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| 1 | Structure and coalbed methane occurrence in tectonically deformed coals显示文摘Research on structure of tectonically deformed coals(TDC) is a key issue in coal and gas outburst prevention and coalbed methane(CBM) exploitation.This paper presents a summary on the research progress in TDC's structural-genetic classification,tectonic strain influence on coal microstructure,coal porosity system,coal chemical structure and constituents,and their relationship with the excess coalbed methane.Previous studies suggested that tectonic deformation had significant influence on coal microstructure,coal super microstructure,and even chemical macromolecular structure.The main mechanisms of coal deformation are the tectonic stress degradation and polycondensation metamorphism(dynamical metamorphism).Besides,under different deformation mechanisms,the ultra-and micro-structure and chemical constituents of TDC presented distinct characteristics.Based on these achievements,we propose one possible evolutionary trend of TDC with different deformation mechanisms,and suggest that the coal and gas outburst in the TDC,especially in the mylonitic coals,may be not only controlled by geological structure,but also influenced by the tectonic stress degradation of ductile deformation.Therefore,further study on TDC should be focused on the controlling mechanism of deformation on structure and composition of coal,generation conditions and occurrence state of excess coalbed methane from deformation mechanism of coal. | HOU QuanLin LI HuiJun FAN JunJia JU YiWen WANG TianKai LI XiaoShi WU YuDong | 2012 | Science China Earth Sciences2012，55，11： | 49 |
| 2 | Spatiotemporal variability of permafrost degradation on the Qinghai-Tibet Plateau显示文摘Based on data from six meteorological stations in the permafrost regions, 60 boreholes for long-term monitoring of permafrost temperatures, and 710 hand-dug pits and shallow boreholes on the Qinghai-Tibet Plateau (QTP), the spatiotemporal variability of permafrost degradation was closely examined in relation to the rates of changes in air, surface, and ground temperatures. The de-cadal averages and increases in the mean annual air temperatures (MAATs) from 1961-2010 were the largest and most persistent during the last century. MAATs rose by 1.3℃, with an average increase rate of 0.03℃/yr. The average of mean annual ground surface temperatures (MAGSTs) increased by 1.3℃ at an average rate of 0.03℃/yr. The rates of changes in ground temperatures were -0.01 to 0.07℃/yr. The rates of changes in the depths of the permafrost table were -1 to +10 cm/yr. The areal extent of permafrost on the QTP shrank from about 1.50×106 km2 in 1975 to about 1.26×106 km2 in 2006. About 60% of the shrinkage in area of permafrost occurred during the period from 1996 to 2006. Due to increasing air temperature since the late 1980s, warm (>-1℃) permafrost has started to degrade, and the degradation has gradually expanded to the zones of transitory (-1 to -2℃) and cold (<-2℃) permafrost. Permafrost on the southern and southeastern plateau degrades more markedly. It is projected that the degradation of permafrost is likely to accelerate, and substantial changes in the distributive features and thermal regimes of permafrost should be anticipated. However, regarding the relationships between degrading permafrost and the degradation of rangelands, it is still too early to draw reliable conclusions due to inadequate scientific criteria and evidence. | HuiJun Jin DongLiang Luo ShaoLing Wang LanZhi Lv JiChun Wu | 2011 | Research in Cold and Arid Regions2011，3，4： | 16 |
| 3 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 4 | Idealized Numerical Simulations of Tropical Cyclone Formation Associated with Monsoon Gyres显示文摘Monsoon gyres have been identified as one of the important large-scale circulation patterns associated with tropical cyclone(TC)formation in the western North Pacific.A recent observational analysis indicated that most TCs form near the center of monsoon gyres or at the northeast end of the enhanced low-level southwesterly flows on the southeast–east periphery of monsoon gyres.In the present reported study,idealized numerical experiments were conducted to examine the tropical cyclogenesis associated with Rossby wave energy dispersion with an initial idealized monsoon gyre.The numerical simulations showed that the development of the low-level enhanced southwesterly flows on the southeast–east