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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 3 | Species clarification of the prize medicinal Ganoderma mushroom“Lingzhi”显示文摘“Lingzhi”is a mushroom that has been renowned in China for more than 2,000 years because of its claimed medicinal properties plus its symbolic fortune.“Lingzhi”has high economic value mostly as a dietary supplement in the modern market especially in East Asia,and its medicinal functions have become a hot study topic.For over a century,the highly prized medicinal fungus,known as“Lingzhi”in East Asia,has been assigned to Ganoderma lucidum,a species originally described from Europe.Molecular studies in recent years have revealed that the commercially cultivated‘G.lucidum’(“Lingzhi”)in East Asia is a different species from the true G.lucidum.The present study aims to clarify the species identity of“Lingzhi”based on morphological studies and analysis of rDNA nuc-ITS sequences,and additional gene fragments of mt-SSU,RPB1,RPB2,and TEF1-αof“Lingzhi”were provided.All Ganoderma species that mostly resemble“Lingzhi”in phylogeny and/or morphology were included for analysis.We propose a new species G.lingzhi for“Lingzhi”,which has an East Asia distribution.The most striking characteristics which differentiate G.lingzhi from G.lucidum are the presence of melanoid bands in the context,a yellow pore surface and thick dissepiments(80–120μm)at maturity.G.curtisii is most closely related to G.lingzhi in phylogeny and is from North America.Ganoderma flexipes,G.multipileum,G.sichuanense,G.tropicum and‘G.tsugae’,are also closely related with G.lingzhi and are reported from China.These species are compared and discussed.‘Ganoderma tsuage’reported from China is determined as conspecific with G.lucidum,hence the distribution of G.lucidum extends from Europe to northeastern China. | Yun Cao Sheng-Hua Wu Yu-Cheng Dai | 2012 | Fungal Diversity2012，，5： | 25 |
| 4 | Carbon isotopic composition of modern soil and paleosol as a response to vegetation change on the Chinese Loess Plateau显示文摘The relationship between the carbon isotopic composition of paleosols and paleovegetation on the Loess Plateau is still unclear. One of the main reasons is that we are short of knowledge about the characteristics of the carbon isotopic composition of modern soil in this area. A preliminary investigation of the carbon isotopic compositions of the modern soil and the loess/paleosol sequence on the Loess Plateau shows that the carbon isotopic composition of modern soil is consistent with the distribution of modern plants on the Loess Plateau, where the ecosystem is dominated by a mixture of C4 and C3 plants. Comparing theδ13C values of modern soil and loess-paleosol sequences from the Xunyi profile, we conclude that C3 plants dominated the landscape during loess sediment stages, while C4 plants expanded during paleosol stages. | LIU Weiguo NING Youfeng AN Zhisheng WU Zhenghai LU Huayu CAO Yunning | 2005 | Science China Earth Sciences2005，48，1： | 24 |
