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| 1 | 加拿大基层医疗改革的创新型及多元化策略显示文摘基层医疗卫生服务体系在世界各国的医疗卫生服务系统中均发挥着重要作用。在过去十年中,加拿大省及地方卫生系统运用了多种方法改善基层医疗卫生服务,改革方案涵盖了目标医疗组织架构、医疗服务者薪酬、医疗服务者数量、医疗服务质量及安全性等方面,改革成果大大提升了家庭医学这个专业实践领域的吸引力,家庭医学吸引了越来越多的医学应届毕业生。这对我国健全基层医疗卫生服务体系具有重要借鉴意义。为此,本刊特别翻译和报道了加拿大基层医疗改革的创新型及多元化策略,敬请关注! | Erin Strumpf Jean-Frédéric Levesque Natalie Coyle Brian Hutchison Marsha Barnes Robert J.Wedel 魏亚萌 | 2015 | 中国全科医学2015，18，31： | 4 |
| 2 | 缺氧中和缺氧后亚低温时炎症基因表达谱的变化显示文摘目的了解缺氧中和缺氧后亚低温时炎症相关基因的变化。方法将体外培养的人脑血管内皮细胞(HCEC)分为对照组和实验组。对照组细胞常规培养,实验组细胞去掉细胞培养液,更换为无血清、低糖M199,置于缺氧箱房中,再分为2组:Ⅰ组为常温缺氧后低温恢复;Ⅱ组为低温缺氧后常温恢复。取细胞并分离总RNA后,用DNA微列阵技术观察缺氧以及缺氧中和缺氧后亚低温时HCEC炎症相关基因表达谱的变化。结果1)白介素-1受体1型(IL-1R1)、类1型白介素-1受体(IL-1RL1)、白介素-1β(IL-1β)、白介素-11(IL-11)、γ-干扰素调节因子2(IRF2)和集落刺激因子1(CSF1)分别在某些时间点上调;白介素-1受体拮抗剂(IL-1RN)、白介素-6(IL-6)、γ-干扰素受体2(IFNGR2)、集落刺激因子3受体(CSF3R)、淋巴细胞黏附因子1(SELL)、细胞间黏附因子3(ICAM3)、血小板/内皮细胞黏附因子(PECAM1)和内皮细胞黏附因子1(SELE)则在不同的时间点下调;γ-干扰素诱导蛋白30(IFI30)在某一些时间点上调,但在低温缺氧后常温恢复时下调;肿瘤坏死因子家庭成员7(TNFRSF7)则仅在低温时下调。2)缺氧4 h、32℃低温使下调基因增多。结论缺氧可以使IL-1βI、L-1RL1I、L-1R1等部分损伤性炎症基因表达上调,IL-11的上调可能为保护性反应;TNF基因表达的上调可能起双重作用。 | 崔红 张万东 Jamie Hutchison Danica Stanimirovic | 2006 | 首都医科大学学报2006，27，1： | 4 |
| 3 | Acute Intramural Hematoma of the Aorta: A Mystery in Evolution显示文摘 | Arturo Evangelista Debabrata Mukherjee Rajendra H. Mehta Patrick T. O’Gara Rossella Fattori Jeanna V. Cooper Dean E. Smith Jae K. Oh Stuart Hutchison Udo Sechtem Eric M. Isselbacher Christoph A. Nienaber Linda A. Pape Kim A. Eagle | 2005 | Circulation2005，，8： | 2 |
| 4 | Transmission of the U.S. subprime crisis to emerging markets: Evidence on the decoupling–recoupling hypothesis显示文摘 | Michael Dooley Michael Hutchison | 2009 | Journal of International Money and Finance2009，，8： | 2 |
| 5 | On the mechanics of delamination and spalling in compressed films显示文摘 | Evans A G Hutchison J W | 1993 | Int J Solids Structures1993，74，2： | 2 |
| 6 | On the mechanics of delamination and spalling in compressed films显示文摘 | Evans A G Hutchison J W | 1993 | Int J Solids Structures1993，74，2： | 2 |
| 7 | Challenges in acute post-operative pain management显示文摘 | ROB W. HUTCHISON | 2007 | 2007 (6 Su)2007，，6： | 2 |
| 8 | Garnet provenance studies, juxtaposition of Laurentian marginal terranes and timing of the Grampian Orogeny in Scotland 显示文摘 | Hutchison A R Oliver G J H | 1988 | Bulletin of the Geological Society London1988，155，： | 1 |
| 9 | AAV-2 mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B显示文摘 | Manno C S Chew A J Hutchison S | 2003 | Blood2003，101，8： | 1 |
| 10 | A role for platelets and endothelial selectins in tumor necro-sis factor-α-induced leukocyte recruitment in the brain microvasculature显示文摘 | Carvalho-Tavares J Hickey MJ Hutchison J | 2000 | Circ Res2000，87，12： | 1 |
| 11 | The ‘Raiang accretionary prism’ and ‘the Lupar line’ problem of Borneo显示文摘 | Hutchison C S | 1986 | Bulletin of the Geological Society of Malaysia1986，20，： | 1 |
| 12 | Developmental potential of embryos produced by in-vitro fertilization from gonadotropin-releasing hormone antagonist-treated macaques stimulated with recombinant human follicle stimulating hormonealone orin combination with luterinzing hormone 显示文摘 | Weston AM Zelinski-wooten MB Hutchison JS | 1996 | Hum Repred1996，11，： | 1 |
| 13 | Lamins in disease:why do ubiquitously expressed nuclear envelope proteins give rise to tissue-specific disease phenotypes?显示文摘 | Hutchison CJ Alvarez-Reyes M Vaughan OA | 2001 | J Cell Sci2001，114，1： | 1 |
| 14 | The architecture of a deciduous forest canopy in eastern Tennessee, USA 显示文摘 | HUTCHISON B A MATT D R MCMILLEN R T | 1986 | Journal of Ecology1986，74，3： | 1 |
| 15 | The removal of mercury from water by open chain ligands containing multiple sulfurs显示文摘 | Hutchison A Atwood D Q Santilliann-Jiminez E | 2008 | Journal of Hazardous Materials2008，156，： | 1 |
| 16 | Hypothermia therapy after traumatic brain injury in children显示文摘 | Hutchison JS Ward RE Lacroix J | 2008 | N Engl J Med2008，358，23： | 1 |
| 17 | Transfusion strate- gies for patients in pediatric intensive care units显示文摘 | Lacroix J H6bert PC Hutchison JS | 2007 | N Engl J Med2007，356，16： | 1 |
| 18 | Mastitis in the first year postpartum 显示文摘 | Vogel A Hutchison B L Mitchell E A | 1999 | Birth1999，26，4： | 1 |
| 19 | Osteochondral defects of the talus treated with fresh osteochondral allograft transplanta- tion显示文摘 | Gross AE Agnidis Z Hutchison CR | 2001 | Foot Ankle Int2001，11，： | 1 |
| 20 | Opportunities for im- proving milk production efficiency in dairy cattle: triennial lactation symposium 显示文摘 | Connor E E Hutchison J L Olson K M | 2011 | J Anim Sci2011，90，： | 1 |
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