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| 1 | Rabdosia serra alleviates dextran sulfate sodium salt-induced colitis in mice through anti-inflammation,regulating Th17/Treg balance,maintaining intestinal barrier integrity,and modulating gut microbiota显示文摘Rabdosia serra(R.serra),an important component of Chinese herbal tea,has traditionally been used to treat hepatitis,jaundice,cholecystitis,and colitis.However,the chemical composition of R.serra and its effect against colitis remain unclear.In this study,the chemical composition of the water extract of R.serra was analyzed using ultra performance liquid chromatography coupled with a hybrid linear ion trap quadrupole-orbitrap mass spectrometer(UPLC-LTQ-Orbitrap-MS).A total of 46 compounds,comprising ent-kaurane diterpenoids,flavonoids,phenolic acids,and steroids,were identified in the water extract of R.serra,and the extract could significantly alleviate dextran sulfate sodium salt-induced colitis by improving colon length,upregulating anti-inflammatory factors,downregulating proinflammatory factors,and restoring the balance of T helper 17/T regulatory cells.R.serra also preserved intestinal barrier function by increasing the level of tight junction proteins(zonula occludens 1 and occludin)in mouse colonic tissue.In addition,R.serra modulated the gut microbiota composition by increasing bacterial richness and diversity,increasing the abundance of beneficial bacteria(Muribaculaceae,Bacteroides,Lactobacillus,and Prevotellaceae_UCG-001),and decreasing the abundance of pathogenic bacteria(Turicibacter,Eubacterium_fissicatena_group,and Eubacterium_xylanophilum_group).Gut microbiota depletion by antibiotics further confirmed that R.serra alleviated colitis in a microbiota-dependent manner.Overall,our findings provide chemical and biological evidence for the potential application of R.serra in the management of colitis. | Hongyi Li Yi Wang Shumin Shao Hui Yu Deqin Wang Chuyuan Li Qin Yuan Wen Liu Jiliang Cao Xiaojuan Wang Haibiao Guo Xu Wu Shengpeng Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 4 |
| 2 | The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages显示文摘The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies;however, the underlying mechanism remains underexplored. In this study, we discovered that impaired macrophage phagocytosis contributed to the psychological stressevoked tumor susceptibility, and the stress hormone glucocorticoid(GC) was identified as a principal detrimental factor. Mechanistically, GC disturbed the balance of the 'eat me' signal receptor(low-density lipoprotein receptor-related protein-1, LRP1) and the 'don’t eat me' signal receptor(signal regulatory protein alpha, SIRPa). Further analysis revealed that GC led to a direct, glucocorticoid receptor(GR)-dependent trans-repression of LRP1 expression, and the repressed LRP1, in turn, resulted in the elevatedgene level of SIRPa by down-regulating mi RNA-4695-3 p. These data collectively demonstrate that stress induces the imbalance of the LRP1/SIRPa axis and entails the disturbance of tumor cell clearance by macrophages. Our findings provide the mechanistic insight into psychological stress-evoked tumor susceptibility and indicate that the balance of LRP1/SIRPa axis may serve as a potential therapeutic strategy for tumor treatment. | Yanping Wu Xiang Luo Qingqing Zhou Haibiao Gong Huaying Gao Tongzheng Liu Jiaxu Chen Lei Liang Hiroshi Kurihara Yi-Fang Li Rong-Rong He | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
| 3 | Wavelength-Dependent Solar N_(2) Fixation into Ammonia and Nitrate in Pure Water显示文摘Solar-driven N_(2) fixation using a photocatalyst in water presents a promising alternative to the traditional Haber-Bosch process in terms of both energy efficiency and environmental concern.At present,the product of solar N_(2) fixation is either NH_(4)^(+)or NO_(3)^(-).Few reports described the simultaneous formation of ammonia(NH_(4)^(+))and nitrate(NO_(3)^(-))by a photocatalytic reaction and the related mechanism.In this work,we report a strategy to photocatalytically fix nitrogen through simultaneous reduction and oxidation to produce NH_(4)^(+)and NO_(3)^(-)byW18O49 nanowires in pure water.The underlying mechanism of wavelength-dependent N_(2) fixation in the presence of surface