| 5 | Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells显示文摘AIM:To investigate the apoptotic activities of casticin in hepatocellular carcinoma(HCC) cells and its molecular mechanisms.METHODS:PLC/PRF/5 and Hep G2 cell lines were cultured in vitro and the inhibitory effect of casticin on the growth of cells was detected by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolim bromide(MTT) assay.The apoptotic cell death was examined using the cell apoptosis enzyme linked immunosorbent assay(ELISA) detection kit,flow cytometry(FCM) after propidium iodide(PI) staining and DNA agarose gel electrophoresis.The caspase activities were measured using ELISA.Reactive oxygen species(ROS) production was evaluated by FCM after dichlorodihydrofluorescein diacetate(DCFH-DA) probe labeling.Intracellular glutathione(GSH) content was measured using a glutathione assay kit.The expression of death receptor(DR)4 and DR5 proteins was analyzed by Western blotting and FCM.RESULTS:Casticin significantly inhibited the growth of human HCC(PLC/PRF/5 and Hep G2) cells in a dosedependent manner(P < 0.05).Casticin increased the percentage of the sub-G1 population in HCC cells in a concentration-dependent manner.The potency of casticin to PLC/PRF/5 cells was higher than that of 5-flurouracil(26.8% ± 4.8% vs 17.4% ± 5.1%) at 10 μmol/L for 24 h.Casticin increased the levels of Histone/DNA fragmentation and the levels of active caspase-3,-8 and-9 in a concentration-dependent manner(P < 0.05).Treatment with 30 μmol/L casticin for 24 h resulted in the formation of a DNA ladder.Casticin reduced the GSH content(P < 0.05),but did not affect the level of intracellular ROS in PLC/PRF/5 and Hep G2 cells.The thiol antioxidants,acetylcysteine(NAC) and GSH restored GSH content and attenuated casticin-induced apoptosis.In contrast,the nonthiol antioxidants,butylated hydroxyanisole and mannitol failed to do so.In the HCC cells treated with casticin for 24 h,DR5 protein level was increased.The expression of DR5 protein induced by casticin was inhibited by NAC.Pretreatment with DR5/Fc chimera protein,a blocking antibody,effectively attenuated the induction of apoptosis by casticin.CONCLUSION:Casticin-induced apoptosis of HCC cells is involved in GSH depletion and DR5 upregulation. | Jun Yang Yun Yang Li Tian Xi-Feng Sheng Fei Liu Jian-Guo Cao | 2011 | World Journal of Gastroenterology2011，17，38： | 21 |
| 6 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 7 | Prognostic analysis of patients with gastrointestinal stromal tumors: a single unit experience with surgical treatment of primary disease显示文摘背景胃肠的 stromal 肿瘤(大意) ,胃肠的道的间充质的肿瘤的最普通的类型,是一个最近公认的肿瘤。大意的生物行为是高度可变的。外科的切除术为大意仍然是主要治疗。在这研究,我们回顾地与 181 个大意病人一起分析了我们的外科的经验决定治疗和病理学的特征和这些大意 patients.Methods 的预后因素的效果在 Ren 收到了在1999年1月和2007年12月之间的外科的切除术的有大意的 181 个病人的 clinicopathological 特征和后续数据 Ji 医院回顾地被考察。包括 CD117 (工具包) 的 Immunohistochemical 污点, CD34,和另外的标记被使用。肿瘤尺寸,有丝分裂的索引和另外的病理学的参数被记录。根据 NIH 风险组层化系统的一致基于最大的肿瘤尺寸和有丝分裂的索引(每 50 高力量地),肿瘤被分类进 very-low-risk 组( 15 个肿瘤,8.3%),低风险的组( 48 ,26.5%),中间风险的组( 52 ,28.7%)并且高风险的组( 66 ,36.5%)。预示的因素被考克斯分析包括年龄,性别,肿瘤尺寸,肿瘤地点,有丝分裂的索引, NIH 范畴和外科的过程分析。结果(59.1%) 107 181 个肿瘤位于胃, 51 (28.2%) 在小肠, 9 (5.0%) 在冒号和直肠,并且 14 (7.7%) 在另外的地点包括网膜和肠系膜。病人的中部的年龄是 58 (范围, 24-84 ) 年,和 102 个病人(56.4%) 是男性的。肿瘤尺寸从 0.5 ~ 30 厘米,当吝啬的尺寸是 7.02 厘米时。转移在 7 个病人被发现。(97.2%) 176 181 个病人经历了激进的切除术,并且在他们之中, 26 个病人与邻近的机关支持者一起收到了广泛的切除术到肿瘤。为在 immunostaining 的 KIT 蛋白质(CD117 ) 的积极的率是 94.5%(171/181 ) ,当那为 CD34 是 86.2% 时(156/181 ) 。1- , 3- ,和 181 个病人的 5 年的幸存率被估计分别地是 95.2% , 87.9% 和 78.5% 。在 multivisceral 切除术的年龄,肿瘤尺寸,肿瘤地点,有丝分裂的索引, NIH 范畴,和存在或缺席有重要差别(P < 0.05 ) 。但是在在这些组之间的性别没有重要差别。比例的模型揭示了的考克斯危险那个先进临床的阶段和大肿瘤尺寸贡献了更坏的预后。因为复发和转移或高复发风险,与 imatinib 被对待的病人显示出外科的切除术是的稳定的 disease.Conclusions 为主要大意的治疗的标准答案。NIH 分类简单、有效评估大意行为和预后。指向的治疗象 imatinib 那样,一个工具包酷氨酸 kinase 禁止者,可以在大意的治疗起一个重要作用。 | CAO Hui ZHANG Yun WANG Ming SHEN Dan-ping SHENG Zhi-yong NI Xing-zhi WU Zhi-yong LIU Qiang SHEN Yan-ying SONG Yan-yan | 2010 | Chinese Medical Journal2010，，2： | 20 |
