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| 1 | Immune secondary response and clonal selection inspired optimizers显示文摘The immune system's ability to adapt its B cells to new types of antigen is powered by processes known as clonal selection and affinity maturation. When the body is exposed to the same antigen,immune system usually calls for a more rapid and larger response to the antigen,where B cells have the function of negative adjustment. Based on the clonal selection theory and the dynamic process of immune response,two novel artificial immune system algorithms,secondary response clonal programming algorithm (SRCPA) and secondary response clonal multi-objective algorithm (SRCMOA),are presented for solving single and multi-objective optimization problems,respectively. Clonal selection operator (CSO) and secondary response operator (SRO) are the main operators of SRCPA and SRCMOA. Inspired by the clonal selection theory,CSO reproduces individuals and selects their improved maturated progenies after the affinity mat-uration process. SRO copies certain antibodies to a secondary pool,whose members do not participate in CSO,but these antibodies could be activated by some external stimulations. The update of the secondary pool pays more attention to maintain the population diversity. On the one hand,decimal-string representation makes SRCPA more suitable for solving high-dimensional function optimiza-tion problems. Special mutation and recombination methods are adopted in SRCPA to simulate the somatic mutation and receptor edit-ing process. Compared with some existing evolutionary algorithms,such as OGA/Q,IEA,IMCPA,BGA and AEA,SRCPA is shown to be able to solve complex optimization problems,such as high-dimensional function optimizations,with better performance. On the other hand,SRCMOA combines the Pareto-strength based fitness assignment strategy,CSO and SRO to solve multi-objective optimization problems. The performance comparison between SRCMOA,NSGA-Ⅱ,SPEA,and PAES based on eight well-known test problems shows that SRCMOA has better performance in converging to approximate Pareto-optimal fronts with wide distributions. | Maoguo Gong Licheng Jiao Lining Zhang Haifeng Du | 2009 | Progress in Natural Science:Materials International2009，19，2： | 24 |
| 2 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 3 | Critical influenza (H1N1) pneumonia: imaging manifestations and histopathological findings显示文摘 | LI Hong-jun CHENG Jing-liang LINing LI Yun-fang ZHANG Hui-mao | 2012 | Chinese Medical Journal2012，，12： | 12 |
| 4 | Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage显示文摘The microglia-mediated inflammatory reaction promotes neuronal damage under cerebral ischemia/hypoxia conditions. We therefore speculated that inhibition of hypoxia-induced microglial activation may alleviate neuronal damage. To test this hypothesis, we co-cultured ginsenoside Rb1, an active component of ginseng, and cortical neurons. Ginsenoside Rb1 protected neuronal morphology and structure in a single hypoxic culture system and in a hypoxic co-culture system with microglia, and reduced neuronal apoptosis and caspase-3 production. The protective effect was observable prior to placing in co-culture. Additionally, ginsenoside Rb1 inhibited levels of tumor necrosis factor-α in a co-culture system containing activated N9 microglial cells. Ginsenoside Rb1 also significantly decreased nitric oxide and superoxide production induced by N9 microglia. Our findings indicate that ginsenoside Rb1 attenuates damage to cerebral cortex neurons by downregulation of nitric oxide, superoxide, and tumor necrosis factor-α expression in hypoxia-activated microglia. | Lining Ke Wei Guo Jianwen Xu Guodong Zhang Wei Wang Wenhua Huang | 2014 | Neural Regeneration Research2014，9，3： | 11 |