defects is proposed,with an emphasis on oxygen vacancies that not only facilitate the activation and dissociation of N_(2) but also improve light absorption and the separation of the photoexcited carriers.Both NH_(4)^(+)and NO_(3)^(-)can be produced in pure water under a simulated solar light and even till the wavelength reaching 730 nm.The maximum quantum efficiency reaches 9%at 365 nm.Theoretical calculation reveals that disproportionation reaction of the N_(2) molecule is more energetically favorable than either reduction or oxidation alone.It is worth noting that the molar fraction of NH_(4)^(+)in the total product(NH_(4)^(+)plus NO_(3)^(-))shows an inverted volcano shape from 365nm to 730 nm.The increased fraction of NO_(3)^(-)from 365 nm to around 427 nm results from the competition between the oxygen evolution reaction(OER)at W sites without oxygen vacancies and the N_(2) oxidation reaction(NOR)at oxygen vacancy sites,which is driven by the intrinsically delocalized photoexcited holes.From 427nm to 730 nm,NOR is energetically restricted due to its higher equilibrium potential than that of OER,accompanied by the localized photoexcited holes on oxygen vacancies.Full disproportionation of N_(2) is achieved within a range of wavelength from~427nm to~515 nm.This work presents a rational strategy to efficiently utilize the photoexcited carriers and optimize the photocatalyst for practical nitrogen fixation. | Wenju Ren Zongwei Mei Shisheng Zheng Shunning Li Yuanmin Zhu Jiaxin Zheng Yuan Lin Haibiao Chen Meng Gu Feng Pan | 2020 | Research2020，，1： | 1 |
| 4 | Fabbrication and Atomic Force Microscopy/Friction Force Microscopy (AFM/FFM) Studies of Polyacrylamide Carbon Nanotubes(PAM-CNTs) Copolymer Thin Films 显示文摘 | Xuefeng Li Wenchao Guan Haibiao Yan | 2004 | Materials Chemistry and Physics2004，88，1： | 1 |
| 5 | Fabrication and atomic force microscopy/friction force microscopy (AFM/FFM) studies of polyacrylamide-carbon nanotubes (PAM-CNTs) copolymer thin films显示文摘 | Xuefeng Li Wenchao Guan Haibiao Yan Lan Huang | 2004 | Materials Chemistry and Physics2004，88，： | 1 |
| 6 | Modulating proton binding energy on the tungsten carbide nanowires surfaces for boosting hydrogen evolution in acid显示文摘ungsten carbides have attracted wide attentions as Pt substitute electrocatalysts for hydrogen evolution reaction (HER), due to their good stability in an acid environment and Pt-like behaviour in hydrolysis. However, quantum chemistry calculations predict that the strong tungsten-hydrogen bonding hinders hydrogen desorption and restricts the overall catalytic activity. Synergistic modulation of host and guest electronic interaction can change the local work function of a compound, and therefore, improve its electrocatalytic activity over either of the elements individually. Herein, we develop a creative and facile solid-state approach to synthesize self-supported carbon-encapsulated single-phase WC hybrid nanowires arrays (nanoarrays) as HER catalyst. The theoretical calculations reveal that carbon encapsulation modifies the Gibbs free energy of H* values for the WC adsorption sites, endowing a more favorable C@WC active site for HER. The experimental results exhibit that the hybrid WC nanoarrays possess remarkable Pt-like catalytic behavior, with superior activity and stability in an acidic media, which can be compared to the best non-noble metal catalysts reported to date for hydrogen evolution reaction. The present results and the facile synthesis method open up an exciting avenue for developing cost-effective catalysts with controllable morphology and functionality for scalable hydrogen generation and other carbide nanomaterials applicable to a range of electrocatalytic reactions. | Qjngshui Hong Tangyi Li Shisheng Zheng Haibiao Chen Wenju Ren Honghao Chu Kuangda Xu Zongwei Mei Feng Pan | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 7 | Estimation of Postmortem Interval by Postmortem Myocardial Computed Tomography Value显示文摘Background:The estimation of postmortem interval(PMI)is one of the most important topics in forensic medicine research.We speculate that with an increased PMI,the computed tomography(CT)values of different tissues may show regular changes.Purpose:To use postmortem computed tomography(PMCT)to measure the myocardial CT