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| 1 | High-entropy(Ca_(0.2)Sr_(0.2)Ba_(0.2)La_(0.2)Pb_(0.2))TiO_(3) perovskite ceramics with A-site short-range disorder for thermoelectric applications显示文摘Novel high-entropy perovskite-type(Ca_(0.2)Sr_(0.2)Ba_(0.2)La_(0.2)Pb_(0.2))TiO_(3)(CSBLP)ceramics with cubic structure of Pm-3 m space group were successful prepared by solid-state reaction method.Results of XRD,SEM-EDS,HRTEM confirmed a homogeneous distribution and equimolar arrangement of multicomponent cations on the A-site.The high-entropy CSBLP ceramics showed long-range structural order and short-range chemical disorder with widely dispersed nanoscale grains varying sizes of 4-6 nm in the microstructure.Because of increased configurational entropy,the CSBLP ceramic has an enhanced Seebeck coefficient(|S|=272μV/K at 1073 K)and low thermal conductivity(k=1.75 W/m·K at 1073 K)when annealed at1300℃.This work demonstrates the possibility of effectively reducing thermal conductivity and improving the performance of thermoelectric oxides through high-entropy composition design. | Ping Zhang Zhihao Lou Mengjie Qin Jie Xu Jiatong Zhu Zongmo Shi Qian Chen Michael J.Reece Haixue Yan Feng Gao | 2022 | Journal of Materials Science & Technology2022，，2： | 3 |
| 2 | Adjunctive sepsis therapy with aminophylline(STAP):a randomized controlled trial显示文摘Background:Sepsis is a serious disease caused by infection.Aminophylline has anti-asthma and anti-inflammatory effects.We aimed to explore the safety and effect of aminophylline in sepsis.Methods:We conducted a clinical randomized controlled trial involving 100 patients diagnosed with sepsis within 48 h after intensive care unit(ICU)admission in two sites.All patients were randomized in a 1:1 ratio to receive standard therapy with or without aminophylline.The primary clinical outcome was all-cause mortality at 28 days.Results:From September 27,2018 to February 12,2020,we screened 277 septic patients and eventually enrolled 100 patients,with 50 assigned to the aminophylline group and 50 to the usual-care group.At 28 days,7 of 50 patients(14.0%)in the aminophylline group had died,compared with 16 of 50(32.0%)in the usual-care group(P=0.032).Cox regression showed that the aminophylline group had a lower hazard of death(hazard ratio=0.312,95%confidence interval:0.129–0.753).Compared with the usual-care group,patients in the aminophylline group had a longer survival time(P=0.039 by the log-rank test).The effects of aminophylline on vasopressor dose,oxygenation index,and sequential organ failure assessment score were timedependent with treatment.There were no significant differences in total hospitalization days,ICU hospitalization days,and rates of serious adverse events(all P>0.05).No adverse events were observed in the trial.Conclusions:Aminophylline as an adjunct therapy could significantly reduce the risk of death and prolong the survival time of patients with sepsis.Trial registration:ChiCTR.org.cn,ChiCTR1800019173. | Ruifang Zhang Huan Liu Dongmei Dai Xianfei Ding Dong Wang Yan Wang Xuexiu Shi Shuguang Zhang Xiaoguang Duan Haixu Wang Yonggang Luo Shaohua Liu Bing Han Xiaojuan Zhang Yu Fang Jing Yang Wangbin Xu Tongwen Sun | 2022 | Chinese Medical Journal2022，135，23： | 2 |
| 3 | Toughening of zirconia/alumina composites by the addition of graphene platelets显示文摘 | Jian Liu Haixue Yan Mike J. Reece Kyle Jiang | 2012 | Journal of the European Ceramic Society2012，，16： | 1 |