| 5 | Evidences of rapid erosion driven by climate in the Yarlung Zangbo (Tsangpo) Great Canyon,the eastern Himalayan syntaxis显示文摘Climate and tectonism are both particularly intense in the Yarlung Zangbo (Tsangpo) Great Canyon in the eastern Himalayan syntaxis,which is characterized by the most rapid landscape evolution of anywhere in the world.Thus,the eastern Himalayan syntaxis is one of the best locations to study the interactions between climate and tectonics.This paper investigates the cooling ages of the Doxong La-Baibung profile using apatite fission track (AFT) dating on 11 bedrock samples at elevations ranging from 4210 to 710 m.There are topographic,climatic,metamorphic,and thermochronological gradients in the profile,providing good conditions to study interactions between climate and tectonics.AFT ages ranged from 4.6±0.6 Ma to 1.7±0.3 Ma,and the mean fission track lengths ranged from 11.0 to 12.4 μm.It was found that the cooling rates revealed by AFT ages increased with decreasing elevation.However,the tendency of the cooling rates revealed by the 40 Ar-39 Ar ages was different from that indicated by the AFT ages.Moreover,for most districts of the eastern Himalayan syntaxis,the compiled AFT age distribution correlates well with the annual average precipitation,indicating the coupling of the cooling and erosion rates of the near-surface rock and precipitation.The geothermal history modeling results indicate an obvious increase in the cooling and erosion rate between 1.0 and 0.5 Ma.This age is consistent with other research findings for this time,when the vapor channel of the Yarlung Zangbo Great Canyon began to take effect.These evidences suggest that climate,especially precipitation,has acting as a key factor influencing the rapid cooling and erosion in the Yarlung Zangbo Great Canyon since 1-0.5 Ma. | YU XiangJiang JI JianQing GONG JunFeng SUN DongXia QING JianChun WANG LiNing ZHONG DaLai ZHANG ZhiCheng | 2011 | Chinese Science Bulletin2011，56，11： | 11 |
| 6 | Increased expression of human T-cell immunoglobulin-and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 prototypic 自体免疫的疾病。天生、适应的免疫合作地贡献 SLE 的发展。介绍抗原的房间(APC ) 被建议了连接天生、适应的免疫。T 房间 immunoglobulin-domain-containing 和 mucin-domain-containing molecule-4 (Tim-4;另外作为 Timd4 知道) ,首先在 APC 的表面上表示了,是 TIM 家庭,的一个成员作为免疫系统的潜在的管理者收到了许多注意的分子的一个最近描述的组。在这研究,我们使用了量的即时反向的抄写聚合酶链反应从 SLE 病人在外部血 mononuclear 房间( PBMC )检验 Tim-4 的 mRNA 表示并且进一步在 PBMC 和浆液肿瘤坏死因素( TNF )分析了在 Tim-4 和 Tim-1 (为 Tim-4 的潜在的 ligand )的表示之间的关联-伪层次。结果证明在 PBMC 的那个 Tim-4 mRNA 表达式比在健康控制在 SLE 病人是显著地更高的,特别在疾病的活跃阶段的那些病人。而且, Tim-4 mRNA 层次密切在 SLE 病人然而并非在控制组在 PBMC 并且与浆液 TNF- 伪层次与 Tim-1 mRNA 层次被相关。一起拿,这些结果证明 Tim-4 可以涉及 SLE 的致病。 | Peiqing Zhao Liyun Xu Piming Wang Xiaohong Liang Jianni Qi Peng Liu Chun Guo Lining Zhang Chunhong Ma Lifen Gao | 2010 | Cellular & Molecular Immunology2010，7，2： | 11 |
| 7 | Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice显示文摘可观的证据显示那种类型 1 个 T 助手(Th1 )- 并且当时,调停 Th17 的有免疫力的回答支持动脉粥样硬化患者匾的形成那 CD4 + CD25 + 规章的 T 房间(Tregs ) 有的 Foxp3 + 保护的效果。然而,因为令人满意的匾破裂模型的缺乏,在匾破裂遗体的多样的 CD4 + 淋巴细胞子集的功能糟糕理解。这里,我们在颈动脉动脉上用一本高脂肪的食谱和领子放置建立了动脉粥样硬化患者匾破裂的一个鼠科的模型,并且在 apolipoprotein 电子大美人与 lipopolysaccharide, phenylephrine 注射和寒冷的联合由短期的刺激触发了匾破裂(ApoE −/−) 老鼠。我们由 PCR,流动 cytometry, ELISA 和 immunohistochemistry 调查了在 Th1 房间, Th17 房间和 Tregs 和匾破裂之间的协会。总共, 75 %(18/24 ) 脆弱的匾,而是没有稳定的匾,显示出的破裂特征。Th17 房间的比例在处理以后在 splenocytes 之中被增加,但是在 Th1 房间和 Tregs 的层次的变化不与破裂有关。而且,处理在浆液并且在匾破裂的区域导致了 interleukin-17 (IL-17 ) 的高水平。在 vitro, IL-17 增加了 apoptosis 的水平,与匾破裂联系的一个主要因素,在有教养的鼠科的脉管的光滑的肌肉房间。Th17 房间和 IL-17 可以涉及短期的刺激在 ApoE −/− 老鼠。 | Tian Ma Qi Gao Faliang Zhu Chun Guo Qun Wang Fei Gao Lining Zhang | 2013 | Cellular & Molecular Immunology2013，10，4： | 9 |