value(unit:Hounsfield Unit,HU)of the heart to explore its pattern in postmortem change,and to discuss whether it can serve as a new parameter for PMI estimation.Methods:A total of 10 healthy adult New Zealand rabbits were selected and then put into a 20℃ incubator after being sacrificed.Within 0-156 h after death,CT scans were performed every 12 h to detect changes in the myocardial CT value of the heart over time.Regression analysis was used to determine the relationship between the myocardial CT value of the heart and PMI.At the same time,HE and Masson were used to stain the cardiac tissue sections detected by PMCT at Oh,48h and 156h,respectively.Results:During 0-156 h,the overall myocardial CT value showed a trend of first rising and then decreasing with the increase of PMI.The fitting regression equation was y=-2873.193+143.866x-1.728x2(x:myocardial CT value,unit:Hu;y:PMI,unit:h,R2=0.466,P<0.05).During 48-156 h,the overall myocardial CT value decreased gradually with the increase of PMI.The fitting regression equation was y=-93.038+18.700x-0.321x2(x:myocardial CT value,unit:Hu;y:PMI,unit:h,R2=0.963,P<0.001).The results of the morphological changes of the myocardial tissue structure after death showed that the myocardial cell structure was relatively complete at 0-48 hours after death;and the myocardial cell structure disappeared at 156 hours after death.Conclusions:Our results revealed evident postmortem changes in the myocardial CT value of the heart.Accordingly,measuring the myocardial CT value through PMCT shows promise for being used as a parameter for PMI estimation in forensic medicine and is worthy of further studies.The morphological changes of the myocardial tissue structure after death provide morphological basis for postmortem changes of tissue density,and further prove the reasons for the changes of CT value. | Zhiyuan An Hongxia He Qing Niu Haibiao Zhu Yucong Wang Ran Liu Weiliang Hou Peng Tang Tiantong Yang Dong Zhao | 2021 | Journal of Forensic Science and Medicine2021，7，3： | 1 |
| 8 | Promoting operating voltage to 2.3 V by a superconcentrated aqueous electrolyte in carbon-based supercapacitor显示文摘Aqueous supercapacitors(SCs)have attracted more and more attention for their safety,fast charge/discharge capability and ultra-long life.However,the application of aqueous SCs is limited by the low working voltage due to the narrow electrochemical stability window(ESW)of wate r.Herein,we report a new'water in salt'(WIS)electrolyte by dissolving potassium bis(fluorosulfonyl)amide(KFSI)in water with an ultra-high mass molar concentration of 37 mol/kg.The highly concentrated electrolyte can achieve a wide ESW of 2.8 V.The WIS electrolyte enables a safe carbon-based symmetrical supercapacitor to operate stably at 2.3 V with an ultra-long cycle life and excellent rate performance.The energy density reaches 20.5 Wh/kg at 2300 W/kg,and the capacity retention is 83.5%after 50,000 cycles at a current density of 5 A/g.This new electrolyte will be a promising candidate for future high-voltage aqueous supercapacitors. | Man Zhang Weijian Wang Xianhui Liang Chang Li Wenjun Deng Haibiao Chen Rui Li | 2021 | Chinese Chemical Letters2021，32，7： | 1 |
| 9 | Fabrication and atomic force microscopy/friction force microscopy(AFM/FFM) studies of polyacrylamide-carbon nanotubes(PAM-CNTs) copolymer thin films 显示文摘 | Xuefeng Li Wenchao Guan Haibiao Yan | 2004 | Materials Chemistry and Physics2004，88，： | 1 |
| 10 | Additive-state-decomposition-based station-keeping control for autonomous aerial refueling显示文摘Dear editor,Aerial refueling(AR) is an effective method of increasing the endurance and range of aircraft by refueling them in flight [1, 2]. Station-keeping control is the basis of autonomous aerial refueling(AAR). The station-keeping control for AAR is a difficult task for two main reasons. First,the receiver is disturbed by the atmospheric turbulence and the wake vortex of the tanker. Secondly, owing to the fuel injection in the refueling process, the mass and the center of mass of the receiver will change. | Jinrui REN Quan QUAN Haibiao MA Kai-Yuan CAI | 2021 | Science China(Information Sciences)2021，64，11： | 1 |
| 11 | A finite element variational multiscale method for incompressible flows based on two local gauss integrations显示文摘 | Haibiao Zheng Yanren Hou Feng Shi Lina Song | 2009 | Journal of Computational Physics2009，，16： | 1 |