periphery of monsoon gyres can be induced by Rossby wave energy dispersion.Mesoscale convective systems emerged from the northeast end of the enhanced southwesterly flows with mid-level maximum relative vorticity.The simulated TC formed in the northeast of the monsoon gyre and moved westward towards the center of the monsoon gyre.The numerical experiment with a relatively smaller sized initial monsoon gyre showed the TC forming near the center of the initial monsoon gyre.The results of the present study suggest that Rossby wave energy dispersion can play an important role in TC formation in the presence of monsoon gyres. | LIANG Jia WU Liguang ZONG Huijun | 2014 | Advances in Atmospheric Sciences2014，31，2： | 13 |
| 5 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 6 | Mapping the permafrost stability on the Tibetan Plateau for 2005–2015显示文摘Data scarcity is a major obstacle for high-resolution mapping of permafrost on the Tibetan Plateau(TP).This study produces a new permafrost stability distribution map for the 2010 s(2005–2015)derived from the predicted mean annual ground temperature(MAGT)at a depth of zero annual amplitude(10–25 m)by integrating remotely sensed freezing degree-days and thawing degree-days,snow cover days,leaf area index,soil bulk density,high-accuracy soil moisture data,and in situ MAGT measurements from 237 boreholes on the TP by using an ensemble learning method that employs a support vector regression model based on distance-blocked resampled training data with 200 repetitions.Validation of the new permafrost map indicates that it is probably the most accurate of all currently available maps.This map shows that the total area of permafrost on the TP,excluding glaciers and lakes,is approximately 115.02(105.47–129.59)×10^4 km^2.The areas corresponding to the very stable,stable,semi-stable,transitional,and unstable types are 0.86×10^4,9.62×10^4,38.45×10^4,42.29×10^4,and 23.80×10^4 km^2,respectively.This new map is of fundamental importance for engineering planning and design,ecosystem management,and evaluation of the permafrost change in the future on the TP as a baseline. | Youhua RAN Xin LI Guodong CHENG Zhuotong NAN Jinxing CHE Yu SHENG Qingbai WU Huijun JIN Dongliang LUO Zhiguang TANG Xiaobo WU | 2021 | Science China Earth Sciences2021，64，1： | 11 |
| 7 | Sensor design and implementation for a downhole NMR fluid analysis laboratory显示文摘This paper tries to build a multi-functional downhole nuclear magnetic resonance (NMR) fluid analysis laboratory that can evaluate fluid information in real time at reservoir conditions at a depth of several thousand meters. The aim is to monitor the pollution of the formation fluids and quantitatively evaluate NMR characteristics of the fluids. It focuses on the design of the structure and parameters of a sensor with zero stray fields. Two separate coils are designed to measure NMR characteristics of flowing or static fluids. A method is proposed to use the Bloch equation, to guide the optimization of the NMR sensor. Finally, the measured results confirm that the design is reasonable. There is a homogeneous static field (perpendicular to the axial direction) in the center of the sensor, and there are no stray external fields. The novel design of pre-polarization magnet improves the signal to noise ratio, while shortening the sensor length. | Wu Baosong Xiao Lizhi Li Xin Yu Huijun An Tianlin | 2012 | Petroleum Science2012，9，1： | 10 |
| 8 | Editorial Statement显示文摘At the request of Dr. Hideharu AKIYOSHI of the National Institute for Environmental Studies (NIES) of Japan and with the apology of Dr. ZHOU Libo for his misconduct, we hereby announce that the paper of 'Middle-High Latitude N2O Distributions Related to the Arctic Vortex Breakup', authored by ZHOU Libo, ZOU Han, and GAO Yongqi, be retracted from Volume 23, No. 2, March 2006 of Advances in Atmospheric Sciences (AAS) on page number 215-223. This paper will not be considered as a published paper in AAS, and it will not appear in any future reference or record. In fact, this paper should not have been submitted for consideration for publication in AAS, because it was based on the scientific ideas and research | WU Guoxiong WANG Huijun Da-Lin ZHANG | 2006 | Advances in Atmospheric Sciences2006，23，4： | 8 |