| 8 | A Highly Pathogenic Strain of Porcine Deltacoronavirus Caused Watery Diarrhea in Newborn Piglets显示文摘Porcine deltacoronavirus(PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and China's Mainland. Here we isolated a strain of PDCoV, named CHN-GD-2016,from the intestinal content of a diseased newborn piglet with severe diarrhea in a pig farm in Guangdong, China. PDCoV CHN-GD-2016 could be identified by immunofluorescence with PDCoV specific rabbit antisera, and typical crown-shaped particles with spiky surface projections of this PDCoV were observed with electron microscopy. Genomic analysis showed that the PDCoV CHN-GD-2016 was closely related to other Chinese PDCoV strains, with the highest sequence similarity with the strain CHN/Tianjin/2016. Importantly, inoculation of newborn piglets with 1×10~5 TCID_(50) of CHN-GD-2016 by oral feeding successfully reproduced clear clinical symptoms, including vomiting, dehydration, and severe diarrhea in piglets. In addition, the virus RNA in rectal swabs from 1 to 7 days post inoculation was detected, macroscopic and microscopic lesions in small intestine were observed, and viral antigen was also detected in the small intestines with immunohistochemical staining. Collectively, the data show in this study confirms that PDCoV is present in Guangdong,China and is highly pathogenic in newborn piglets. | Zhichao Xu Huiling Zhong Qingfeng Zhou Yunping Du Li Chen Yun Zhang Chunyi Xue Yongchang Cao | 2018 | Virologica Sinica2018，33，2： | 16 |
| 9 | Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage显示文摘Ferroptosis is a form of iron-dependent regulated cell death.Evidence of its existence and the effects of its inhibitors on subarachnoid hemorrhage(SAH)is still lacking.In the present study,we found that liproxstatin-1 protected HT22 cells against hemin-induced injury by protecting mitochondrial functions and ameliorating lipid peroxidation.In in vivo experiments,we demonstrated the presence of characteristic shrunken mitochondria in ipsilateral cortical neurons after SAH.Moreover,liproxstatin-1 attenuated the neurological deficits and brain edema,reduced neuronal cell death,and restored the redox equilibrium after SAH.The inhibition of ferroptosis by liproxstatin-1 was associated with the preservation of glutathione peroxidase 4 and the downregulation of acylCoA synthetase long-chain family member 4 as well as cyclooxygenase 2.In addition,liproxstatin-1 decreased the activation of microglia and the release of IL-6,IL-1 b,and TNF-a.These data enhance our understanding of cell death after SAH and shed light on future preclinical studies. | Yang Cao Yin Li Chao He Feng Yan Jian-Ru Li Hang-Zhe Xu Jian-Feng Zhuang Hang Zhou Yu-Cong Peng Xiong-Jie Fu Xiao-Yang Lu Yuan Yao Yu-Yu Wei Yun Tong Yi-Fu Zhou Lin Wang | 2021 | Neuroscience Bulletin2021，37，4： | 16 |
