9 | Effects of wettability on three-phase flow in porous media 显示文摘 | HUI M H BLUNT M J | 2000 | Journal of Physical Chemistry: B2000，104，16： | 1 |
| 10 | ELMO1 and Dock 180,a bipartite Racl guanine nucleotide exchange factor,promote human glioma cell invasion显示文摘 | Jarzynka M J Hu B Hui K M | 2007 | Cancer Res2007，67，15： | 1 |
| 11 | CD8( + ) T-cell re- sponses to adeno-associated virus eapsid in humans显示文摘 | Mingozzi F Maus M V Hui D J | 2007 | Nat Med2007，13，4： | 1 |
| 12 | Effect of heat treatment on mierostructure and mechanical properties of Cr Ni Mo Nb steel显示文摘 | Wang M Q Dong H Hui W J | 2007 | Materials Science and Technology2007，23，8： | 1 |
| 13 | Proteomic analysis of strawberry leaves infected with Colletotrichum fragariae显示文摘 | Fang X P Chen W Y Xin Y Hengmu Z Chengqi Y Hong Y Hui L Wenfei X Shuzhen W Guizhen Z Hongbo L Liang J Huasheng M Songlin R | 2012 | Journal of proteomics2012，75，： | 1 |
| 14 | A low-complexity space-time RAKE receiver for DS-CDMA communica- tions 显示文摘 | Ramos J Zoltowski M D Liu Hui | 1997 | IEEE Signal Processing Letters1997，4，9： | 1 |
| 15 | Molecular analysis of hypoxanthine phosphoribosyltransferase gene deletions induced by alpha- and X- radiation in human lymphoblastoid cells显示文摘 | Bao C Y Ma A H Evans H H Horng M F Mencl J Hui T E Sedwick W D | 1995 | Mutation Research1995，326，： | 1 |
| 16 | Effective-Medium for Weakly Nonlinear Composites显示文摘 | Bergman D J Hui P M | 1988 | Phys Rev B1988，38，10： | 1 |
| 17 | Bringing a probiotic- containing functional food to the market: microbiological, product, regulatory and labeling issues显示文摘 | Sanders M Huis in' t Veld J | 1999 | Antonie van Leeuwenhoek1999，76，： | 1 |
| 18 | Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell careinoma 显示文摘 | Li Z J Mack S C Mak T H Angers S Taylor M D Hui C C | 2014 | Oncogene2014，33，： | 1 |
| 19 | Phase stability and structural features of matrix-embedded hardening precipitates in Al-Mg-Si alloys in the early stages of evolution显示文摘 | van HUIS M A CHEN J H SLUITER M H F ZANDBERGEN H W | 2007 | Acta Materialia2007，55，： | 1 |
| 20 | Beyond insulin resistance in NASH :TNF or acliponectin 显示文摘 | Hui J M Hodge A Kench I G | 2004 | Hepatology2004，40，1： | 1 |
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