| 8 | 在由巨噬细胞并且从而的增加的 IL-10 表示的规划房间死亡 4 结果的缺乏在 hyperlipidemic 鼠标稀释动脉粥样硬化显示文摘(Pdcd4 ) 规划房间死亡 4 是抄写和翻译和肿瘤 suppressor 的一个最新定义的禁止者。最近的研究建议了 Pdcd4 可以也涉及一些煽动性的疾病。然而,它在动脉粥样硬化的角色,动脉的墙的长期的发炎,尚待被调查。这里,我们发现在老鼠的那 Pdcd4 缺乏在巨噬细胞增加了 IL-10 的表示并且减少在 T 房间的 IL-17 的表示面对在 vitro 并且在高导致脂肪的动脉粥样硬化患者匾的一个联系动脉粥样硬化的激发器。重要地,击倒 Pdcd4 在喂的 Apoe −/− 老鼠在动脉粥样硬化患者损害导致了减少一本高胖的食谱。这效果能被与抵销的抗体堵住 IL-10 然而并非由外长的 IL-17 的申请部分颠倒。进一步机械学的研究表明 Pdcd4 否定地以一种 ERK1/2 依赖、 p38 依赖的方式调整了 IL-10 的表示。这些结果证明那 Pdcd4 缺乏通过反煽动性的 cytokine IL-10 的 upregulation 部分地在 hyperlipidemic 老鼠稀释动脉粥样硬化。这显示内长的 Pdcd4 支持动脉粥样硬化因此与动脉粥样硬化为病人代表一个潜在的治疗学的目标。 | Yang Jiang Qi Gao Liyang Wang Chun Guo Faliang Zhu Bo Wang Qun Wang Fei Gao Youhai Chen Lining Zhang | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 9 | OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia显示文摘Oxysterol binding protein like 2(OSBPL2), an important regulator in cellular lipid metabolism and transport, was identified as a novel deafness-causal gene in our previous work. To resemble the phenotypic features of OSBPL2 mutation in animal models and elucidate the potential genotypephenotype associations, the OSBPL2-disrupted Bama miniature(BM) pig model was constructed using CRISPR/Cas9-mediated gene editing, somatic cell nuclear transfer(SCNT) and embryo transplantation approaches, and then subjected to phenotypic characterization of auditory function and serum lipid profiles. The OSBPL2-disrupted pigs displayed progressive hearing loss(HL) with degeneration/apoptosis of cochlea hair cells(HCs) and morphological abnormalities in HC stereocilia, as well as hypercholesterolaemia. High-fat diet(HFD) feeding aggravated the development of HL and led to more severe hypercholesterolaemia. The dual phenotypes of progressive HL and hypercholesterolaemia resembled in OSBPL2-disrupted pigs confirmed the implication of OSBPL2 mutation in nonsydromic hearing loss(NSHL) and contributed to the potential linkage between auditory dysfunction and dyslipidaemia/hypercholesterolaemia. | Jun Yao Huasha Zeng Min Zhang Qinjun Wei Ying Wang Haiyuan Yang Yajie Lu Rongfeng Li Qiang Xiong Lining Zhang Zhibin Chen Guangqian Xing Xin Cao Yifan Dai | 2019 | Journal of Genetics and Genomics2019，46，8： | 7 |
| 10 | Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries显示文摘Soft tissue injury is very common and associated with pain,tissue swelling and even malformation if not treated on time.Treating methods include cryotherapy,electrical therapy,ultrasound therapy and anti-inflammatory drug,but none of them is completely satisfying.In this work,for a better therapeutic effect,drug therapy and pulsed electromagnetic field(PEMF)therapy were combined.We constructed a drug delivery system using the tetra-PEG/agar hydrogel(PA).By incorporating Fe3O4 NPs into the hydrogel network,a magnetism-responsive property was achieved in the system.The cytotoxicity and in vivo study showed a good biocompatibility of the PA/Fe3O4 hydrogel.A magnetism-controlled release was attained by the incorporation of Fe3O4.Finally,in vivo study showed a better performance of the DS-loaded PA/Fe3O4 compared with the commercially available DS ointment regarding the recovery of the injured soft tissue.Therefore,this magnetism-responsive hydrogel may represent a promising alternative to treat soft tissue injury. | Lining Zhang Xiuqin Zuo Shengjie Li Mi Sun Huimin Xie Kai Zhang Jikun Zhou Liyun Che Junxuan Ma Zishan Jia Fei Yang | 2019 | Bioactive Materials2019，4，1： | 7 |