| 10 | Performance analysis and comparison of PoW,PoS and DAG based blockchains显示文摘In the blockchain,the consensus mechanism plays a key role in maintaining the security and legitimation of contents recorded in the blocks.Various blockchain consensus mechanisms have been proposed.However,there is no technical analysis and comparison as a guideline to determine which type of consensus mechanism should be adopted in a specific scenario/application.To this end,this work investigates three mainstream consensus mechanisms in the blockchain,namely,Proof of Work(PoW),Proof of Stake(PoS),and Direct Acyclic Graph(DAG),and identifies their performances in terms of the average time to generate a new block,the confirmation delay,the Transaction Per Second(TPS)and the confirmation failure probability.The results show that the consensus process is affected by both network resource(computation power/coin age,buffer size)and network load conditions.In addition,it shows that PoW and PoS are more sensitive to the change of network resource while DAG is more sensitive to network load conditions. | Bin Cao Zhenghui Zhang Daquan Feng Shengli Zhang Lei Zhang Mugen Peng Yun Li | 2020 | Digital Communications and Networks2020，6，4： | 15 |
| 11 | Effect of Nitrate on Activities and Transcript Levels of Nitrate Reductase and Glutamine Synthetase in Rice显示文摘Real-time polymerase chain reaction analysis was used to compare the effect of NO-3on the activities of nitrate reductase(NR)and glutamine synthetase(GS),and the transcript levels of two NR genes,OsNia1 and OsNia2,two cytosolic GS1 genes,OsGln1;1 and OsGln1;2,and one plastid GS2 gene OsGln2,in two rice(Oryza sativa L.)cultivars Nanguang(NG)and Yunjing(YJ).Both cultivars achieved greater biomass and higher total N concentration when grown in a mixed N supply than in sole NH+ 4nutrition.Supply of NO -3increased NR activity in both leaves and roots.Expression of both NR genes was also substantially enhanced and transcript levels of OsNia2 were significantly higher than those of OsNia1.NO-3also caused an increase in GS activity,but had a complex effect on the expression of the three GS genes.In roots,the OsGln1;1 transcript increased,but OsGln1;2 decreased.In leaves,NO-3had no effect on the GS1 expression,but the transcript for OsGln2 increased both in the leaves and roots of rice with a mixed supply of N.These results suggested that the increase in GS activity might be a result of the complicated regulation of the various GS genes. In addition,the NO-3 induced increase of biomass,NR activity,GS activity,and the transcript levels of NR and GS genes were proportionally higher in NG than in YJ,indicating a stronger response of NG to NO-3nutrition than YJ. | CAO Yun FAN Xiao-Rong SUN Shu-Bin XU Guo-Hua HU Jiang SHEN Qi-Rong | 2008 | Pedosphere2008，18，5： | 14 |
| 12 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 13 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 14 | Effect of Rapid Eye Movement Sleep Behavior Disorder on Obstructive Sleep Apnea Severity and Cognition of Parkinson's Disease Patients显示文摘 | Jun-Ying Huang Jin-Ru Zhang Yun Shen Hui-Jun Zhang Yu-Lan Cao Cheng-Jie Mao Ya-Ping Yang Jing Chen Chun-Feng Liu Jie Li | 2018 | Chinese Medical Journal2018，，8： | 12 |