| 9 | Simultaneous determination of 74 pesticide residues in Panax notoginseng by QuEChERS coupled with gas chromatography tandem mass spectrometry显示文摘This study established a method for the simultaneous determination of 74 pesticide residues in Panax notoginseng by QuEChERS pretreatment method coupled with GC-MS/MS,and carried out pesticide residue analysis on 20 batches of market samples in China.The samples were extracted with acetonitrile,cleaned up with primary secondary amine(PSA)and octadecylsilane(C18)and determined by GC-MS/MS in multiple reaction monitoring(MRM)mode.Matrix-matched calibration was recommended to combat the matrix effect.A good linearity was observed in the range of 10−500 ng/mL with correlation coefficients≥0.9950.The mean recoveries for most of the pesticides were in the range of 70%−120%with RSD<20%.The limits of detection ranged 0.28–2.00μg/kg,while the limits of quantification were 0.94–6.65μg/kg.Following the application of“top-down”approach,the expanded measurement uncertainty for all the analytes was<30%.The proposed method was successfully applied to determine pesticide residues in 20 market samples in China,where 9 pesticides were detected and quintozene exceeded the criteria domestically and abroad. | Huijun Li Jieshan Wu Chao Chen Wenfeng Xin Wensheng Zhang | 2021 | Food Science and Human Wellness2021，10，2： | 8 |
| 10 | Tauroursodeoxycholic acid(TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2显示文摘Influenza is a persistent threat to human health and there is a continuing requirement for updating antiinfluenza strategies. Initiated by observations of different endoplasmic reticulum(ER) responses of host to seasonal H1N1 and highly pathogenic avian influenza(HPAI) A H5N1 infections, we identified an alternative antiviral role of tauroursodeoxycholic acid(TUDCA), a clinically available ER stress inhibitor, both in vitro and in vivo. Rather than modulating ER stress in host cells, TUDCA abolished the proton conductivity of viral M2 by disrupting its oligomeric states, which induces inefficient viral infection. We also showed that M2 penetrated cells, whose intracellular uptake depended on its proton channel activity,an effect observed in both TUDCA and M2 inhibitor amantadine. The identification and application of TUDCA as an inhibitor of M2 proton channel will expand our understanding of IAV biology and complement current anti-IAV arsenals. | Ning Li Yanxu Zhang Shuangxiu Wu Ruodan Xu Zhiqing Li Jindong Zhu Hongliang Wang Xiao Li Mingyao Tian Huijun Lu Ningyi Jin Chengyu Jiang | 2019 | Science Bulletin2019，64，3： | 6 |
| 11 | Re-examination of Tropical Cyclone Formation in Monsoon Troughs over the Western North Pacific显示文摘The monsoon trough(MT) is one of the large-scale patterns favorable for tropical cyclone(TC) formation over the western North Pacific(WNP). This study re-examines TC formation by treating the MT as a large-scale background for TC activity during May–October. Over an 11-year(2000–10) period, 8.3 TC formation events on average per year are identified to occur within MTs, accounting for 43.1% of the total TC formation events in the WNP basin. This percentage is much lower than those reported in previous studies. Further analysis indicates that TC formation events in monsoon gyres were included at least in some previous studies. The MT includes a monsoon confluence zone where westerlies meet easterlies and a monsoon shear line where the trade easterlies lie north of the monsoon westerlies. In this study, the large-scale flow pattern associated with TC formation in the MT is composited based on the reference point in the confluence zone where both the zonal and meridional wind components are zero with positive vorticity. While previous studies have found that many TCs form in the confluence zone, the composite analysis indicates that nearly all of the TCs formed in the shear region, since the shear region is associated with stronger low-level relative vorticity than the confluence zone. The prevailing easterly vertical shear of zonal wind and barotropic instability may also be conducive to TC formation in the shear region, through the development of synoptic-scale tropical disturbances in the MT that are necessary for TC formation. | ZONG Huijun WU Liguang | 2015 | Advances in Atmospheric Sciences2015，32，7： | 5 |