| 11 | An epidermal sEMG tattoo-like patch as a new human–machine interface for patients with loss of voice显示文摘Throat cancer treatment involves surgical removal of the tumor,leaving patients with facial disfigurement as well as temporary or permanent loss of voice.Surface electromyography(sEMG)generated from the jaw contains lots of voice information.However,it is difficult to record because of not only the weakness of the signals but also the steep skin curvature.This paper demonstrates the design of an imperceptible,flexible epidermal sEMG tattoo-like patch with the thickness of less than 10μm and peeling strength of larger than 1N cm−1 that exhibits large adhesiveness to complex biological surfaces and is thus capable of sEMG recording for silent speech recognition.When a tester speaks silently,the patch shows excellent performance in recording the sEMG signals from three muscle channels and recognizing those frequently used instructions with high accuracy by using the wavelet decomposition and pattern recognization.The average accuracy of action instructions can reach up to 89.04%,and the average accuracy of emotion instructions is as high as 92.33%.To demonstrate the functionality of tattoo-like patches as a new human–machine interface(HMI)for patients with loss of voice,the intelligent silent speech recognition,voice synthesis,and virtual interaction have been implemented,which are of great importance in helping these patients communicate with people and make life more enjoyable. | Huicong Liu Wei Dong Yunfei Li Fanqi Li Jiangjun Geng Minglu Zhu Tao Chen Hongmiao Zhang Lining Sun Chengkuo Lee | 2020 | Microsystems & Nanoengineering2020，6，1： | 6 |
| 12 | Perioperative factors related to prognosis of regular hepatectomy in comparison with irregular hepatectomy显示文摘 | Feng Zhiqiang Li Hongqi Zhang Jinqian Xu Lining Xiao Mei Huang Zhiqiang Zhang Hongyi | 2014 | Chinese Medical Journal2014，，2： | 4 |
| 13 | Fine particulate matter(PM_(2.5)/PM_(1.0)) in Beijing,China: Variations and chemical compositions as well as sources显示文摘Particulate matter(i.e.,PM_(1.0) and PM_(2.5)),considered as the key atmospheric pollutants,exerts negative effects on visibility,global climate,and human health by associated chemical compositions.However,our understanding of PM and its chemical compositions in Beijing under the current atmospheric environment is still not complete after witnessing marked alleviation during 2013–2017.Continuous measurements can be crucial for further air quality improvement by better characterizing PM pollution and chemical compositions in Beijing.Here,we conducted simultaneous measurements on PM in Beijing during 2018–2019.Results indicate that annualmean PM_(1.0) and PM_(2.5) concentrations were 35.49±18.61μg/m^(3) and 66.58±60.17μg/m^(3),showing a positive response to emission controls.The contribution of sulfate,nitrate,and ammonium(SNA)played an enhanced role with elevated PM loading and acted as the main contributors to pollution episodes.Discrepancies observed among chemical species between PM_(1.0) and PM_(2.5) in spring suggest that sand particles trend to accumulate in the range of 1–2.5μm.Pollution episodes occurred accompanied with southerly clusters and high formation of SNA by heterogeneous reactions in summer and winter,respectively.Results from positive matrix factorization(PMF)combined with potential source contribution function(PSCF)models showed that potential areas were seasonal dependent,secondary and vehicular sources became much more important compared with previous studies in Beijing.Our study presented a continuous investigation on PM and sources origins in Beijing,which provides a better understanding for further emission control as well as a reference for other cities in developing countries. | Lining Luo Xiaoxuan Bai Shuhan Liu Bobo Wu Wei Liu Yunqian Lv Zhihui Guo Shumin Lin Shuang Zhao Yan Hao Jiming Hao Kai Zhang Aihua Zheng Hezhong Tian | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 14 | Antigenicity of tissues and organs from GGTA1/CMAH/β4GalNT2 triple gene knockout pigs显示文摘Clinical xenotransplantations have been hampered by human preformed antibody-mediated damage of the xenografts.To overcome biological incompatibility