| 4 | Enhanced energy storage performance under low electric field in Sm^(3+) doped AgNbO_(3) ceramics显示文摘Herein,Ag_(1-3x)Sm_(x)NbO_(3)(0≤x≤0.025)antiferroelectric ceramics were successfully synthesized by solid state methods.The effect of Sm 3þdoping on the structure,property and energy storage performance were studied.With the increasing Sm^(3+)concentrations,the average grain size decreased.Meanwhile,the stability of high temperature M phases(i.e.,the structure between T_(f) and T_(3))was expanded,which led to low loss for energy storage.Both of structure analysis and ferroelectric tests revealed the existence of weakly polar/AFE-like phase below T_(f).The Sm 3þdoping tended to suppress the ferroelectric behavior and expand the stability of antiferroelectricity.Consequently,a significantly enhanced energy storage performance(W_(rec)=3.8 J/cm^(3),η=73%)could be achieved in Ag_(0.97)Sm_(0.01)NbO_(3) ceramic,which was almost 1.5 times larger than that in non-doped AgNbO_(3)(W_(rec)=2.4 J/cm^(3),η=45%)under the similar applied field of 1705 kV/cm±.In particular,the performance of the ceramic showed great temperature stability with variation of±5%from 25℃ to 125℃.These results indicated that the Ag_(0.97)Sm_(0.01)NbO_(3) ceramic could be an ideal lead-free candidate used in the energy storage field. | Jing Li Li Jin Ye Tian Chao Chen Yu Lan Qingyuan Hu Chao Li Xiaoyong Wei Haixue Yan | 2022 | Journal of Materiomics2022，8，2： | 1 |
| 5 | Enhanced piezoelectricity in Na and Ce co-doped CaBi_(4)Ti_(4)O_(15) ceramics for high-temperature applications显示文摘The sodium(Na)and Ce co-doped calcium bismuth titanate(CBT;CaBi_(4)Ti_(4)O_(15))Aurivillius ceramics in a Ca_(1-x)(Na_(0.5)Ce_(0.5)),Bi_(4)Ti_(4)O_(15)(CNCBT;doping content(x)=0,0.03,0.05,0.08 and 0.12)system were synthesized by the conventional solid-state sintering method.All compositions show a single-phase orthorhombic(space group:A2jam)structure at room temperature.The shift of the Curie point(T_(c))towards lower temperatures(T)on doping results from the increased tolerance factor(t).The substitution-enhanced ferroelectric performance with large maximum polarization(P_(m))and facilitated domain switching is evidenced by the developed electrical polarization-electric field(P-E)and electrical current-electric field(I-E)hysteresis loops.The piezoelectric coefficient(d_(33)=20.5±0.1 pC/N)of the x=0.12 sample is about four times larger than that of pure CBT.The improved piezoelectric properties can be attributed to the high remanent polarization(P_(r))and relatively high dielectric permittivity(ε′).In addition,multi-sized(micron and sub-micron)domain structures were observed in the CNCBT ceramics by the piezoresponse force microscope(PFM).The multiple-sized ferroelectric domain structure with smaller domains is beneficial to the easy domain switching,enhanced ferroelectric performance,and improved piezoelectric properties of the CNCBT ceramics.The designed Aurivillius-phase ferroelectric ceramics with the T_(c) around 765℃and high piezoelectric coefficient(d_(33))are suitable for high-temperature piezoelectric applications. | Zimeng Hu Vladimir Koval Hangfeng Zhang Kan Chen Yajun Yue Dou Zhang Haixue Yan | 2023 | Journal of Advanced Ceramics2023，12，7： | 1 |
| 6 | The effect of texture on the properties of Bi 3.15 Nd 0.85 Ti 3 O 12 ceramics prepared by spark plasma sintering显示文摘 | Hongtao Zhang Haixue Yan Xiaodong Zhang Mike J. Reece Jing Liu Zhijian Shen Yanmei Kan Peiling Wang | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 7 | The effect of (Li,Ce) and (K,Ce) doping in Aurivillius phase material CaBi 4 Ti 4 O 15显示文摘 | Haixue Yan Zhen Zhang Weimin Zhu Lianxin He Youhua Yu Chengen Li Jiaguang Zhou | 2004 | Materials Research Bulletin2004，，9： | 1 |