| 12 | A detached petal disc assay and virus-induced gene silencing facilitate the study of Botrytis cinerea resistance in rose flowers显示文摘Fresh-cut roses(Rosa hybrida)are one of the most important ornamental crops worldwide,with annual trade in the billions of dollars.Gray mold disease caused by the pathogen Botrytis cinerea is the most serious fungal threat to cut roses,causing extensive postharvest losses.In this study,we optimized a detached petal disc assay(DPDA)for artificial B.cinerea inoculation and quantification of disease symptoms in rose petals.Furthermore,as the identification of rose genes involved in B.cinerea resistance could provide useful genetic and genomic resources,we devised a virusinduced gene silencing(VIGS)procedure for the functional analysis of B.cinerea resistance genes in rose petals.We used RhPR10.1 as a reporter of silencing efficiency and found that the rose cultivar‘Samantha’showed the greatest decrease in RhPR10.1 expression among the cultivars tested.To determine whether jasmonic acid and ethylene are required for B.cinerea resistance in rose petals,we used VIGS to silence the expression of RhLOX5 and RhEIN3(encoding a jasmonic acid biosynthesis pathway protein and an ethylene regulatory protein,respectively)and found that petal susceptibility to B.cinerea was affected.Finally,a VIGS screen of B.cinerea-induced rose transcription factors demonstrated the potential benefits of this method for the high-throughput identification of gene function in B.cinerea resistance.Collectively,our data show that the combination of the DPDA and VIGS is a reliable and highthroughput method for studying B.cinerea resistance in rose. | Xiaoqian Cao Huijun Yan Xintong Liu Dandan Li Mengjie Sui Jie Wu Hongqiang Yu Zhao Zhang | 2019 | Horticulture Research2019，6，1： | 5 |
| 13 | Preparation of Ag@AgCl-doped TiO_2/sepiolite and its photocatalytic mechanism under visible light显示文摘A cube-like Ag@Ag Cl-doped TiO_2/sepiolite(denoted Ag@Ag Cl–TiO_2/sepiolite) was successfully synthesized via a novel method. X-ray diffraction, scanning electron microscopy, energy dispersion X-ray fluorescence, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and diffuse reflectance ultraviolet–visible spectroscopy were performed to determine the structure and physicochemical properties of Ag@Ag Cl–TiO_2/sepiolite. SEM micrographs revealed that Ag@Ag Cl nanoparticles and TiO_2 film are well deposited on the surface of tube-like sepiolite. As a result, Ag@Ag Cl–TiO_2/sepiolite exhibits a red shift relative to TiO_2/sepiolite. Photocatalytic experiments demonstrated that the dosage of catalysts plays an important role during photocatalysis. The photoelectrochemical activities of Ag@Ag Cl–TiO_2/sepiolite and TiO_2/sepiolite were also investigated. Photocurrent responses confirmed that the ability of Ag@Ag Cl–TiO_2/sepiolite to separate photo-generated electron–hole pairs is stronger than that of TiO_2/sepiolite. Methylene Blue degradation is also improved under alkaline conditions and visible light irradiation because more UOH is produced by visible light excitation.This excellent catalytic ability is mainly attributed to the formed Ag nanoparticles and the Schottky barrier at the Ag/TiO_2 interface. Active species analysis indicated that UO2-and h+are implicated as active species in photocatalysis. Therefore, catalysts are excited to produce abundant electron–hole pairs after they absorb photons in photocatalysis. | Shaomin Liu Dinglong Zhu Jinglin Zhu Qing Yang Huijun Wu | 2017 | Journal of Environmental Sciences2017，29，10： | 5 |
| 14 | Sliding mode H_∞ control for a class of uncertain nonlinear state-delayed systems显示文摘A new proportional-integral (PI) sliding surface is designed for a class of uncertain nonlinear state-delayed systems. Based on this, an adaptive sliding mode controller (ASMC) is synthesized, which guarantees the occurrence of sliding mode even when the system is undergoing parameter uncertainties and external disturbance. The resulting sliding mode has the same order as the original system, so that it becomes easy to solve the H_∞ control problem by designing a memoryless H_∞ state feedback controller. A delay-dependent sufficient condition is proposed in terms of linear matrix inequalities (LMIs), which guarantees the sliding mode robust asymptotically stable and has a noise attenuation level γ in an H_∞ sense. The admissible state feedback controller can be found by solving a sequential minimization problem subject to LMI constraints by applying the cone complementary linearization method. This design scheme combines the strong robustness of the sliding mode control with the H_∞ norm performance. A numerical example is given to illustrate the effectiveness of the proposed scheme. | Wu Ligang Wang Changhong Gao Huijun Zhang Lixian | 2006 | Journal of Systems Engineering and Electronics2006，17，3： | 4 |