between pigs and humans,one strategy is to remove the major antigens[Gal,Neu5 Gc,and Sd(a)]present on pig cells and tissues.Triple gene(GGTAI,CMAH,and β4 GalNT2)knockout(TKO)pigs were produced in our laboratory by CRISPR-Cas9 targeting.To investigate the antigenicity reduction in the TKO pigs,the expression levels of these three xenoantigens in the cornea,heart,liver,spleen,lung,kidney,and pancreas tissues were examined.The level of human IgG/IgM binding to those tissues was also investigated,with wildtype pig tissues as control.The results showed that aGal,Neu5 Gc,and Sd(a)were markedly positive in all the examined tissues in wildtype pigs but barely detected in TKO pigs.Compared to wildtype pigs,the liver,spleen,and pancreas of TKO pigs showed comparable levels of human IgG and IgM binding,whereas corneas,heart,lung,and kidney of TKO pigs exhibited significantly reduced human IgG and IgM binding.These results indicate that the antigenicity of TKO pig is significantly reduced and the remaining xenoantigens on porcine tissues can be eliminated via a gene targeting approach. | Ronggen Wang Miaomiao Ruan Runjie Zhang Lei Chen Xiaoxue Li Bin Fang Chu Li Xueyang Ren Jiying Liu Qiang Xiong Lining Zhang Yong Jin Lin Li Rongfeng Li Ying Wang Haiyuan Yang Yifan Dai | 2019 | The Journal of Biomedical Research2019，33，4： | 3 |
| 15 | The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras显示文摘 | Yael Gus-Brautbar Derek Johnson Li Zhang Honghong Sun Peng Wang Shirley Zhang Lining Zhang Youhai H. Chen | 2012 | Molecular Cell2012，，5： | 2 |
| 16 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 17 | Overexpressing dominant-negative FGFR2-IIIb impedes lung branching morphogenesis in pigs显示文摘Genetic studies with mouse models have shown that fibroblast growth factor receptor 2-IIIb(FGFR2-IIIb)plays crucial roles in lung development and differentiation. To evaluate the effect of FGFR2-IIIb in pig lung development, we employed somatic cell nuclear transfer(SCNT) technology to generate transgenic pig fetuses overexpressing the transmembrane(dn FGFR2-IIIb-Tm) and soluble(dn FGFR2-IIIb-HFc) forms of the dominant-negative human FGFR2-IIIb driven by the human surfactant protein C(SP-C) promoter,which was specifically expressed in lung epithelia. Eight dn FGFR2-IIIb-Tm transgenic and twelve dn FGFR2-IIIb-HFc transgenic pig fetuses were collected from three and two recipient sows, respectively.Repression of FGFR2-IIIb in lung epithelia resulted in smaller lobes and retardation of alveolarization in both forms of dn FGFR2-IIIb transgenic fetuses. Moreover, the dn FGFR2-IIIb-HFc transgenic ones showed more deterioration in lung development. Our results demonstrate that disruption of FGFR2-IIIb signaling in the epithelium impedes normal branching and alveolarization in pig lungs, which is less severe than the results observed in transgenic mice. The dn FGFR2-IIIb transgenic pig is a good model for the studies of blastocyst complementation as well as the mechanisms of lung development and organogenesis. | Qin Chen Bin Fang Ying Wang Chu Li Xiaoxue Li Ronggen Wang Qiang Xiong Lining Zhang Yong Jin Manling Zhang Xiaorui Liu Lin Li Lisha Mou Rongfeng Li Haiyuan Yang Yifan Dai | 2018 | Journal of Genetics and Genomics2018，45，3： | 2 |