| 15 | Hydrogen peroxide modulates abscisic acid signaling in root growth and development in Arabidopsis显示文摘Exogenous abscisic acid(ABA)can inhibit root growth and promote formation of more root hairs in the root tip of Arabidopsis.However,the molecular mechanisms that underlie root ABA signaling are largely unknown.We report here that hydrogen peroxide(H2O2)reduces the root growth of wild type, and the phenotype of H2O2 on the root growth is similar to ABA response.Meanwhile ABA-induced changes in the morphology of root system can be partly reversed by ascorbic acid in wild type and abolished in NADPH oxidase defective mutant atrbohF and atrbohC.Further,ABA can induce H2O2 accumulation in the root cells and enhance transcription level of OXI1,which is necessary for many more AOS-dependent processes such as root hair growth in Arabidopsis.Our results suggest that H2O2 as an important signal molecule is required for the ABA-regulated root growth and development in Arabidopsis. | BAI Ling ZHOU Yun ZHANG XiaoRan SONG ChunPeng Cao MingQing | 2007 | Chinese Science Bulletin2007，52，8： | 12 |
| 16 | A^200 ka pollen record from Okinawa Trough:Paleoenvironment reconstruction of glacial-interglacial cycles显示文摘Pollen analysis was carried out on the Core MD982194 of 29.78 m retrieved from the Middle Okinawa Trough which was dated as old as^200 ka BP.The results revealed that pollen assemblages mainly presented an alternation of coniferous and herb pollen.The coniferous saccate pollen,principally Pinus and Tsuga,predominated in most parts of the core,especially highlighted in the interstadial stages including MIS 1,3,5 and MIS7,whereas the herb pollen significantly increased in the glacial periods.Thus the pollen flora and their percentages showed the sensitive changes under the influence of ice volume during the glacial and interglacial periods.Our record from this core has first documented that the percentage of Cyperaceae was extremely high in the glacial stages with a notable increase in Artemisia,Gramineae,Asteraceae,Chenopodiaceae,and freshwater algae,which can be used as a proxy for sea-level change at the study site because of their close negative correlation of the orbital-scale changes in sea level.The distance between the continental coastline and the Okinawa Trough has deeply shortened due to the sea-level drop in the LGM.As a result,the sediment materials from Yangtze River were extensively deposited on the flat,exposed continental shelf owing to the rapid decline of river flow speed,leading to that pollen grains from Okinawa Trough are derived mainly from the flat coastal vegetation of exposed continental shelf at glacial stages.Changes of pollen assemblage were consistent with the variation of temperature and humidity,which showed that the percentage of arboreal pollen was highly augmented at MIS 7,5 and MIS 1,corresponding to the strengthening of the East Asian summer monsoon and increasing of rainfall.Moreover,the peak of Pinus percentage in MIS 5.3,5.1 and MIS 3.3 may be closely linked by orbital and sub-orbital cycles of solar radiation and monsoonal variability.The present study of core MD981294 implied lower temperature and precipitation during the lowest sea-level stage(LGM),and more visibly testified that the vegetation of