| 8 | Ordered coalescence of nano-crystals in alkaline niobate ceramics with high remanent polarization显示文摘Lead-free alkali niobates Na_(0.5)K_(0.5)NbO_(3)(NKN)ceramics,with significantly enhanced ferroelectric remanent polarization(Pr),were prepared using Spark Plasma Sintering(SPS).Three types of boundaries were observed in the ceramics,being grain boundaries between faceted grains,domain boundaries that separate ferroelectric domains inside individual grains,and nanoscale sub-grain boundaries that reveal the nano-scale mosaicity of individual grains.Part of the sub-grain boundaries were from initial powder particles.The other sub-grain boundaries were built by ordered coalescence of nano-crystals during rapid SPS process.It was worthwhile to emphasize that the ordered coalescence of nano-crystals in bulk ceramics during sintering takes place and completes within minutes.These sub-grain features would disappear at higher temperature by long time sintering.Rapid Spark Plasma Sintering allowed us to capture this transient microstructure.The significantly enhanced ferroelectric Pr of NKN was attributed to nanoscale sub-boundaries,which stimulated the dynamics of ferroelectric domain formation and switching. | Zhijian Shen Daniel Gruner Mirva Eriksson Lyubov M.Belova Ce-Wen Nan Haixue Yan | 2017 | Journal of Materiomics2017，3，4： | 1 |
| 9 | Nortriterpenoids from the fruit stalk of Schisandra chinensis (Turcz.) Baill.显示文摘Objective:The fruit stalk of Schisandra chinensis(Turcz.)Baill.(S.chinensis)has been found to contain bioactive components similar to the fruit of S.chinensis.Here,we report a recent discovery about new nortriterpenoids with a novel skeleton and anti-gastric cancer activity,which were isolated from the fruit stalk of S.chinensis.Methods:The chemical components of ethyl acetate extract from 70%ethanol extract from S.chinensis fruit stalk were separated,purified,and identified by liquid chromatography methods(silica gel,ODS,HPLC)and extensive spectroscopic analyses(NMR,IR,UV,MS,CD).Results:Two new nortriterpenoids,schilancitrilactone M and 25-hydroxyl schindilactone D(1 and 2),along with ten known nortriterpenoids(3-12)were isolated from the fruit stalk of S.chinensis.The isolated compounds were tested for their cytotoxic activities against MGC-803 cells,and the results showed that compounds 6-8 possessed significant activities with IC50 of 9.01,11.77,and 2.74μmol/L,respectively.Conclusion:Twelve nortriterpenoids including two new compounds were isolated from the fruit stalk of S.chinensis for the first time.Among them,compounds 6-8 showed significant anti-gastric cancer activities.We postulated that the fruit stalk of S.chinensis could be used as an anti-gastric cancer drug. | Yan Liu Xiaohui Rong Yuanhang Chang Juan Pan Wei Guan Haixue Kuang Bingyou Yang | 2022 | Frigid Zone Medicine2022，2，2： | 1 |
| 10 | Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C显示文摘Human-specific duplicated genes contributed to phenotypic innovations during the origin of our own species, such as an enlarged brain and highly developed cognitive abilities. While prior studies on transgenic mice carrying the human-specific SRGAP2C gene have shown enhanced brain connectivity, the relevance to humans remains unclear due to the significant evolutionary gap between humans and rodents. In this study, to investigate the phenotypic outcome and underlying genetic mechanism of SRGAP2C, we generated transgenic cynomolgus macaques (Macaca fascicularis) carrying the human-specific SRGAP2C gene. Longitudinal MRI imaging revealed delayed brain development with region-specific volume changes, accompanied by altered myelination levels in