| 18 | A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex显示文摘Tuberous sclerosis complex(TSC)is a dominant genetic neurocutaneous syndrome characterized by multiple organ hamartomas.Although rodent models bearing a germline mutation in either TSC1 or TSC2 gene have been generated,they do not develop pathogenic lesions matching those seen in patients with TSC because of the significant differences between mice and humans,highlighting the need for an improved large animal model of TSC.Here,we successfully generate monoallelic TSC1-modified Bama miniature pigs using the CRISPR/Cas9 system along with somatic cell nuclear transfer(SCNT)technology.The expression of phosphorylated target ribosomal protein S6 is significantly enhanced in the piglets,indicating that disruption of a TSC1 allele activate the mechanistic target of rapamycin(mTOR)signaling pathway.Notably,differing from the mouse TSC models reported previously,the TSC1^(+/−)Bama miniature pig developed cardiac rhabdomyoma and subependymal nodules,resembling the major clinical features that occur in patients with TSC.These TSC1^(+/−)Bama miniature pigs could serve as valuable large animal models for further elucidation of the pathogenesis of TSC and the development of therapeutic strategies for TSC disease. | Xiaoxue Li Tingdong Hu Jiying Liu Bin Fang Xue Geng Qiang Xiong Lining Zhang Yong Jin Xiaorui Liu Lin Li Ying Wang Rongfeng Li Xiaochun Bai Haiyuan Yang Yifan Dai | 2020 | Journal of Genetics and Genomics2020，47，12： | 2 |
| 19 | Structural geology and favorable exploration prospect belts in northwestern Sichuan Basin, SW China显示文摘The northwestern Sichuan region has experienced multi-stage tectonic evolution including marine cratonic basin from the Sinian to the Middle Triassic and intra-continental basin from the Late Triassic to the Cenozoic. Several regional tectonic activities caused complicated stratigraphic distribution and structural deformations in the deep-buried layers. During the key tectonic periods, some characteristic sedimentary and deformation structures were formed, including the step-shaped marginal carbonate platform of Dengying Formation, the western paleo-high at the end of Silurian, and the passive continental margin of the Late Paleozoic–Middle Triassic. The Meso-Cenozoic intra-continental compressional tectonic processes since the Late Triassic controlled the formation of complex thrusting structures surrounding and inside the northwestern basin. The northern Longmenshan fold-thrust belt has a footwall in-situ thrust structure,which is controlled by two sets of detachments in the Lower Triassic and Lower Cambrian and presents as a multi-level deformation structure with the shallow folds, the middle thin-skin thrusts and the deeper basement-involved folds. The thrust belt in front of the Micangshan Mountain shows a double-layer deformation controlled by the Lower Triassic salt detachment, which is composed by the upper monocline and deep-buried imbricate thrust structures. The interior of the basin is characterized by several rows of large-scale basement-involved folds with NEE strike direction. From the perspective of structural geology, the favorable exploration reservoirs and belts in northwestern Sichuan have obvious zoning characteristics. The favorable exploration layers of Dengying Formation of Upper Sinian are mainly distributed in the eastern and northern areas of the northwestern Sichuan Basin, in which the Jiulongshan structural belt, Zitong syncline and Yanting slope are the most favorable. The Lower Paleozoic was transformed by Caledonian paleo-uplift and late Cenozoic folding, and the midwest area such as the Zitong syncline is a potential area for hydrocarbon exploration. The favorable part of the Upper Paleozoic is mainly distributed in the northern Longmenshan belt and its frontal area, where the deep-buried thin-skin thrust structures in the footwall are the key exploration targets. | CHEN Zhuxin LI Wei WANG Lining LEI Yongliang YANG Guang ZHANG Benjian YIN Hong YUAN Baoguo | 2019 | Petroleum Exploration and Development2019，46，2： | 1 |
| 20 | Inclusion Complex of Trimethoprim with β-Cyclodextrin显示文摘 | LINing ZHANG Yun-hui WU Ya-nan | 2005 | Journal of Pharmaceutical and Biomedical Analysis2005，39，： | 1 |
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