the flat plain on the exposed continental shelf was dominated by intrazonal communities such as halophyte grasslands and freshwater wetlands instead of zonal steppe or semi-arid desert.All above evidence demonstrated that the fundamental changes of pollen assemblage and their origins in Okinawa Trough since^200 ka BP were affected by combine factors including the coastline position and climate fluctuation.Moreover,the substantial shortening of distance between shoreline and the Okinawa Trough driven by orbital insolation cycles was clearly indicated by the pollen spectra,whereas the source-area climate signal of the pollen record was largely weakened. | ZHENG Zhuo HUANG KangYou DENG Yun CAO LingLong YU ShaoHua Jean-Pierre SUC Serge BERNE Franois GUICHARD | 2013 | Science China Earth Sciences2013，56，10： | 11 |
| 17 | Intra-operative frozen section diagnosis of breast lesions:a retrospective analysis of 13 243 Chinese patients显示文摘背景尽管为胸肿瘤学的 cytological 方法在最近的十年被使用了, intra 起作用的冻结的节在做治疗学的决定一直在起一个重要作用。我们分析了冻结的节的一个大系列最后 15 年为汉语诊断在内的胸损害的盒子。经验被期望与胸 lesions.Methods 增加盒子的诊断精确性数据从连续与在 1988 ~ 2002 之间的 intra 起作用的冻结的节诊断的胸损害的 13243 个盒子与在由盒子举止的一种情况中的石蜡节相比。原因假否定、积极诊断象一样推迟诊断是 analyzed.Results 117 个盒子(0.9%) 虚伪地被诊断,与一个假积极盒子和 116 个假否定盒子。47 个盒子(0.4%) 的诊断被推迟。几损害的比例有 patients'ages 的特征。损害的六种类型(假侵略,仙子乳突淋瘤,乳头管的腺瘤,红润的 adenosis , sclerosing adenosis ,和淀粉粒质房间肿瘤)可以导致假积极,并且四种类型(词法变化反应化疗,很好区分的乳突的癌,侵略的小叶片的癌,并且管状的癌)到一假否定。粗野、显微镜的调查结果可能在在三的显微镜、临床的调查结果打的损害(光线的疤和红润的 adenosis ) 的二种类型是不一致的(ganulomatous 乳腺炎乳房,管 ectasia,和胖坏死) ,并且三种类型(丰富的胖或硬术的纸巾;边线损害和变化化疗以后) 错误地是可能的 Intra 起作用的冻结的节能精确地识别的 classified.Conclusions 在许多例子的胸损害,由于诊断限制的更诊断的经验和理解,导致更少错误。 | NIU Yun FU Xi-lin YU Yong Peizhong Peter Wang CAO Xu-chen | 2007 | Chinese Medical Journal2007，，8： | 11 |
| 18 | Optimal in vitro culture conditions for murine predominant immature CD8a^+ dendritic cells显示文摘背景使用树枝状的房间(DC2 ) 移植建立的不成熟的 CD8a+ 的前景为在未来的自体免疫的疾病的 immunologic 忍耐和处理是有希望的。然而,为导致 DC2 的方法仍然正在被探索。现在的学习被瞄准调查处于为准备大数字 f 的 vitro 条件最佳从鼠科的骨头髓 cells.Methods 的占优势的 DC2 在不同条件下面有教养的三组骨头髓房间被检验,也就是一个 导致cytokine 的试验性的组( cytokine 组),有刺激因素的granulocyte巨噬细胞殖民地的低集中的一个控制组( GM-CSF ,低 GM-CSF 组)并且没有 ndogenous cytokines 的一个控制组。cytokine 组与 5 ng/ml GM-CSF 是有教养的, 25 ng/ml Fit3 ligand (Flt3L ) , 20 ng/ml interleukin 4 (IL-4 ) 并且 100 ng/ml 干细胞因素(SCF ) 。低 GM-CSF 控制组与 0.4 ng/ml GM-CSF, 25 ng/ml FIt3L 和 100 ng/ml SCF 是有教养的,没有 IL-4。没有 dditional cytokines,没有外长的 cytokines 的控制组是有教养的。所有房间在 5% CO2 下面在 37 点是有教养的。在天 3, 7 和 16, 4 颜色流动 cytometry 被执行分析房间显型,和全部的房间数字被认为分析房间收益。阶段对比显微镜学被用来观察到 cytokine 组更高展出了的房间 morphologies.Results 分配 f 典型不成熟的 CD8a+ DC 特别在白天 3 上,但是全部的房间数字和 DC2 比例在延长文化期间减少了。低 GM-CSF 控制组在天显示出象 cytokine 组的一样的趋势 16 和 22,但是生产更高全部的房间数字(P < 0.05 ) 与更低的 DC2 比例和房间数字。没有外长的 cytokines 的控制组自发地产生了 DC2 的某个比例,但是与低全部的房间和 DC2 数字,那很快减少了,特别在延长文化期间(天 7 和 16 , P < 0.05 ) .Conclusions 文化面对 5 ng/ml GM-CSF , 25 ng/ml Flt3L , 20 ng/ml IL-4 和 100 ng/ml SCF 能很快从鼠科的骨头髓房间导致占优势的不成熟的CD8a+ DC 的大数量。因此,这些为在 vitro 准备鼠科的不成熟的 DC2 代表最佳的文化条件。 | NA Ning XU Lin CAO Kai-yuan LUO Yun YUAN Guang-qing XIANG Peng HONG Liang-qing LI Shu-nong | 2009 | Chinese Medical Journal2009，，3： | 11 |