| 12 | Revealing the anion intercalation behavior and surface evolution of graphite in dual-ion batteries via in situ AFM显示文摘Graphite as a positive electrode material of dual ion batteries(DIBs)has attracted tremendous attentions for its advantages including low lost,high working voltage and high energy density.However,very few literatures regarding to the real-time observation of anion intercalation behavior and surface evolution of graphite in DIBs have been reported.Herein,we use in situ atomic force microscope(AFM)to directly observe the intercalation/de-intercalation processes of PF6^-in graphite in real time.First,by measuring the change in the distance between graphene layers during intercalation,we found that PF6^-intercalates in one of every three graphite layers and the intercalation speed is measured to be 2μm-min^-1.Second,graphite will wrinke and suffer structural damnages at high voltages,along with severe electrolyte decomposition on the surface.These findings provide useful information for further optimizing the capacity and the stability of graphite anode in DIBs. | Kai Yang Langlang Jia Xinhua Liu Zijian Wang Yan Wang Yiwei Li Haibiao Chen Billy Wu Luyi Yang Feng Pan | 2020 | Nano Research2020，13，2： | 1 |
| 13 | Analysis of the Factors Influencing the Solid-liquid Separation Experiment of Guar Gum Waste Liquid显示文摘Based on the water quality detection and analysis of guar gum waste liquid,as well as the data of experiments on the treatment of waste liquid under different viscosity and pH conditions,the influencing factors of solid-liquid separation under conventional'coagulation+filtration'treatment process are studied.Under the conventional'coagulation+filtration'treatment process,the viscosity of guar gum waste liquid is lower than 3 mPa·s;the pH is 6-7.5;the filtration accuracy is not lower than 20μm,which can meet better treatment conditions.This experimental study provides an experimental basis for the optimal design of the treatment process of guar gum waste liquid. | Xiaorong REN Zhanyou HE Siwei ZHANG Haibiao WEI Jian YAO | 2020 | Meteorological and Environmental Research2020，11，4： | 0 |
| 14 | Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1^(high)CD11b^(+)cells elimination in hepatocellular carcinoma显示文摘Cryoablation(CRA)and microwave ablation(MWA)are two main local treatments for hepatocellular carcinoma(HCC).However,which one is more curative and suitable for combining with immunotherapy is still controversial.Herein,CRA induced higher tumoral PD-L1 expression and more T cells infiltration,but less PD-L1^(high)CD11b^(+)myeloid cells infiltration than MWA in HCC.Furthermore,CRA had better curative effect than MWA for anti-PD-L1 combination therapy in mouse models.Mechanistically,anti-PD-L1 antibody facilitated infiltration of CD8^(+)T cells by enhancing the secretion of CXCL9 from cDC1 cells after CRA therapy.On the other hand,anti-PD-L1 antibody promoted the infiltration of NK cells to eliminate PD-L1^(high)CD11b^(+)myeloid cells by antibody-dependent cell-mediated cytotoxicity(ADCC)effect after CRA therapy.Both aspects relieved the immunosuppressive microenvironment after CRA therapy.Notably,the wild-type PD-L1 Avelumab(Bavencio),compared to the mutant PD-L1 atezolizumab(Tecentriq),was better at inducing the ADCC effect to target PD-L1^(high)CD11b^(+)myeloid cells.Collectively,our study uncovered the novel insights that CRA showed superior curative effect than MWA in combining with anti-PD-L1 antibody by strengthening CTL/NK cell immune responses,which provided a strong rationale for combining CRA and PD-L1 blockade in the clinical treatment for HCC. | Jizhou Tan Ting Liu Wenzhe Fan Jialiang Wei Bowen Zhu Yafang Liu Lingwei Liu Xiaokai Zhang Songling Chen Haibiao Lin Yuanqing Zhang Jiaping Li | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