| 15 | Spatiotemporal characteristics of freezing and thawing of the active layer in the source areas of the Yellow River(SAYR)显示文摘Based on the analysis of data on temperatures and moisture of soils in the active layer at four different permafrost sites in the source areas of the Yellow River(SAYR)in 2010–2012,the freeze–thaw processes of soils in the active layer were compared and contrasted for understanding the spatiotemporal variations.At the four studied sites,the thickness and mean annual temperature of permafrost are different.The temperatures at the top of permafrost(TTOP),i.e.,the maximum depth(s)of seasonal frost and/or thaw penetration,are-1.9°C at the Chalaping site(CLP),-0.9°C at the site on the southern bank of the Zhaling Lake(ZLH),-0.4°C at the Maduo Town site(MDX),and 1.1°C at the site on the northern bank of the Eling Lake(ELH).Differences in the mean annual ground temperature of permafrost and TTOPs may be responsible for the differentiations in the freeze–thaw processes of soils in the active layer.With rising TTOPs,the ground thawing started earlier:CLP in early June,ZLH in late May,MDX in early May,and ELH in mid-April,while the freezing began later:CLP in early October,ZLH in early to midOctober,MDX in mid-October,and ELH in the mid-to late October.With increasing TTOPs,the freeze-up periods for permafrost sites were shortened:202 days at CLP,130 days at ZLH,100 days at MDX,and the period of complete thaw was 89 days at ELH.At the CLP and ZLH sites,the two-directional ground freezing(downwards from ground surfaces and upwards from the permafrost table)and thawing finished in the same year,but the ground freezing at the MDX continued to the end of the nextJanuary,with very slow freezing rates in the end.At the ELH site,ground freezing kept on until early May when thawing began on the surface,and upward and downward thawing became increasingly stable in late June to early July.At each site,with rising TTOPs,the downward freezing accelerated in comparison with the upward freezing,and with an increasing proportion of downward frozen depth,and with the larger ratios of freezing to thawing duration.In summary,the patterns of thawing and freezing processes in the active layer in the SAYR differ from those in other parts of the Qinghai–Tibet Plateau to a noticeable extent. | Dongliang Luo Huijun Jin Lanzhi Lü Qingbai Wu | 2014 | Chinese Science Bulletin2014，59，24： | 4 |
| 16 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 17 | Relationships of nitrous oxide fluxes with water quality parameters in free water surface constructed wetlands显示文摘The effects of chemical oxygen demand(COD)concentration in the influent on nitrous oxide(N_(2)O)emissions,together with the relationships between N_(2)O and water quality parameters in free water surface constructed wetlands,were investigated with laboratoryscale systems.N_(2)O emission and purification performance of wastewater were very strongly dependent on COD concentration in the influent,and the total N_(2)O emission in the system with middle COD influent concentration was the least.The relationships between N_(2)O and the chemical and physical water quality variables were studied by using principal component scores in multiple linear regression analysis to predict N_(2)O flux.The multiple linear regression model against principal components indicated that different water parameters affected N_(2)O flux with different COD concentrations in the influent,but nitrate nitrogen affected N_(2)O flux in all systems. | Juan WU Jian ZHANG Wenlin JIA Huijun XIE Bo ZHANG | 2009 | Frontiers of Environmental Science & Engineering2009，3，2： | 3 |
| 18 | Late Cretaceous Transpressional Fault System: A Case Study of the Yishu Fault Belt, Shandong Province, Eastern China显示文摘On the basis of field observations of the structures of three profiles from the Linshu region, deformation characteristics and the tectonic background of the Yishu fault belt in the Late Cretaceous–Early Cenozoic have been discussed in detail.Three structural profiles, whose deformations consist mainly of earlier transpressional faults and later normal faults, were developed for the Mengtuan Formation of the Lower Cretaceous Dasheng Group.Typical positive flower structures, duplex structures, and break-through faults were found in these profiles.On the basis of analyses of the structural deformation and previous geochronological studies, it was concluded that the earlier transpressional faults of the profiles were triggered by the sinistral transpression of the Yishu fault belt in the Late Cretaceous–Early Paleogene, and that the later normal faults, formed during the Late Paleogene–Neogene extension, truncated the earlier transpressional faults.With consideration of the tectonic evolution of the Tan-Lu fault belt and the different drift directions of the Pacific plate since the Cretaceous, we suggest that the major tectonic events of the Late Cretaceous–Neogene in eastern China were mainly controlled by the subduction of the Pacific plate. | LI Chunlin WANG Zongxiu WU Qingzi LIU Yongqing GAO Wanli TAN Yuanlong KUANG Hongwei LI Huijun | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 3 |
