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| 1 | Curcumin’s prevention of inflammation-driven early gastric cancer and its molecular mechanism显示文摘Worldwide,gastric cancer is the second leading cause of cancer deaths and the fifth most common malignant tumor.Gastric cancer is believed to be caused by a variety of factors,such as genetics,epigenetics,and environmental influences.Among the pathogenic factors,inflammation has been considered as one of the main risk factors for gastric cancer.There are currently limited ways to prevent gastric cancer.Although the combined application of aspirin and non-steroidal anti-inflammatory drugs can reduce the risk,it has great side effects and can easily cause gastric perforation or gastric bleeding.Therefore,an alternative plan is urgently needed.Curcumin is the yellow pigment in the rhizome of the plant turmeric.Current studies have found that curcumin has a protective effect on gastric mucosal damage caused by non-steroidal anti-inflammatory drugs,gastric mucosal damage in rats,and gastric mucosal damage caused by stress bleeding and Helicobacter pylori infection.Curcumin shows significant antiinflammatory and anti-cancer activities by regulating DNA methylation,histone modification,nuclear factor erythrocyte 2 related factor 2 and other related signal pathways.In this article,the latest evidence of curcumin for epigenetic changes in gastric cancer and its potential contribution to gastric cancer were discussed. | Wensen Zhang Na Cui Jin Ye Bingyou Yang Yanping Sun Haixue Kuang | 2022 | Chinese Herbal Medicines2022，14，2： | 3 |
| 2 | Screening and comparison of the immunosuppremive activities of polysaccharides from the stems of Ephedra sinica Stapf显示文摘 | Haixue Kuang Yonggang Xia Bingyou Yang | 2011 | Carbohydrate Polymers2011，83，2： | 1 |
| 3 | Screening and comparison of the immunosuppressive activities of polysaccharides from the stems of Ephedra sinica Stapf显示文摘 | Haixue Kuang Yonggang Xia Bingyou Yang | 2011 | Carbohydrate Polymers2011，83，2： | 1 |
| 4 | Nortriterpenoids from the fruit stalk of Schisandra chinensis (Turcz.) Baill.显示文摘Objective:The fruit stalk of Schisandra chinensis(Turcz.)Baill.(S.chinensis)has been found to contain bioactive components similar to the fruit of S.chinensis.Here,we report a recent discovery about new nortriterpenoids with a novel skeleton and anti-gastric cancer activity,which were isolated from the fruit stalk of S.chinensis.Methods:The chemical components of ethyl acetate extract from 70%ethanol extract from S.chinensis fruit stalk were separated,purified,and identified by liquid chromatography methods(silica gel,ODS,HPLC)and extensive spectroscopic analyses(NMR,IR,UV,MS,CD).Results:Two new nortriterpenoids,schilancitrilactone M and 25-hydroxyl schindilactone D(1 and 2),along with ten known nortriterpenoids(3-12)were isolated from the fruit stalk of S.chinensis.The isolated compounds were tested for their cytotoxic activities against MGC-803 cells,and the results showed that compounds 6-8 possessed significant activities with IC50 of 9.01,11.77,and 2.74μmol/L,respectively.Conclusion:Twelve nortriterpenoids including two new compounds were isolated from the fruit stalk of S.chinensis for the first time.Among them,compounds 6-8 showed significant anti-gastric cancer activities.We postulated that the fruit stalk of S.chinensis could be used as an anti-gastric cancer drug. | Yan Liu Xiaohui Rong Yuanhang Chang Juan Pan Wei Guan Haixue Kuang Bingyou Yang | 2022 | Frigid Zone Medicine2022，2，2： | 1 |
| 5 | GC- MS method for determination and pharmacokinetic study of four phenylpropanoids in rat plasma after oral administration of the essential oil of Acorus tatarinowii Schott rhizomes显示文摘 | WANG Zhibin WANG Qiuhong YANG Bingyou | 2014 | Journal of Ethnopharmacology2014，155，2： | 1 |
| 6 | Screening and comparison of the immunosuppressive activities of polysaccharides from the stems of Ephedra sinica Stapf显示文摘 | Haixue Kuang Yonggang Xia Bingyou Yang | 2011 | Carbohydrate Polymers2011，83，： | 1 |
| 7 | Screening and comparison of antioxidant activities of polysaccharides from Coriolus versicolor显示文摘 | Xiaowen Sun Yanping Sun Qingbo Zhang Hongwei Zhang Bingyou Yang Zhibin Wang Weiguo Zhu Bin Li Qiuhong Wang Haixue Kuang | 2014 | International Journal of Biological Macromolecules2014，，： | 1 |
| 8 | NEW ANTIPROLIFERATIVE WITHANOLIDES FROM THE SEEDS OF DATURA METEL显示文摘Three new with anolides,daturaselines A-C(1-3),and three new with anolides glycosides,daturasesides A-C(4-6),were isolated and identified from ethyl acetate-soluble fraction of ethanol extract of Datura metel seeds.The structures of new compounds were established according to the 1D and 2D NMR spectra,combined with high resolution | Bingyou Yang Yan Liu Peiyan Zhang Yangang Cheng Qiuhong Wang Hai-xue Kuang | 2015 | World Journal of Traditional Chinese Medicine2015，1，4： | 0 |
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