| 15 | Single-cell transcriptomics reveals cell type diversity of human prostate显示文摘Extensive studies have been performed to describe the phenotypic changes occurring during malignant transformation of the prostate.However,the cell types and associated changes that contribute to the development of prostate diseases and cancer remain elusive,largely due to the heterogeneous composition of prostatic tissues.Here,we conduct a comprehensive evaluation of four human prostate tissues by singlecell RNA sequencing(sc RNA-seq)to analyze their cellular compositions.We identify 18 clusters of cell types,each with distinct gene expression profiles and unique features;of these,one cluster of epithelial cells(Ep)is found to be associated with immune function.In addition,we characterize a special cluster of fibroblasts and aberrant signaling changes associated with prostate cancer(PCa).Moreover,we provide insights into the epithelial changes that occur during the cellular senescence and aging.These results expand our understanding of the unique functional associations between the diverse prostatic cell types and the contributions of specific cell clusters to the malignant transformation of prostate tissues and PCa development. | Yang Chen Peng Zhang Jinling Liao Jiwen Cheng Qin Zhang Tianyu Li Haiying Zhang Yonghua Jiang Fangxing Zhang Yanyu Zeng Linjian Mo Haibiao Yan Deyun Liu Qinyun Zhang Chunlin Zou Gong-Hong Wei Zengnan Mo | 2022 | Journal of Genetics and Genomics2022，49，11： | 0 |
| 16 | N2O Decomposition Catalyzed by K+-doped Bi0.02Co显示文摘 | TURSUN Mamutj an WANG Bingshuai JIANG Yan YU Haibiao SUN Xingtao WANG Xinping | 2016 | Chemical Research in Chinese Universities2016，32，3： | 0 |
| 17 | Recent progress in Li and Mn rich layered oxide cathodes for Li-ion batteries显示文摘Li and Mn rich(LMR)layered oxides,written as xLi_(2) MnO_(3)·(1-x)LiMO_(2)(M=Mn,Ni,Co,Fe,etc.),have been widely reported in recent years due to their high capacity and high energy density.The stable structure and superior performance of LMR oxides make them one of the most promising candidates for the next-generation cathode materials.However,the commercialization of these materials is hindered by several drawbacks,such as low initial Coulombic efficiency,the degradation of voltage and capacity during cycling,and poor rate performance.This review summarizes research progress in solving these concerns of LMR cathodes over the past decade by following three classes of strategies:morphology design,bulk design,and surface modification.We elaborate on the processing procedures,electrochemical performance,mechanisms,and limitations of each approach,and finally put forward the concerns left and the possible solutions for the commercialization of LMR cathodes. | Yiwei Li Zhibo Li Cong Chen Kai Yang Bo Cao Shenyang Xu Ni Yang Wenguang Zhao Haibiao Chen Mingjian Zhang Feng Pan | 2021 | Journal of Energy Chemistry2021，30，10： | 0 |
| 18 | Application of Virtopsy in Forensic Pathology显示文摘Virtopsy employs computed tomography and magnetic resonance imaging,which are commonly used in clinical medicine,to determine the cause and manner of death.Virtopsy is a multidisciplinary technique that combines forensic medicine,pathology,radiology,computer graphics,biomechanics,and physics.Virtopsy is rapidly gaining importance in forensic science and has been extensively studied in several areas of forensic pathology.In this study,we reviewed domestic and international research on causes of death,traffic injuries,medical disputes,gunshot trauma,postmortem changes,and inference of time of death to discuss with colleagues the role of virtopsy in forensic pathology. | Wang Yucong Zhu Haibiao Liu Ran Zhang Haidong Zhao Dong Wang Xu Yang Tiantong | 2021 | Journal of Forensic Science and Medicine2021，7，1： | 0 |
| 19 | Design of Wuzhou Arcade Naturalist City Display Based on 3D Panoramic Technology显示文摘 | Haibiao Wu | 2014 | International English Education Research2014，，5： | 0 |
| 20 | A Posteriori Error Estimate for Stabilized Low-Order Mixed FEM for the Stokes Equations显示文摘This paper is concerned with a stabilized approach to low-order mixed finite element methods for the Stokes equations.We will provide a posteriori error analysis for the method.We present two a posteriori error indicators which will be demonstrated to be globally upper and locally lower bounds for the error of the finite element discretization.Finally two numerical experiments will be carried out to show the efficiency on constructing adaptive meshes. | Yinnian He Cong Xie Haibiao Zheng | 2010 | Advances in Applied Mathematics and Mechanics2010，2，6： | 0 |
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