the temporal and occipital regions. On a cellular level, the transgenic monkeys exhibited increased deep-layer neurons during fetal neurogenesis and delayed synaptic maturation in adolescence. Moreover, transcriptome analysis detected neotenic expression in molecular pathways related to neuron ensheathment, synaptic connections, extracellular matrix and energy metabolism. Cognitively, the transgenic monkeys demonstrated improved motor planning and execution skills. Together, our findings provide new insights into the mechanisms by which the newly evolved gene shapes the unique development and circuitry of the human brain. | Xiaoyu Meng Qiang Lin Xuerui Zeng Jin Jiang Min Li Xin Luo Kaimin Chen Haixu Wu Yan Hu Cirong Liu Bing Su | 2023 | National Science Review2023，10，11： | 1 |
| 11 | Piezoelectric Strontium Niobate and Calcium Niobate Ceramics with Super-High Curie Points显示文摘 | Huanpo Ning Haixue Yan Michael J Reece | 2010 | Journal of the American Ceramic Society2010，93，5： | 1 |
| 12 | Thermal de- poling of high Curie point Aurivillius phase ferroelectrie ceramics 显示文摘 | YAN Haixue ZHANG Hongtao DONG Xianlin | 2005 | Appl Phys Lett2005，87，8： | 1 |
| 13 | 显示文摘 | Yan Haixue Li Chengen Zhou Jiaguang | 2001 | Appl Phys Lett2001，40，： | 1 |
| 14 | Effect of a site substitution on the properties of CaBi2 Nb2 09 ferroelectric ceramics显示文摘 | Zhang Xiaodong Yan Haixue Reece Michael J | 2008 | J am ceram soc2008，91，9： | 1 |
| 15 | Exploration about superior anti-counterfeiting ability of Sm^(3+) doped KSr_(2)Nb_(5)O_(15) photochromic ceramics:Origin and atomic-scale mechanism显示文摘Reversible luminescence modulation behavior upon the photochromic effect endows the photochromic ceramics with 3reat potential in anti-counterfeiting and data storage applications.Here,Sm^(3+)-doped KSr_(2)Nb_(5)O_(15) photochromic ceramics exhibit superior anti-counterfeiting ability:good covertness and considerable modulation ratio of luminescent emission intensity after photochromic reaction.The results show that the photochromism originated from oxygen and cation vacancies,which were directly identified by electron paramagnetic resonance and positron annihilation lifetime spectra.Unexpectedly,oxygen vacancies work more effectively than cation vacancies during photochromic reactions.Moreover,the extraordinary anti-counterfeiting ability was attributed to the high energy transfer rate,which was particularly caused by the short mean distance below 1 nm between the Sm^(3+) and vacancies.The work here has provided atomic-scale structural evidence and made a progress in understanding the photochromic origins and mechanism in color-center theory. | Shuyao Cao Jiatong Zhu Qian Chen Junting Liu Changying Wu Leilei Li Jie Xu Haixue Yan Feng Gao | 2022 | Journal of Materiomics2022，8，1： | 1 |
| 16 | 显示文摘 | Yan Haixue Li Chengen | 2000 | Jpn J Appl Phys2000，39，111： | 1 |
| 17 | Preparation and electric properties of bismuth layer-structured ceramics Bi3NbTiO9 solid solution显示文摘 | ZHANG ZHEN YAN HAIXUE DONG XIANLIN | 2003 | Materials Research Bulletin2003，38，2： | 1 |
| 18 | B-site donor and acceptor doped aurivillius phase Bi3NbTiO9 ceramics显示文摘 | YAN HAIXUE ZHANG HONGTAO ZHANG ZHEN | 2006 | Journal of the European Ceramic Society2006，26，13： | 1 |
| 19 | The sintering and grain growth behaviour of ceramic-carbon nanotube nanocomposites显示文摘 | Fawad Inam Yan Haixue Ton Peijs | 2010 | Compos Sci Techn2010，70，： | 1 |
| 20 | Pie- zoelectric ceramics with super-high curie points 显示文摘 | YAN Haixue NING Huanpo KAN Yanmei | 2009 | The American Ceramic Society2009，92，10： | 1 |
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