| 19 | Very high baseline HIV viremia impairs efficacy of non-nucleoside reverse transcriptase inhibitor-based ART:a longterm observation in treatment-naïve patients显示文摘Background:It is not completely clear whether a very high pre-therapy viral load(≥500000 copies/ml)can impair the virological response.The aim of this study was to examine the influence of very high baseline HIV-RNA levels on long-term virological responses under one type of regimen.Methods:A retrospective study was performed based on data from two multicenter cohorts in China from January to November 2009,and from May 2013 to December 2015.Untreated HIV infected adults between 18 and 65 years old were recruited before receiving non-nucleoside reverse transcriptase inhibitor-based regimen.All patients had baseline HIV-RNA levels over 500 copies/ml,good adherence,and were followed for at least 24 weeks.Virological suppression was defined as the first HIV-RNA<50 copies/ml.Virological failure was defined as any of incomplete viral suppression(HIV-RNA≥200 copies/ml without virological suppression within 24 weeks of treatment)and viral rebound(confirmed HIV-RNA level≥50 copies/ml after virological suppression).Chi-square test,Kaplan–Meier analysis,Cox proportional hazards model and Logistic regression were used to compare virological response between each pretreated viral load stratum.Results:A total of 758 treatment-naïve HIV patients in China were enlisted.Median follow-up time(IQR)was 144(108–276)weeks.By week 48,rates of virological suppression in three groups(<100000,100000–500000 and≥500000 copies/ml)were 94.1,85.0,and 63.8%,respectively(P<0.001).Very high baseline HIV viremia over 500000 copies/ml were found to be associated with delayed virological suppression(≥500000 vs<100000,adjusted relative hazard=0.455,95%CI:0.32–0.65;P<0.001)as well as incomplete viral suppression(≥500000 vs<100000,adjusted odds ratio[aOR]=6.084,95%CI:2.761–13.407;P<0.001)and viral rebound(≥50000 vs<100000,aOR=3.671,95%CI:1.009–13.355,P=0.048).Conclusions:Very high levels of pre-treatment HIV-RNA were related with delayed efficacy of NNRTI-based ART and increased risk of treatment failure.More potent initial regimens should be considered for those with this clinical character. | Shuai Chen Yang Han Xiao-Jing Song Yan-ling Li Ting Zhu Hong-Zhou Lu Xiao-Ping Tang Tong Zhang Min Zhao Yun He Sheng-Hua He Min Wang Yong-Zhen Li Shao-Biao Huang Yong Li Jing Liu Wei Cao Tai-Sheng Li | 2020 | Infectious Diseases of Poverty2020，9，3： | 10 |
| 20 | Selective inhibition of Hepatocarcinoma cells by apatite nanoparticles显示文摘The effects of HAP nanoparticles on growth of primary normal animal liver cells and on growth of hepatocarcinoma cell line Bel 7402 in vitro were studied respectively and were compared with each other.The results showed that HAP nanoparticles in certain concentration inhibited growth of cancer cells significantly while did not inhibite normal cells in the same concentration.The inhibition ratio was as high as very high dosage of adriamycin.It was concluded that HAP nanoparticles can selectively inhibited cancer cells. | SUN En jie 1, LI Shi pu 2 ,YAN Yu hua 2 CAO Xian ying 2,FENG Ling yun 2 , XIONG Xian li 2,ZHANG Zhu 2 1 College of Materials Science and Engineering 2 Biomedical Materials And Engineering Center Wuhan University of Science and Technol | 2002 | Chinese Journal of Biomedical Engineering(English Edition)2002，11，2： | 10 |
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