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您的检索式：作者名="Haiyuan Yao"
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| 1 | OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia显示文摘Oxysterol binding protein like 2(OSBPL2), an important regulator in cellular lipid metabolism and transport, was identified as a novel deafness-causal gene in our previous work. To resemble the phenotypic features of OSBPL2 mutation in animal models and elucidate the potential genotypephenotype associations, the OSBPL2-disrupted Bama miniature(BM) pig model was constructed using CRISPR/Cas9-mediated gene editing, somatic cell nuclear transfer(SCNT) and embryo transplantation approaches, and then subjected to phenotypic characterization of auditory function and serum lipid profiles. The OSBPL2-disrupted pigs displayed progressive hearing loss(HL) with degeneration/apoptosis of cochlea hair cells(HCs) and morphological abnormalities in HC stereocilia, as well as hypercholesterolaemia. High-fat diet(HFD) feeding aggravated the development of HL and led to more severe hypercholesterolaemia. The dual phenotypes of progressive HL and hypercholesterolaemia resembled in OSBPL2-disrupted pigs confirmed the implication of OSBPL2 mutation in nonsydromic hearing loss(NSHL) and contributed to the potential linkage between auditory dysfunction and dyslipidaemia/hypercholesterolaemia. | Jun Yao Huasha Zeng Min Zhang Qinjun Wei Ying Wang Haiyuan Yang Yajie Lu Rongfeng Li Qiang Xiong Lining Zhang Zhibin Chen Guangqian Xing Xin Cao Yifan Dai | 2019 | Journal of Genetics and Genomics2019，46，8： | 7 |
| 2 | A Preliminary Study on Hydrate Anti-agglomerant Applied in Multiphase Flow Pipeline显示文摘 | Haiyuan Yao Qingping Li Guangjin Chen Jing Gong | 2013 | Journal of Energy and Power Engineering2013，7，2： | 1 |
| 3 | 生物多样性和环境因素对亚热带森林树木生物量和生物量生长的解耦影响显示文摘生物多样性与生态系统功能之间的关系已成为森林生态系统研究的核心问题。然而,在具有不同人类干扰历史的亚热带森林群落中,关于环境因子对生物多样性与生态系统功能关系影响的研究仍然较少。在本研究中,选择位于中国东部浙江省的34个亚热带森林样地,在考虑样方中的环境因子的基础上,利用线性模型,分析样地中木本植物多样性(物种、功能和谱系多样性)与样方内木本植物生物量或生物量变化量之间的关系。物种多样性和功能多样性,并非谱系多样性,与生物量和生物量的变化量之间存在显着相关性。生物量或生物量变化量与年平均温度和海拔高度之间存在显著的正相关关系。此外,在考虑环境因子和森林群落的演替阶段时,生物量变化量与功能多样性的关系显著强于生物量变化量与谱系多样性或物种多样性之间的关系。这些研究结果表明,生物多样性与生态系统功能之间的关系可能取决于生物多样性指数的选择和环境条件。 | Ravi Mohan Tiwari Jinliang Liu Yuchu Xie Shenhao Yao Shenglong Liu Sumei Wu Julian Liu Haiyuan Qian Zupei Lei Hongwei Zhang Lei Zhong Boliang Wei Mingjian Yu | 2023 | Journal of Plant Ecology2023，16，1： | 0 |
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