| 19 | High-risk phenotypes of genetic disease in a Neonatal Intensive Care Unit population显示文摘To the Editor: Genetic diseases contribute to 35% of deaths during the first year of life and are a significant cause of intensive care.[1] A previous study based on the China Neonatal Genomes Project investigated the genetic causes of early infant deaths and found that >25% of deceased neonates with genetic diagnoses can be cured if diagnosed in time.[2] Therefore, it is crucial to target and diagnose neonates with genetic diseases as early as possible. According to our experience, the typical phenotypes, such as special facial features or multiple congenital anomalies (MCAs), indicate a high risk of genetic disease and lead physicians to perform genetic testing in neonates as early as possible. However, in practice, infants without typical phenotypes typically undergo a long and costly diagnostic process before genetic diagnoses are confirmed. Moreover, a recent survey by the American College of Medical Genetics and Genomics (ACMG) and other national professional organizations indicated that there are insufficient numbers of qualified geneticists to fulfil genetic service needs.[3] The ACMG published the general clinical features for genetic testing indications. For example, patients with phenotypes or family history data that strongly implicate a genetic cause may undergo genetic testing.[1] However, the study indicated that many genetic conditions arise de novo or are inherited with no family history.[1] A previous study attempted to apply the non-phenotype-driven panel approach in neonates admitted to the neonate intensive care unit (NICU).[4] However, at present, the diagnostic yield is only 3.45% (1/29).[4] In addition, the economic and ethical issues associated with genomic screening remain challenging. Therefore, the available indications for genetic testing may improve the management of genetic diseases. | Tiantian Xiao Qi Ni Huiyao Chen Huijun Wang Lin Yang Bingbing Wu Yun Cao Guoqiang Cheng Laishuan Wang Liyuan Hu Hongfang Mei Yulan Lu Mengchun Gong Xinran Dong Wenhao Zhou | 2022 | Chinese Medical Journal2022，，5： | 2 |
| 20 | Simulation study on three casting processes for a marine propeller hub body显示文摘The mold filling and solidification process of a marine propeller hub were simulated using ProCAST. Three casting processes–gravity casting, centrifugal casting and low pressure casting–were compared in order to get the best process. The heat transfer coefficient of the casting/mold interface was determined using a reverse method. The simulated results of velocity, temperature and shrinkage porosity distribution were discussed in detail for the three casting processes. A smooth filling was found in all three casting processes, especially the low pressure casting exhibiting a better filling performance than the other two, but the solidification processes were different. The casting did not experience the sequential solidification, and the feeding paths were blocked, leading to shrinkage porosity defects in the riser and the bottom of the casting in gravity casting and in the upper zone of the casting in low pressure casting. While, the sequential solidification was well controlled in the solidification process of centrifugal casting, and majority of the shrinkage porosity defects can only be observed in the riser. It could be concluded that the centrifugal casting process is the most suitable casting process for the production of propeller hub body. The casting experiments verified the simulation results, and a defect-free propeller hub was obtained by centrifugal casting with a rotational speed of 150 r·min-1. | Wang Tongmin Li Jia Wu Li Jie Jinchuan Cao Zhiqiang Kang Huijun | 2013 | China Foundry2013，10，6： | 2 |
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